Daily Archives: November 2, 2022
Phase 2 RCT | A single injection of a monoclonal antibody was 88% effective for malaria prevention over 6 months.
2 Nov, 2022 | 14:30h | UTCSafety and Efficacy of a Monoclonal Antibody against Malaria in Mali – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Monoclonal antibody prevents malaria infection in African adults – National Institutes of Health
Commentary: Monoclonal antibody infusion 88% effective against malaria – CIDRAP
Related Study: Phase 1 Study | Low-dose subcutaneous or intravenous monoclonal antibody can prevent malaria in a human challenge model.
Commentary on Twitter
In this phase 2 trial in Mali, an antimalarial monoclonal antibody (CIS43LS) at the higher dose (40 mg per kilogram) was approximately 88% effective at preventing P. falciparum infection as compared with placebo. #TropMed22 https://t.co/UGeBHOPhKY pic.twitter.com/uFX7w3qV0G
— NEJM (@NEJM) November 1, 2022
NICE Guideline | Osteoarthritis in over 16s: diagnosis and management.
2 Nov, 2022 | 14:29h | UTC
NICE Guideline Update | Lung cancer: diagnosis and management.
2 Nov, 2022 | 14:28h | UTCLung cancer: diagnosis and management – National Institute for Health and Care Excellence
RCT | Povidone-iodine and chlorhexidine gluconate are similarly effective for preventing SSI in open fractures.
2 Nov, 2022 | 14:27h | UTCAqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial – The Lancet (link to abstract – $ for full-text)
Related:
Antiseptic Skin Agents to Prevent Surgical Site Infection After Incisional Surgery: A Randomized, Three-armed Combined Non-inferiority and Superiority Clinical Trial (NEWSkin Prep Study) – Annals of Surgery (link to abstract – $ for full-text)
Single-arm P2 study | Eliminating breast surgery for invasive breast cancer in exceptional responders to neoadjuvant systemic therapy.
2 Nov, 2022 | 14:23h | UTCEliminating breast surgery for invasive breast cancer in exceptional responders to neoadjuvant systemic therapy: a multicentre, single-arm, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary: Elimination of Surgery Explored for Selected Breast Cancer Patients – HealthDay
Commentary on Twitter
Online first: #Eliminating breast #surgery for invasive #breastcancer in exceptional #responders to #neoadjuvant systemic #therapy: a multicentre, single-arm, phase 2 trial https://t.co/lxZa62zFZT pic.twitter.com/TS1dKqFhF1
— The Lancet Oncology (@TheLancetOncol) October 26, 2022
RCT | Intensive BP control after thrombectomy for ischemic stroke is associated with increased risk of poor functional outcomes.
2 Nov, 2022 | 14:26h | UTCIntensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
1/ A #MorningPaper from @TheLancet on #Stroke. This large study randomised 821 patients into aggressive BP management (sBP <120mmHg) vs 140-180mmHg. Trial stopped early due to safety concerns. @neuro_at_ic @e1v1m1 @SomaBanerjee73 @StrokeImperialhttps://t.co/vnvnnI1KLq
— Kevin Tsang (@drtintin99) October 29, 2022
Post-trial follow-up | Endarterectomy vs. stenting vs. best medical treatment for asymptomatic carotid artery stenosis.
2 Nov, 2022 | 14:25h | UTCCarotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
Commentary on Twitter
5 year results of SPACE 2 in @TheLancetNeuro show low event rates in all groups. With best medical therapy only 3.1%, CEA+BMT 2.5%, CAS+BMT 4.4%. Study underpowered for firm conclusions. @CREST2_Study will have close to 2500 pts@ESOstroke @WorldStrokeOrg https://t.co/nUE0WxWidk
— Seemant Chaturvedi (@ChaturvediNeuro) September 17, 2022
Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study.
2 Nov, 2022 | 14:21h | UTCCommentary: SLE Rates Vary Worldwide and Require Further Study, Study Emphasizes – AJMC
M-A | Perioperative interventions to reduce pancreatic fistula following pancreatoduodenectomy.
2 Nov, 2022 | 14:22h | UTCPerioperative interventions to reduce pancreatic fistula following pancreatoduodenectomy: meta-analysis – British Journal of Surgery (link to abstract – $ for full-text)
Commentary on Twitter
Perioperative interventions to reduce POPF ? following pancreatoduodenectomy @BJSurgery
? Meta analysis reveal RCTs small and underpowered
Possible role for the following:
⛽️ External pancreatic duct drainage
? Ulinastatin
? Invagination techniquehttps://t.co/IqPMLjb1Er pic.twitter.com/wv6RQUE3lY— Giovanni Marchegiani (@Gio_Marchegiani) June 29, 2022
EULAR points to consider to support people with rheumatic and musculoskeletal diseases in work participation.
2 Nov, 2022 | 14:20h | UTCNews Release: Supporting workers with rheumatic and musculoskeletal diseases – European Alliance of Associations for Rheumatology