Archives
Long-term follow-up of a RCT | Outcomes after catheter-based renal artery denervation for resistant hypertension.
20 Sep, 2022 | 13:33h | UTCLong-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial – The Lancet (free registration required)
Commentary: SYMPLICITY HTN-3’s Late Surprise: Sustained BP Drop at 3 Years Despite Earlier Miss – TCTMD
Original Study: A Controlled Trial of Renal Denervation for Resistant Hypertension – New England Journal of Medicine
RCT | Myopia control effect of repeated low-level red-light therapy in children.
20 Sep, 2022 | 13:31h | UTCCommentary: Repeated Low-Level Red-Light Therapy Reduces Myopia Progression in Children – HCP Live
Brief Review | Source control in the management of sepsis and septic shock.
20 Sep, 2022 | 13:32h | UTCSource control in the management of sepsis and septic shock – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Source control to eliminate origin of infection, control contamination, restore premorbid anatomy/function in #sepsis & septic shock
🧫 think outside (abdominal) box
🧫 have multidisciplinary approach
🧫 first do NO (additional) harm#FOAMcc on @yourICM
🖇 https://t.co/GrA0oR5lf0 pic.twitter.com/ZyPaFF3qFH— Intensive Care Medicine (@yourICM) September 15, 2022
Preliminary results of a RCT | Once-only colonoscopy vs. two rounds of fecal immunochemical testing 2 years apart for colorectal cancer screening.
20 Sep, 2022 | 13:29h | UTCOnce-only colonoscopy or two rounds of faecal immunochemical testing 2 years apart for colorectal cancer screening (SCREESCO): preliminary report of a randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary: Two Rounds of FIT vs Single Colonoscopy as a One-time CRC Screening – Medscape (free registration required)
Network M-A | Associations between statins and adverse events in secondary prevention of cardiovascular disease.
20 Sep, 2022 | 13:30h | UTC
Consensus Paper | Pediatric robotic surgery: issues in management.
20 Sep, 2022 | 13:28h | UTC
Guideline on pharmacological interventions for long-term secondary prevention after ischemic stroke or transient ischemic attack.
20 Sep, 2022 | 13:27h | UTCEuropean Stroke Organisation (ESO) guideline on pharmacological interventions for long-term secondary prevention after ischaemic stroke or transient ischaemic attack – European Stroke Journal (free for a limited period)
Guidelines on treatment of patients with intracranial atherosclerotic disease.
20 Sep, 2022 | 13:26h | UTCEuropean Stroke Organisation guidelines on treatment of patients with intracranial atherosclerotic disease – European Stroke Journal (free for a limited period)
Guidelines on management of unruptured intracranial aneurysms.
20 Sep, 2022 | 13:25h | UTCEuropean Stroke Organisation (ESO) guidelines on management of unruptured intracranial aneurysms – European Stroke Journal (free for a limited period)
Guideline on screening for subclinical atrial fibrillation after stroke or transient ischemic attack of undetermined origin.
20 Sep, 2022 | 13:25h | UTCEuropean Stroke Organisation (ESO) guideline on screening for subclinical atrial fibrillation after stroke or transient ischaemic attack of undetermined origin – European Stroke Journal (free for a limited period)
M-A of randomized trials | Hyperthermic intraperitoneal chemotherapy (HIPEC) for the management of primary advanced and recurrent ovarian cancer.
20 Sep, 2022 | 13:23h | UTCRelated:
Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer – New England Journal of Medicine
M-A of randomized trials | Effectiveness and cost-effectiveness of oral nutritional supplements in frail older people who are malnourished or at risk of malnutrition.
20 Sep, 2022 | 13:24h | UTCInvited Commentary: Do oral nutritional supplements effectively reduce malnutrition or its adverse outcomes in older people with frailty? – The Lancet Health Longevity
RCT | Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis.
20 Sep, 2022 | 13:20h | UTCCommentary: Dupilumab Eases Atopic Dermatitis in Children Younger Than 6 Years – HealthDay
Single-arm phase 1/2 study | Tumor-agnostic efficacy and safety of Selpercatinib in patients with RET fusion-positive solid tumors other than lung or thyroid tumors.
20 Sep, 2022 | 13:18h | UTCInvited Commentary: Tissue-agnostic RET inhibition: can you trust your target? – The Lancet Oncology
Commentary from the author on Twitter (thread – click for more)
🥁🚨Hot off the press in Lancet Oncology 👉So honored to share A MAJOR milestone in #PrecisionMedicine
👉Tumour-agnostic efficacy + safety of Selpercatinib in RET fusion-positive solid tumours -LIBRETTO-001 @TheLancetOncol @myESMO #ESMO22 @MDAndersonNews https://t.co/xriueGKju0 pic.twitter.com/e0fkih6Aov— Vivek Subbiah, MD (@VivekSubbiah) September 12, 2022
RCTs | Linzagolix with and without hormonal add-back therapy for the treatment of symptomatic uterine fibroids.
20 Sep, 2022 | 13:19h | UTC
Case report and brief review | Severe thrombotic complications secondary to antiphospholipid syndrome and undiagnosed systemic lupus erythematosus.
20 Sep, 2022 | 13:17h | UTC
RCT | Deucravacitinib vs. placebo and Apremilast in moderate to severe plaque psoriasis.
20 Sep, 2022 | 13:16h | UTC
A simple score to identify increased risk of transthyretin amyloid cardiomyopathy in heart failure with preserved ejection fraction.
20 Sep, 2022 | 13:16h | UTCA Simple Score to Identify Increased Risk of Transthyretin Amyloid Cardiomyopathy in Heart Failure With Preserved Ejection Fraction – JAMA Cardiology (link to abstract – $ for full-text)
Commentary on Twitter
This cohort study found that a simple 6 variable clinical score may be used to guide use of PYP and increase recognition of cardiomyopathy (ATTR-CM) among patients with HFpEF in the community. https://t.co/2fzCZf97Mp #Research
— JAMA Cardiology (@JAMACardio) September 7, 2022
Evaluation of an ambulatory ECG analysis platform using deep neural networks in routine clinical practice.
20 Sep, 2022 | 13:14h | UTC
Commentary on Twitter
An AI-based Holter ECG analysis strategy saves time and performs similarly compared with a conventional approach @EloiMarijon #AHAJournals https://t.co/lK7h0po4xj
— JAHA (@JAHA_AHA) September 15, 2022
RCT | Cerebral embolic protection during transcatheter aortic-valve replacement did not significantly reduce the incidence of periprocedural stroke.
19 Sep, 2022 | 12:49h | UTCCerebral Embolic Protection during Transcatheter Aortic-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
PROTECTED TAVR: No Less Stroke With Embolic Protection, but Some See Hope – TCTMD
Presumed Clinical Benefits of TAVR Cerebral Protection Remain Unproven — Large trial comes up short in proving a definitive benefit to debris filters – MedPage Today (free registration required)
News Release: Cerebral Embolic Protection During Transcatheter Aortic-Valve Replacement – Cedars-Sinai
Commentary on Twitter
In a randomized trial involving patients with aortic stenosis, the use of a cerebral protection device during TAVR did not decrease the risk of periprocedural stroke, but there were fewer disabling strokes. #TCT2022 https://t.co/wBgNlgmIty pic.twitter.com/EViLG19shX
— NEJM (@NEJM) September 17, 2022
RCT | Multiple doses of prophylactic intravenous antibiotics are no better than a single dose in implant-based breast reconstruction.
19 Sep, 2022 | 12:48h | UTC
Commentary on Twitter
Multiple-dose antibiotic prophylaxis was not superior to a single-dose regimen in preventing surgical site infection and implant removal after implant-based breast reconstruction in this RCT. https://t.co/p7GbNRMPfW #OAResarch
— JAMA Network Open (@JAMANetworkOpen) September 16, 2022
Cohort Study | Seven healthy lifestyle habits linked to reduced risk of dementia in people with diabetes.
19 Sep, 2022 | 12:45h | UTCAssociation of Combined Healthy Lifestyle Factors With Incident Dementia in Patients With Type 2 Diabetes – Neurology (link to abstract – $ for full-text)
News Release: Seven healthy lifestyle habits may reduce dementia risk for people with diabetes – American Academy of Neurology
Commentary: Lifestyle Factors May Cut Dementia Risk in Patients With Diabetes – HealthDay
Cluster RCT | Effects of real-time prescription benefit recommendations on patient out-of-pocket costs.
19 Sep, 2022 | 12:47h | UTCEffects of Real-time Prescription Benefit Recommendations on Patient Out-of-Pocket Costs: A Cluster Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Invited Commentary: Real-time Prescription Benefit Tools—The Promise and Peril – JAMA Internal Medicine (free for a limited period)
Commentary on Twitter
Real-time Prescription Benefits (RTPB) uses patient out-of-pocket (OOP) cost to recommend lower-cost med alternatives to prescribers. In a RCT, RTPB reduced med OOP costs by 11%, though recommendations were only made for a small proportion of orders. https://t.co/xXviGvnbKw pic.twitter.com/naeciB3CDg
— JAMA Internal Medicine (@JAMAInternalMed) September 12, 2022
M-A | Nonpharmacological interventions to lengthen sleep duration in healthy children.
19 Sep, 2022 | 12:44h | UTCNonpharmacological Interventions to Lengthen Sleep Duration in Healthy Children: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)
Editorial: Children’s Sleep and Our Power to Improve It – JAMA Pediatrics (free for a limited period)
Commentary: Data Demonstrates the Best Intervention for Pediatric Sleep Health is Earlier Bedtime – HCP Live
Commentary on Twitter
Supporting children to go to bed earlier can increase sleep duration in healthy children, and interventions to encourage earlier bedtimes should be included. https://t.co/i8BzSKwlQX #Research
— JAMA Pediatrics (@JAMAPediatrics) September 14, 2022
Guideline | Procedural sedation in the emergency department.
19 Sep, 2022 | 12:43h | UTCProcedural Sedation in the Emergency Department – Royal College of Emergency Medicine (PDF)