Archives
A first, small study suggests Omicron is a larger threat to Covid-19 immunity than other variants.
8 Dec, 2021 | 10:22h | UTCOriginal Study: SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection – medRxiv
Commentary from the author on Twitter (thread – click for more)
We have completed our first experiments on neutralization of Omicron by Pfizer BNT162b2 vaccination elicited immunity
Manuscript available at https://t.co/rGaEB9GdmS
and should be available on medRxiv in the coming days
— Alex Sigal (@sigallab) December 7, 2021
See also (thread – click for more)
New work from AHRI's @sigallab strongly suggests that the SARS-CoV-2 #Omicron variant escapes antibody immunity induced by the Pfizer vaccine, but that considerable immunity is retained in people who were both vaccinated & previously infected. https://t.co/AZWi3qexin pic.twitter.com/3phPFyKEPh
— Africa Health Research Institute (@AHRI_News) December 7, 2021
RCT: In patients with severe Covid-19, high-flow oxygen therapy reduced the likelihood of invasive mechanical ventilation and decreased the time to clinical recovery compared to conventional oxygen therapy.
8 Dec, 2021 | 10:15h | UTCRelated:
Phase 2 RCT: Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule.
8 Dec, 2021 | 10:12h | UTCInvited Commentary: Booster doses for inactivated COVID-19 vaccines: if, when, and for whom – The Lancet Infectious Diseases
Video | COVID-19 Update: Omicron Variant.
8 Dec, 2021 | 10:09h | UTCCOVID-19 Update: Omicron Variant – JAMA
Beyond Omicron: what’s next for COVID’s viral evolution.
8 Dec, 2021 | 10:06h | UTCBeyond Omicron: what’s next for COVID’s viral evolution – Nature
AAN Practice Advisory: Antiseizure medication withdrawal in patients who are seizure-free.
8 Dec, 2021 | 09:59h | UTC
Prevention and management of hyperkalemia in patients treated with renin–angiotensin–aldosterone system inhibitors.
8 Dec, 2021 | 09:58h | UTC
Editorial: Omicron is bad, but the global response is worse – “The pandemic will not end while vaccine equity keeps getting pushed to the margins”.
8 Dec, 2021 | 10:07h | UTCOmicron is bad but the global response is worse – Nature
ESC Position Paper: Optimal follow-up after acute pulmonary embolism.
8 Dec, 2021 | 10:02h | UTC
Commentary on Twitter
Do you routinely discuss how/when to resume sporting activities and traveling with your PE patients? Or future cardiovascular risk? Check this recent ESC/ERS position paper on optimal follow-up of acute PE for these and other key aspects of counselling: https://t.co/KEQ7FnFwXX
— Erik Klok (@Erik_Klok_MD) December 7, 2021
Bronchiolitis: evidence and guidance for practice.
8 Dec, 2021 | 09:55h | UTCBronchiolitis: evidence and guidance for practice – Evidently Cochrane
Review: Perioperative pain management issues unique to older adults undergoing surgery.
8 Dec, 2021 | 09:52h | UTC
What Is of Recent Interest in Cardiac Imaging?: Insights From the JACC Family of Journals.
8 Dec, 2021 | 09:54h | UTC
Raising awareness for time-limited trial discussion upon ICU triage and admission.
8 Dec, 2021 | 09:57h | UTCRaising awareness for time-limited trial discussion upon ICU triage and admission – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Enhancing situational awareness/prompt time-limited trial discussion vs burden/harm of inappropriate #ICU admission
F functional impairment
R recurrent hospitalisations
A advanced malignancy/chronic diseases
I irreversible organ failure
L long 🏥 stayhttps://t.co/C3aR2lbZtt pic.twitter.com/IB0xjSGVup— Intensive Care Medicine (@yourICM) December 6, 2021
M-A: Efficacy and safety associated with immune checkpoint inhibitors in unresectable hepatocellular carcinoma.
8 Dec, 2021 | 09:48h | UTC
Commentary on Twitter
This meta-analysis of RCTs shows immune checkpoint inhibitors are associated with demonstrated the superior efficacy and safety of versus standard systemic therapies in patients with unresectable hepatocellular carcinoma. https://t.co/fJdFng69qH
— JAMA Network Open (@JAMANetworkOpen) December 6, 2021
Evaluation and management of pelvic organ prolapse.
8 Dec, 2021 | 09:50h | UTCEvaluation and Management of Pelvic Organ Prolapse – Mayo Clinic Proceedings
ESMO Clinical Practice Guideline update on the use of immunotherapy in early stage and advanced renal cell carcinoma.
8 Dec, 2021 | 09:45h | UTC
Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
8 Dec, 2021 | 09:47h | UTC
Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.
7 Dec, 2021 | 10:19h | UTCNews Release: Young people recover quickly from rare myocarditis side effect of COVID-19 vaccine – American Heart Association
Study shows increased immunogenicity of extended mRNA SARS-CoV-2 vaccine dosing intervals.
7 Dec, 2021 | 10:21h | UTCImmunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals – JAMA
Commentary on Twitter (thread – click for more)
1/ Not surprisingly, a longer delay between 1st & 2nd doses of mRNA COVID vaccines (i.e. 6-7 weeks rather than 3-4 weeks) results in better immune responses.https://t.co/XhiU6u0hYb
— Céline Gounder, MD, ScM, FIDSA 🇺🇦 (@celinegounder) December 3, 2021
The risk of postoperative complications following major elective surgery in active or resolved COVID-19 in the United States – Major, elective surgery 0–4 weeks after Covid-19 is associated with greatly increased risk of postoperative complications; surgery performed 4–8 weeks after infection is still associated with an increased risk of pneumonia.
7 Dec, 2021 | 10:23h | UTCRelated:
Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery
ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.
Position statement: Perioperative management of post-COVID-19 surgical patients.
The world has the tools to end the coronavirus pandemic. They’re not being used properly.
7 Dec, 2021 | 10:15h | UTCThe world has the tools to end the coronavirus pandemic. They’re not being used properly – CNN
Care of older people and people requiring palliative care with COVID-19: guidance from the Australian National COVID-19 Clinical Evidence Taskforce.
7 Dec, 2021 | 10:12h | UTC
WHO Report: More malaria cases and deaths in 2020 linked to COVID-19 disruptions.
7 Dec, 2021 | 08:55h | UTCNews Release: More malaria cases and deaths in 2020 linked to COVID-19 disruptions – World Health Organization
Report: World Malaria Report 2021 – World Health Organization
Commentaries:
More people died of malaria in 2020 than in 2019. Here’s why – NPR
Malaria kills 180,000 more people annually than previously thought, says WHO – The Guardian
Commentary on Twitter (thread – click for more)
#COVID19 pandemic has disrupted #malaria services, leading to a marked increase in cases and deaths: 14 million more cases in 2020 compared to 2019, and 69,000 more deaths – new report.
➡️https://t.co/M9sNo2Pn4u #EndMalaria pic.twitter.com/g6MKFVpQKf— World Health Organization (WHO) (@WHO) December 6, 2021
Perspective | ‘It’s misinformation at worst.’ Weak health studies can do more harm than good, scientists say.
7 Dec, 2021 | 10:17h | UTC
Review of 4,470 cases of Multisystem Inflammatory Syndrome in Children in the US.
7 Dec, 2021 | 10:08h | UTCRelated:
An Update on Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2.
Ten Things to Know About Multisystem Inflammatory Syndrome in Children (MIS-C).
Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.
Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.
Clinical Update: Acute covid-19 and multisystem inflammatory syndrome in children
Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)
SR: Multisystem inflammatory syndrome in children related to COVID-19