Archives
#AHA21 – [News release – not published yet] RCT: Long-term, low-dose aspirin did not affect risk of dementia in adults with type 2 diabetes.
16 Nov, 2021 | 08:30h | UTCOriginal Study: Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes
#AHA21 – Among patients with intermittent atrial fibrillation, n-of-1 trials with 466 patients found alcohol, but not caffeine, increased the risk of atrial fibrillation events.
16 Nov, 2021 | 08:29h | UTCIndividualized Studies of Triggers of Paroxysmal Atrial Fibrillation: The I-STOP-AFib Randomized Clinical Trial – JAMA Cardiology (free for a limited period)
Commentary: Avoiding AF Triggers Doesn’t Improve Quality of Life: I-STOP-AFib – TCTMD
Commentary on Twitter
Study found randomization to N-of-1 trial #Afib trigger testing fails to improve QOL but reduces number of Afib episodes. Testing alcohol associated with more Afib, but caffeine is not https://t.co/LElYEBUEcs
— JAMA Cardiology (@JAMACardio) November 14, 2021
#AHA21 – M-A: Among patients with left main coronary disease, there was no statistically significant difference in 5-year all-cause death between percutaneous coronary intervention with drug-eluting stents vs. coronary artery bypass grafting.
16 Nov, 2021 | 08:31h | UTCPercutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting in left main coronary artery disease: an individual patient data meta-analysis – The Lancet (free registration required)
Commentary: No Mortality Difference Between PCI and CABG for Left Main PCI: Meta-analysis – TCTMD
Review: Treatment landscape of triple-negative breast cancer — expanded options, evolving needs.
16 Nov, 2021 | 08:23h | UTCTreatment landscape of triple-negative breast cancer — expanded options, evolving needs – Nature Reviews Clinical Oncology (free for a limited period)
Commentary on Twitter
A Review in @NatRevClinOncol describes the current and upcoming therapeutic landscape of triple-negative breast cancer. https://t.co/bcFTef01t1 pic.twitter.com/zFPyeeCnD5
— Nature Portfolio (@NaturePortfolio) November 15, 2021
Systematic Review: Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome.
16 Nov, 2021 | 08:25h | UTCSummary: Immunosuppressive treatment for adults with idiopathic membranous nephropathy – Cochrane Library
Original Study: Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome – Cochrane Library
M-A: Prediction of extubation outcome in critically ill patients.
16 Nov, 2021 | 08:27h | UTC
Review and algorithm: Dysphagia aortica.
16 Nov, 2021 | 08:19h | UTCDysphagia aortica – European Surgery
Review: Cardiac device troubleshooting in the intensive care unit.
16 Nov, 2021 | 08:21h | UTC
Commentary on Twitter
Cardiac device troubleshooting in the intensive care unit: an educational review by @JeroenDauw et al. in #EHJACVC on how to deal with common issues of pacemakers, implantable cardioverter-defibrillators, & cardiac resynchronization devices in the CICU https://t.co/CISh3QVH2E pic.twitter.com/vHnfGdq6gU
— European Society of Cardiology Journals (@ESC_Journals) November 15, 2021
Decarbonising healthcare in low and middle income countries: potential pathways to net zero emissions.
16 Nov, 2021 | 08:15h | UTC
Commentary on Twitter
Healthcare in low and middle income countries has a high carbon footprint. Reducing emissions should be integral to plans for universal health coverage, say @FRasheed2 and colleagues https://t.co/wO90qRFvS5 @jeromebaddley @PoornimaPrabha3 @MartenRobert @WISHQatar
— The BMJ (@bmj_latest) November 14, 2021
Review | Glycemic management in diabetes: old and new approaches.
16 Nov, 2021 | 08:17h | UTCGlycaemic management in diabetes: old and new approaches – The Lancet Diabetes & Endocrinology (free registration required)
Commentary on Twitter
New—Glycaemic management in #diabetes: old and new approaches https://t.co/fuONBq6Xyf #T1D #T2D #FREE to read with registration (also FREE) until 29-Nov pic.twitter.com/Zn1xdbRKld
— The Lancet Diabetes & Endocrinology (@TheLancetEndo) November 15, 2021
[Preprint] Risk of severe COVID-19 is rare among fully vaccinated individuals in England.
14 Nov, 2021 | 20:10h | UTCCommentary: Risk of severe COVID-19 is rare among fully vaccinated individuals in England – News Medical
Long-term outcomes of patients with active melanoma brain metastases treated with combination nivolumab plus ipilimumab.
16 Nov, 2021 | 08:14h | UTCLong-term outcomes of patients with active melanoma brain metastases treated with combination nivolumab plus ipilimumab (CheckMate 204): final results of an open-label, multicentre, phase 2 study – The Lancet Oncology (link to abstract – $ for full-text)
Original Study: Study: Combination Immunotherapy for Melanoma Brain Metastases
Podcast | Obstetrics for the Internist: What to Expect.
16 Nov, 2021 | 08:18h | UTC#305 OB for the Internist: What to Expect – The Curbsiders
Phase 4 RCT: Concomitant administration of COVID-19 vaccines (AstraZeneca or Pfizer) with seasonal influenza vaccines in adults is safe and preserves antibody responses to both vaccines.
14 Nov, 2021 | 20:14h | UTC
Large populational study finds prior SARS-CoV-2 infection reduces the risk of breakthrough infection following mRNA vaccination.
14 Nov, 2021 | 20:12h | UTCCommentaries:
Vaccine plus previous infection may offer enhanced COVID-19 protection – CIDRAP
Commentary on Twitter
Study found prior #SARSCoV2 infection was associated with lower risk for breakthrough infection among persons receiving the SARS-CoV-2 mRNA vaccines; however, the observational study design precludes direct comparison of infection risk btwn the 2 vaccines https://t.co/1RLuKSGPjy
— JAMA (@JAMA_current) November 1, 2021
Populational study in Qatar showed the effectiveness against SARS-CoV-2 Delta-induced severe, critical or fatal disease was 93.4% for the Pfizer vaccine and 96.1% for Moderna.
14 Nov, 2021 | 20:11h | UTC
Commentary on Twitter
A study in @NatureMedicine shows that mRNA COVID-19 vaccines are highly effective at preventing severe outcomes and death caused by the SARS-CoV-2 Delta variant in Qatar despite substantially lower effectiveness at blocking infection. https://t.co/V09Ma583fy pic.twitter.com/QG2HaDsrCo
— Nature Portfolio (@NaturePortfolio) November 4, 2021
What influences people’s responses to public health messages for managing risks and preventing infectious diseases? A rapid systematic review of the evidence and recommendations.
14 Nov, 2021 | 20:06h | UTC
Commentary on Twitter
COVID-19 messages should:
1) be developed with communities
2) address uncertainty immediately + with transparency
3) focus on unifying messages from sources
4) frame messages aimed at increasing understanding, social responsibility + ind control https://t.co/faxtAgngAI— Caroline Tomes FFPH (@carotomes) November 12, 2021
SARS-CoV-2 vaccines are safe and immunogenic in most people with cancer, according to study.
14 Nov, 2021 | 20:05h | UTCNews Release: SARS-CoV-2 vaccines are safe and immunogenic in most people with cancer, according to study – Harvard Medical School
Original study: Immunogenicity and Reactogenicity of SARS-CoV-2 Vaccines in Patients With Cancer: The CANVAX Cohort Study – Journal of Clinical Oncology
Commentary from the author on Twitter (thread – click for more)
The CANVAX study is out in @JCO_ASCO! https://t.co/WKrU6dQIEB
Grateful to >1000 CANVAX participants, study leads ( @JustinGainor, @MGHPathology, @BalazsLab) and so many co-authors incl. @arthur_kim_ID, @KimberlyBlumen1, @joanhowMD, @dradityabardia
Much more to come!— Vivek Naranbhai, MD, PhD, DPhil (@vivek_naranbhai) November 10, 2021
#AHA21 – RCT: Among children and adolescents who had screening echocardiograms and were identified as having latent rheumatic heart disease, secondary antibiotic prophylaxis with penicillin G benzathine for 2 years was associated with reduced echocardiographic progression (0.8 vs. 8.2% in the control group).
14 Nov, 2021 | 20:03h | UTCSecondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – American College of Cardiology
Commentaries on Twitter
One of most important studies ever Rheumatic Heart Disease @NEJM https://t.co/U8FuNHLqCJ RCT evidence 2ry prophylaxis reduces progression latent RhD pic.twitter.com/UycTElr7QM
— Michael Marks (@dr_michaelmarks) November 13, 2021
Penicillin slowed the devastating impact of rheumatic heart disease among children in Uganda. Findings of a large-scale, randomized controlled trial were completed in Uganda. Group A strep underlies rheumatic heart disease. New England Journal of Medicine https://t.co/1PKFJ12FvC
— delthia ricks 🔬 (@DelthiaRicks) November 13, 2021
#AHA21 – Pooled data from six prospective cohorts found higher sodium and lower potassium intakes were associated in a dose–response manner with a higher cardiovascular risk.
14 Nov, 2021 | 19:58h | UTC24-Hour Urinary Sodium and Potassium Excretion and Cardiovascular Risk – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Less sodium and more potassium could be key in lowering risk of cardiovascular disease – The Harvard Gazette
Related study: Cohort Study: Joint Association of Urinary Sodium and Potassium Excretion with Cardiovascular Events and Mortality
Commentary on Twitter
In a study involving 10,709 adults, higher sodium intake was significantly associated with higher cardiovascular risk in a dose–response manner with a daily sodium intake of approximately 2000 to 6000 mg. #AHA21 https://t.co/9LDWvDKeUU pic.twitter.com/28yK4mBfdH
— NEJM (@NEJM) November 13, 2021
Editorial: COVID is disrupting scientific careers around the world.
14 Nov, 2021 | 20:08h | UTCCOVID is disrupting scientific careers around the world – Nature
See also:
Scientists count the career costs of COVID – Nature
Potentially long-lasting effects of the pandemic on scientists – Nature
#AHA21 – RCT: Concomitant tricuspid repair in patients undergoing surgery for degenerative mitral regurgitation reduced tricuspid regurgitation progression but increased the need for permanent pacemaker implantation.
14 Nov, 2021 | 20:00h | UTCConcomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Tricuspid Repair During Mitral Surgery Slows Disease Progression at 2 Years – TCTMD
CTCR-MVS: Concomitant Tricuspid Repair in Patients With MR – American College of Cardiology
#AHA21 – RCT: In asymptomatic patients with severe aortic stenosis, early surgery improved outcomes compared to conservative treatment.
14 Nov, 2021 | 20:01h | UTCAortic Valve ReplAcemenT versus Conservative Treatment in Asymptomatic SeveRe Aortic Stenosis: The AVATAR Trial – Circulation (free for a limited period)
News release: Surgery to replace heart valve beneficial even with no symptoms of severe aortic stenosis – American Heart Association
Commentaries:
AVATAR Supports Early SAVR in Asymptomatic Severe AS Patients – TCTMD
Related study: #AHA19 – Randomized Trial: Early Surgery Improves Outcomes in Asymptomatic Patients with Very Severe Aortic Stenosis
Commentary on Twitter
#OriginalResearch SimPub#AHA21: The #AVATAR RCT of 157 patients with asymptomatic severe #AS and normal LVEF found that early #SAVR associated w/reduced composite outcome of death, MI, stroke or HF hospitalization compared to mgmt. https://t.co/SdMiWHOPnp #AHAJournals pic.twitter.com/jCcWVZfzse
— Circulation (@CircAHA) November 13, 2021
#AHA21 – RCT: Among patients undergoing cardiac surgery, routine posterior left pericardiotomy can prevent postoperative atrial fibrillation.
14 Nov, 2021 | 19:53h | UTCPosterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery: an adaptive, single-centre, single-blind, randomised, controlled trial – The Lancet (free registration required)
Commentaries:
A short cut to prevent postoperative atrial fibrillation – The Lancet (free registration required)
#AHA21 – [Not published Yet] A small, randomized study showed stopping ticagrelor only 2-3 days before bypass surgery may be safe.
14 Nov, 2021 | 19:56h | UTCCommentary: RAPID CABG: No Penalty to Early Surgery for ACS After Stopping Ticagrelor – TCTMD