M-A: Examination of dosing of antipsychotic drugs for relapse prevention in patients with stable schizophrenia.

Examination of Dosing of Antipsychotic Drugs for Relapse Prevention in Patients With Stable Schizophrenia: A Meta-analysis – JAMA Psychiatry (free for a limited period)

Commentaries on Twitter

Crucial literature review on optimal antipsychotic dosing for long term maintenance in #Schizophrenia.

Conclusion: Seek Goldilocks "just right"- definitely not high because of bad side effects, but not so low as to risk relapse.

Often easier said than done. https://t.co/RBBPBMzn9D

— Allen Frances (@AllenFrancesMD) August 20, 2021

Doses higher than 5mg/day risperidone equivalent are not more effective for relapse prevention than lower doses in #schizophrenia. But caution is required at the lower end of the dose-response curve where relapse risk disproportionally increases https://t.co/kQcnuRtzYU

— JAMA Psychiatry (@JAMAPsych) August 19, 2021