Systematic Reviews & Meta-analysis
Meta-analysis: Omega-3 Fats Not Beneficial for Diabetes Prevention or Treatment
22 Aug, 2019 | 10:53h | UTCCommentaries: The role of nutrition in disease prevention—how we can find better answers? – The BMJ Opinion (free) AND Omega-3 fats have little or no effect on type 2 diabetes – BMJ (free) AND Lack of omega-3 effect on type 2 diabetes confirmed – Medicine Matters (free) AND Fish oil pills ‘no benefit’ for type 2 diabetes – BBC (free)
Related Randomized Trial: Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus (free study and commentaries)
Meta-Analysis: Maternal Influenza Vaccination is Not Associated with Harmful Effects on Birth Outcomes
20 Aug, 2019 | 08:24h | UTCRelated Research: Cohort Study: Flu Vaccine in Pregnancy Safe for Children and Mothers (free)
Related ACOG Guideline: Influenza Vaccination During Pregnancy (free)
“maternal influenza vaccination is not associated with harmful effects on birth outcomes. The beneficial effects reported from previous studies on preterm birth, low birth weight, and fetal death could not be confirmed.”
Meta-Analysis: Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults
20 Aug, 2019 | 08:20h | UTCCommentaries: The Dynamics of Frailty Among Older Adults – JAMA Network Open (free) AND Frailty is a medical condition, not an inevitable result of aging – Monash University (free)
Related: Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report – Age and Ageing (free) AND A Review of Frailty Syndrome and Its Physical, Cognitive and Emotional Domains in the Elderly – Geriatrics (free) AND Frailty: Identifying elderly patients at high risk of poor outcomes – Canadian Family Physician (free)
Meta-analysis: The Global Prevalence of Anxiety Among Medical Students
18 Aug, 2019 | 22:04h | UTCRelated: Medical student wellbeing – a consensus statement from Australia and New Zealand – BMC Medical Education (free) AND Prevalence of Depression, Depressive Symptoms, and Suicidal Ideation Among Medical Students: A Systematic Review and Meta-Analysis – JAMA (free)
[Abstract Only] Meta-analysis: Association Between Electronic Cigarette Use and Marijuana Use Among Adolescents and Young Adults
18 Aug, 2019 | 21:54h | UTCAssociation Between Electronic Cigarette Use and Marijuana Use Among Adolescents and Young Adults: A Systematic Review and Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)
Commentaries: Youth Who Use E-Cigarettes May Be More Likely to Use Marijuana, Study Finds – Psychiatric News Alert (free) AND Teens who vape three times more likely to use marijuana – UPI (free) AND Vaping linked to marijuana use in young people, research says – CNN (free)
[Abstract Only] Meta-analysis: Long-term Macrolide Treatment Reduces the Frequency of Exacerbations in Patients with Bronchiectasis
18 Aug, 2019 | 21:19h | UTCLong-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Related Commentary on Twitter
A NEW ? systematic review and individual patient data meta-analysis :long-term macrolide treatment significantly reduces the frequency of exacerbations in patients with bronchiectasis, with similar benefits observed in all subgroups based on patient characteristics. #IDTwitter https://t.co/pey2x23BRf
— Antibiotic Steward (@ABsteward) August 10, 2019
[Abstract Only] Meta-analysis: Inhaled Antibiotics Provide Limited Benefit for the Treatment of Bronchiectasis in Adults
18 Aug, 2019 | 21:18h | UTCThe efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Related Commentary on Twitter
The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis. New data from an analysis of nearly 2600 patients finds only limited benefits associated with inhaled antibiotic use across 16 trials. https://t.co/q4ixUb5Q7p@EMBARCnetwork @EuroRespSoc @lunguk
— EMBARC (@EMBARCnetwork) August 9, 2019
Systematic Review: Resident Physicians are at Increased Risk for Dangerous Driving After Extended-duration Work Shifts
16 Aug, 2019 | 08:02h | UTCSource: Hospital Medicine Virtual Journal Club
Meta-Analysis: Association Between Vitamin D Supplementation and Mortality
16 Aug, 2019 | 07:59h | UTCRelated: Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention (link to abstract and commentary) AND NICE Guideline: Vitamin D Supplementation (free)
Vitamin D supplementation was not associated with all-cause mortality, cardiovascular mortality, or non-cancer, non-cardiovascular mortality. However, Vitamin D supplementation statistically significantly reduced the risk of cancer death by 16%.
Related Commentary on Twitter
Vitamin D supplementation alone was not associated with all cause mortality in adults compared with placebo or no treatment. However, it was associated with a reduced risk of cancer mortality by 16%, finds #BMJResearch https://t.co/jc4Tdxl6Bb
— The BMJ (@bmj_latest) August 12, 2019
Meta-Analysis: Lobectomy vs. Segmentectomy in Stage I Non-Small Cell Lung Cancer
13 Aug, 2019 | 01:07h | UTC
Systematic Review: Vitamin D Supplementation for Women During Pregnancy
13 Aug, 2019 | 01:03h | UTCVitamin D supplementation for women during pregnancy – Cochrane Library (free)
Summary: Is vitamin D supplementation beneficial or harmful for women during pregnancy? – Cochrane Library (free)
Systematic Review: Emergency Department Interventions for Older Adults
13 Aug, 2019 | 01:01h | UTC
Meta-Analysis: Medications that Reduce or Increase the Risk of New Onset Diabetes
11 Aug, 2019 | 22:24h | UTC“α-Glucosidase inhibitors, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, metformin, orlistat, phentermine/topiramate, and pioglitazone significantly reduced the risk of biochemical conversion to T2DM, whereas statins and nateglinide increased the risk”
Meta-Analysis: Alcohol Use in Pregnancy and Miscarriage
11 Aug, 2019 | 22:23h | UTCCommentary: Alcohol exposure during pregnancy linked with dose-dependent increase in miscarriage risk – News Medical (free)
Meta-Analysis: Neonatal, Infant, and Childhood Growth Following Metformin vs. Insulin Treatment for Gestational Diabetes
11 Aug, 2019 | 22:15h | UTCCommentary: Does metformin treatment for GDM adversely affect offspring? – Univadis (free registration required)
Meta-Analysis: Atrial Fibrillation Ablation with Pulmonary Vein Isolation vs. Without
11 Aug, 2019 | 21:33h | UTC
Systematic Review: Screening for Melanoma is Not Supported or Refuted by Current Evidence
11 Aug, 2019 | 21:16h | UTCScreening for reducing morbidity and mortality in malignant melanoma – Cochrane Library (free)
Summary: Screening for malignant melanoma (a type of skin cancer) – Cochrane Library (free)
Featured Review: Evidence for the benefits and harms of screening for malignant melanoma – Cochrane Library (free)
Meta-Analysis: High-flow Nasal Cannula Oxygen Therapy vs. Conventional Oxygen Therapy After Planned Extubation
11 Aug, 2019 | 21:09h | UTC
Financial Conflicts of Interest in Systematic Reviews: Associations with Results, Conclusions, and Methodological Quality
6 Aug, 2019 | 07:55h | UTCSummary: Financial conflicts of interests and results, conclusions, and quality of systematic reviews – Cochrane Library (free)
Breastfeeding: A Round Up of Cochrane Evidence
5 Aug, 2019 | 02:12h | UTCBreastfeeding: A round up of Cochrane evidence – Evidently Cochrane (free)
Systematic Review: Interventions for Ulceration and Other Skin Changes Caused by Nerve Damage in Leprosy
2 Aug, 2019 | 01:02h | UTCInterventions for ulceration and other skin changes caused by nerve damage in leprosy – Cochrane Library (free)
Summary: Treatments for ulcers (wounds) and other skin changes in people with leprosy – Cochrane Library (free)
Systematic Review: Lifestyle Changes for Treating Psoriasis
2 Aug, 2019 | 01:01h | UTCLifestyle changes for treating psoriasis – Cochrane Library (free)
Related Commentary on Twitter
Lifestyle changes for treating #psoriasis – https://t.co/IqJHV5TDVE Cochrane Systematic Review includes RCTs with 1163 participants. Low‐calorie diet + exercise programme probably results in a greater reduction in the severity of psoriasis but effects vary. #skin
— The Cochrane Library (@CochraneLibrary) July 22, 2019
Meta-Analysis: Transvaginal Sonography vs. MRI for the Diagnosis of Rectosigmoid Endometriosis
2 Aug, 2019 | 00:15h | UTCCommentary: Transvaginal ultrasound and MRI achieve similar accuracy for diagnosing lower bowel endometriosis – NIHR Signal (free)
[Abstract Only] Meta‐analysis of Effect of Routine Enteral Nutrition on Postoperative Outcomes after Pancreatoduodenectomy
2 Aug, 2019 | 00:12h | UTCMeta‐analysis of effect of routine enteral nutrition on postoperative outcomes after pancreatoduodenectomy – British Journal of Surgery (link to abstract – $ for full-text)
Source: EvidenceAlerts
Meta-Analysis: Association of Early Interventions With Birth Outcomes and Child Linear Growth in Low-Income and Middle-Income Countries
31 Jul, 2019 | 01:56h | UTC
Related Commentary on Twitter
New @JAMANetworkOpen meta-analyses of 169 randomized trials including 302,061 participants concludes it is important to intervene early for child development in LMICs, during pregnancy if possible, & combine interventions from multiple domains https://t.co/YQnIqlz1P1 pic.twitter.com/q48D3SWhqm
— Keith Godfrey (@KeithMGodfrey) July 28, 2019