Systematic Reviews & Meta-analysis
Systematic Review: Influenza Vaccine for Patients with COPD
6 Jul, 2018 | 09:30h | UTCInfluenza vaccine for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)
Summary: Influenza vaccine for people with chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)
Systematic Review: Treatments for Heart Failure with Preserved Ejection Fraction
6 Jul, 2018 | 03:08h | UTCRelated Meta-Analysis: Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis – Heart (free)
This Cochrane review suggests mineralocorticoid receptor antagonists may be of benefit to reduce hospitalizations, while the meta-analysis in Heart suggests beta-blockers may improve all-cause and cardiovascular mortality…
Systematic Review: Donepezil for Dementia Due to Alzheimer’s Disease
29 Jun, 2018 | 02:36h | UTCDonepezil for dementia due to Alzheimer’s disease – Cochrane Library (free)
Summary: Donepezil for people with dementia due to Alzheimer’s disease – Cochrane Library (free)
Systematic Review: Saline Irrigation for Allergic Rhinitis
29 Jun, 2018 | 02:25h | UTCSaline irrigation for allergic rhinitis – Cochrane Library (free)
Summary: Nasal saline for allergic rhinitis – Cochrane Library (free)
Meta-Analysis: Oxygen Saturation Targets and Death or Disability in Extremely Preterm Infants
29 Jun, 2018 | 02:15h | UTCAssociation Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration – JAMA (link to abstract – $ for full-text)
Commentaries: Oxygen for preterm infants, what dose of this toxic drug is the right dose? #NeoEBM – Neonatal Research (free) AND Lower and higher oxygen saturation targets result in equal but contrasting outcomes for extremely preterm infants – 2 Minute Medicine (free)
Systematic Reviews: Neonatal Interventions for Preventing Cerebral Palsy
24 Jun, 2018 | 19:33h | UTCSummary: Interventions for babies from birth to one month of life for preventing cerebral palsy: an overview of Cochrane Systematic Reviews (free)
Systematic Review: Prophylactic Abdominal Drainage for Pancreatic Surgery
24 Jun, 2018 | 19:32h | UTCProphylactic abdominal drainage for pancreatic surgery – Cochrane Library (free)
Summary: Drain use after pancreatic surgery – Cochrane Library (free)
Meta-Analysis: Determinants of Clinical Outcomes in Patients with Angina but Without Obstructive Coronary Artery Disease
24 Jun, 2018 | 19:23h | UTCCommentaries: Outcomes in Patients With Angina but Without Obstructive CAD – American College of Cardiology (free)
Systematic Review: Nicotine Replacement Therapy vs Control for Smoking Cessation
7 Jun, 2018 | 02:55h | UTCNicotine replacement therapy versus control for smoking cessation – Cochrane Library (free)
Summary: Can nicotine replacement therapy (NRT) help people quit smoking? – Cochrane Library (free)
Systematic Review: Stent Placement vs. Surgical Palliation in Malignant Gastric Outlet Obstruction
6 Jun, 2018 | 21:50h | UTCSummary: Stent placement versus surgery to control symptoms of a blocked stomach outlet caused by inoperable cancer – Cochrane Library (free)
Meta-Analysis: Concomitant Fibromyalgia Common in Patients with Inflammatory Arthritis
29 May, 2018 | 20:09h | UTCCommentary: Comorbid fibromyalgia common in patients with inflammatory arthritis – MedwireNews (free)
Systematic Review: Effects of Physical Exercise on Cognitive Function in Parkinson’s Disease
29 May, 2018 | 18:36h | UTC
Meta-Analysis: Pharmacological Therapies for the Treatment of Opioid-induced Constipation
29 May, 2018 | 17:50h | UTCEfficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis – Gut (link to abstract – $ for full-text)
Commentary: Naloxone, naldemedine appear best for opioid-induced constipation after laxatives – ACP Gastroenterology (free)
Systematic Review: Non-pharmacological Interventions for Treating Chronic Prostatitis/Chronic Pelvic Pain Syndrome
24 May, 2018 | 22:56h | UTCNon-pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome – Cochrane Library (free)
Summary: Intervention for treating chronic prostatitis and chronic pelvic pain in men – Cochrane Library (free)
Systematic Review: Epidurals for Pain Relief in Labor
24 May, 2018 | 22:53h | UTCEpidural versus non-epidural or no analgesia for pain management in labour – Cochrane Library (link to abstract – $ for full-text)
Summary: Epidurals for pain relief in labour – Cochrane Library (free)
Meta-Analysis: Corticosteroids for Patients with Septic Shock
23 May, 2018 | 12:28h | UTCLow-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis – Critical Care Medicine (free for a limited period)
Source: Critical Care Reviews Newsletter
“In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaffected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced”.
Meta-Analysis: Aldosterone Antagonists for ST-Segment Elevation Myocardial Infarction Without Heart Failure
23 May, 2018 | 12:28h | UTCAldosterone Antagonist Therapy and Mortality in Patients With ST-Segment Elevation Myocardial Infarction Without Heart Failure: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Invited Commentary: Mineralocorticoid Receptor Antagonists in ST-Segment Elevation Myocardial Infarction – JAMA Internal Medicine (free for a limited period)
Aldosterone antagonists are beneficial for patients with STEMI and reduced ejection fraction. This meta-analysis suggests that patients with STEMI and LVEF greater than 40% or without heart failure also have improved outcomes with aldosterone antagonists.
Systematic Review: Psychological and Pharmacological Treatments for Posttraumatic Stress Disorder
21 May, 2018 | 13:00h | UTCSummary: Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder
Systematic Review: Psychological Therapies for Treatment-resistant Depression in Adults
18 May, 2018 | 02:31h | UTCPsychological therapies for treatment-resistant depression in adults – Cochrane Library (free)
Summary: Are psychological therapies effective in treating depression that did not get better with previous treatment? – Cochrane Library (free)
Meta-Analysis: Complete Revascularization During Primary PCI Improve Outcomes in Patients With Multivessel Disease
16 May, 2018 | 01:09h | UTCComplete Revascularization During Primary Percutaneous Coronary Intervention Reduces Death and Myocardial Infarction in Patients With Multivessel Disease: Meta-Analysis and Meta-Regression of Randomized Trials – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)
Commentary: Complete Revascularization During PCI for Multivessel STEMI – American College of Cardiology (free)
Related: Meta-Analysis of Culprit-Only vs Multivessel PCI in Patients with STEMI and Multivessel Coronary Disease (link to abstract, commentaries and Cochrane Review on the subject)
Meta-Analysis: Resistance Exercise for Depressive Symptoms
16 May, 2018 | 00:54h | UTCAssociation of Efficacy of Resistance Exercise Training With Depressive Symptoms: Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries: Resistance Exercise Might Improve Depression Symptoms – NEJM Physician’s First Watch (free) AND Resistance exercise may reduce depressive symptoms in adults – MedicalXpress (free) AND Resistance Exercise Training May Alleviate Some Depressive Symptoms – MedicalResearch.com (free)
Systematic Review: Adverse Events of Methylphenidate for ADHD in Children and Adolescents
16 May, 2018 | 00:52h | UTCMethylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of adverse events in non-randomised studies – Cochrane Library (link to abstract – $ for full-text)
“Our findings suggest that methylphenidate may be associated with a number of serious adverse events as well as a large number of non-serious adverse events in children and adolescents, which often lead to withdrawal of methylphenidate”.
Systematic Review: Grommets (Ventilation Tubes) for Recurrent Acute Otitis Media in Children
16 May, 2018 | 00:45h | UTCGrommets (ventilation tubes) for recurrent acute otitis media in children – Cochrane Library (free)
Summary: Grommets for children with recurring acute middle ear infections – Cochrane Library (free)
Systematic Review: Induction of Labor for Improving Birth Outcomes for Women at or Beyond Term
11 May, 2018 | 02:50h | UTCInduction of labour for improving birth outcomes for women at or beyond term – Cochrane Library (free)
Summary: Induction of labour in women with normal pregnancies at or beyond term – Cochrane Library (free)
Systematic Review: Prophylactic Vaccination Against HPV to Prevent Cervical Cancer
10 May, 2018 | 17:56h | UTCProphylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors – Cochrane Library (link to abstract and summary – $ for full-text)
News Release: Does HPV vaccination prevent the development of cervical cancer? Are there harms associated with being vaccinated? – Cochrane Library (free)
Scientific Expert Reaction: Cochrane Review on HPV vaccine for cervical cancer prevention in girls and women – Cochrane Library (free)
Commentary: Major review backs cervical cancer shots, especially for teens – Reuters (free)