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Perspective: Ten Dubious Beliefs in Neurocritical Care

23 May, 2018 | 12:26h | UTC

Ten dubious beliefs in neurocritical care – PulmCrit (free)

 


Cohort Study: Using Alternatives to the Car and Mortality Risk

23 May, 2018 | 12:19h | UTC

Using alternatives to the car and risk of all-cause, cardiovascular and cancer mortality – Heart (free)

Commentaries: Avoiding the car for travel could significantly lower risk of illness and death – BMJ, via EurekAlert (free) AND Ditching the car may reduce your risk of dying from heart disease and stroke by almost a third – The Conversation (free)

 


Research: Physiology-Stratified Analysis of ORBITA

23 May, 2018 | 12:22h | UTC

Fractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Single-Vessel Coronary Artery Disease: Physiology-Stratified Analysis of ORBITA – Circulation (free PDF)

Commentaries: New ORBITA Findings May Offer Modest Symptomatic Pain Relief To Interventional Cardiologists – Cardiobrief (free) AND New ORBITA Insights: Invasive Physiology Tests Track Closely With Ischemia, but Not Symptom Improvement – TCTMD (free)

See more on the repercussions of the ORBITA Trial: Percutaneous coronary intervention in stable angina (ORBITA) (link to abstract and commentaries) AND Placebo Effect of the Heart (free commentaries) AND Sham Surgeries: A Tale of Medical Reversals & the Role of the Media (free commentaries)

 


Randomized Trial: Cannabidiol Reduces Seizures in Patients with Lennox–Gastaut Syndrome

23 May, 2018 | 12:22h | UTC

Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Cannabidiol significantly reduces seizures in patients with severe form of epilepsy – NYU School of Medicine (free) AND Cannabis Drug Reduces Drop Seizures in Severe Epilepsy – Medscape (free registration required) AND Cannabidiol Significantly Reduces Seizures in Patients with Lennox-Gastaut Syndrome – MD Magazine (free)

 


Report: Open Water Drowning and Risks for Children

23 May, 2018 | 12:18h | UTC

Report: Hidden Hazards: An Exploration of Open Water Drowning and Risks for Children – Safe Kids Worldwide (free PDF)

Commentaries: New drowning study warns about the dangers of swimming in open water – Today (free) AND New report highlights danger of childhood drowning in open water – News Medical (free)

 


Register-based Retrospective Study: Pediatric Exposures to ADHD Medications are an Increasing Problem

23 May, 2018 | 12:15h | UTC

Pediatric ADHD Medication Exposures Reported to US Poison Control Centers – Pediatrics (link to abstract – $ for full-text)

Commentaries: Unnecessary and accidental use of ADHD drugs increases over 60%, study suggests – CNN (free) AND Add ADHD Meds To Call Burden For Poison Control Centers – American Council on Science and Health (free) AND As ADHD Diagnoses Increased, So Did Calls to Poison Control – U.S. News (free) AND More U.S. kids overdosing on ADHD drugs – Reuters (free)

 


Opinion: Scientists Should be Solving Problems, Not Struggling to Access Journals

23 May, 2018 | 12:16h | UTC

Scientists should be solving problems, not struggling to access journals – The Guardian (free)

 


Review: A Causal Mechanism for Childhood Acute Lymphoblastic Leukemia

23 May, 2018 | 12:14h | UTC

A causal mechanism for childhood acute lymphoblastic leukaemia – Nature Reviews Cancer (free for a limited period)

Commentaries: New study reveals likely cause of childhood leukaemia – eCancer News (free) AND Most common childhood cancer ‘partly caused by lack of infection’ – The Guardian (free) AND Expert reaction to review looking at possible causes and triggers of acute lymphoblastic childhood leukaemia – Science Media Centre (free)

 


Retrospective Cohort: More Patients Choosing Active Surveillance for Low-Risk Prostate Cancer

23 May, 2018 | 12:17h | UTC

Use of Conservative Management for Low-Risk Prostate Cancer in the Veterans Affairs Integrated Health Care System From 2005-2015 – JAMA (free for a limited period)

Commentaries: VA health care successfully reduces ‘rush to treatment’ rates for low-risk prostate cancer – eCancer News (free) AND Watching but not treating cancer can be hard. Sometimes it’s the right approach – The Washington Post (a few articles per month are free)

 


Review: Management of Cold Related Injuries

23 May, 2018 | 12:16h | UTC

Brrr! ED Presentation, Evaluation, and Management of Cold Related Injuries – emDocs (free)

 


Cohort Study: Amyloid-β (1-40) Predicts Mortality in Acute Coronary Syndrome

23 May, 2018 | 12:13h | UTC

Amyloid-β (1-40) and Mortality in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Amyloid Biomarker Predictive of Mortality in Non-STEMI Heart Attack – MedicalResearch.com (free) AND Amyloid-Beta (1–40) Strong Predictor of Mortality in Acute Coronary Syndrome – NEJM Physician’s First Watch (free)

 


Pre-Post Intervention Study: Adverse Events Decline After Elimination of Contact Precautions

23 May, 2018 | 12:12h | UTC

Noninfectious Hospital Adverse Events Decline After Elimination of Contact Precautions for MRSA and VRE – Infection Control & Hospital Epidemiology (link to abstract – $ for full-text)

Commentary: Hospital adverse events decline after routine contact precautions removed – Healio (free registration required)

 


Randomized Controlled Trial: Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes

23 May, 2018 | 12:13h | UTC

Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Autoinflammatory Syndromes Show Dramatic Response to Canakinumab – RheumNow (free)

 


Tue, May 22 – 10 Stories of The Day!

22 May, 2018 | 00:58h | UTC

 

1 – Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection – New England Journal of Medicine (free)

Commentaries: Procalcitonin-Guided Care Doesn’t Reduce Antibiotics for Lower Respiratory Tract Infection – NEJM Journal Watch (free) AND Infection blood test of limited value in reducing antibiotic use – MedicalXpress (free)

 

2 – Joint statement from the American College of Surgeons Committee on Trauma (ACS COT) and the American College of Emergency Physicians (ACEP) regarding the clinical use of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) (free)

Commentary: EMCrit Guest Post – The good, the bad, and the ugly of the Joint Statement on REBOA by Zaffer Qasim (free)

Source: Critical Care Reviews Newsletter

 

3 – Committee Opinion: Postpartum Pain Management – American College of Obstetricians and Gynecologists (free)

News Release: ACOG Recommends Postpartum Pain Management Approach Tailored to Patients (free)

Commentaries: ACOG: Postpartum Pain Management Requires Individualized Approach – MedPage Today (free registration required) AND OB/GYN Group Releases Guidance on Managing Postpartum Pain – NEJM Physician’s First Watch (free)

 

4 – WHO supports Ebola vaccination of high risk populations in the Democratic Republic of the Congo – World Health Organization (free)

Commentaries: Experimental Ebola Vaccinations, Considered ‘Paradigm Shift,’ Begin In Congo – NPR (free) AND Ebola vaccine drive launches in DRC as cases rise to 49 – CIDRAP (free) AND Congo begins giving experimental Ebola vaccine to medics – Reuters (free)

See also: Frequently asked questions on Ebola virus disease vaccine – World Health Organization (free)

“Health workers operating in affected areas in the Democratic Republic of the Congo are being vaccinated today and community outreach has started to prepare for the ring vaccination” (via @WHO see Tweet)

 

5 – Health care is an essential human right – and so is a proper diagnosis – The Conversation (free)

Related Commentary: For First Time, W.H.O. Names Some Lab Tests ‘Essential’ – The New York Times (10 articles per month are free)

See Original WHO Report: List of Essential In Vitro Diagnostics First edition (2018) – World Health Organization (free report and news release)

 

6 – Review: Autism spectrum disorder: advances in diagnosis and evaluation – The BMJ (free for a limited period)

 

7 – Opinion: Don’t Put That in My Heart Until You’re Sure It Really Works – The New York Times (10 articles per month are free)

Commentary: Cardiologist wants more rigorous testing before devices, techniques are adopted – Cardiovascular Business (free)

See also: Commentaries (PRO and Con) on the CABANA Trial (all free)

 

8 – Richard Lehman’s weekly journal review, 21 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Review: Identifying and managing depression in patients with coronary artery disease – Journal of the American Academy of Pas (free)

Commentaries: Depression in Patients With CAD – American College of Cardiology (free) AND Early Depression Diagnosis is Deadly Serious for Patients with Coronary Artery Disease – Florida State University, via NewsWise (free)

 

10 – Association of Burden of Atrial Fibrillation With Risk of Ischemic Stroke in Adults With Paroxysmal Atrial Fibrillation: The KP-RHYTHM Study – JAMA Cardiology (free)

Commentaries: Atrial Fibrillation Burden and Stroke Risk – American College of Cardiology (free) AND Greater burden of atrial fibrillation linked to higher stroke risk – Kaiser Permanente, via EurekAlert (free)

 


Guideline Summary: CVD and Risk Management Standards in Diabetes

21 May, 2018 | 13:20h | UTC

Summary with Key Points: CVD and Risk Management Standards in Diabetes – American College of Cardiology (free)

Original Synopsis: Cardiovascular Disease and Risk Management: Review of the American Diabetes Association Standards of Medical Care in Diabetes 2018 – Annals of Internal Medicine (free)

 


Wed, May 23 – 10 Stories of The Day!

23 May, 2018 | 00:05h | UTC

 

1 – Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis – Critical Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

“In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaffected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced”.

 

2 – Aldosterone Antagonist Therapy and Mortality in Patients With ST-Segment Elevation Myocardial Infarction Without Heart Failure: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Mineralocorticoid Receptor Antagonists in ST-Segment Elevation Myocardial Infarction – JAMA Internal Medicine (free for a limited period)

Aldosterone antagonists are beneficial for patients with STEMI and reduced ejection fraction. This meta-analysis suggests that patients with STEMI and LVEF greater than 40% or without heart failure also have improved outcomes with aldosterone antagonists.

 

3 – Effect of More vs Less Frequent Follow-up Testing on Overall and Colorectal Cancer–Specific Mortality in Patients With Stage II or III Colorectal Cancer: The COLOFOL Randomized Clinical Trial – JAMA (free for a limited period)

Related Trial: Association Between Intensity of Posttreatment Surveillance Testing and Detection of Recurrence in Patients With Colorectal Cancer (free for a limited period)

Commentaries: Surveillance intensity not associated with earlier detection of recurrence or improved survival in colorectal cancer – MedicalXpress (free) AND CRC: No Increase in Survival with Stepped-Up Surveillance – MedPage Today (free registration required) AND CRC recurrence surveillance studies: No benefit to high-intensity strategy – Oncology Practice (free)

 

4 – Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma – New England Journal of Medicine (free)

Related Article: Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma – New England Journal of Medicine (free)

Editorial: New Biologics for Asthma (free)

Commentary: Dupilumab Improves Severe Asthma – NEJM Physician’s First Watch (free)

 

5 – Five-Year Outcomes with PCI Guided by Fractional Flow Reserve – New England Journal of Medicine (free)

Commentary: FFR in PCI for Stable CAD: Lasting Benefit Shown by FAME 2, SCAAR Data – TCTMD (free)

 

6 – Pro/Con Debate: CTA as the Initial Test in Stable Angina – American College of Cardiology

Pro: Coronary CTA Should Be the Initial Test in Most Patients with Stable Chest Pain (free)

Con: Coronary CTA Should Be the Initial Test in Most Patients with Stable Chest Pain (free)

 

7 – How PrEP, the pill to prevent HIV, may be fueling a rise in other STDs – Vox (free)

Original Meta-Analysis: Effects of Pre-exposure Prophylaxis for the Prevention of Human Immunodeficiency Virus Infection on Sexual Risk Behavior in Men Who Have Sex With Men: A Systematic Review and Meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)

See also: Guidelines on HIV Pre-exposure Prophylaxis (all free)

 

8 – Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults – Heart (free)

Commentaries: BMJ’s scrambled message on eggs and heart disease: a recipe for rotten news coverage – Health News Review (free) AND Expert reaction to eggs and CVD – Science Media Centre (free) AND No, Eating Eggs Will NOT Protect You From Cardiovascular Death – The Methods Man (free)

 

9 – Rapid Recommendations: Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline – The BMJ (free)

“We issue a strong recommendation for use of atraumatic needles in all patients (adults and children) undergoing lumbar puncture because they decrease complications and are no less likely to work than conventional needles”

 

10 – New BMJ Series: Universal Health Coverage

“The BMJ in partnership with The Harvard Global Health Institute are launching a collection of articles that will explore how to achieve effective Universal Health Coverage (UHC)”

Analysis: Rethinking assumptions about delivery of healthcare: implications for universal health coverage (free)

Opinion: Non-communicable diseases must be part of Universal Health Coverage (free)

Opinion: Ensuring effective investments in Universal Health Coverage at the national level (free)

Opinion: Paying and investing in community health workers accelerates universal health coverage (free)

 


Randomized Trial: Comparison of Intubation Techniques in Patients with Difficult Airways

21 May, 2018 | 13:18h | UTC

Effect of Use of a Bougie vs Endotracheal Tube and Stylet on First-Attempt Intubation Success Among Patients With Difficult Airways Undergoing Emergency Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: JC: Don’t blame it on the Bougie – St Emlyn’s (free) AND EM Nerd-The Peculiar Case of the Parallel Pathways – EmNerd (free) AND The humble bougie markedly boosts first-pass intubation success – Univadis (free registration required)

 


Guideline: Management of Lichen Sclerosus

21 May, 2018 | 13:16h | UTC

British Association of Dermatologists guidelines for the management of lichen sclerosus, 2018 – British Journal of Haematology (free)

Editorial: Updates in lichen sclerosis: British Association of Dermatologists guidelines for the management of lichen sclerosus 2018 (free)

Source: New Clinical Practice Guidelines, May 2018 Edition – Medscape (free registration required)

 


AHA Scientific Advisory: Eating Fish Twice a Week Reduces Cardiovascular Diseases

21 May, 2018 | 13:16h | UTC

Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease: A Science Advisory from the American Heart Association – Circulation (free PDF)

News Release: Keep saying yes to fish twice a week for heart health (free)

AHA News: Eating fish twice a week reduces heart, stroke risk (free)

Commentary: Omega-3 Fatty Acids and Coronary Heart Disease: A Very Fishy Story (free)

Top Ten Things to Know: Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease (free PDF)

 


Perspective: Europe’s Open-access Drive Escalates as University Stand-offs Spread

21 May, 2018 | 13:17h | UTC

Europe’s open-access drive escalates as university stand-offs spread – Nature News (free)

 


Cohort Study: Risk of Suicide Following an Alcohol-related Emergency Hospital Admission

21 May, 2018 | 13:19h | UTC

Risk of suicide following an alcohol-related emergency hospital admission: An electronic cohort study of 2.8 million people – PLOS One (free)

Commentaries: Emergency hospital admissions for alcohol a red flag for suicide risk – new study – Public Health Wales (free) AND Alcohol-Related Emergency Admissions: A Marker for Suicide Risk – NEJM Journal Watch (free for a limited period)

 


Guideline: Surgical Management of Lower Urinary Tract Symptoms attributed to BPH

21 May, 2018 | 13:14h | UTC

Surgical Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia (2018) – American Urological Association (free)

Commentary: AUA: Guideline on Surgical Management of BPH-Related Lower Urinary Tract Symptoms – MPR (free)

 


WHO Report: World Health Statistics 2018

21 May, 2018 | 13:15h | UTC

Report: World Health Statistics 2018: Monitoring health for the SDGs – World Health Organization (free)

Commentary: World Health Statistics: Over Half Of World’s Population Lack Essential Healthcare – WHO – Vigil 360 (free)

 


Disease Outbreak News: WHO Statement Regarding the Ebola Outbreak in 2018

21 May, 2018 | 13:13h | UTC

Statement on the 1st meeting of the IHR Emergency Committee regarding the Ebola outbreak in 2018 – World Health Organization (free)

Commentaries: WHO: Ebola in DRC not global emergency; ring vaccination starts in 2 days – CIDRAP (free) AND Ebola outbreak is concerning, but falls short of global emergency, WHO panel says – STAT (free)

 


ACOG Guideline: Postpartum Pain Management

21 May, 2018 | 13:14h | UTC

Committee Opinion: Postpartum Pain Management – American College of Obstetricians and Gynecologists (free)

News Release: ACOG Recommends Postpartum Pain Management Approach Tailored to Patients (free)

Commentary: ACOG: Postpartum Pain Management Requires Individualized Approach – MedPage Today (free)

 


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