Archives

Cohort Study: Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA.

22 Jun, 2022 | 12:07h | UTC

Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA: a cohort study in claims databases – The Lancet

Commentaries:

COVID-19 mRNA vaccination and myocarditis or pericarditis – The Lancet

Myocarditis and Pericarditis After the COVID-19 mRNA Vaccination – American College of Cardiology

Related:

SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort Study of 23 Million Residents – JAMA Cardiology

Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals – UK Health Security Agency

Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

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Review: SARS-CoV-2 infection and COVID-19 vaccination in pregnancy.

22 Jun, 2022 | 12:09h | UTC

SARS-CoV-2 infection and COVID-19 vaccination in pregnancy – Nature Reviews Immunology

 

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Review: Sex differences in sequelae from COVID-19 infection and in long COVID syndrome.

22 Jun, 2022 | 12:06h | UTC

Sex differences in sequelae from COVID-19 infection and in long COVID syndrome: a review – Current Medical Research and Opinion

Commentary: Women more likely to have long COVID, different symptom profile – CIDRAP

 

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Guidelines for the use of cardiac magnetic resonance in pediatric congenital and acquired heart disease.

22 Jun, 2022 | 11:31h | UTC

Society for Cardiovascular Magnetic Resonance/European Society of Cardiovascular Imaging/American Society of Echocardiography/Society for Pediatric Radiology/North American Society for Cardiovascular Imaging Guidelines for the Use of Cardiac Magnetic Resonance in Pediatric Congenital and Acquired Heart Disease: Endorsed by The American Heart Association – Circulation: Cardiovascular Imaging

 

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ASCO Guideline: Management of metastatic clear cell renal cell carcinoma.

22 Jun, 2022 | 11:30h | UTC

Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline – Journal of Clinical Oncology

 

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Consensus Recommendations: Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities.

22 Jun, 2022 | 11:25h | UTC

Part 1: Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities: a consensus and clinical recommendations of the Italian Society of Anesthesia and Intensive Care (SIAARTI)–Part 1 – Journal of Anesthesia, Analgesia and Critical Care

Part 2: Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities: a consensus and clinical recommendations of the Italian Society of Anesthesia and Intensive Care (SIAARTI)—part 2 – Journal of Anesthesia, Analgesia and Critical Care

 

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Comparing the Pfizer and Moderna Covid vaccines for young children.

22 Jun, 2022 | 12:02h | UTC

Comparing the Pfizer and Moderna Covid vaccines for young children – STAT

Related: FDA advisers OK COVID-19 vaccines for youngest kids – CIDRAP

 

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Guideline review: EASL clinical practice guidelines: drug-induced liver injury.

22 Jun, 2022 | 11:27h | UTC

Guideline review: EASL clinical practice guidelines: drug-induced liver injury (DILI) – Frontline Gastroenterology

Original Article: EASL Clinical Practice Guidelines: Drug-induced liver injury – Journal of Hepatology

 

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Position Paper: Diagnosis and management of infections caused by multidrug-resistant bacteria.

22 Jun, 2022 | 11:23h | UTC

A position paper for the diagnosis and management of infections caused by multidrug-resistant bacteria: Endorsed by the Italian Society of Infection and Tropical Diseases (SIMIT), the Italian Society of Anti-Infective Therapy (SITA), the Italian Group for Antimicrobial Stewardship (GISA), the Italian Association of Clinical Microbiologists (AMCLI), and the Italian Society of Microbiology (SIM) – International Journal of Antimicrobial Agents

Related Guideline:

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 2.0 – Infectious Diseases Society of America

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 1.0 – Infectious Diseases Society of America

 

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Review: Advanced interventions in the pre-hospital resuscitation of patients with non-compressible hemorrhage after penetrating injuries.

22 Jun, 2022 | 11:21h | UTC

Advanced interventions in the pre-hospital resuscitation of patients with non-compressible haemorrhage after penetrating injuries – Critical Care

 

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Cohort Study: Association between short-term, chronic localized and chronic widespread pain and risk for cardiovascular disease.

22 Jun, 2022 | 11:18h | UTC

The association between short-term, chronic localized and chronic widespread pain and risk for cardiovascular disease in the UK Biobank – European Journal of Preventive Cardiology

 

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RCT: Efficacy and safety of varenicline for smoking cessation in patients with type 2 diabetes.

22 Jun, 2022 | 11:16h | UTC

Efficacy and Safety of Varenicline for Smoking Cessation in Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA Network Open

Author Interview: Efficacy and Safety of Varenicline in Patients With Type 2 Diabetes – JAMA

 

Commentary on Twitter

This randomized clinical trial (CoEHAR) found the use of varenicline in smoking cessation programs for patients with diabetes resulted in prolonged abstinence. @CoeharUnict @RiccardoPolosa https://t.co/Sd57LMcsbJ

— JAMA Network Open (@JAMANetworkOpen) June 21, 2022

 

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RCT: Multispecies probiotic for the prevention of antibiotic-associated diarrhea in children.

22 Jun, 2022 | 11:12h | UTC

Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Commentary: Mixed Results With Probiotic for Kids’ Antibiotic-Related Diarrhea— Randomized trial misses strictly defined endpoint, but researchers point to benefit – MedPage Today (free registration required)

 

Commentary on Twitter

Study found administration of a multispecies #probiotic to children had no significant effect on the risk of antibiotic-associated diarrhea caused by #Cdifficile or of unknown etiology, but reduced the overall risk of diarrhea regardless of the etiology. https://t.co/Mdq3tl8csb

— JAMA Pediatrics (@JAMAPediatrics) June 21, 2022

 

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Retrospective cohort study: Association of patient characteristics with postoperative mortality in children undergoing tonsillectomy.

22 Jun, 2022 | 11:14h | UTC

Association of Patient Characteristics With Postoperative Mortality in Children Undergoing Tonsillectomy in 5 US States – JAMA (free for a limited period)

Editorials: Mortality After Pediatric Tonsillectomy—Does the “D” Word Have a Place in Tonsillectomy Discussions? – JAMA Otolaryngology-Head & Neck Surgery

 

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RCT: High-flow nasal cannula vs. conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia.

22 Jun, 2022 | 11:09h | UTC

High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial – Critical Care

 

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Randomized cross-over study: closed-loop oxygen control improves oxygen therapy in acute hypoxemic respiratory failure patients under high flow nasal oxygen.

22 Jun, 2022 | 11:08h | UTC

Closed-loop oxygen control improves oxygen therapy in acute hypoxemic respiratory failure patients under high flow nasal oxygen: a randomized cross-over study (the HILOOP study) – Critical Care

 

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Systematic Review: Music therapy for people with substance use disorders.

22 Jun, 2022 | 11:02h | UTC

Music therapy for people with substance use disorders – Cochrane Library

Summary: Music therapy for people with substance use disorder – Cochrane Library

 

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Anxiety in the medically ill: a systematic review of the literature.

22 Jun, 2022 | 11:05h | UTC

Anxiety in the Medically Ill: A Systematic Review of the Literature – Frontiers in Psychology

 

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M-A: Contemporary trends in global mortality of sepsis among young infants less than 90 days.

22 Jun, 2022 | 11:03h | UTC

Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis – Frontiers in Pediatrics

 

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Cardiovascular disease in primary Sjögren’s syndrome: raising clinicians’ awareness.

22 Jun, 2022 | 10:55h | UTC

Cardiovascular Disease in Primary Sjögren’s Syndrome: Raising Clinicians’ Awareness – Frontiers in Immunology

 

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RCT: Modified ligation procedure for prolapsed hemorrhoids vs. stapled hemorrhoidectomy for the management of symptomatic hemorrhoids.

22 Jun, 2022 | 10:59h | UTC

Modified ligation procedure for prolapsed haemorrhoids versus stapled haemorrhoidectomy for the management of symptomatic haemorrhoids (MoLish): randomized clinical trial – BJS Open

 

Commentary on Twitter

https://twitter.com/BjsOpen/status/1527612605099126787

 

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Cohort Study: Polypharmacy, potentially inappropriate medications, and drug-drug interactions in vulnerable older adults with advanced cancer initiating cancer treatment.

22 Jun, 2022 | 10:51h | UTC

Polypharmacy, Potentially Inappropriate Medications, and Drug-Drug Interactions in Vulnerable Older Adults With Advanced Cancer Initiating Cancer Treatment – The Oncologist

Commentaries:

Polypharmacy can lead to harmful drug interactions, especially among cancer patients – News Medical

Analysis Underscores Risks of Polypharmacy in Elderly Patients With Cancer – AJMC

 

Commentary on Twitter

Our new article in @OncJournal : In a large cohort of older adults with advanced cancer, polypharmacy &PIM are very common. Nonprescription meds are frequently PIMs &involved in potential harmful drug interactions @WilmotCancer @rochgerionc @myCARGhttps://t.co/bA7W4kyybm pic.twitter.com/zFI3EgS320

— Mostafa R Mohamed (@m_refaat84) April 2, 2022

Under a https://creativecommons.org/licenses/by/4.0/ license

 

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Long-term follow-up of a RCT: Nivolumab plus cabozantinib vs. sunitinib in first-line treatment for advanced renal cell carcinoma.

22 Jun, 2022 | 10:48h | UTC

Nivolumab plus cabozantinib versus sunitinib in first-line treatment for advanced renal cell carcinoma (CheckMate 9ER): long-term follow-up results from an open-label, randomised, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: CheckMate 9ER update confirms first-line nivolumab plus cabozantinib benefits for advanced RCC – medwire News

Original Study: Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma – New England Journal of Medicine

 

Commentary from the author on Twitter (thread – click for more)

1/ CheckMate-9ER extended f/u (media f/u=32.9mo) results out in @TheLancetOncol: preplanned final OS analysis, updated PFS, OR & safety of Cabo/Nivo vs. Sun in 1L RCC. Also includes prespecified & post-hoc subgroup analyses. https://t.co/OJduO7Q2ar@OncoAlert @DanaFarber_GU pic.twitter.com/0EQN5gWu5I

— Toni Choueiri, MD (@DrChoueiri) June 8, 2022

 

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Phase II RCT: Switch maintenance endocrine therapy plus bevacizumab after bevacizumab plus paclitaxel in advanced or metastatic estrogen receptor-positive, HER2-negative breast cancer.

22 Jun, 2022 | 10:49h | UTC

Switch maintenance endocrine therapy plus bevacizumab after bevacizumab plus paclitaxel in advanced or metastatic oestrogen receptor-positive, HER2-negative breast cancer (BOOSTER): a randomised, open-label, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Switch to Maintenance Endocrine Therapy Plus Bevacizumab After First-Line Paclitaxel/Bevacizumab Induction in Advanced Estrogen Receptor–Positive, HER2-Negative Breast Cancer – The ASCO Post

 

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Review: Health and clinical impacts of air pollution and linkages with climate change.

21 Jun, 2022 | 11:13h | UTC

Health and Clinical Impacts of Air Pollution and Linkages with Climate Change – NEJM Evidence

Editorial: Fossil-Fuel Pollution and Climate Change — A New NEJM Group Series

 

Commentary on Twitter

In this review article in the NEJM Group series on #ClimateChange, Keswani and colleagues review the linkages between climate change and #AirPollution and suggest strategies that clinicians may use to mitigate the adverse health impacts of air pollution. https://t.co/dp0YETCqkY pic.twitter.com/lE8i1BklpD

— NEJM Evidence (@NEJMEvidence) June 15, 2022

 

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