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RCT: In patients with cardiogenic shock receiving VA-ECMO, moderate hypothermia did not significantly reduce 30-day mortality. 42% of patients in the moderate hypothermia group died vs. 51% in the normothermia group (adjusted odds ratio, 0.71 [95% CI, 0.45 to 1.13], P = .15).

13 Feb, 2022 | 22:11h | UTC

Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Hypothermia vs. Normothermia for Cardiogenic Shock Patients on VA-ECMO – American College of Cardiology

Commentary on Twitter

In this RCT, for patients with cardiogenic shock receiving venoarterial ECMO, moderate hypothermia for 24 hours compared with normothermia did not significantly decrease 30-day mortality. https://t.co/0LKYJ1bNB3 pic.twitter.com/KmXPAlvqh9

— JAMA (@JAMA_current) February 2, 2022

RCT: In patients with contaminated ventral hernias undergoing repair, synthetic Mesh reduced hernia recurrence risk compared with biologic Mesh.

13 Feb, 2022 | 22:05h | UTC

Biologic vs Synthetic Mesh for Single-stage Repair of Contaminated Ventral Hernias: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)

Commentary on Twitter

Multicenter randomized clinical trial found synthetic mesh demonstrated significantly lower hernia recurrence risk than biologic mesh in patients undergoing single-stage repair of clean-contaminated and contaminated ventral hernias. https://t.co/CADZPSYGBc

— JAMA Surgery (@JAMASurgery) January 19, 2022

Opinion | There’s no autism epidemic. But there is an autism diagnosis epidemic.

13 Feb, 2022 | 22:02h | UTC

There’s no autism epidemic. But there is an autism diagnosis epidemic – STAT

Opinion: Time to retire the concept of Transient Ischemic Attack.

13 Feb, 2022 | 22:01h | UTC

Time to Retire the Concept of Transient Ischemic Attack – JAMA (free for a limited period)

Commentary on Twitter

After spending my entire career studying TIAs, Don Easton and I are recommending we retire the term. It isn't clear that TIAs ever existed, at least as they were conceptualized. Rise up Acute Ischemic Cerebrovascular Event/Syndrome. https://t.co/FeG31pPHey

— Clay Johnston (@ClayJohnstonMD) February 11, 2022

Sleep assessment in critically ill adults: established methods and emerging strategies.

13 Feb, 2022 | 21:55h | UTC

Sleep Assessment in Critically Ill Adults: Established Methods and Emerging Strategies – Critical Care Explorations

Commentary on Twitter

#CritCareExplore @SCCM Critically ill patients sleep poorly while in the ICU with potential implications for several important outcomes. This review summarizes both current methods and new strategies to measure sleep in these challenging environments. https://t.co/2jtpHe4MKp pic.twitter.com/c5jnqwR3Mh

— Critical Care Explorations (@CritCareExplore) February 12, 2022

Study shows a lack of association of Group A Streptococcal infections and onset of tics.

13 Feb, 2022 | 22:04h | UTC

Lack of Association of Group A Streptococcal Infections and Onset of Tics: European Multicenter Tics in Children Study – Neurology (link to abstract – $ for full-text)

News Release: Does strep throat lead to the development of tics? – American Academy of Neurology

Commentaries:

Strep Does Not Lead to Tics, Study Finds – NeurologyToday

Group A Strep Infection Not Tied to Tics in Children With Family History – HealthDay

Commentary on Twitter

https://twitter.com/ChristosGanos/status/1491415406418231300

Review: Management of venous thromboembolism in pregnancy.

13 Feb, 2022 | 21:57h | UTC

Management of venous thromboembolism in pregnancy – Thrombosis Research

Management of high-risk pulmonary embolism in pregnancy.

Study: Diagnosis of Pulmonary Embolism During Pregnancy

Imaging is the only way to diagnose blood clots in pregnancy

Prevention and Treatment of Pregnancy-Associated Venous Thromboembolism: Critical Appraisal of International Guidelines

ED management of the post-laryngectomy patient.

13 Feb, 2022 | 21:44h | UTC

ED Management of the Post-Laryngectomy Patient – emDocs

Review: Global accessibility of therapeutics for diabetes mellitus.

13 Feb, 2022 | 21:51h | UTC

Global accessibility of therapeutics for diabetes mellitus – Nature Reviews Endocrinology (if the link is paywalled, try this one)

New WHO report maps barriers to insulin availability and suggests actions to promote universal access – “100 years after its discovery, insulin still out of reach for many living with diabetes”.

Editorial | Insulin for all: a hope yet to be realized.

One hundred years of insulin therapy.

The state of diabetes treatment coverage in 55 low-income and middle-income countries – fewer than one in ten people with diabetes in LMICs receive comprehensive care such as low-cost medicines to reduce blood sugar, blood pressure and cholesterol levels, in addition to counseling on diet, exercise and weight.

Betibeglogene Autotemcel gene therapy for Non–beta0/beta0 Genotype beta-thalassemia.

13 Feb, 2022 | 21:46h | UTC

Betibeglogene Autotemcel Gene Therapy for Non–β⁰/β⁰ Genotype β-Thalassemia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary on Twitter

Visual Abstract: Betibeglogene Autotemcel Gene Therapy for Non–β0/β0 Genotype β-Thalassemia. https://t.co/2GOCGxrruv pic.twitter.com/zLvuuuByXN

— NEJM (@NEJM) February 8, 2022

Aromatase inhibitors vs. tamoxifen in premenopausal women with estrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomized trials

13 Feb, 2022 | 21:32h | UTC

Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials – The Lancet Oncology

Commentaries:

Aromatase Inhibitors May Benefit Premenopausal Women With Breast Cancer – HealthDay

Aromatase inhibitors are better than tamoxifen at reducing the risk of breast cancer recurrence in premenopausal as well as postmenopausal women – Cancer Research UK

Guideline for the management Herpes Simplex 1 and cosmetic interventions.

13 Feb, 2022 | 21:41h | UTC

Guideline for the Management Herpes Simplex 1 and Cosmetic Interventions – The Journal of Clinical and Aesthetic Dermatology

Guideline for the prevention, diagnosis, and management of acute bacterial soft tissue infections following nonsurgical cosmetic procedures.

13 Feb, 2022 | 21:40h | UTC

Guideline for the Prevention, Diagnosis, and Management of Acute Bacterial Soft Tissue Infections Following Nonsurgical Cosmetic Procedures – The Journal of Clinical and Aesthetic Dermatology

IDSA guidance and ESCMID guidelines: complementary approaches toward a care standard for MDR Gram-negative infections.

11 Feb, 2022 | 08:51h | UTC

IDSA guidance and ESCMID guidelines: complementary approaches toward a care standard for MDR Gram-negative infections – Clinical Microbiology and Infection

Original Guidelines:

European guidelines for the treatment of infections caused by Multidrug-resistant Gram-negative bacilli.

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.

Consensus opinion for the management of soft tissue filler induced vision loss.

13 Feb, 2022 | 21:36h | UTC

Consensus Opinion for The Management of Soft Tissue Filler Induced Vision Loss – The Journal of Clinical and Aesthetic Dermatology

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

11 Feb, 2022 | 08:53h | UTC

News Release: How does cannabis use affect brain health? Caution advised, more research needed – American Heart Association

Original Statement: Use of Marijuana: Effect on Brain Health: A Scientific Statement From the American Heart Association – Stroke

Commentary on Twitter

Use of Marijuana: Effect on Brain Health: A Scientific Statement From the American Heart Association #BrainHealth #ISC22 #AHAJournals https://t.co/LoGbVRfzf4 @American_Heart pic.twitter.com/DyNbFzA0Lw

— Stroke AHA/ASA (@StrokeAHA_ASA) February 10, 2022

RCT: Trametinib improves progression-free survival compared to standard of care in patients with recurrent low-grade serous ovarian cancer.

13 Feb, 2022 | 21:30h | UTC

Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): an international, randomised, open-label, multicentre, phase 2/3 trial – The Lancet

News Release: Trametinib represents potential new standard-of-care for patients with recurrent low-grade serous ovarian carcinoma – M. D. Anderson Cancer Center

Commentary on Twitter

Trial findings suggest MEK inhibitor, trametinib, represents new standard-of-care option for patients with recurrent low-grade serous carcinoma. https://t.co/69glZZdrZF pic.twitter.com/UHeccCj1Rn

— The Lancet (@TheLancet) February 10, 2022