Archives
RCT: Prophylactic Use of Compression Sleeves Reduces the Incidence of Arm Swelling in Women at High Risk of Breast Cancer–Related Lymphedema.
4 Feb, 2022 | 08:35h | UTC
Review: Extraosseous calcification in kidney disease.
4 Feb, 2022 | 08:40h | UTCExtraosseous calcification in kidney disease – Cleveland Clinic Journal of Medicine
Geriatric Choosing Wisely choice of recommendations in France: a pragmatic approach based on clinical audits.
4 Feb, 2022 | 08:46h | UTCSee complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Soft tissue sarcoma: Recognizing a rare disease.
4 Feb, 2022 | 08:41h | UTCSoft tissue sarcoma: Recognizing a rare disease – Cleveland Clinic Journal of Medicine
Five-Year Survival Outcomes From the PACIFIC Trial: Durvalumab After Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer.
4 Feb, 2022 | 08:38h | UTCOriginal Study: Randomized Trial: Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC
ESSM Position Statement: Sexual Wellbeing After Gender Affirming Surgery.
4 Feb, 2022 | 08:34h | UTCESSM Position Statement “Sexual Wellbeing After Gender Affirming Surgery” – Sexual Medicine
Hyaluronic acid injections have increased for knee arthritis in the US, despite guideline recommendations against their use.
4 Feb, 2022 | 08:32h | UTCHyaluronic Acid Injections for Knee Osteoarthritis: Has Utilization Among Medicare Beneficiaries Changed Between 2012 and 2018? – The Journal of Bone & Joint Surgery (link to abstract – $ for full-text)
News Release: Hyaluronic acid injections have increased for knee arthritis – despite recommendations against their use
Related Guideline: Treatment of Osteoarthritis of the Knee: Evidence-Based Guideline, 2nd Edition – Journal of the American Academy of Orthopaedic Surgeons
Podcast: Infective Endocarditis Pearls.
4 Feb, 2022 | 08:27h | UTCInfective Endocarditis Pearls – The Curbsiders
Viewpoint: social media and the transformation of the physician-patient relationship.
4 Feb, 2022 | 08:28h | UTC
Study showed aminotransferase levels are often unremarkable in patients with alcohol-related cirrhosis and have a poor correlation with complications or death.
4 Feb, 2022 | 08:30h | UTCNormal or Near Normal Aminotransferase Levels in Patients with Alcoholic Cirrhosis – American Journal of Medical Sciences (link to abstract – $ for full-text)
First patients vaccinated in clinical trial of HIV experimental vaccine that uses Moderna’s mRNA technology.
4 Feb, 2022 | 08:25h | UTC
Perspective: What’s next for digital mental health companies?
4 Feb, 2022 | 08:24h | UTCWhat’s next for digital mental health companies? – STAT
An observational study including 15.670 people using methotrexate and 2.689 using leflunomide showed the incidences of discontinuation related to cytopenia, liver enzyme elevation, or kidney function decline.
4 Feb, 2022 | 08:21h | UTC
Psychosis in systemic lupus erythematosus (SLE): a 40-year experience of a specialist center showed most patients (66.7%) had full remission with a combination of antipsychotics and immunosuppressive therapy.
4 Feb, 2022 | 08:20h | UTC
Thrombolytic use for STEMI: what ED clinicians should know.
4 Feb, 2022 | 08:23h | UTCThrombolytic Use for STEMI: What ED Clinicians Should Know – emDocs
[Preprint] Results from the first Covid-19 human challenge study (deliberately infecting individuals in a controlled environment).
3 Feb, 2022 | 09:48h | UTCSafety, tolerability and viral kinetics during SARS-CoV-2 human challenge – Research Square
Commentaries:
Scientists deliberately gave people COVID — here’s what they learnt – Nature
First COVID-19 human challenge study yields infection clues – CIDRAP
Exposure to one nasal droplet enough for Covid infection – study – The Guardian
Related:
World’s first coronavirus “Human Challenge” study receives ethics approval in the UK (several texts on the subject) Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.
Perspective: Challenges in inferring intrinsic severity of the SARS-CoV-2 Omicron variant.
3 Feb, 2022 | 09:58h | UTCChallenges in Inferring Intrinsic Severity of the SARS-CoV-2 Omicron Variant – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Omicron’s spread in South Africa has led to fewer hospitalizations and deaths than were seen during previous waves. But caution is warranted when it comes to making inferences about omicron’s intrinsic severity using population-level observations. #COVID19 https://t.co/xVb3tm8juc pic.twitter.com/HwNVvb5zpC
— NEJM (@NEJM) February 2, 2022
[Preprint] SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.
3 Feb, 2022 | 09:50h | UTCSARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters – Nature
See also: [Preprint] Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron – Nature
Commentary: Omicron causes less severe illness in animal models than previous variants – University of Wisconsin–Madison
Commentary on Twitter
Two reports @nature today for decreased pathogenicity of Omicron in experimental models cf prior variants, now 8 studies all concordant, summarized herehttps://t.co/1dVXE1eRkNhttps://t.co/E8PJylfwp0 pic.twitter.com/c3gqi9MhID
— Eric Topol (@EricTopol) January 21, 2022
Consensus Statement: Preoperative management of medications for psychiatric diseases.
3 Feb, 2022 | 09:59h | UTC
Cohort Study: In high-transmission settings, the use of malaria-preventing mosquito nets in early childhood was associated with increased survival decades later.
3 Feb, 2022 | 08:56h | UTCCommentaries:
Malaria-preventing bed nets save children’s lives—with impacts that can last for decades – Science
Mosquito nets in young children save lives into adulthood – University of Basel
RCT: In patients with advanced esophageal squamous-cell carcinoma, both nivolumab plus chemotherapy and nivolumab plus ipilimumab resulted in longer overall survival than chemotherapy alone.
3 Feb, 2022 | 09:46h | UTCNivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary (2021 ASCO Annual Meeting): Nivolumab Plus Chemotherapy and Nivolumab Plus Ipilimumab as First-Line Treatment for Patients With Advanced Esophageal Cancer – The ASCO Post
Commentary on Twitter
First-line treatment of advanced esophageal squamous-cell carcinoma with either nivolumab plus chemo or nivolumab plus ipilimumab resulted in a significant overall survival benefit and durable responses as compared with chemo alone. https://t.co/a000bDsh1N pic.twitter.com/NuY2eX58gp
— NEJM (@NEJM) February 2, 2022
Omicron’s sister variant spreads faster. So why did the one we call Omicron hit first?
3 Feb, 2022 | 08:54h | UTCOmicron’s sister variant spreads faster. So why did the one we call Omicron hit first? – STAT
Related:
BA.2 is like Omicron’s sister. Here’s what we know about it so far – The Conversation
Perspective: The origins, development, and context of the Lancet Commission on the Value of Death – “Death has turned from being a family, social, and cultural event to primarily a medical event”.
3 Feb, 2022 | 08:51h | UTCThe origins, development, and context of the Lancet Commission on the Value of Death – The BMJ
Cluster randomized controlled trial: An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients.
3 Feb, 2022 | 08:53h | UTCRelated:
The “Choosing Wisely” initiative in infectious diseases – German Society of Infectious Diseases (link to abstract – $ for full-text)
Infectious Diseases Society of America: Five Things Physicians and Patients Should Question
Guideline: atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS).
3 Feb, 2022 | 08:48h | UTC