Systematic Reviews & Meta-analysis
Systematic Review: Antifungal Prophylaxis for Cryptococcal Disease in HIV‐positive People
6 Sep, 2018 | 02:31h | UTCPrimary antifungal prophylaxis for cryptococcal disease in HIV‐positive people – Cochrane Library (free for a limited period)
Summary: Preventing cryptococcal disease in HIV-positive people – Cochrane Library (free)
“Antifungal prophylaxis reduced the risk of developing and dying from cryptococcal disease. Therefore, where CrAG screening is not available, antifungal prophylaxis may be used in patients with low CD4 counts at diagnosis and who are at risk of developing cryptococcal disease.”
Randomized Trial: Endovascular vs. Open Repair for Patients with Ruptured Abdominal Aortic Aneurysm
6 Sep, 2018 | 02:27h | UTCCommentary: Endovascular aortic repair (EVAR) surgery more beneficial for ruptured abdominal aortic aneurysms than open repair – NIHR Signal (free)
Systematic Review: Topical Hemostats in Trauma and Emergency Surgery
2 Sep, 2018 | 02:00h | UTCA systematic review on the use of topical hemostats in trauma and emergency surgery – BMC Surgery (free)
Emergency Department Crowding: A Systematic Review of Causes, Consequences and Solutions
2 Sep, 2018 | 01:56h | UTCEmergency department crowding: A systematic review of causes, consequences and solutions – PLOS One (free)
Meta-Analysis: Effectiveness of Interventions for Managing Multiple High-Burden Chronic Diseases in Older Adults
31 Aug, 2018 | 03:01h | UTCCommentaries: Care coordination improves health of older patients with multiple chronic diseases – CMAJ, via EurekAlert (free) AND Seniors healthier when medical care is coordinated – Reuters (free)
Related: Ten Recommendations: Designing a High-Performing Health Care System for Patients with Complex Needs (free Guidance and related perspectives) AND Multimorbidity: A Priority for Global Health Research (free research and commentaries)
Meta-Analysis: Environmental Toxic Metal Contaminants and Risk of Cardiovascular Disease
31 Aug, 2018 | 02:42h | UTCEditorial: Environmental metals and cardiovascular disease (free)
Commentary: Experts warn of cardiovascular risk from heavy metal pollution – University of Cambridge (free)
“Since metals are associated with cardiovascular disease even at relatively low levels of exposure, population wide strategies to minimize exposure can further contribute to overall cardiovascular prevention efforts” (from @bmj_latest see Tweet)
Overview of Cochrane Reviews: Assisted Reproductive Technology
31 Aug, 2018 | 01:51h | UTCAssisted reproductive technology: an overview of Cochrane Reviews – Cochrane Library (free for a limited period)
Cochrane Review: Xpert® MTB/RIF Test for Diagnosing Extrapulmonary TB
31 Aug, 2018 | 01:48h | UTCXpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance – Cochrane Library (free for a limited period)
Summary: Xpert® MTB/RIF test for diagnosing extrapulmonary tuberculosis and rifampicin resistance – Cochrane Library (free)
Commentary: Cochrane review looks at the accuracy of Xpert® MTB/RIF for the diagnosis of extrapulmonary TB – Liverpool School of Tropical Medicine (free)
Systematic Review: Antibiotics for Prolonged Wet Cough in Children
31 Aug, 2018 | 01:40h | UTCAntibiotics for prolonged wet cough in children – Cochrane Library (link to abstract and plain language summary – $ for full-text)
Commentary: Antibiotics for pediatric chronic wet cough: Cochrane review – Univadis (free registration required)
Systematic Review: Glucocorticoids for Croup in Children
23 Aug, 2018 | 23:46h | UTCGlucocorticoids for croup in children – Cochrane Library (free for a limited period)
Summary: Glucocorticoids for croup in children – Cochrane Library (free)
Commentary: Glucocorticoid Therapy Examined in Pediatric Patients With Croup – MPR (free)
Systematic Review: Phosphate Binders to Prevent Complications of Chronic Kidney Disease
23 Aug, 2018 | 23:40h | UTCPhosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) – Cochrane Library (free for a limited period)
Summary: Phosphate binders to prevent complications of chronic kidney disease – Cochrane Library (free)
Meta-Analysis: Effect of Procalcitonin-Guided Antibiotic Treatment on Clinical Outcomes in ICU patients
23 Aug, 2018 | 23:21h | UTCCommentary: Procalcitonin guidance linked to improved sepsis survival – Univadis (free registration required)
Meta-Analysis: Corticosteroids in Sepsis
23 Aug, 2018 | 22:32h | UTCCorticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis – Critical Care Medicine (free)
Related: Corticosteroid therapy for sepsis: a clinical practice guideline – The BMJ (free)
Systematic Review: Endovascular Coiling vs. Neurosurgical Clipping for Aneurysmal Subarachnoid Hemorrhage
17 Aug, 2018 | 02:36h | UTCEndovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage – Cochrane Library (free for a limited period)
Summary: Endovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage – Cochrane Library (free)
Meta-Analysis: Absolute Risk and Predictors of the Growth of Acute Spontaneous Intracerebral Hemorrhage
17 Aug, 2018 | 02:25h | UTCCommentary: Brain scan checklist set to boost care for stroke survivors – University of Edinburgh, via EurekAlert (free)
Systematic Reviews: Treatments for Women with Gestational Diabetes Mellitus
17 Aug, 2018 | 02:00h | UTCTreatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews – Cochrane Library (free)
Systematic Review: Interventions for Preventing Falls in Older People
17 Aug, 2018 | 01:13h | UTC
Meta-Analysis: Treatment Choices for ADHD
11 Aug, 2018 | 03:23h | UTCCommentaries: Refining treatment choices for ADHD – The Lancet Psychiatry (free) AND ADHD medications: Of all available drugs, methylphenidate should be first option for short-term treatment in children – ScienceDaily (free) AND Analysis of ADHD Drugs: Use Methylphenidate in Kids, Amphetamines in Adults – Physician’s First Watch (free)
Related: Cochrane Review: Adverse Events of Methylphenidate for ADHD in Children and Adolescents (link to abstract and free summary) AND Short Review: Stimulants for ADHD in children (free) AND Opinion: Drug treatment of ADHD – tenuous scientific basis (free)
Systematic Review: Nonsurgical Treatments for Urinary Incontinence in Women
11 Aug, 2018 | 03:19h | UTCSee also: Full Report (free PDF)
Systematic Review: Treatment for Bipolar Disorder in Adults
11 Aug, 2018 | 03:04h | UTCSee also: Full Report (free PDF) AND Evidence Summary (free PDF)
Systematic Reviews: Red Blood Cell Transfusion to Treat or Prevent Complications in Sickle Cell Disease
11 Aug, 2018 | 02:14h | UTCRed blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews – Cochrane Library (link to abstract – $ for full-text)
Summary: An overview of Cochrane Reviews on red blood cell transfusions to treat or prevent sickle cell disease-related complications – Cochrane Library (free)
Systematic Review: Colloids vs Crystalloids for Fluid Resuscitation in Critically Ill People
11 Aug, 2018 | 02:02h | UTCColloids versus crystalloids for fluid resuscitation in critically ill people – Cochrane Library (link to abstract – $ for full-text)
Summary: Colloids or crystalloids for fluid replacement in critically people – Cochrane Library (free)
“Using starches, dextrans, albumin or FFP (moderate-certainty evidence), or gelatins (low-certainty evidence), versus crystalloids probably makes little or no difference to mortality. Starches probably slightly increase the need for blood transfusion and RRT (moderate-certainty evidence), and albumin or FFP may make little or no difference to the need for renal replacement therapy (low-certainty evidence)”.
Meta-Analysis: Efficacy and Safety of Further Lowering of LDL Cholesterol in Patients Starting With Very Low Levels
3 Aug, 2018 | 11:38h | UTCEfficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels: A Meta-analysis – JAMA Cardiology (free for a limited period)
Author Interview: Efficacy and Safety of Further Lowering of LDL Cholesterol in Patients Starting With Very Low Levels (free)
Meta-Analysis: Pharmacological Treatment of Arterial Hypertension in Children and Adolescents
3 Aug, 2018 | 02:54h | UTCCommentary: Pediatric hypertension: ACEi/ARBs look like the best choice – Univadis (free)
“According to the present analysis, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers could represent the best choice as antihypertensive treatment for pediatric hypertension. However, because of the paucity of available data for the other classes of antihypertensive drugs, definitive conclusions are not allowed and further randomized controlled trials are warranted.”
Systematic Review: Mirror Therapy for Improving Motor Function After Stroke
26 Jul, 2018 | 20:21h | UTCMirror therapy for improving motor function after stroke – Cochrane Library (link to abstract – $ for full-text)
Summary: Mirror therapy for improving movement after stroke – Cochrane Library (free)