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Systematic Reviews & Meta-analysis

Systematic Review: Partial breast irradiation versus whole breast radiotherapy for early breast cancer.

15 Sep, 2021 | 08:46h | UTC

Partial breast irradiation versus whole breast radiotherapy for early breast cancer – Cochrane Library

 

Commentary on Twitter

https://twitter.com/CochraneUK/status/1433703573402046467

 

Systematic review finds there is insufficient evidence that AI breast cancer screening is accurate enough to replace human scrutiny.

10 Sep, 2021 | 05:12h | UTC

Insufficient evidence that AI breast cancer screening is accurate enough to replace human scrutiny – The BMJ

Original study: Use of artificial intelligence for image analysis in breast cancer screening programmes: systematic review of test accuracy – The BMJ

 

Commentary on Twitter

 

Editorial | Anticholinergic drugs and dementia: time for transparency in the face of uncertainty.

9 Sep, 2021 | 08:57h | UTC

Anticholinergic drugs and dementia: time for transparency in the face of uncertainty – Cochrane Library

Systematic review: Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome – Cochrane Library

 

Commentary on Twitter

 

Tube feeding for people with severe dementia: making decisions.

7 Sep, 2021 | 10:39h | UTC

Tube feeding for people with severe dementia: making decisions – Evidently Cochrane

Original article: Systematic review: Enteral tube feeding for people with severe dementia – “We found no evidence that tube feeding improves survival; improves quality of life; reduces pain; reduces mortality; decreases behavioural and psychological symptoms of dementia”.

 

Systematic review: evaluation of dietary patterns and all-cause mortality.

6 Sep, 2021 | 10:43h | UTC

Evaluation of Dietary Patterns and All-Cause Mortality: A Systematic Review – JAMA Network Open

 

Commentary on Twitter (thread – click for more)

 

Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.

6 Sep, 2021 | 10:45h | UTC

Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 – The Lancet Neurology

Invited commentary: Integrated approach to stroke burden: are we doing enough? (free registration required)

 

Commentaries on Twitter

 

M-A: Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia.

6 Sep, 2021 | 10:40h | UTC

Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre–post studies – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentary: Long-acting injectable antipsychotics: more effective than oral medications at preventing hospitalisation and relapse in schizophrenia according to new review – The Mental Elf

 

Commentary on Twitter

https://twitter.com/TheLancetPsych/status/1382314592609693703

 

M-A: Effect of monthly injections of naltrexone on alcohol consumption.

6 Sep, 2021 | 10:39h | UTC

Effect of extended-release naltrexone on alcohol consumption: a systematic review and meta-analysis – Addiction (link to abstract – $ for full-text)

 

Musculoskeletal complications following critical illness: A scoping review.

3 Sep, 2021 | 10:07h | UTC

Musculoskeletal complications following critical illness: A scoping review – Journal of Critical Care

 

Commentary on Twitter

 

Treatment of urinary tract infections in infants <2 Months: A Living Systematic Review - short and long duration of parenteral antibiotics were associated with a similar risk of UTI recurrence.

2 Sep, 2021 | 08:19h | UTC

Treatment of UTIs in Infants <2 Months: A Living Systematic Review – Hospital Pediatrics

 

Systematic review: In individuals with hemophilia A or B, there is evidence from RCTs that prophylaxis with clotting factor concentrates, as compared to on‐demand treatment, may reduce bleeding frequency.

2 Sep, 2021 | 08:17h | UTC

Clotting factor concentrates for preventing bleeding and bleeding‐related complications in previously treated individuals with haemophilia A or B – Cochrane Library

 

M-A: non-invasive tests for advanced fibrosis can reduce the need for biopsy in patients with non-alcoholic fatty liver disease.

2 Sep, 2021 | 08:14h | UTC

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis – Gut

 

Commentary on Twitter

 

M-A of randomized trials: Effectiveness of the modified Valsalva maneuver in adults with supraventricular – “The meta-analysis demonstrated a significantly higher success rate for reconversion to sinus rhythm when using the modified VM compared to the standard VM in patients with an SVT (odds ratio = 4.36; 95% confidence interval, 3.30–5.76; P < 0.001)”.

26 Aug, 2021 | 08:51h | UTC

Effectiveness of the modified Valsalva manoeuvre in adults with supraventricular tachycardia: a systematic review and meta-analysis – European Journal of Emergency Medicine (link to abstract – $ for full-text)

Related: Randomized Trial: Standard Valsalva vs. Modified Valsalva for Cardioversion of SVT (studies and commentaries on the subject)

Video: Modified Valsalva manoeuvre for supraventricular tachycardia – The Lancet

 

Preventing stillbirth: What’s the latest evidence?

25 Aug, 2021 | 08:38h | UTC

Preventing stillbirth: What’s the latest evidence? – Evidently Cochrane

Special collection: Stillbirth prevention and respectful bereavement care – Cochrane Library

 

Commentary on Twitter (thread – click for more)

 

M-A: GLP-1 receptor agonists reduce major adverse cardiovascular events, all-cause mortality, hospital admission for heart failure, and worsening kidney function in patients with type 2 diabetes.

22 Aug, 2021 | 22:50h | UTC

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Related: Guideline: SGLT-2 inhibitors or GLP-1 receptor agonists for adults with type 2 diabetes – This guidance recommends a risk-based approach, advising against starting SGLT-2 inhibitors or GLP-1 receptor agonists in patients with three or fewer cardiovascular risk factors and without established CVD or CKD.

 

M-A: The role of SGLT2 inhibitors in heart failure.

22 Aug, 2021 | 22:46h | UTC

The Role of SGLT2 Inhibitors in Heart Failure: A Systematic Review and Meta-Analysis – Cardiology Research and Practice

Related:

ESC Position Paper: Cardiac, renal, and metabolic effects of SGLT2 inhibitors.

Guideline: SGLT-2 inhibitors or GLP-1 receptor agonists for adults with type 2 diabetes – This guidance recommends a risk-based approach, advising against starting SGLT-2 inhibitors or GLP-1 receptor agonists in patients with three or fewer cardiovascular risk factors and without established CVD or CKD.

Summary: SGLT2 inhibitors and GLP-1 receptor agonists established and emerging indications.

M-A: SGLT2 inhibitors decrease cardiovascular death and heart failure hospitalizations in patients with heart failure.

Meta-analysis: Association of SGLT2 inhibitors with cardiovascular and kidney outcomes in patients with Type 2 diabetes

#ESCCongress – [Abstract Only] SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: A meta-analysis of the EMPEROR-Reduced and DAPA-HF trials

[Abstract Only] Randomized Trial: SGLT2 Inhibitor Improves Outcomes in Patients with Heart Failure Even in the Absence of Diabetes

 

M-A of randomized trials: The effect of higher versus lower protein delivery in critically ill patients – “In critically ill patients, a higher daily protein delivery was not associated with any improvement in clinical or patient-centered outcomes”.

20 Aug, 2021 | 08:57h | UTC

The effect of higher versus lower protein delivery in critically ill patients: a systematic review and meta-analysis of randomized controlled trials – Critical Care

 

M-A: Examination of dosing of antipsychotic drugs for relapse prevention in patients with stable schizophrenia.

20 Aug, 2021 | 09:04h | UTC

Examination of Dosing of Antipsychotic Drugs for Relapse Prevention in Patients With Stable Schizophrenia: A Meta-analysis – JAMA Psychiatry (free for a limited period)

 

Commentaries on Twitter

 

M-A: Prevalence, management and impact of chronic obstructive pulmonary disease in atrial fibrillation.

20 Aug, 2021 | 09:01h | UTC

Prevalence, management and impact of chronic obstructive pulmonary disease in atrial fibrillation: a systematic review and meta-analysis of 4,200,000 patients – European Heart Journal (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Support surfaces for managing pressure ulcers: which to choose?

18 Aug, 2021 | 08:26h | UTC

Support surfaces for managing pressure ulcers: which to choose? – Evidently Cochrane

 

Systematic review: Systemic corticosteroids for the treatment of COVID‐19.

17 Aug, 2021 | 09:11h | UTC

Systemic corticosteroids for the treatment of COVID‐19 – Cochrane Library

Summary: Are corticosteroids given orally or by injection an effective treatment for people with COVID-19? – Cochrane Library

 

Commentary on Twitter (thread – click for more)

 

Systematic review: Enteral tube feeding for people with severe dementia – “We found no evidence that tube feeding improves survival; improves quality of life; reduces pain; reduces mortality; decreases behavioural and psychological symptoms of dementia”.

16 Aug, 2021 | 00:54h | UTC

Enteral tube feeding for people with severe dementia – Cochrane Library

Summary: Enteral tube feeding for people with severe dementia – Cochrane Library

Related: Viewpoint: Tube Feeding and Deteriorating Patients (resources on the subject)

 

Commentary on Twitter

 

Systematic review: Kinesio taping provides little or no benefit for rotator cuff disease.

16 Aug, 2021 | 00:52h | UTC

Kinesio taping for rotator cuff disease – Cochrane Library

Summary: Kinesio taping for rotator cuff disease – Cochrane Library

 

Commentary on Twitter

https://twitter.com/CochraneUK/status/1426468681677254658

 

M-A: Targeted temperature management following out-of-hospital cardiac arrest – “Routine use of moderate or deep hypothermia in comatose survivors of OHCA may potentially be associated with more harm than benefit”.

16 Aug, 2021 | 00:55h | UTC

Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets – Intensive Care Medicine (free for a limited period)

Related: RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.

 

Commentary on Twitter

 

M-A: Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients.

13 Aug, 2021 | 09:01h | UTC

Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis – Intensive Care Medicine

 

Commentary on Twitter

 

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