Daily Archives: August 5, 2021 | LinksMedicus Free Medical News & Perspectives

SARS-CoV-2 Variants in Patients with Immunosuppression.

5 Aug, 2021 | 09:02h | UTC

SARS-CoV-2 Variants in Patients with Immunosuppression – New England Journal of Medicine

Commentary on Twitter

In the pandemic, immunocompromised people (~3% of Americans) are not getting adequate recognition for the potential of in-host evolution of the virus (highlighted studies) and the need for far better approaches to protect them https://t.co/XDT1VxC9ZK @NEJM pic.twitter.com/ciw1WD9EzC

— Eric Topol (@EricTopol) August 4, 2021

RCT: In noncritically ill patients hospitalized with Covid-19, therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge compared with usual-care thromboprophylaxis.

5 Aug, 2021 | 09:07h | UTC

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19 – New England Journal of Medicine

Editorial: Surviving Covid-19 with Heparin?

Commentaries:

Full-dose blood thinners reduce the need for organ support in moderately ill COVID-19 patients, but not in critically ill patients – National Institutes of Health

Therapeutic-Dose Heparin in COVID-19: Who Benefits, Who Doesn’t – TCTMD

Canadian-Led International Study: Full-Dose Blood Thinners Benefit Moderately Ill COVID-19 Patients – University of Manitoba

Commentary on Twitter

In noncritically ill patients with #COVID19, anticoagulation increased the probability of survival to hospital discharge without organ support. https://t.co/3JzKdmL3SB #IDTwitter pic.twitter.com/iDjSelp2HL

— NEJM (@NEJM) August 4, 2021

RCT: In critically ill patients with Covid-19, therapeutic anticoagulation with heparin did not result in improved outcomes compared to usual-care pharmacologic thromboprophylaxis.

5 Aug, 2021 | 09:04h | UTC

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 – New England Journal of Medicine

Editorial: Surviving Covid-19 with Heparin?

Commentaries:

Full-dose blood thinners reduce the need for organ support in moderately ill COVID-19 patients, but not in critically ill patients – National Institutes of Health

Therapeutic-Dose Heparin in COVID-19: Who Benefits, Who Doesn’t – TCTMD

Commentary on Twitter

Anticoagulation did not improve hospital survival in critically Ill patients with #COVID19. https://t.co/E8RXE01jbF pic.twitter.com/9idGxgbUas

— NEJM (@NEJM) August 4, 2021

RCT: Subcutaneous REGEN-COV antibody combination prevented symptomatic Covid-19 infection in previously uninfected household contacts of infected persons.

5 Aug, 2021 | 09:01h | UTC

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19 – New England Journal of Medicine

RCT: Bamlanivimab plus Etesevimab reduce mortality and hospitalization in ambulatory patients with early Covid-19 (within 3 days of a positive test) who are at risk for clinical deterioration (i.e., older people, obese, diabetics, immunocompromised, with CV disease).

[Preprint] RECOVERY trial finds Regeneron’s monoclonal antibody combination reduces deaths for hospitalized COVID-19 patients who have not mounted their own immune response.

Commentary on Twitter

Subcutaneous REGEN-COV prevented symptomatic #COVID19 and asymptomatic #SARSCoV2 infection in previously uninfected household contacts. https://t.co/rRNFTjS9hX pic.twitter.com/B7qXeyWKUb

— NEJM (@NEJM) August 4, 2021

How to wear a mask and not fog up your glasses.

5 Aug, 2021 | 08:56h | UTC

How to wear a mask and not fog up your glasses – The Philadelphia Inquirer

Covid: WHO calls for booster pause to vaccinate poorer nations.

5 Aug, 2021 | 08:59h | UTC

Covid: WHO calls for booster pause to vaccinate poorer nations – BBC

Myocarditis and pericarditis after vaccination for COVID-19.

5 Aug, 2021 | 08:57h | UTC

Myocarditis and Pericarditis After Vaccination for COVID-19 – JAMA

Analysis finds benefits of COVID-19 vaccination outweigh risks of rare cases of myocarditis.

CDC: Use of mRNA COVID-19 vaccine after reports of myocarditis among vaccine recipients – “Continued use of mRNA COVID-19 vaccines in all recommended age groups will prevent morbidity and mortality from COVID-19 that far exceed the number of cases of myocarditis expected”.

Case Series: Myocarditis following immunization with mRNA COVID-19 vaccines.

CDC: mRNA vaccines are likely linked to cases of myocarditis and pericarditis – 1,226 cases of myocarditis or pericarditis have been reported mostly in people under 30.

ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.

5 Aug, 2021 | 08:55h | UTC

News release: American Society of Anesthesiologists and Anesthesia Patient Safety Foundation Say Preoperative Testing for COVID-19 is Essential, Regardless of Vaccination

See guidance: ASA and APSF Statement on Perioperative Testing for the COVID-19 Virus

Position statement: Perioperative management of post-COVID-19 surgical patients.

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

WSES Position Paper: The management of surgical patients in the emergency setting during COVID-19 pandemic

Preparing previously COVID-19-positive patients for elective surgery: A framework for preoperative evaluation

Opinion: Watch the U.K. to Understand Delta – “The country lifted all its COVID-19 restrictions just as Delta peaked. What happens next will tell us how well vaccines are working.”

5 Aug, 2021 | 08:52h | UTC

Watch the U.K. to Understand Delta – The Atlantic

WHO Global Patient Safety Action Plan 2021-2030.

5 Aug, 2021 | 08:51h | UTC

Global Patient Safety Action Plan 2021-2030 – World Health Organization

Commentary on Twitter

Delighted to launch the @WHO Global #PatientSafety Action Plan 2021 – 2030, focusing on:
-understanding the extent of the problem
-closing policy gaps
-addressing inadequate application of safety science in policies
-putting policies into practicehttps://t.co/63Fj1xgVEX

— Tedros Adhanom Ghebreyesus (@DrTedros) August 4, 2021

Coronavirus infections three times lower in double vaccinated people – REACT.

5 Aug, 2021 | 08:53h | UTC

Coronavirus infections three times lower in double vaccinated people – REACT – Imperial College London

AAOS Guideline: Pharmacologic, physical, and cognitive pain alleviation for musculoskeletal extremity/pelvis surgery.

5 Aug, 2021 | 08:49h | UTC

Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery – American Academy of Orthopaedic Surgeons

Evidence summary: Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery

News release: Clinical Practice Guideline and Appropriate Use Criteria for the Evaluation of Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery

Guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy.

5 Aug, 2021 | 08:47h | UTC

European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force—Second revision – European Journal of Neurology

UEG and ESNM consensus on gastroparesis.

5 Aug, 2021 | 08:46h | UTC

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis – UEG Journal

RCT: Similar outcomes with Milrinone vs. Dobutamine in the treatment of cardiogenic shock.

5 Aug, 2021 | 08:44h | UTC

Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock – New England Journal of Medicine (link to abstract – $ for full-text)

Visual abstract: Milrinone vs. Dobutamine in Cardiogenic Shock

Commentary: Inotrope Showdown Leaves No Winner in Cardiogenic Shock – MedPage Today (link to abstract – $ for full-text)

RCT: Therapeutic hypothermia may cause harm in moderate or severe neonatal encephalopathy in low-income and middle-income countries.

5 Aug, 2021 | 08:43h | UTC

Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh – The Lancet Global Health

News release: Brain injury treatment may cause harm in low and middle income nations – Imperial College London

Commentary: Hypoxic ischaemic encephalopathy in low resource settings—time to stop cooling? – The Lancet Global Health

Methodology over metrics: current scientific standards are a disservice to patients and society.

5 Aug, 2021 | 08:42h | UTC

Methodology over metrics: current scientific standards are a disservice to patients and society – Journal of Clinical Epidemiology

The frequency of medical reversals in a cross-sectional analysis of high-impact oncology journals, 2009–2018.

5 Aug, 2021 | 08:37h | UTC

The frequency of medical reversals in a cross-sectional analysis of high-impact oncology journals, 2009–2018 – BMC Oncology

Meta-Research: A Comprehensive Review of Randomized Trials Leading to “Medical Reversals” in Three Medical Journals

Frequency of Medical Reversal Among Published Randomized Controlled Trials Assessing Cardiopulmonary Resuscitation

Review: Medical Reversals in Family Practice

Sham Surgeries: A Tale of Medical Reversals & the Role of the Media

International consensus recommendations on key outcome measures for organ preservation after (chemo) radiotherapy in patients with rectal cancer.

5 Aug, 2021 | 08:38h | UTC

International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer – Nature Reviews Clinical Oncology

Cancer care in the wake of a cyberattack: how to prepare and what to expect.

5 Aug, 2021 | 08:41h | UTC

Cancer Care in the Wake of a Cyberattack: How to Prepare and What to Expect – JCO Oncology Practice

Commentary on Twitter

The paper we wish we never had to write based upon our #cyberattack experience at the @UVMcancercenter.

Cancer care in the wake of a cyberattack: How to prepare and what to expect. @UVMMedCenter @UVMLarnerMed #medtwitter https://t.co/W3xGcuhZrs pic.twitter.com/cEHYUOt7yU

— Tim Plante, MD MHS (@tbplante) August 4, 2021