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In patients with resectable NSCLC, neoadjuvant nivolumab plus chemo results in longer event-free survival and a greater likelihood of pathological complete response than chemo alone. #AACR22 https://t.co/ILjdRZQ7dJ pic.twitter.com/1JfiUw18R6

— NEJM (@NEJM) April 11, 2022

COVID-19 disease severity in children infected with the Omicron variant.

12 Apr, 2022 | 09:47h | UTC

COVID-19 Disease Severity in Children Infected with the Omicron Variant – Clinical Infectious Diseases

Commentary on Twitter

COVID-19 Disease Severity in Children Infected with Omicron
Among Delta infected
84.2% had mild
15.7% had moderate
0.1% had severe/critical disease
Among Omicron infected
97.8% had mild
2.2% had moderate
None had severe/critical disease (P < .001 https://t.co/ZHhVpY8LuG

— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 11, 2022

M-A: The clinical effect and safety of new preoperative fasting time guidelines for elective surgery.

12 Apr, 2022 | 09:51h | UTC

The clinical effect and safety of new preoperative fasting time guidelines for elective surgery: a systematic review and meta-analysis – Gland Surgery

An international multidisciplinary consensus statement on fasting before procedural sedation in adults and children – Anaesthesia

Does my hospitalized patient need an NPO-after-midnight order preoperatively?

ESPEN practical guideline: Clinical nutrition in surgery – “Preoperative fasting from midnight is unnecessary in most patients. Patients undergoing surgery, who are considered to have no specific risk of aspiration, shall drink clear fluids until 2 h before anesthesia. Solids shall be allowed until 6 h before anesthesia.”

Pro-Con Debate: 1- vs 2-Hour Fast for Clear Liquids Before Anesthesia in Children.

Editorial: The rationale for the recommendations of the European Pediatric Fasting Guideline – “the authors of the 2021 ESAIC pediatric guideline have found reasons to recommend reductions to the minimum fasting times for infant formula to 4 h, for breast milk to 3 h and for clear fluids to 1 h”.

Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: Application to Healthy Patients Undergoing Elective Procedures: An Updated Report by the American Society of Anesthesiologists Task Force on Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration

Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology

Clear fluids fasting for elective paediatric anaesthesia: The European Society of Anaesthesiology consensus statement – European Journal of Anaesthesiology

Canadian Pediatric Anesthesia Society statement on clear fluid fasting for elective pediatric anesthesia – Canadian Journal of Anesthesia (free)

M-A of randomized controlled trials: Intrathoracic vs. cervical anastomosis in esophagectomy for esophageal cancer.

12 Apr, 2022 | 08:47h | UTC

Intrathoracic versus cervical anastomosis in esophagectomy for esophageal cancer: A meta-analysis of randomized controlled trials – Surgery

Aspirin for primary cardiovascular prevention in patients with diabetes: uncertainties and opportunities.

12 Apr, 2022 | 08:45h | UTC

Aspirin for Primary Cardiovascular Prevention in Patients with Diabetes: Uncertainties and Opportunities – Thrombosis and Haemostasis

Related Guideline:

USPSTF draft statement revises previous guidance and now recommends against initiating low-dose aspirin use for the primary prevention of CVD in adults aged 60 years or older.

Related Randomized Trials:

Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease

Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

Related Meta-Analysis:

Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events

Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine

Related Opinions:

Aspirin for Primary Prevention: Is This the End of the Road?

Evidence evolving on aspirin as prevention – ACP Internist

Empyema: ED presentation, evaluation, and management.

12 Apr, 2022 | 08:44h | UTC

Empyema: ED Presentation, Evaluation, and Management – emDocs

Editorial | Who? When? Where? How? Still the alpha and omega of extracorporeal cardiopulmonary resuscitation.

12 Apr, 2022 | 08:49h | UTC

Who? When? Where? How? Still the alpha and omega of extracorporeal cardiopulmonary resuscitation – European Heart Journal. Acute Cardiovascular Care

Original Study: The association between time to extracorporeal cardiopulmonary resuscitation and outcome in patients with out-of-hospital cardiac arrest – European Heart Journal. Acute Cardiovascular Care (link to abstract – $ for full-text)

RCT: In patients with refractory out-of-hospital cardiac arrest, a strategy of intra-arrest transport, extracorporeal cardiopulmonary resuscitation, and immediate invasive assessment did not significantly improve survival with a favorable neurological outcome (OR 1.63; 95% CI 0.93 to 2.85; P = .09).

Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications.

Guidelines for extracorporeal cardiopulmonary resuscitation in children and adults

Commentary on Twitter

Focus on eCPR-Who? When? Where? How? Excellent editorial by Prof A. Combes in #EHJACVC https://t.co/VJy8X09wb6 @drmilicaa @krychtiukmd @EHJACVCEiC @JohannesGrand @rafavidalperez @ACVCPresident @cvrints @umityasarsinan1 @JasonKatzMD @susannaprice @mrubini pic.twitter.com/mf085I13dc

— European Society of Cardiology Journals (@ESC_Journals) April 11, 2022