Systematic Reviews & Meta-analysis
Systematic Review: Once‐daily vs. Multiple‐daily Dosing with Intravenous Aminoglycosides for Cystic Fibrosis
11 Sep, 2019 | 00:05h | UTCOnce‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis – Cochrane Library (free)
Systematic Review: Prolonged Thromboprophylaxis with Low Molecular Weight Heparin for Abdominal or Pelvic Surgery
11 Sep, 2019 | 00:04h | UTCProlonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery – Cochrane Library (free)
A Systematic Review of Clinical Guidelines on the Management of Acute, Community-acquired CNS Infections
9 Sep, 2019 | 00:07h | UTCRelated: The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults (free) AND ESCMID guideline: diagnosis and treatment of acute bacterial meningitis (free) AND Meningitis (bacterial) and meningococcal septicaemia in under 16s: recognition, diagnosis and management – National Institute for Health and Care Excellence (free) AND Management of suspected viral encephalitis in adults – Association of British Neurologists and British Infection Association National Guidelines (free) AND Management of suspected viral encephalitis in children – Association of British Neurologists and British Paediatric Allergy, Immunology and Infection Group National Guidelines (free)
Meta-Analysis: Perioperative Fluid Restriction in Abdominal Surgery
8 Sep, 2019 | 23:54h | UTCSource: EvidenceAlerts
Systematic Review: Altering the Availability or Proximity of Food, Alcohol, and Tobacco Products to Change their Selection and Consumption
8 Sep, 2019 | 23:02h | UTCAltering the availability or proximity of food, alcohol, and tobacco products to change their selection and consumption – Cochrane Library (free)
Summary: Altering the availability or proximity of food, alcohol, and tobacco products to change their selection and consumption – Cochrane Library (free)
Related Commentary on Twitter
Could changing the availability (the range &/or amount of options) of certain food products or their proximity (the distance at which they are positioned) to potential consumers help people make healthier choices? Read the evidence from @CochranePH here: https://t.co/kVVQQWAOyT pic.twitter.com/vrBtDVjgWT
— The Cochrane Library (@CochraneLibrary) September 6, 2019
Systematic Review: Hypofractionation (Fewer, Larger Doses of Daily Radiation) for Clinically Localized Prostate Cancer Results in Similar Oncologic Outcomes
8 Sep, 2019 | 23:00h | UTCHypofractionation for clinically localized prostate cancer – Cochrane Library (free)
Systematic Review: Chlorhexidine Bathing of the Critically Ill for the Prevention of Hospital‐acquired Infection
8 Sep, 2019 | 23:01h | UTCChlorhexidine bathing of the critically ill for the prevention of hospital‐acquired infection – Cochrane Library (free)
Summary: Bathing critically ill patients with chlorhexidine to prevent hospital-acquired infections – Cochrane Library (free)
“Due to the very low-certainty evidence available, it is not clear whether bathing with chlorhexidine reduces hospital-acquired infections, mortality, or length of stay in the ICU”
Systematic Review: Taxanes for Adjuvant Treatment of Early Breast Cancer
8 Sep, 2019 | 22:59h | UTCTaxanes for adjuvant treatment of early breast cancer – Cochrane Library (free)
Summary: Taxane-containing chemotherapy for women after surgery for early breast cancer – Cochrane Library (free)
Systematic Review: Antiarrhythmics for Maintaining Sinus Rhythm after Cardioversion of Atrial Fibrillation
6 Sep, 2019 | 09:03h | UTCAntiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation – Cochrane Library (free)
Systematic Review: Comparative Effectiveness of Analgesics To Reduce Acute Pain in the Prehospital Setting
5 Sep, 2019 | 08:22h | UTCSee also: Full Report (free PDF) AND Evidence Summary (free PDF) AND Journal Citation in Prehospital Emergency Care (free)
Systematic Review of Guidelines and Consensus Statements: Diagnosis and Treatment for Hyperuricemia and Gout
4 Sep, 2019 | 08:36h | UTCRelated Guidelines: 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout – Annals of Rheumatic Disease (free) AND Management of Acute and Recurrent Gout: A Clinical Practice Guideline From the American College of Physicians (free) AND Diagnosis of Acute Gout: A Clinical Practice Guideline From the American College of Physicians (free) AND The British Society for Rheumatology Guideline for the Management of Gout – Rheumatology (free)
Systematic Review: Antipsychotics for Treating Delirium in Hospitalized Adults
3 Sep, 2019 | 01:29h | UTC
Systematic Review: Antipsychotics for Preventing Delirium in Hospitalized Adults
3 Sep, 2019 | 01:27h | UTC
Meta-Analysis: Menopausal Hormone Therapy Increases Breast Cancer Risk
30 Aug, 2019 | 08:55h | UTCCommentaries: Menopausal hormones: definitive evidence for breast cancer – The Lancet (free) AND Menopausal hormone therapy and 20-year breast cancer mortality – The Lancet (free) AND Hormone therapy during menopause raises breast cancer risk for years, study finds – STAT (free) AND Expert reaction to study looking at HRT use and risk of breast cancer – Science Media Centre (free)
Systematic Review: Treatments for the Prevention and Management of Suicide
27 Aug, 2019 | 01:45h | UTC
Meta-Analysis: Preoperative Physical Exercise Interventions in Patients with Non-Small-Cell Lung Cancer
27 Aug, 2019 | 00:15h | UTCRelated: Preoperative exercise training for patients with non‐small cell lung cancer – Cochrane Library (free) AND Preoperative patient preparation in enhanced recovery pathways – Journal of Anaesthesiology Clinical Pharmacology (free)
Systematic Review: Early Experience with Transcatheter Mitral Valve Replacement
25 Aug, 2019 | 21:30h | UTC“TMVR was a feasible, less invasive alternative for treating severe mitral regurgitation in patients with high or prohibitive surgical risk”
Meta-Analysis: Quality of Dietary Fat and Genetic Risk of Type 2 Diabetes
25 Aug, 2019 | 21:07h | UTCCommentaries: Interventions for type 2 diabetes successful across the genetic landscape – Massachusetts General Hospital (free) AND Genetics no barrier to dietary modification benefits on type 2 diabetes risk – medwire News (free)
Meta-Analysis: Any Level of Physical Activity Decreases Risk of Premature Death
25 Aug, 2019 | 21:05h | UTCEditorial: Every step you take – The BMJ (free)
Commentaries: “Sit less—move more and more often”: all physical activity is beneficial for longevity – The BMJ Opinion (free) AND ‘Sit less, move more’ may be key advice for living longer – NHS Choices (free) AND Every Little Step Helps – Any Physical Activity Linked to Decreased Mortality – MedicalResearch.com (free)
Systematic Review: Management of Glucose Control in Noncritically Ill, Hospitalized Patients Receiving Parenteral and/or Enteral Nutrition
23 Aug, 2019 | 08:34h | UTCRelated Guidelines: Diabetes Care in the Hospital: Standards of Medical Care in Diabetes—2019 – American Diabetes Association (free) AND In-Hospital Management of Diabetes – Diabetes Canada Clinical Practice Guidelines Expert Committee (free)
Related Reviews: Glucose Management in Hospitalized Patients – American Family Physician (free) AND Update on Glucose Management Among Noncritically Ill Patients Hospitalized on Medical and Surgical Wards – Journal of the Endocrine Society (free)
Meta-analysis: Omega-3 Fats Not Beneficial for Diabetes Prevention or Treatment
22 Aug, 2019 | 10:53h | UTCCommentaries: The role of nutrition in disease prevention—how we can find better answers? – The BMJ Opinion (free) AND Omega-3 fats have little or no effect on type 2 diabetes – BMJ (free) AND Lack of omega-3 effect on type 2 diabetes confirmed – Medicine Matters (free) AND Fish oil pills ‘no benefit’ for type 2 diabetes – BBC (free)
Related Randomized Trial: Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus (free study and commentaries)
Meta-Analysis: Maternal Influenza Vaccination is Not Associated with Harmful Effects on Birth Outcomes
20 Aug, 2019 | 08:24h | UTCRelated Research: Cohort Study: Flu Vaccine in Pregnancy Safe for Children and Mothers (free)
Related ACOG Guideline: Influenza Vaccination During Pregnancy (free)
“maternal influenza vaccination is not associated with harmful effects on birth outcomes. The beneficial effects reported from previous studies on preterm birth, low birth weight, and fetal death could not be confirmed.”
Meta-Analysis: Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults
20 Aug, 2019 | 08:20h | UTCCommentaries: The Dynamics of Frailty Among Older Adults – JAMA Network Open (free) AND Frailty is a medical condition, not an inevitable result of aging – Monash University (free)
Related: Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report – Age and Ageing (free) AND A Review of Frailty Syndrome and Its Physical, Cognitive and Emotional Domains in the Elderly – Geriatrics (free) AND Frailty: Identifying elderly patients at high risk of poor outcomes – Canadian Family Physician (free)
Meta-analysis: The Global Prevalence of Anxiety Among Medical Students
18 Aug, 2019 | 22:04h | UTCRelated: Medical student wellbeing – a consensus statement from Australia and New Zealand – BMC Medical Education (free) AND Prevalence of Depression, Depressive Symptoms, and Suicidal Ideation Among Medical Students: A Systematic Review and Meta-Analysis – JAMA (free)
[Abstract Only] Meta-analysis: Association Between Electronic Cigarette Use and Marijuana Use Among Adolescents and Young Adults
18 Aug, 2019 | 21:54h | UTCAssociation Between Electronic Cigarette Use and Marijuana Use Among Adolescents and Young Adults: A Systematic Review and Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)
Commentaries: Youth Who Use E-Cigarettes May Be More Likely to Use Marijuana, Study Finds – Psychiatric News Alert (free) AND Teens who vape three times more likely to use marijuana – UPI (free) AND Vaping linked to marijuana use in young people, research says – CNN (free)