TOP 10 Medical News Stories

“we are issuing an Expression of Concern to alert readers to the fact that serious scientific questions have been brought to our attention. We will update this notice as soon as we have further information.”

9 – Editorial: Expression of Concern: Mehra MR et al. Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. N Engl J Med. DOI: 10.1056/NEJMoa2007621 – New England Journal of Medicine

Commentary: Top medical journals raise concerns about data in two studies related to Covid-19 – STAT

“We have asked the authors to provide evidence that the data are reliable. In the interim and for the benefit of our readers, we are publishing this Expression of Concern about the reliability of their conclusions.”

10 –COVID-19 Updates / 03 June 2020 Edition

03 June 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Tue June 02 – 10 Stories of The Day!

2 Jun, 2020 | 05:15h | UTC

1 – Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis – The Lancet

Commentaries: Most comprehensive study to date provides evidence on optimal physical distancing, face masks, and eye protection to prevent spread of COVID-19 – The Lancet AND Physical distancing, face masks, and eye protection for prevention of COVID-19 – The Lancet AND Medical Workers Should Use Respirator Masks, Not Surgical Masks – The New York Times AND Expert reaction to review of optimal physical distancing, face masks, and eye protection to prevent spread of COVID-19 – Science Media Centre AND Evidence supports physical distancing, masks, and eye protection to help prevent COVID-19 – McMaster University AND Social distancing and masks reduce risk of getting Covid-19, review finds – CNN

2 – Rapid assessment of service delivery for NCDs during the COVID-19 pandemic – World Health Organization

News Release: COVID-19 significantly impacts health services for noncommunicable diseases – World Health Organization

Commentary: COVID-19 Has ‘Severely’ Disrupted Chronic Disease Care, WHO Warns – Health Policy Watch

3 – Maintaining essential health services: operational guidance for the COVID-19 context – World Health Organization

News Release: Maintaining essential health services: new operational guidance for the COVID-19 context

4 – Epidemiology of COVID-19 Among Children in China – Pediatrics

Commentaries: COVID-19 in Children: Initial Characterization of the Pediatric Disease – Pediatrics AND Coronavirus: is it safe for children to return to school? – The Conversation

5 – Acute myocardial injury: a novel clinical pattern in children with COVID-19 – The Lancet Child & Adolescent Health

6 – Airborne Spread of SARS-CoV-2 and a Potential Role for Air Disinfection – JAMA

7 – Anthony Fauci on Covid-19 reopenings, vaccines, and moving at ‘warp speed’ – STAT

8 – Universities will never be the same after the coronavirus crisis – Nature

9 – Remdesivir Shows Modest Improvement in Moderate COVID-19 Patients

10 –COVID-19 Updates / 02 June 2020 Edition

02 June 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Mon June 01 – 10 Stories of The Day!

1 Jun, 2020 | 04:04h | UTC

1 – Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study – The Lancet

Commentaries: Mitigating the risks of surgery during the COVID-19 pandemic – The Lancet AND COVID-19 patients who undergo surgery are at increased risk of postoperative death – University of Birmingham AND Clinicians must carefully balance risk of complications linked to SARS-CoV2 infection with risks of delaying surgery – The Lancet

2 – Cohort Studies: Clinical Impact of COVID-19 on Patients with Cancer

Study 1: Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study – The Lancet

Study 2: COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study – The Lancet

Commentaries: Studies highlight COVID-19 impact on cancer patients – CIDRAP AND Cancer, coronavirus are a dangerous mix, new studies find – MedicalXpress AND Cancer, coronavirus are a dangerous mix, new studies find – Associated Press AND Cancer and COVID-19: what do we really know? – The Lancet

3 – An open letter to Mehra et al and The Lancet – Zenodo

4 – Will Evidence-Based Medicine Survive COVID-19? – Boston Review

5 – Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review – JAMA Neurology

Commentary: Expert reaction a review and a case study looking at neurological manifestations associated with COVID-19 disease and other coronaviruses – Science Media Centre

6 – Ramipril in High Risk Patients with COVID-19 – Journal of the American College of Cardiology

7 – Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting – Anesthesia & Analgesia

8 – German S1 guidelines for the diagnosis and treatment of perianal dermatitis (anal eczema) – Journal of the German Society of Dermatology

9 – Guidelines on the use of liver biopsy in clinical practice from the British Society of Gastroenterology, the Royal College of Radiologists and the Royal College of Pathology – Gut

10 –COVID-19 Updates / 01 June 2020 Edition

01 June 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Fri May 29 – 10 Stories of The Day!

29 May, 2020 | 03:36h | UTC

1 – Shielding from covid-19 should be stratified by risk – The BMJ

2 – COVID-19: in the footsteps of Ernest Shackleton – Thorax

Commentaries: New Paper Finds Startling Number Of Asymptomatic Covid-19 Carriers – Forbes AND Asymptomatic COVID-19 cases may be more common than suspected – NBC News AND Cruise ship study hints at many ‘silent’ COVID-19 infections – The BMJ

3 – Comparison of Clinical Characteristics of Patients with Asymptomatic vs Symptomatic Coronavirus Disease 2019 in Wuhan, China – JAMA Network Open

Commentaries: 40% of COVID-19 patients may be asymptomatic as disease progresses – UPI AND How Common Are Asymptomatic Cases of COVID-19? – U.S News

4 – Using Controlled Trials to Resolve Key Unknowns About Policy During the COVID-19 Pandemic – JAMA

5 – Conducting Clinical Research During the COVID-19 Pandemic: Protecting Scientific Integrity – JAMA

6 – For Seniors, COVID-19 Sets Off A Pandemic Of Despair – Kaiser Health News

7 – Wastewater testing gains traction as a Covid-19 early warning system – STAT

8 – Ethical guidelines for deliberately infecting volunteers with COVID-19 – Journal of Medical Ethics

Commentary: COVID-19 vaccine development: New guidelines for ethical approach to infecting trial volunteers – University of Warwick

9 – Ethical guidelines for COVID-19 tracing apps – Nature

10 –COVID-19 Updates / 29 May 2020 Edition

29 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Thu May 28 – 10 Stories of The Day!

28 May, 2020 | 10:03h | UTC

1 – Clinical management of COVID-19 – World Health Organization

2 – Remdesivir for 5 or 10 Days in Patients with Severe Covid-19 – New England Journal of Medicine

3 – Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19: A Living Systematic Review – Annals of Internal Medicine

4 – Face coverings for the public: Laying straw men to rest – Journal of Evaluation in Clinical Practice

5 – Reducing transmission of SARS-CoV-2 – Science

6 – The unexpected side effect of Covid-19 – CNN

“After Covid-19, if we dare imagine the day, it will be important to ask who was harmed by delayed and forgone medical care. But the severe financial strains on individuals and public budgets make it just as essential to ask who benefited from avoiding interventions with no salutatory effect.”

7 – Evaluation and Management Considerations for Neonates At Risk for COVID-19 – Centers for Disease Control and Prevention

Commentary: New CDC Guidelines: Test All Newborns With Covid-19 Positive Moms – Forbes

8 – No evidence blanket ‘do-not-resuscitate’ orders for COVID-19 patients are necessary – American Heart Association

Original Study: Survival After In-Hospital Cardiac Arrest In Critically Ill Patients: Implications For Covid-19 Outbreak? – Circulation: Cardiovascular Quality and Outcomes

9 – Review of trials currently testing treatment and prevention of COVID-19 – Clinical Microbiology and Infection

10 –COVID-19 Updates / 28 May 2020 Edition

28 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Wed May 27 – 10 Stories of The Day!

27 May, 2020 | 02:50h | UTC

1 – Revealing the toll of COVID-19: A technical package for rapid mortality surveillance and epidemic response – World Health Organization

2 – WHO Manifesto for a healthy recovery from COVID-19 – World Health Organization

3 – “Is It Safe for Me to Go to Work?” Risk Stratification for Workers during the Covid-19 Pandemic – New England Journal of Medicine

4 – When You Can be Around Others After You Had or Likely Had COVID-19 – Centers for Disease Control and Prevention

“I think or know I had COVID-19, and I had symptoms”.

You can be with others after:

3 days with no fever AND
Symptoms improved AND
10 days since symptoms first appeared”

5 – Loss of Smell and Taste in 2013 European Patients With Mild to Moderate COVID-19 – Annals of Internal Medicine

6 – Just the Facts: What drugs are safe and effective for COVID-19? – Canadian Journal of Emergency Medicine

“Apart from supportive care, there are no current effective therapeutics for COVID-19”

7 – The Totality of the Evidence – Boston Review

See other interesting perspectives from the Boston Review: Models v. Evidence AND Good Science Is Good Science

“Given what we know now, it is reasonable to consider alternatives to population-wide lockdown, even as we focus on protecting those most at risk and support health care systems to care for patients who are sick.”

8 – Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—a Living Working Document – Circulation: Heart Failure

9 – Efficacy and safety of convalescent plasma for severe COVID-19 based on evidence in other severe respiratory viral infections: a systematic review and meta-analysis – Canadian Medical Association Journal

10 –COVID-19 Updates / 27 May 2020 Edition

27 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Tue May 26 – 10 Stories of The Day!

26 May, 2020 | 10:08h | UTC

1 – COVID-19 and Cardiovascular Disease – Circulation

2 – SARS-CoV-2 in Pregnancy: A Comprehensive Summary of Current Guidelines – Journal of Clinical Medicine

3 – Placental Pathology in COVID-19 – American Journal of Clinical Pathology

Commentaries: Placentas from COVID-19-positive pregnant women show injury – Northwestern University AND Expert reaction to study looking at placentas from COVID19-positive pregnant women – Science Media Centre AND Covid-19 appears to attack placenta during pregnancy, study says – CNN AND Placenta Injury Observed in Pregnant Women Who Test Positive For Coronavirus – Forbes

4 – Critical Perspective: Evidence-Based Medicine for the Management of COVID-19 ARDS – American Thoracic Society

5 – Report: Smart testing for COVID-19 virus and antibodies – CIDRAP

News Release: In new report, CIDRAP at the University of Minnesota proposes smart and strategic approach to COVID-19 testing

See also: Reports 1 and 2

6 – Perspective: In Pandemic, Many Seeing Upsides to Telemedicine

Part I: In pandemic, many seeing upsides to telemedicine – CIDRAP

Part II: COVID-19 reveals telehealth barriers, solutions – CIDRAP

7 – On coughing and airborne droplet transmission to humans – Physics of Fluids

Commentaries: Six feet not far enough to stop virus transmission in light winds – American Institute of Physics AND Expert reaction to paper studying mechanisms of coughing and airborne transmission of viruses – Science Media Centre AND Why 6 feet may not be enough social distance to avoid COVID-19 – Science News

8 – Here’s what needs to happen before we can all get vaccinated for COVID-19 – CBC

9 – Androgenetic Alopecia Present in the Majority of Hospitalized COVID-19 Patients – the “Gabrin sign” – Journal of the American Academy of Dermatology

10 –COVID-19 Updates / 26 May 2020 Edition

26 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Mon May 25 – 10 Stories of The Day!

25 May, 2020 | 02:08h | UTC

1 – Remdesivir for the Treatment of Covid-19 — Preliminary Report – New England Journal of Medicine

Commentaries: Preliminary report on NIAID trial of remdesivir – PulmCrit AND Peer-reviewed data shows remdesivir for COVID-19 improves time to recovery – National Institutes of Health AND Covid-19 study details benefits of treatment with remdesivir, and also its limitations – STAT

2 – Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis – The Lancet

Commentaries: Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous? – The Lancet AND What a big new study on malaria drugs as Covid-19 treatments tells us — and what it doesn’t – STAT AND Hydroxychloroquine May Cause More Harm Than Benefit To COVID-19 Patients, Says New Lancet Study – Health Policy Watch

3 – Why countries should stop using anti-malarial drugs for COVID-19 – The Conversation

4 – Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial – The Lancet

Commentaries: First human trial of COVID-19 vaccine finds it is safe and induces rapid immune response – The Lancet AND Early Study Of Covid-19 Vaccine Developed In China Sees Mixed Results – Forbes AND Coronavirus Vaccine Shows Promising Early Results in China – The New York Times AND A Chinese biotech just published the first human data for its coronavirus vaccine candidate, supporting further trials – Business Insider AND Experts skeptical after researchers report positive vaccine results – CNN AND Two COVID-19 Vaccine Candidates Induce Immune Response In Healthy Volunteers – Health Policy Watch

5 – The world needs Covid-19 vaccines. It may also be overestimating their power – STAT

6 – SARS-CoV2 vaccines: Slow is fast – Science

7 – Susceptibility to and transmission of COVID-19 amongst children and adolescents compared with adults: a systematic review and meta-analysis – medRxiv

Commentaries: Children appear half as likely to catch COVID-19 as adults – London School of Hygiene & Tropical Medicine AND Expert reaction to systematic review preprint looking at susceptibility to SARS-CoV-2 infection in children and adolescents compared with adults – Science Media Centre

8 – Coronavirus Disease 2019 Test Results After Clinical Recovery and Hospital Discharge Among Patients in China – JAMA Network Open

Commentaries: Expert reaction to study on PCR testing results from 60 people after clinical recovery from COVID-19 – Science Media Centre AND 16% of recovered patients test positive for COVID-19 weeks after discharge: study – UPI

9 – SARS-CoV-2 RNA in wastewater anticipated COVID-19 occurrence in a low prevalence area – Water Research

10 –COVID-19 Updates / 25 May 2020 Edition

25 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Fri May 22 – 10 Stories of The Day!

22 May, 2020 | 05:01h | UTC

1 – Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 – New England Journal of Medicine

Commentary: Lungs of deceased COVID-19 patients show distinctive features – Brigham and Women’s Hospital

2 – Choosing Wisely in the COVID-19 Era: Preventing Harm to Healthcare Workers – Journal of Hospital Medicine

3 – SARS2-CoV-2 and Stroke in a New York Healthcare System – Stroke

News Release: Stroke rates among COVID-19 patients are low, but cases are more severe; overall stroke hospital admissions are down globally – American Heart Association

Commentary: COVID-19 patients may have lower stroke rates than previously suggested – NYU Grossman School of Medicine

4 – Ten reasons why immunity passports are a bad idea – Nature

5 – How coronavirus lockdowns stopped flu in its tracks – Nature

“Reported rates of influenza and other infections have fallen sharply, but some communicable diseases may see a rise.”

6 – 15 drugs being tested to treat COVID-19 and how they would work – Nature

7 – Which interventions work best in a pandemic? – Science

8 – Ethics of controlled human infection to address COVID-19 – Science

9 – Open access: how COVID-19 will change the way research findings are shared – Wellcome

10 –COVID-19 Updates / 22 May 2020 Edition

22 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Thu May 21 – 10 Stories of The Day!

21 May, 2020 | 09:29h | UTC

1 – SARS-CoV-2 infection protects against rechallenge in rhesus macaques – Science

Commentaries: Infection With SARS-CoV-2 Protects Against Re-infection – At Least in Rhesus Macaques – Technology Networks AND Prototype Vaccine Protects Monkeys From Coronavirus – The New York Times

2 – Audio Interview: Capitalizing on Immune Responses to Covid-19 – New England Journal of Medicine

3 – Olfactory Dysfunction in COVID-19: Diagnosis and Management – JAMA

4 – Early Short Course Corticosteroids in Hospitalized Patients with COVID-19 – Clinical Infectious Diseases

5 – Unconventional approaches to mechanical ventilation—step-by-step through the COVID-19 crisis – Critical Care

6 – A Critical Look at A Preprint Inferring the Covid-19 Infection Fatality Rate – by Hilda Bastian

Original Preprint: The infection fatality rate of COVID-19 inferred from seroprevalence data – medRxiv

7 – COVID-19 in Children: Clinical Approach and Management – The Indian Journal of Pediatrics

8 – Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy – European Heart Journal

Commentary: Outcomes of Patients Hospitalized for COVID-19 and Cardiac Disease – American College of Cardiology

9 – Cardiovascular Considerations in Treating Patients With Coronavirus Disease 2019 (COVID-19) – Journal of Cardiovascular Pharmacology

See also: COVID-19: Updates for Cardiologists

10 –COVID-19 Updates / 21 May 2020 Edition

21 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Wed May 20 – 10 Stories of The Day!

20 May, 2020 | 10:03h | UTC

1 – Editorial: Lack of efficacy of hydroxychloroquine in covid-19 – The BMJ

Original Research: Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial – The BMJ

Related Meta-analysis (preprint): Hydroxychloroquine in COVID-19: A systematic review and meta-analysis – medRxiv

2 – Covid Patients Testing Positive After Recovery Aren’t Infectious, Study Shows – Bloomberg

3 – Keep your nose out of it: why saliva tests could offer a better alternative to nasal COVID-19 swabs – The Conversation

Original Article: Saliva—Friend and Foe in the COVID-19 Outbreak – Diagnostics

4 – Reducing the Risk of Diagnostic Error in the COVID-19 Era – Journal of Hospital Medicine

5 – Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study – The Lancet

Commentaries: Critically ill patients with COVID-19 in New York City – The Lancet AND Nearly 40% of critically ill COVID-19 patients in New York City died, study finds – UPI

6 – Personal Protective Equipment and Covid-19 – New England Journal of Medicine

7 – The Covid-19 Pandemic and the Incidence of Acute Myocardial Infarction – New England Journal of Medicine

8 – Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward – Science Immunology

9 – Why do some COVID-19 patients infect many others, whereas most don’t spread the virus at all? – Science

10 –COVID-19 Updates / 20 May 2020 Edition

20 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Tue May 19 – 10 Stories of The Day!

19 May, 2020 | 04:42h | UTC

1 – Management of acute kidney injury in patients with COVID-19 – The Lancet Respiratory Medicine

2 – Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic – The Lancet Psychiatry

3 – Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic – Circulation

4 – Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody – Nature

Commentary: Cross-neutralization of SARS and COVID-19 coronaviruses by a monoclonal antibody – News Medical

5 – Seroprevalence of SARS-CoV-2–Specific Antibodies Among Adults in Los Angeles County, California, on April 10-11, 2020 – JAMA

“the prevalence of antibodies to SARS-CoV-2 was 4.65%. The estimate implies that approximately 367 000 adults had SARS-CoV-2 antibodies, which is substantially greater than the 8430 cumulative number of confirmed infections in the county on April 10”

6 – Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV): An Unprecedented Partnership for Unprecedented Times – JAMA

Commentary: NIH Director: Defeating COVID-19 requires unprecedented action and collaboration – National Institutes of Health

Related Viewpoint: Planning for a COVID-19 Vaccination Program – JAMA

7 – Coronavirus: hamster research shows effectiveness of masks ‘huge’ in Covid-19 battle, Hong Kong scientists say – South China Morning Post

8 – Early data show Moderna Covid-19 vaccine generates immune response – STAT

9 – Decline in Child Vaccination Coverage During the COVID-19 Pandemic — Michigan Care Improvement Registry, May 2016–May 2020 – CDC Morbidity and Mortality Weekly Report

Commentaries: More evidence US childhood vaccinations are dropping amid coronavirus pandemic – CNN AND Michigan reports a sharp drop in child vaccinations after the CDC warned missed shots could lead to a measles resurgence across the US – Business Insider

10 –COVID-19 Updates / 19 May 2020 Edition

19 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Mon May 18 – 10 Stories of The Day!

18 May, 2020 | 02:22h | UTC

1 – Multisystem inflammatory syndrome in children and adolescents with COVID-19 – World Health Organization

News Release: Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19

2 – Policy Brief: COVID-19 and the Need for Action on Mental Health – World Health Organization

News Release: Substantial investment needed to avert mental health crisis – World Health Organization

Commentary: “Mental health services are an essential part of all government responses to COVID-19” – United Nations

3 – New NICE Covid-19 Rapid Guidelines: Chronic Kidney Disease & Interstitial Lung Disease

COVID-19 rapid guideline: chronic kidney disease – National Institute for Health and Care Excellence

COVID-19 rapid guideline: interstitial lung disease – National Institute for Health and Care Excellence

4 – Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial – The BMJ

Commentary: Further evidence does not support hydroxychloroquine for patients with COVID-19 – BMJ

5 – Severe Covid-19 – New England Journal of Medicine

6 – Understanding pathophysiology of hemostasis disorders in critically ill patients with COVID-19 – Intensive Care Medicine

7 – Tracheostomy in the COVID-19 era: global and multidisciplinary guidance – The Lancet Respiratory Medicine

Commentary: Walking the line between benefit and harm from tracheostomy in COVID-19 – The Lancet Respiratory Medicine

8 – More Harm Than Good? The Net Impact of COVID-19 Policies Is What Matters for Health – Center for Global Development

9 – Clinical and Chest Radiography Features Determine Patient Outcomes In Young and Middle Age Adults with COVID-19 – Radiology

10 –COVID-19 Updates / 18 May 2020 Edition

18 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Fri May 15 – 10 Stories of The Day!

15 May, 2020 | 03:55h | UTC

1 – An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study – The Lancet

Commentaries: Kawasaki-like disease: emerging complication during the COVID-19 pandemic – The Lancet AND Kawasaki-like COVID-19 complication found in Italian kids – CIDRAP AND What we know about the new Covid-19-linked illness in children – Vox AND Coronavirus: Children affected by rare Kawasaki-like disease – BBC

2 – Early Safety Indicators of COVID-19 Convalescent Plasma in 5,000 Patients – medRxiv

Commentary: Convalescent plasma is safe to treat COVID-19: nationwide study – NBC News

3 – Convalescent plasma or hyperimmune immunoglobulin for people with COVID‐19: a rapid review – Cochrane Library

Summary: Plasma from people who have recovered from COVID-19 to treat individuals with COVID-19 – Cochrane Library

4 – COVID-19 review of national clinical practice guidelines for key questions relating to the care of pregnant women and their babies – Cochrane Pregnancy and Childbirth

5 – Masks help stop the spread of coronavirus – the science is simple and I’m one of 100 experts urging governors to require public mask-wearing – The Conversation

6 – The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission – Proceedings of the National Academy of Sciences

Commentaries: Expert reaction to study looking at speech-generated droplets and COVID-19 transmission – Science Media Centre AND Loud Talking Can Spread More than 1,000 Coronavirus Particles in the Air for 14 Minutes: Study – The Science Times AND Simply talking in confined spaces may be enough to spread the coronavirus, researchers say – USA Today AND Loud talking could leave coronavirus in the air for up to 14 minutes – MIT Technology Review

7 – Preventing a Parallel Pandemic — A National Strategy to Protect Clinicians’ Well-Being – New England Journal of Medicine

Related: The Covid-19 Crisis too Few are Talking About: Health Care Workers’ Mental Health (commentaries on the subject)

8 – Audio Interview: Finding Reliable Information about Covid-19 – New England Journal of Medicine

9 – Surgery during the COVID‐19 pandemic: operating room suggestions from an international Delphi process – British Journal of Surgery

10 –COVID-19 Updates / 15 May 2020 Edition

15 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Thu May 14 – 10 Stories of The Day!

14 May, 2020 | 10:18h | UTC

1 – Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis – The Lancet Gastroenterology & Hepatology

2 – SARS-CoV-2 Rates in BCG-Vaccinated and Unvaccinated Young Adults – JAMA

3 – Before/after study of short-course steroid in COVID-19 – PulmCrit

Original Study (Preprint): Early Short Course Corticosteroids in Hospitalized Patients with COVID-19 – medRxiv

4 – Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study – The Lancet

Commentaries: Scientists develop online calculator to predict individual’s risk of dying from Covid-19 – The Independent AND Expert reaction to study estimating excess deaths over one year directly or indirectly related to COVID-19 based on underlying health conditions and age of UK population, and making comments on the effect of easing the lockdown – Science Media Centre

See calculator: OurRisk.CoV

5 – Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study – The Lancet Global Health

Commentaries: As COVID-19 devastates already fragile health systems, over 6,000 additional children under five could die a day, without urgent action – UNICEF AND Unicef: 6,000 children could die every day due to impact of coronavirus – The Guardian

6 – Virtual care: new models of caring for our patients and workforce – The Lancet Digital Health

7 – The potential impact of COVID-19 on psychosis: A rapid review of contemporary epidemic and pandemic research – Schizophrenia Research

Commentary: Evidence suggests a small but important number of people will develop coronavirus-related psychosis – Orygen and La Trobe University

8 – Coronavirus Test Shortages Trigger a New Strategy: Group Screening – Scientific American

9 – Endovascular Therapy for Patients With Acute Ischemic Stroke During the COVID-19 Pandemic: A Proposed Algorithm – Stroke

Commentary: Endovascular Therapy for Acute Ischemic Stroke During COVID-19 Pandemic – American College of Cardiology

10 – Coronavirus Disease (COVID-19) Updates / 14 May 2020 Edition

14 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Wed May 13 – 10 Stories of The Day!

13 May, 2020 | 02:20h | UTC

1 – Practice Pointer: Interpreting a covid-19 test result – The BMJ

2 – Waste in covid-19 research – The BMJ

Related Landmark Paper from the Author: Avoidable waste in the production and reporting of research evidence – The Lancet (free registration required)

3 – Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19 – JAMA Internal Medicine

Related Preprint Study (just published): Development and validation of the COVID-19 severity index (CSI): a prognostic tool for early respiratory decompensation – medRxiv AND Calculation Tool: https://covidseverityindex.org/

4 – Virus Wars: Return of Lopinavir/Ritonavir (along with ribavirin and interferon) – PulmCrit

Original Article: Triple Therapy Antiviral Combination Seems Promising for COVID-19 in Open-label, Randomized, Phase 2 Trial (study and commentaries)

5 – New Zealand eliminates COVID-19 – The Lancet

6 – A close relative of SARS-CoV-2 found in bats offers more evidence it evolved naturally – Cell Press

Original Article: A novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1/S2 cleavage site of the spike protein – Current Biology

7 – Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19 – Journal of Clinical Virology

8 – Telepsychiatry and the Coronavirus Disease 2019 Pandemic—Current and Future Outcomes of the Rapid Virtualization of Psychiatric Care – JAMA Psychiatry

9 – A Pandemic Benefit: The Expansion of Telemedicine – The New York Times

Related: COVID-19: Rapidly Converting to “Virtual Practices” (several commentaries on the subject) AND A digital embrace to blunt the curve of COVID19 pandemic – npj Digital Medicine

10 – Coronavirus Disease (COVID-19) Updates / 13 May 2020 Edition

13 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Tue May 12 – 10 Stories of The Day!

12 May, 2020 | 03:41h | UTC

1 – Association of Treatment with Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State – JAMA

2 – Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units – JAMA Pediatrics

Commentaries: A study of 48 children in intensive care with the coronavirus found 18 needed ventilators. Most had underlying conditions – Business Insider AND Study Offers Details of U.S. Children Severely Sickened by Coronavirus – The New York Times

3 – Considerations for public health and social measures in the workplace in the context of COVID-19 – World Health Organization

4 – The cost of inaction: COVID-19-related service disruptions could cause hundreds of thousands of extra deaths from HIV – World Health Organization

Original Preprints: Potential effects of disruption to HIV programmes in sub-Saharan Africa caused by COVID-19: results from multiple mathematical models AND Estimation of the potential effects of disruption to HIV programs in sub-Saharan Africa caused by COVID-19: results from multiple models APPENDIX

5 – AIDS, TB And Malaria Set To Get Deadlier Due To Coronavirus – Forbes

6 – Abdominal Imaging Findings in COVID-19: Preliminary Observations – Radiology

News Release: Imaging reveals bowel abnormalities in patients with COVID-19 – Radiological Society of North America

7 – Real-time tracking of self-reported symptoms to predict potential COVID-19 – Nature Medicine

Commentaries: New AI diagnostic can predict COVID-19 without testing – King’s College London AND Expert reaction to study looking at possibility of using real-time tracking of self-reported symptoms to predict potential COVID-19 without testing – Science Media Centre AND Coronavirus: research reveals way to predict infection – without a test – The Conversation AND Loss of smell and taste may actually be one of the clearest signs of COVID-19 – Science News

8 – Ethics and governance for digital disease surveillance – Science

9 – Richard Lehman’s Covid-19 Reviews, 11 May 2020 – The BMJ Opinion

In this weekly round-up, Richard Lehman looks at a personal selection of articles of relevance to clinicians dealing with covid-19

10 – Coronavirus Disease (COVID-19) Updates / 12 May 2020 Edition

12 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Mon May 11 – 10 Stories of The Day!

11 May, 2020 | 00:44h | UTC

1 – Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial – The Lancet

Commentaries: Interferon beta-1b for COVID-19 – The Lancet AND New triple antiviral drug combination shows early promise for treating COVID-19 in phase 2 randomized trial – The Lancet AND A Drug Cocktail Hastens Recovery in Some Coronavirus Patients – The New York Times AND Triple drug therapy helps coronavirus patients recover more quickly, study finds – CNN AND Triple antiviral drug shows early promise in COVID-19 trial – Reuters AND Expert reaction to a study about a phase 2 trial of a triple antiviral drug combination treatment for COVID-19 – Science Media Centre

2 – Do Not Stay at Home: We Are Ready for You – NEJM Catalyst

“We must never lose sight of all the other patients who need our care today. Patients with any symptom indicating an emergency or severe disease must NOT stay at home.”

3 – Surfing the Waves of the COVID-19 Pandemic As A Cardiovascular Clinician – Circulation (PDF)

4 – Collateral Effect of Covid-19 on Stroke Evaluation in the United States – New England Journal of Medicine

Commentary: Stroke evaluations drop by nearly 40% during COVID-19 pandemic – Washington University School of Medicine

5 – Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study – The Lancet Rheumatology

Commentaries: Expert reaction to study looking at use of arthritis drug anakinra in hospitalised patients with severe COVID-19 – Science Media Centre AND Small study of patients with severe COVID-19 treated with the arthritis drug anakinra finds clinical improvements – The Lancet

6 – Mechanical Thrombectomy in the Era of the COVID-19 Pandemic: Emergency Preparedness for Neuroscience Teams: A Guidance Statement From the Society of Vascular and Interventional Neurology – Stroke

Commentaries: Guidance for Treating Stroke Patients During COVD-19 Crisis Developed – Boston University School of Medicine AND Mechanical Thrombectomy and Emergency Preparedness Guidance in COVID-19 Era – American College of Cardiology

7 – Impact of climate and public health interventions on the COVID-19 pandemic: A prospective cohort study – Canadian Medical Association Journal

News Release: Canadian study finds temperature, latitude not associated with COVID-19 spread – Canadian Medical Association Journal

8 – The emerging long-term complications of Covid-19, explained – Vox

9 – COVID-19 Research in Brief: 2 May to 8 May, 2020 – Nature Medicine

10 – Coronavirus Disease (COVID-19) Updates / 11 May 2020 Edition

11 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Fri May 08 – 10 Stories of The Day!

8 May, 2020 | 10:44h | UTC

1 – Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 – New England Journal of Medicine

Editorial: The Urgency of Care during the Covid-19 Pandemic — Learning as We Go

2 – Audio Interview: Studying Potential Covid-19 Therapies – New England Journal of Medicine

3 – Treatment of Community-Acquired Pneumonia During the Coronavirus Disease 2019 (COVID-19) Pandemic – Annals of Internal Medicine

4 – RCEM Position Statement COVID-19: Resetting Emergency Department Care – The Royal College of Emergency Medicine

Commentary: Emergency departments must not return to pre-covid days of overcrowding and lack of safety, says college – The BMJ

5 – Modeling shield immunity to reduce COVID-19 epidemic spread – Nature Medicine

Commentaries: Immunity of Recovered COVID-19 Patients Could Cut Risk of Expanding Economic Activity – Georgia Institute of Technology AND After Recovery From the Coronavirus, Most People Carry Antibodies – New York Times

6 – OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients – medRxiv

Press release: Risk factors for COVID-19 death revealed in world’s largest analysis of patient records to date

Commentary: Risk factors for COVID-19 death revealed in world’s largest analysis of patient records to date – London School of Hygiene & Tropical Medicine

7 – Repeated seroprevalence of anti-SARS-CoV-2 IgG antibodies in a population-based sample from Geneva, Switzerland – medRxiv

8 – COVID-19 in Older People: A Rapid Clinical Review – Age and Ageing

9 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Left-Sided Colonic Diverticulitis – Diseases of the Colon & Rectum

News Release: Treatment for Diverticulitis – updated ASCRS Guidelines published in Diseases of the Colon & Rectum

10 – Coronavirus Disease (COVID-19) Updates / 08 May 2020 Edition

08 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Thu May 07 – 10 Stories of The Day!

7 May, 2020 | 09:36h | UTC

1 – Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19

Related IDSA Coronavirus Guidelines: Part 1: Treatment and Management AND Part 2: Infection Prevention

2 – Molecular testing for acute respiratory tract infections: clinical and diagnostic recommendations from the IDSA’s Diagnostics Committee – Clinical Infectious Diseases

3 – COVID-19 rapid guideline: acute kidney injury in hospital – National Institute for Health and Care Excellence

4 – Interpreting Diagnostic Tests for SARS-CoV-2 – JAMA

5 – AGS Position Statement: Resource Allocation Strategies and Age‐Related Considerations in the COVID‐19 Era and Beyond – Journal of the American Geriatrics Society

News Release: Position statement addresses difficult issue: allocating scare resources in COVID-19 era – American Geriatrics Society

“Age should never be used as a means for categorically excluding someone from what is ordinarily the standard of care, nor should age “cut-offs” be used in allocation strategies.”

6 – Hyperinflammatory shock in children during COVID-19 pandemic – The Lancet

Commentaries: Researchers report “unprecedented cluster” of inflammatory problems in children amid pandemic – CNN AND Expert reaction to report on 8 children with hyperinflammatory shock during the COVID-19 pandemic – Science Media Centre AND Mysterious inflammatory syndrome in children potentially linked to COVID-19 reported in Montreal – National Post AND A New Coronavirus Threat to Children – The New York Times AND What to Know About Kawasaki Disease, the Pediatric Inflammatory Condition Possibly Linked to COVID-19 – TIME AND Kawasaki Disease—The Latest Weird Illness From Coronavirus – Forbes

7 – Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study – Annal of Internal Medicine

8 – Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19 – Journal of the American College of Cardiology

Commentaries: Giving blood thinners to severely ill Covid-19 patients is gaining ground – STAT AND Blood thinners may improve survival among hospitalized COVID-19 patients – Mount Sinai Hospital AND Anticoagulation Associated With Improved Outcomes in Hospitalized COVID-19 Patients – American College of Cardiology AND Expert reaction to study looking at blood thinners in hospitalised patients with COVID-19 – Science Media Centre

9 – Acute limb ischaemia in two young, non-atherosclerotic patients with COVID-19 – The Lancet

10 – Coronavirus Disease (COVID-19) Updates / 07 May 2020 Edition

07 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)