Daily Archives: April 11, 2023
RCT | Low-dose olanzapine enhances appetite & weight gain in chemotherapy patients
11 Apr, 2023 | 14:41h | UTCRandomized Double-Blind Placebo-Controlled Study of Olanzapine for Chemotherapy-Related Anorexia in Patients With Locally Advanced or Metastatic Gastric, Hepatopancreaticobiliary, and Lung Cancer – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentaries:
Low-dose olanzapine improves appetite in chemotherapy patients – MDedge
Commentary on Twitter
This trial is as good as it gets ⭐️⭐️⭐️⭐️⭐️
✅Patient centered supportive care trial
✅Inexpensive medication
✅Conducted in a LMIC
✅Clinically relevant endpoint
✅ Randomized/double-blinded study
✅Potential to immediately change practicehttps://t.co/3nRrFJaS20Kudos!
— Manni Mohyuddin (@ManniMD1) March 29, 2023
Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews
11 Apr, 2023 | 14:39h | UTCRelated:
SR | Nonopioid pharmacological management of acute low back pain
M-A | Limited evidence for analgesic effectiveness in acute low back pain treatment
M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain
Guideline Interventions for the management of acute and chronic low back pain.
M-A: Little benefit from muscle relaxants for adults with non-specific low back pain.
RCT | Exploring the potential of peritumoral lidocaine infiltration to improve outcomes in early breast cancer
11 Apr, 2023 | 14:37h | UTCEffect of Peritumoral Infiltration of Local Anesthetic Before Surgery on Survival in Early Breast Cancer – Journal of Clinical Oncology (link to abstract – $ for full-text)
Blinded, randomized trial of sonographer versus AI cardiac function assessment
11 Apr, 2023 | 14:34h | UTCBlinded, randomized trial of sonographer versus AI cardiac function assessment – Nature
News Release: Is artificial intelligence better at assessing heart health? – Cedars-Sinai Medical Center
ChatGPT et al? Not so fast, say journal editors
11 Apr, 2023 | 14:36h | UTCChatGPT et al? Not So Fast, Say Journal Editors – TCTMD
Related:
AI-Generated Medical Advice—GPT and Beyond – JAMA (free for a limited period)
Chat GPT will change Medicine – Vinay Prasad’s Observations and Thoughts
The use of ChatGPT and other large language models in surgical science – BJS Open
ChatGPT vs. NCI: analyzing the quality of cancer information on myths and misconceptions
Artificial Intelligence in Medicine & ChatGPT: De-Tether the Physician – Journal of Medical Systems (if the link is paywalled, try this one)
Can artificial intelligence help for scientific writing? – Critical Care
Artificial intelligence in academic writing: a paradigm-shifting technological advance
Perspective | ChatGPT-assisted diagnosis: is the future suddenly here?
Perspective | Generating scholarly content with ChatGPT: ethical challenges for medical publishing
ChatGPT: Will It Transform the World of Health Care? – UCSF Department of Medicine
ChatGPT and the future of medical writing (ChatGPT itself wrote this paper)
ChatGPT: five priorities for research – Nature
The path forward for ChatGPT in academia – Lumo’s Newsletter
ChatGPT is fun, but not an author – Science
Tools such as ChatGPT threaten transparent science; here are our ground rules for their use – Nature
ChatGPT listed as author on research papers: many scientists disapprove – Nature
Abstracts written by ChatGPT fool scientists
M-A | Timing of allergenic food introduction and risk of immunoglobulin E–mediated food allergy
11 Apr, 2023 | 14:32h | UTCNews Release: Earlier introduction of allergenic foods in children may prevent food allergies – Imperial College London
Commentary: Allergenic Food Introduction Led to Fewer Allergies, Higher Withdrawal Rate from Intervention – HCP Live
Related:
AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease
Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society
Commentary on Twitter
In this study, earlier introduction of multiple allergenic foods was associated with a reduced risk of food allergy but with significant rates of withdrawal from the intervention. https://t.co/lZFkQIH9q7
— JAMA Pediatrics (@JAMAPediatrics) March 27, 2023
Brief Review | Hoarding disorder: evidence and best practice in primary care
11 Apr, 2023 | 14:28h | UTCHoarding disorder: evidence and best practice in primary care – British Journal of General Practice
Screening colonoscopy in seniors: common in patients with limited life expectancy and associated with higher complication risks
11 Apr, 2023 | 14:30h | UTCFrequency of Use and Outcomes of Colonoscopy in Individuals Older Than 75 Years – JAMA Internal Medicine (link to abstract – $ for full-text)
Related: Study reveals overuse of surveillance colonoscopy in older adults with limited life expectancy
Commentary:
In older adults >75 years of age, most screening colonoscopies were in patients in patients with limited life expectancy (defined as <10 years) and associated with increased risk of adverse events. https://t.co/XOsy2UKNRx @Jessica_Halabi @MRothbergMD @burkegastrodoc
— JAMA Internal Medicine (@JAMAInternalMed) April 4, 2023
SR | Epidemiology of injecting drug use, related harms & exposure to behavioral and environmental risks
11 Apr, 2023 | 14:26h | UTCInvited Commentary: Surveillance of injecting drug use as a global health imperative – The Lancet Global Health
News Release: Evidence of injecting drug use found in 190 countries: global review – UNSW Sydney
Related Article: Global coverage of interventions to prevent and manage drug-related harms among people who inject drugs: a systematic review – The Lancet Global Health
M-A | Ambient air pollution and clinical dementia
11 Apr, 2023 | 14:23h | UTCAmbient air pollution and clinical dementia: systematic review and meta-analysis – The BMJ
Editorial: Air pollution and dementia – The BMJ
News Releases:
Air pollution may increase risk for dementia – Harvard T.H. Chan School of Public Health
Exposure to fine particle air pollution linked to heightened dementia risk – BMJ Newsroom
Commentary: Elevated dementia risk even when pollution is below EPA standards – The Harvard Gazette
SR | Global coverage of interventions to prevent and manage drug-related harms among people who inject drugs
11 Apr, 2023 | 14:24h | UTCInvited Commentary: Harm reduction interventions for people who inject drugs – The Lancet Global Health
News Release: Evidence of injecting drug use found in 190 countries: global review – UNSW Sydney
Commentary on Twitter (thread – click for more)
Online first: Global coverage of interventions to prevent and manage drug-related harms among people who inject drugs: a systematic review https://t.co/2xvrQryyLN (1/4)
— The Lancet Global Health (@LancetGH) April 3, 2023
Guideline | First line treatment of newly diagnosed transplant ineligible multiple myeloma
11 Apr, 2023 | 14:22h | UTC
SR | Risk factors for cholangitis after pancreatoduodenectomy
11 Apr, 2023 | 14:21h | UTC
M-A | Irritable bowel syndrome is not associated with an increased risk of polyps and colorectal cancer
11 Apr, 2023 | 14:19h | UTC
Review | Anticoagulation in patients with liver cirrhosis: friend or foe?
11 Apr, 2023 | 14:17h | UTCAnticoagulation in Patients with Liver Cirrhosis: Friend or Foe? – Digestive Diseases and Sciences
Late mortality in childhood cancer survivors: causes & modifiable risk factors
11 Apr, 2023 | 14:16h | UTCSpecific causes of excess late mortality and association with modifiable risk factors among survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort – The Lancet (link to abstract – $ for full-text)
News Release: Healthy lifestyle associated with reduced mortality risk in childhood cancer survivors – St. Jude Children’s Research Hospital
Review | Managing respiratory muscle weakness during weaning from invasive ventilation
11 Apr, 2023 | 14:12h | UTC
RCT | Efficacy and safety of a water-free topical cyclosporine, 0.1%, solution for the treatment of dry eye disease
11 Apr, 2023 | 14:10h | UTCCommentary: ESSENCE-2 Trial Confirms Efficacy of Cyclosporine Solution 0.1% for DED – HCP Live
Commentary on Twitter
ESSENCE-2 trial demonstrated treatment with water-free cyclosporine 0.1% (CyclASol) drops effective and tolerable through Day 29 for treating dry eye related keratitis with rapid onset of action. https://t.co/qJkef2fPTg
— JAMA Ophthalmology (@JAMAOphth) April 6, 2023
RCT | Targeted hypoglossal nerve stimulation may benefit patients with obstructive sleep apnea
11 Apr, 2023 | 14:07h | UTC
Commentary on Twitter
In this study, proximal targeted hypoglossal nerve responses proved safe and effective in treating sleep apnea and improving sleep architecture and quality of life, while comparing favorably with those in distal hypoglossal nerve stimulation trials. https://t.co/yorNGW9uoi
— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) April 6, 2023
Single-arm study | Effects of CAR-T therapy in children with relapsed or refractory high-risk neuroblastoma
11 Apr, 2023 | 14:09h | UTCGD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: CAR-T Therapy Helps Kids Battling Deadly Nervous System Tumors – HealthDay
Commentary on Twitter
Patients with neuroblastoma received CAR-positive T cells targeting a disialoganglioside. Of 63% with a response, 33% had a complete response (some durable). Cytokine release syndrome was common. https://t.co/LDaIoeGfV7
Read the science behind the study: https://t.co/L4D5x1G6BF pic.twitter.com/VfsQKfSVFf
— NEJM (@NEJM) April 5, 2023
M-A | Noninvasive respiratory support after extubation
11 Apr, 2023 | 14:03h | UTC
Review | Pulmonary arterial hypertension in pregnancy
11 Apr, 2023 | 14:06h | UTCPulmonary arterial hypertension in pregnancy – Current Opinion in Cardiology
Preliminary study suggests a PEG-coated hemostatic patch reduces pancreatic fistula post-pancreatoduodenectomy
11 Apr, 2023 | 14:02h | UTC
Commentary on Twitter
POPF prevention ? any help from haemostatic patches?!
? Polyethylene glycol-coated haemostatic patch for prevention: RCT from ??
? POPF reduction 90% (!!!) regardless of other risk factors
? What is your practice?! https://t.co/Fn7OgFgwTR pic.twitter.com/ZjlxuUTZEN
— Giovanni Marchegiani (@Gio_Marchegiani) April 7, 2023
Review | Evaluation and management of chronic thromboembolic pulmonary hypertension
11 Apr, 2023 | 14:00h | UTCEvaluation and Management of Chronic Thromboembolic Pulmonary Hypertension – Chest
M-A | The risk of long-term cardiometabolic disease in women with premature or early menopause
11 Apr, 2023 | 13:59h | UTC