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Review: Classic and exertional heatstroke.

15 Feb, 2022 | 08:43h | UTC

Classic and exertional heatstroke – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Systematic Review: Arthroplasties for hip fracture in adults.

15 Feb, 2022 | 08:41h | UTC

Arthroplasties for hip fracture in adults – Cochrane Library

Summary: Hip replacement surgery in adults – Cochrane Library

Author Interview: Interview with authors of Hip Fracture reviews  – Cochrane Library

 

A large cohort of patients with nephrotic syndrome showed the risk of arterial thromboembolism (HR = 3.11), venous thromboembolism (HR = 7.11), and bleeding (HR = 4.02) was greatly increased after adjusting for confounders.

15 Feb, 2022 | 08:47h | UTC

Risk of arterial thromboembolism, venous thromboembolism, and bleeding in patients with nephrotic syndrome: A population-based cohort study – American Journal of Medicine (link to abstract – $ for full-text)

 

Data Review: How many people die from air pollution?

15 Feb, 2022 | 08:37h | UTC

Data Review: How many people die from air pollution? – Our World in Data

Related:

New WHO Global Air Quality Guidelines aim to save millions of lives from air pollution.

Short-term exposure to ambient air pollution is associated with increased risk of myocardial infarction mortality

1.8 million excess deaths attributable to urban air pollution in 2019, modelling study suggests.

Internalising health-economic impacts of air pollution into climate policy: a global modelling study – The Lancet Planetary Health

Air Pollution Associated with New Causes of Hospital Admissions

Ambient Particulate Air Pollution and Daily Mortality in 652 Cities

Air Pollution and Estimated Life Expectancy Loss

 

A clinician’s guide to Artificial Intelligence (AI): why and how primary care should lead the health care AI revolution.

15 Feb, 2022 | 08:38h | UTC

A Clinician’s Guide to Artificial Intelligence (AI): Why and How Primary Care Should Lead the Health Care AI Revolution – The Journal of the American Board of Family Medicine

Related:

Primer for artificial intelligence in primary care.

A Clinician’s Guide to Artificial Intelligence: How to Critically Appraise Machine Learning Studies

Review | AI and the cardiologist: when mind, heart and machine unite.

Review: Artificial intelligence in health and medicine.

Artificial intelligence projects in healthcare: 10 practical tips for success in a clinical environment.

WHO issues first global report on Artificial Intelligence (AI) in health and six guiding principles for its design and use.

Opinion | AI-facilitated health care requires education of clinicians

Welcoming new guidelines for AI clinical research

 

Why randomized controlled trials matter and the procedures that strengthen them.

15 Feb, 2022 | 08:39h | UTC

Why randomized controlled trials matter and the procedures that strengthen them – Our World in Data

 

Ending the evidence gap for pregnancy, HIV and co-infections: ethics guidance from the PHASES project.

15 Feb, 2022 | 08:35h | UTC

Ending the evidence gap for pregnancy, HIV and co-infections: ethics guidance from the PHASES project – Journal of the International AIDS Society

 

Cluster RCT: An educational safety-promoting program in neonatal intensive care units reduced the rate of adverse events.

15 Feb, 2022 | 08:27h | UTC

An educational programme in neonatal intensive care units (SEPREVEN): a stepped-wedge, cluster-randomised controlled trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

M-A: Single antiplatelet therapy should be used after transcatheter aortic valve implantation in patients without indication for anticoagulation.

15 Feb, 2022 | 08:32h | UTC

Comparing Single- and Dual-Antiplatelet Therapies After Transcatheter Aortic Valve Implantation – The Annals of Thoracic Surgery (link to abstract – $ for full-text)

Related:

M-A: Aspirin alone better than dual antiplatelet therapy after transcatheter aortic valve implantation

#ESCCongress – [Abstract Only] Randomized trial: aspirin with or without clopidogrel after transcatheter aortic-valve implantation

#ACC21 – [Not published yet] RCT: Among patients undergoing TAVR, full-dose apixaban is not superior to standard of care (vitamin K antagonist if indication for oral anticoagulation; antiplatelet therapy if no indication).

#AHA19 – [Abstract Only] Randomized Trial: An Antiplatelet-based Strategy is Associated with Better Outcomes vs. Anticoagulation After Transcatheter Aortic-Valve Replacement

 

Efficacy, durability, and safety of intravitreal Faricimab up to every 16 weeks for neovascular age-related macular degeneration: two randomized, double-masked, phase 3, non-inferiority trials.

15 Feb, 2022 | 08:29h | UTC

Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials – The Lancet (link to abstract – $ for full-text)

Commentary: Trials Show Promise for Intravitreal Faricimab in Retinal Disease – HealthDay

 

Futility in Transcatheter Aortic Valve Implantation: A Search for Clarity.

15 Feb, 2022 | 08:26h | UTC

Futility in Transcatheter Aortic Valve Implantation: A Search for Clarity – Interventional Cardiology

Related: Predictors and clinical outcomes of poor symptomatic improvement after transcatheter aortic valve replacement – Editorial: Transcatheter aortic valve replacement: when should we say no?

 

Pfizer and FDA pull back from plan to expedite review of Covid-19 vaccine in children under 5.

13 Feb, 2022 | 22:51h | UTC

Pfizer and FDA pull back from plan to expedite review of Covid-19 vaccine in young children – STAT

See also:

COVID-19 vaccine for kids under 5 delayed as Pfizer extends trial – CIDRAP

Pfizer postpones FDA request for Covid vaccine for kids under 5 – NBC News

 

WHO’s new International Classification of Diseases (ICD-11) comes into effect.

13 Feb, 2022 | 22:56h | UTC

News Release: WHO’s new International Classification of Diseases (ICD-11) comes into effect – World Health Organization

See also:

ICD-11 Browser

ICD-11 website

ICD-11 coding tool

 

Commentary on Twitter

 

Novavax says protein vaccine works for kids as young as 12.

13 Feb, 2022 | 22:54h | UTC

Novavax says protein vaccine works for kids as young as 12 – Associated Press

Press Release: Novavax Announces Positive Results of COVID-19 Vaccine in Pediatric Population of PREVENT-19 Phase 3 Clinical Trial

Related:

Randomized trial with nearly 30.000 individuals showed Novavax vaccine was safe and had an overall efficacy of 90.4% against symptomatic infections.

RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths.

Opinion | The mRNA vaccines are extraordinary, but Novavax is even better.

(Press release – not published yet) Novavax COVID-19 vaccine demonstrates 90% overall efficacy and 100% protection against moderate and severe disease.

RCT: Novavax vaccine is 49.4% effective against B.1.351 SARS-CoV-2 variant.

[Press release – not published yet] Novavax reports 96% efficacy against original strain of COVID-19, 86% efficacy against B.1.1.7 variant, and 55% efficacy against B1.351 variant

New COVID-19 vaccines: here’s how the promising Novavax and Johnson & Johnson jabs work

Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant

 

Covid-19: What do we know about omicron sublineages?

13 Feb, 2022 | 22:42h | UTC

Covid-19: What do we know about omicron sublineages? – The BMJ

Related:

We regret to inform you that we are now discussing subvariants – Vox

Sudden rise of more transmissible form of Omicron catches scientists by surprise.

Omicron’s sister variant spreads faster. So why did the one we call Omicron hit first?

[Preprint] Study suggests SARS-CoV-2 Omicron subvariants BA.2 is even more transmissible than the original variant.

BA.2 is like Omicron’s sister. Here’s what we know about it so far – The Conversation

 

Commentary on Twitter

 

Conflicting reports raise questions about whether any monoclonals work against Omicron’s sister variant.

13 Feb, 2022 | 22:49h | UTC

Conflicting reports raise questions about whether any monoclonals work against Omicron’s sister variant – STAT

Related:

FDA halts use of antibody drugs that don’t work vs. Omicron.

Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

 

ERS statement on Long COVID-19 follow-up.

13 Feb, 2022 | 22:48h | UTC

European Respiratory Society Statement on Long COVID-19 Follow-Up – European Respiratory Review

 

First research definition for ‘Long COVID’ in kids and young people formally agreed.

13 Feb, 2022 | 22:45h | UTC

News Release: First research definition for ‘Long COVID’ in kids and young people formally agreed – BMJ

Original Article (preprint): Long COVID (Post-COVID-19 condition) in Children: a modified Delphi Process – Archives of Disease in Childhood

Commentaries:

Expert reaction to Delphi consensus study on a long-COVID definition in children – Science Media Centre

Long covid: “Holistic” approach is best, given range of symptoms, say researchers – The BMJ

Related:

Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

 

Special Issue: Evidence-based strategies for better antibiotic prescribing in primary care.

13 Feb, 2022 | 22:40h | UTC

Editorial: Antibiotic stewardship – Australian Journal of General Practice

Antibiotic stewardship: A review of successful, evidence-based primary care strategies – Australian Journal of General Practice

Evidence-based strategies for better antibiotic prescribing – Australian Journal of General Practice

How can general practitioners reduce antibiotic prescribing in collaboration with their patients? – Australian Journal of General Practice

 

RCT: Effects of a 6-month, low-carbohydrate diet on glycemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes.

13 Feb, 2022 | 22:35h | UTC

Effects of a 6-month, low-carbohydrate diet on glycaemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes: An open-label randomized controlled trial – Diabetes, Obesity and Metabolism

 

RCT: Primary Norfloxacin prophylaxis prevents bacterial infections in patients with acute-on-chronic liver failure.

13 Feb, 2022 | 22:37h | UTC

Primary Norfloxacin Prophylaxis for APASL-Defined Acute-on-Chronic Liver Failure: A Placebo-Controlled Double-Blind Randomized Trial – The American Journal of Gastroenterology (link to abstract – $ for full-text)

 

WHO Guideline: Hypertension pharmacological treatment in adults.

13 Feb, 2022 | 22:23h | UTC

Hypertension Pharmacological Treatment in Adults: A World Health Organization Guideline Executive Summary – Hypertension

 

2022 SCCM Guidelines on prevention and management of pain, agitation, neuromuscular blockade, and delirium in critically ill pediatric patients with consideration of the ICU environment and early mobility.

13 Feb, 2022 | 22:19h | UTC

2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility – Pediatric Critical Care Medicine

 

Commentary on Twitter

 

AAST Consensus: Rhabdomyolysis.

13 Feb, 2022 | 22:21h | UTC

Rhabdomyolysis: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document – Trauma Surgery & Acute Care Open

 

FIMS / EFSMA Joint position statement on the International Olympic Committee framework on fairness, inclusion and non-discrimination based on gender identity and sex variations.

13 Feb, 2022 | 22:17h | UTC

Joint position statement of the International Federation of Sports Medicine (FIMS) and European Federation of Sports Medicine Associations (EFSMA) on the IOC framework on fairness, inclusion and non-discrimination based on gender identity and sex variations – BMJ Open Sport & Exercise Medicine

Original Guidance: IOC Framework on fairness, inclusion and non-discrimination on the basis of gender identity and sex variations – International Olympic Committee

Commentary: International Olympic Committee transgender guidance criticised by medical experts – BBC

 

Commentary on Twitter

 

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