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Daily Archives: March 15, 2023

RCT | Patient-reported outcomes 12 years after different treatments for localized prostate cancer

15 Mar, 2023 | 15:24h | UTC

Summary: The article reports on a study that evaluated patient-reported outcomes of 1,643 participants in the ProtecT trial over a period of 7 to 12 years to assess the long-term functional and quality-of-life impacts of prostatectomy, radiotherapy with neoadjuvant androgen deprivation, and active monitoring for localized prostate cancer detected by PSA screening.

The study found that generic quality-of-life scores were similar among the randomized groups over 7 to 12 years. However, although the prostatectomy group had a lower incidence of nocturia, they showed a higher incidence of urinary incontinence and sexual dysfunction compared to the radiotherapy and active monitoring groups. The radiotherapy group had a higher incidence of fecal leakage compared to the other groups.

The study provides evidence that helps patients and their clinicians assess the trade-offs between treatment harms and benefits and make better-informed treatment decisions.

Article: Patient-Reported Outcomes 12 Years after Localized Prostate Cancer Treatment – NEJM Evidence

Original Study: RCT | Localized prostate cancer treatment options have similar 15-year survival outcomes

 

SR | Therapeutics for treating mpox in humans – still no evidence from randomized trials

15 Mar, 2023 | 15:20h | UTC

Therapeutics for treating mpox in humans – Cochrane Library

Summary: Therapeutics for treating mpox – Cochrane Library

 

Updated recommendations for the use of antiretroviral drugs during pregnancy and interventions to reduce perinatal HIV transmission

15 Mar, 2023 | 15:22h | UTC

Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States – Department of Health and Human Services

Commentary: Antiretroviral Therapy During Pregnancy and Interventions to Reduce Perinatal Transmission: 2023 Recommendations – Journal Watch

 

Review | Diagnosis and management of endometriosis

15 Mar, 2023 | 15:19h | UTC

Diagnosis and management of endometriosis – Canadian Medical Association Journal

 

Review | Heart failure with preserved ejection fraction

15 Mar, 2023 | 15:18h | UTC

Heart Failure With Preserved Ejection Fraction: A Review – JAMA (free for a limited period)

Author Interview: Diagnosis and Treatment of Heart Failure with Preserved Ejection Fraction – JAMA

 

ACCP Guidelines | Respiratory management of patients with neuromuscular weakness

15 Mar, 2023 | 15:16h | UTC

Respiratory Management of Patients with Neuromuscular Weakness: An American College of Chest Physicians Clinical Practice Guideline and Expert Panel Report – CHEST

News Release: Clinical practice guideline on respiratory management of patients with neuromuscular weakness – American College of Chest Physicians

 

ESC Consensus Statement | Inotropic therapy in patients with advanced heart failure

15 Mar, 2023 | 15:14h | UTC

Inotropic therapy in patients with advanced heart failure. A clinical consensus statement from the Heart Failure Association of the European Society of Cardiology – European Journal of Heart Failure

 

Consensus Statement | Best current practice and research priorities in active surveillance for prostate cancer

15 Mar, 2023 | 15:11h | UTC

Best Current Practice and Research Priorities in Active Surveillance for Prostate Cancer—A Report of a Movember International Consensus Meeting – European Urology Oncology

 

Consensus Paper | Recommendations for the provision of infective endocarditis services

15 Mar, 2023 | 15:13h | UTC

Expert consensus recommendations for the provision of infective endocarditis services: updated guidance from the Joint British Societies – Heart

 

Out-of-hospital cardiac arrest – review of recent practice-informing trials

15 Mar, 2023 | 15:09h | UTC

Out-of-hospital cardiac arrest – Intensive Care Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 

SR | Yoga may improve frailty markers in older adults

15 Mar, 2023 | 15:08h | UTC

Effect of Yoga on Frailty in Older Adults: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Annals Video Summary: Effect of Yoga on Frailty in Older Adults: A Systematic Review

News Release: Yoga may help to prevent frailty in older adults – American College of Physicians

 

Deprescribing strategies for opioids and benzodiazepines with emphasis on concurrent use: a scoping review

15 Mar, 2023 | 15:06h | UTC

Deprescribing Strategies for Opioids and Benzodiazepines with Emphasis on Concurrent Use: A Scoping Review – Journal of Clinical Medicine

Related:

An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults – Journal of Clinical Medicine

Physician-led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: a randomised trial – Diabetic Medicine

RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Deprescribing proton pump inhibitors – Australian Journal of General Practice

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

 

Review | Approach to the patient with adrenal hemorrhage

15 Mar, 2023 | 15:03h | UTC

Approach to the Patient With Adrenal Hemorrhage – The Journal of Clinical Endocrinology & Metabolism

 

M-A | Risk of recurrence and reintervention after uterine-sparing interventions for symptomatic adenomyosis

15 Mar, 2023 | 15:05h | UTC

Risk of Recurrence and Reintervention After Uterine-Sparing Interventions for Symptomatic Adenomyosis: A Systematic Review and Meta-Analysis – Obstetrics & Gynecology

 

Review | MRI image features with an evident relation to low back pain

15 Mar, 2023 | 15:01h | UTC

MRI image features with an evident relation to low back pain: a narrative review – European Spine Journal

 

RCT | Nirogacestat for desmoid tumors

15 Mar, 2023 | 14:57h | UTC

Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Nirogacestat Improves Outcomes for Patients With Desmoid Tumors – Memorial Sloan Kettering Cancer Center

 

Commentary on Twitter

 

Proposed triggers for retiring a living systematic review

15 Mar, 2023 | 15:02h | UTC

Proposed triggers for retiring a living systematic review – BMJ Evidence-Based Medicine

 

M-A | Comparison of pediatric emergency department visits for attempted suicide before and during the COVID-19 pandemic

15 Mar, 2023 | 14:56h | UTC

Comparison of paediatric emergency department visits for attempted suicide, self-harm, and suicidal ideation before and during the COVID-19 pandemic: a systematic review and meta-analysis – The Lancet Psychiatry

News Release: Emergency department visits for attempted suicides rose globally among youth during pandemic, shows meta-analysis – University of Calgary

 

Review | Surveillance strategies following curative resection and non-operative approach of rectal cancer: how and how long?

15 Mar, 2023 | 14:59h | UTC

Surveillance strategies following curative resection and non-operative approach of rectal cancer: How and how long? Review of current recommendations – World Journal of Gastrointestinal Surgery

 

Review | Prehospital stroke management and mobile stroke units

15 Mar, 2023 | 14:54h | UTC

Prehospital stroke management and mobile stroke units – Current Opinion in Neurology

 

20 million pregnant women with group B streptococcus carriage: consequences, challenges, and opportunities for prevention

15 Mar, 2023 | 14:53h | UTC

20 million pregnant women with group B streptococcus carriage: consequences, challenges, and opportunities for prevention – Current Opinion in Pediatrics

 

M-A | Laparoscopic vs. open distal gastrectomy for locally advanced gastric cancer

15 Mar, 2023 | 14:52h | UTC

Laparoscopic vs. open distal gastrectomy for locally advanced gastric cancer: A systematic review and meta-analysis of randomized controlled trials – Frontiers in Surgery

Related:

Laparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer: 5-Year Outcomes of the KLASS-02 Randomized Clinical Trial – JAMA Surgery

Short-and long-term outcomes of laparoscopic versus open gastrectomy in patients with gastric cancer: a systematic review and meta-analysis of randomized controlled trials – World Journal of Surgical Oncology

Laparoscopic versus open distal gastrectomy for gastric cancer: A systematic review and meta-analysis – Surgery

Laparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer: Five-Year Outcomes From the CLASS-01 Randomized Clinical Trial – JAMA Surgery

Laparoscopic Versus Open Gastrectomy for Gastric Cancer (LOGICA): A Multicenter Randomized Clinical Trial – Journal of Clinical Oncology

Morbidity and Mortality of Laparoscopic vs Open Total Gastrectomy for Clinical Stage I Gastric Cancer: The CLASS02 Multicenter Randomized Clinical Trial – JAMA Oncology

Survival outcomes after laparoscopy-assisted distal gastrectomy versus open distal gastrectomy with nodal dissection for clinical stage IA or IB gastric cancer (JCOG0912): a multicentre, non-inferiority, phase 3 randomised controlled trial – The Lancet Gastroenterology & Hepatology

Effect of Laparoscopic Distal Gastrectomy vs Open Distal Gastrectomy on Long-term Survival Among Patients With Stage I Gastric Cancer: The KLASS-01 Randomized Clinical Trial – JAMA Oncology

 

M-A | Pretest probability assessment and D-Dimer are preferred for the initial evaluation of suspected PE in pregnant women

15 Mar, 2023 | 14:50h | UTC

Noninvasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data – Journal of Thrombosis and Haemostasis

 

Cohort Study | Higher ultra-processed food consumption linked to increased cancer incidence and mortality

15 Mar, 2023 | 14:48h | UTC

Ultra-processed food consumption, cancer risk and cancer mortality: a large-scale prospective analysis within the UK Biobank – eClinicalMedicine

News Release: Ultra-processed foods may be linked to increased risk of cancer – Imperial College London

Commentary: Expert reaction to study looking at ultra-processed foods and risk of different cancers – Science Media Centre

Related:

Association of ultra-processed food consumption with colorectal cancer risk among men and women: results from three prospective US cohort studies – The BMJ

Joint association of food nutritional profile by Nutri-Score front-of-pack label and ultra-processed food intake with mortality: Moli-sani prospective cohort study – The BMJ

Association between consumption of ultra-processed foods and all cause mortality: SUN prospective cohort study – The BMJ

Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé) – The BMJ

 

RCT | Immersive virtual reality intervention reduces pain among pediatric patients undergoing venipuncture

15 Mar, 2023 | 14:46h | UTC

Effects of an Immersive Virtual Reality Intervention on Pain and Anxiety Among Pediatric Patients Undergoing Venipuncture: A Randomized Clinical Trial – JAMA Network Open

Commentary: Immersive Virtual Reality Beneficial for Children Undergoing Venipuncture – HealthDay

 

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