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Extracorporeal membrane oxygenation during respiratory pandemics: past, present, and future.

11 Sep, 2022 | 22:53h | UTC

Extracorporeal Membrane Oxygenation during Respiratory Pandemics: Past, Present, and Future – American Journal of Respiratory and Critical Care Medicine

 

AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma.

11 Sep, 2022 | 22:50h | UTC

AASLD Practice Guidance on Primary Sclerosing Cholangitis and Cholangiocarcinoma – Hepatology

 

Guideline | Perioperative care of patients undergoing major complex spinal instrumentation surgery.

11 Sep, 2022 | 22:49h | UTC

Perioperative Care of Patients Undergoing Major Complex Spinal Instrumentation Surgery: Clinical Practice Guidelines From the Society for Neuroscience in Anesthesiology and Critical Care – Journal of Neurosurgical Anesthesiology

 

RCT | Rezvilutamide vs. Bicalutamide in combination with androgen-deprivation therapy in patients with high-volume, metastatic, hormone-sensitive prostate cancer.

11 Sep, 2022 | 22:52h | UTC

Rezvilutamide versus bicalutamide in combination with androgen-deprivation therapy in patients with high-volume, metastatic, hormone-sensitive prostate cancer (CHART): a randomised, open-label, phase 3 trial – The Lancet Oncology

Commentaries:

Treatment options for metastatic hormone-sensitive prostate cancer – The Lancet Oncology

Rezvilutamide benefits shown in metastatic hormone-sensitive prostate cancer – medwire News

 

Commentary on Twitter

 

Guidelines for cancer treatment during pregnancy: ethics-related content evolution and implications for clinicians.

11 Sep, 2022 | 22:47h | UTC

Guidelines for Cancer Treatment during Pregnancy: Ethics-Related Content Evolution and Implications for Clinicians – Cancers

 

Five-year outcomes in patients with fully magnetically levitated vs. axial-flow left ventricular assist devices in the MOMENTUM 3 randomized trial.

11 Sep, 2022 | 22:43h | UTC

Five-Year Outcomes in Patients With Fully Magnetically Levitated vs Axial-Flow Left Ventricular Assist Devices in the MOMENTUM 3 Randomized Trial – JAMA (free for a limited period)

 

Commentary on Twitter

 

A randomized crossover trial with 12 patients showed that a bihormonal “artificial pancreas” with closed-loop glucose control increases patients’ time on euglycemia after total pancreatectomy.

11 Sep, 2022 | 22:45h | UTC

Bihormonal Artificial Pancreas With Closed-Loop Glucose Control vs Current Diabetes Care After Total Pancreatectomy: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)

Commentary: Novel Bihormonal Artificial Pancreas Beneficial After Pancreatectomy – HealthDay

 

Survey | Medical counseling on sexual enrichment aids: women’s preferences and medical practitioner expertise.

11 Sep, 2022 | 22:42h | UTC

Medical Counseling on Sexual Enrichment Aids: Women’s Preferences and Medical Practitioner Expertise – Obstetrics & Gynecology

 

Screening for high-risk human papillomavirus using passive, self-collected menstrual blood.

11 Sep, 2022 | 22:41h | UTC

Screening for High-Risk Human Papillomavirus Using Passive, Self-Collected Menstrual Blood – Obstetrics & Gynecology

Commentary: Pap smears, be gone? Using menstrual blood to detect HPV – Stanford Medicine

 

Commentary on Twitter

 

Network M-A | Comparative efficacy of lipid‐lowering therapies added to maximally tolerated statins for the reduction of LDL cholesterol.

11 Sep, 2022 | 22:38h | UTC

Network Meta‐Analysis of Randomized Trials Evaluating the Comparative Efficacy of Lipid‐Lowering Therapies Added to Maximally Tolerated Statins for the Reduction of Low‐Density Lipoprotein Cholesterol – Journal of the American Heart Association

 

Study shows vaginal birth is feasible in some patients with low-lying placenta.

11 Sep, 2022 | 22:39h | UTC

Trial of Labor Compared With Elective Cesarean Delivery for Low-Lying Placenta – Obstetrics & Gynecology

Commentary: Vaginal birth possible in 50% of women with low-lying placenta – MDedge

 

RCT | Effects of Nicorandil administration on infarct size in patients with ST‐Segment–Elevation Myocardial Infarction undergoing primary percutaneous coronary intervention.

11 Sep, 2022 | 22:37h | UTC

Effects of Nicorandil Administration on Infarct Size in Patients With ST‐Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: The CHANGE Trial – Journal of the American Heart Association

 

Nonadherence was revealed through measurements of serum concentrations of antihypertensive drugs in one-third of patients with resistant hypertension previously evaluated as adherent.

11 Sep, 2022 | 22:35h | UTC

Nonadherence by Serum Drug Analyses in Resistant Hypertension: 7‐Year Follow‐Up of Patients Considered Adherent by Directly Observed Therapy – Journal of the American Heart Association

 

M-A | Performance of single serum progesterone in the evaluation of symptomatic first-trimester pregnant patients.

11 Sep, 2022 | 22:32h | UTC

Performance of single serum progesterone in the evaluation of symptomatic first-trimester pregnant patients: a systematic review and meta-analysis – Canadian Journal of Emergency Medicine (if the link is paywalled, try this one)

 

M-A | Combination therapy with rifaximin and lactulose in hepatic encephalopathy.

11 Sep, 2022 | 22:33h | UTC

Combination therapy with rifaximin and lactulose in hepatic encephalopathy: A systematic review and meta-analysis – PLOS One

Commentary: Rifaximin Plus Lactulose Linked to Greater Effectiveness, Decreased Mortality in HE – AJMC

 

Systematic Review | Long-term outcomes after non-traumatic out-of-hospital cardiac arrest in pediatric patients.

11 Sep, 2022 | 22:30h | UTC

Long-Term Outcomes after Non-Traumatic Out-of-Hospital Cardiac Arrest in Pediatric Patients: A Systematic Review – Journal of Clinical Medicine

 

Systematic Review | Surgery for the treatment of obesity in children and adolescents.

11 Sep, 2022 | 22:29h | UTC

Surgery for the treatment of obesity in children and adolescents – Cochrane Library

Summary: Surgery for the treatment of obesity in children and adolescents – Cochrane Library

 

RCT | Adjuvant atezolizumab fails to improve outcomes in patients with renal cell carcinoma at increased risk of recurrence following resection.

11 Sep, 2022 | 22:28h | UTC

Adjuvant atezolizumab versus placebo for patients with renal cell carcinoma at increased risk of recurrence following resection (IMmotion010): a multicentre, randomised, double-blind, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentaries:

Adjuvant atezolizumab falls short in renal cell carcinoma – Urology Times

IMmotion010 does not support adjuvant atezolizumab in intermediate-, high-risk RCC – medwire News

 

Commentary from the author on Twitter (thread – click for more)

 

Phase 2 RCT | Adjuvant nivolumab plus ipilimumab or nivolumab alone versus placebo in patients with resected stage IV melanoma with no evidence of disease.

11 Sep, 2022 | 22:25h | UTC

Adjuvant nivolumab plus ipilimumab or nivolumab alone versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED): final results of a randomised, double-blind, phase 2 trial – The Lancet

 

RCT | Overall survival with maintenance Olaparib at a 7-year follow-up in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation.

11 Sep, 2022 | 22:21h | UTC

Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial – Journal of Clinical Oncology

Commentary: Olaparib Maintenance Provides Sustained OS Benefit in Newly Diagnosed, BRCA-Mutated, Advanced Ovarian Cancer – OncLive

 

RCT | Busulfan plus Cyclophosphamide is noninferior to total body irradiation plus Cyclophosphamide for adults Acute B Lymphoblastic Leukemia.

11 Sep, 2022 | 22:24h | UTC

Busulfan Plus Cyclophosphamide Versus Total Body Irradiation Plus Cyclophosphamide for Adults Acute B Lymphoblastic Leukemia: An Open-Label, Multicenter, Phase III Trial – Journal of Clinical Oncology

 

Large study unravels the risk factors for heart failure among childhood cancer survivors.

11 Sep, 2022 | 22:22h | UTC

Risk Factors for Heart Failure Among Pan-European Childhood Cancer Survivors – Journal of Clinical Oncology

 

Cluster RCT | Umbilical cord milking may improve health in non-vigorous term and near-term infants.

8 Sep, 2022 | 14:47h | UTC

News Release: Umbilical cord milking may improve health in non-vigorous term and near-term infants – NIH News Releases

Original Study: Umbilical cord milking in non-vigorous infants: A cluster-randomized crossover trial – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Study suggests many stable patients with ST-Elevation Myocardial Infarction may not require routine admission to a cardiac intensive care unit following PCI reperfusion.

8 Sep, 2022 | 14:45h | UTC

Incidence and Predictors of Adverse Events Among Initially Stable ST‐Elevation Myocardial Infarction Patients Following Primary Percutaneous Coronary Intervention – Journal of the American Heart Association

 

Early versus delayed non–vitamin k antagonist oral anticoagulant therapy after acute ischemic stroke in atrial fibrillation: a registry-based randomized controlled noninferiority study.

8 Sep, 2022 | 14:46h | UTC

Early Versus Delayed Non–Vitamin K Antagonist Oral Anticoagulant Therapy After Acute Ischemic Stroke in Atrial Fibrillation (TIMING): A Registry-Based Randomized Controlled Noninferiority Study – Circulation (free for a limited period)

Related: Defining key design elements of registry-based randomised controlled trials: a scoping review – Trials

 

Commentary on Twitter

 

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