Systematic Reviews & Meta-analysis
Systematic Review: Treatment for HIV-Associated Cryptococcal Meningitis
26 Jul, 2018 | 20:20h | UTCTreatment for HIV-associated cryptococcal meningitis – Cochrane Library (free)
Summary: Treatment for HIV-associated cryptococcal meningitis – Cochrane Library (free)
Systematic Review: Drug Therapy for Early Rheumatoid Arthritis
26 Jul, 2018 | 18:33h | UTCSee also: Full Report (free PDF)
Systematic Review: Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes
26 Jul, 2018 | 18:32h | UTCSee also: Full Report (free PDF) AND Evidence Summary (free PDF)
Systematic Review: Sexual Transmission of Zika Virus and Other Flaviviruses
26 Jul, 2018 | 18:30h | UTCSexual transmission of Zika virus and other flaviviruses: A living systematic review – PLOS Medicine (free) (via @NIAIDNews)
Commentary: Study suggests smaller window for Zika sexual transmission – CIDRAP (free)
Systematic Review: Blood Pressure Targets in People with Cardiovascular Disease
26 Jul, 2018 | 17:56h | UTCSummary: Blood pressure targets in people with cardiovascular disease – Cochrane Library (free)
“Insufficient evidence to justify lower than standard blood pressure targets in ppl w hypertension + CVD” (via @CochraneHTN see Tweet)
Meta-Analysis: Enhanced Recovery After Gastric Cancer Surgery
26 Jul, 2018 | 17:50h | UTCCommentary: Enhanced recovery programmes after stomach cancer surgery reduce hospital stay without increasing complications – NIHR Signals (free)
See also: Enhanced Recovery After Surgery Guidelines and Reviews (all free)
Meta-Analysis: Drugs for Treating Severe Hypertension in Pregnancy
26 Jul, 2018 | 17:44h | UTCCommentary: Drugs for treating severe hypertension in pregnancy compared – Wiley, via ScienceDaily (free)
Systematic Review: Vaccination Against Human Papillomavirus in Males
26 Jul, 2018 | 17:36h | UTCCommentary: HPV vaccination for males: effective and safe – BMC On Medicine (free)
Systematic Review: To Continue Taking or To Stop Taking Antiplatelet Drugs Before Non-Cardiac Surgery
20 Jul, 2018 | 03:31h | UTCTo continue taking or to stop taking antiplatelet drugs for a few days before non-cardiac surgery in adults – Cochrane Library (link to abstract – $ for full-text)
Summary: To continue taking or to stop taking antiplatelet drugs for a few days before non-cardiac surgery in adults – Cochrane Library (free)
“We found low-certainty evidence that either continuation or discontinuation of antiplatelet therapy before non-cardiac surgery may make little or no difference to mortality, bleeding requiring surgical intervention, or ischaemic events”.
Systematic Review: Omega-6 fats for the Primary and Secondary Prevention of Cardiovascular Disease
20 Jul, 2018 | 03:22h | UTCOmega-6 fats for the primary and secondary prevention of cardiovascular disease – Cochrane Library (link to abstract – $ for full-text)
Summary: Omega-6 fats to prevent and treat heart and circulatory diseases – Cochrane Library (free)
Clinical Evidence Synopsis: Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics
20 Jul, 2018 | 03:23h | UTCProbiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics – JAMA (free for a limited period)
Original Article: Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children – Cochrane Library (link to abstract – $ for full-text) AND Summary: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use (free)
Related Meta-Analysis: Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection (free)
Systematic Review: Polyunsaturated Fatty Acids for the Primary and Secondary Prevention of Cardiovascular Disease
20 Jul, 2018 | 03:22h | UTCPolyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease – Cochrane Library (link to abstract – $ for full-text)
Summary: Polyunsaturated fatty acids for prevention and treatment of diseases of the heart and circulation – Cochrane Library (free)
Meta-Analysis: Global Burden of CV Disease in People Living with HIV
20 Jul, 2018 | 03:04h | UTCCommentaries: HIV infection doubles risk of heart disease – University of Edinburgh, via ScienceDaily (free) AND Global Burden of HIV-Related CVD Has Tripled Over Two Decades – TCTMD (free)
Systematic Review: Association Between Nurse Staffing and Omissions in Nursing Care
20 Jul, 2018 | 03:05h | UTCCommentary: Nurse staffing levels linked to reports of missed care in adult wards – NIHR Signal (free)
Systematic Review: Nurses as Substitutes for Doctors in Primary Care
20 Jul, 2018 | 02:44h | UTCNurses as substitutes for doctors in primary care – Cochrane Library (free)
Summary: Nurses as substitutes for doctors in primary care – Cochrane Library (free)
“This updated Cochrane Review indicates that nurses can effectively expand the capacity of the primary care workforce”.
Systematic Review: Vaginal Preparation with Antiseptics Before Cesarean Section for Preventing Postoperative Infections
20 Jul, 2018 | 01:57h | UTCSummary: Vaginal cleansing with antiseptic solution before cesarean delivery to reduce post-cesarean infections – Cochrane Library (free)
Meta-Analysis: Efficacy of Short-Course Antibiotic Treatments for Community-Acquired Pneumonia
13 Jul, 2018 | 02:54h | UTCEfficacy of short-course antibiotic treatments for community-acquired pneumonia in adults: A systematic review and meta-analysis – Antimicrobial Agents and Chemotherapy (link to abstract – $ for full-text)
Commentary: Is Short-Course Antibiotic Treatment for CAP Effective? – MPR (free)
Meta-Analysis: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality
13 Jul, 2018 | 02:47h | UTCAssociation of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free for a limited period)
Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)
Commentaries: Study: Multivitamins Do Not Prevent Strokes, Heart Attacks or Cardiovascular Disease Deaths – University of Alabama at Birmingham, via NewsWise (free) AND Multivitamin-mineral supplements do not reduce heart disease, deaths – Reuters (free)
Related: Supplements Not Effective for CVD Prevention and Treatment (link to abstract and commentaries) AND Multivitamins are probably a waste of money (free commentaries)
Systematic Review: Negative Pressure Wound Therapy for Open Traumatic Wounds
13 Jul, 2018 | 02:31h | UTCNegative pressure wound therapy for open traumatic wounds – Cochrane Library (free)
Summary: Negative pressure wound therapy for open traumatic wounds – Cochrane Library (free)
Related Research: Randomized Trial: Negative Pressure Wound Therapy No Better Than Regular Dressing in Severe Open Fracture of the Lower Limb (link to abstract and commentaries)
Meta-Analysis: Health Benefits of the Great Outdoors
13 Jul, 2018 | 02:20h | UTCThe health benefits of the great outdoors: A systematic review and meta-analysis of greenspace exposure and health outcomes – Environmental Research (free) (via @Mental_Elf and @AllenFrancesMD)
Commentary: It’s official — spending time outside is good for you – University of East Anglia, via ScienceDaily (free)
Systematic Review: Effects of Hyperoxia in Acutely Ill Patients
13 Jul, 2018 | 02:19h | UTCRelated Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)
Source: Critical Care Reviews Newsletter
Systematic Review: Immunosuppressive Treatment for Proliferative Lupus Nephritis
13 Jul, 2018 | 01:15h | UTCImmunosuppressive treatment for proliferative lupus nephritis – Cochrane Library (free)
Summary: Immunosuppressive treatment for people with proliferative lupus nephritis – Cochrane Library (free)
Meta-Analysis: Anticonvulsants in the Treatment of Low Back Pain and Lumbar Radicular Pain
6 Jul, 2018 | 09:37h | UTCCommentaries: Class of drugs used as alternative to opioids for back pain are ineffective, have potentially serious side effects: report – The Globe and Mail (free) AND Anticonvulsant drugs ineffective for low back pain and can cause harm, despite increased prescribing – CMAJ, via EurekAlert (free)
Related Meta-Analysis: Benefits and safety of gabapentinoids in chronic low back pain (free research and commentaries)
Systematic Review: Influenza Vaccine for Patients with COPD
6 Jul, 2018 | 09:30h | UTCInfluenza vaccine for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)
Summary: Influenza vaccine for people with chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)
Systematic Review: Treatments for Heart Failure with Preserved Ejection Fraction
6 Jul, 2018 | 03:08h | UTCRelated Meta-Analysis: Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis – Heart (free)
This Cochrane review suggests mineralocorticoid receptor antagonists may be of benefit to reduce hospitalizations, while the meta-analysis in Heart suggests beta-blockers may improve all-cause and cardiovascular mortality…