Systematic Reviews & Meta-analysis
#ESCCongress | Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomized, double-blind trials.
30 Aug, 2022 | 12:16h | UTCNews Release: Cardiovascular protection from statins greatly outweighs the risk of muscle symptoms – European Society of Cardiology
Commentary: Only Very Small Risk of Muscle Symptoms With Statins: CTT Collaboration – TCTMD
#ESCCongress – Meta-analysis of randomized trials | Angiotensin receptor blockers and Beta-blockers in Marfan syndrome: an individual patient data meta-analysis of randomized trials.
30 Aug, 2022 | 12:15h | UTCNews Release: Drug combination may delay need for surgery in patients with Marfan syndrome – TCTMD
Commentary: ARBs Halve Rate of Aortic Root Enlargement in Marfan: Meta-analysis – TCTMD
#ESCCongress – M-A | Patients with heart failure benefit from dapagliflozin regardless of ejection fraction.
30 Aug, 2022 | 12:14h | UTCNews Release: Patients with heart failure benefit from dapagliflozin regardless of ejection fraction – European Society of Cardiology
Related:
Meta analysis of randomized trials | Association of PD-L1 expression and other variables with benefit from immune checkpoint inhibition in advanced gastroesophageal cancer.
30 Aug, 2022 | 12:07h | UTCAssociation of PD-L1 Expression and Other Variables With Benefit From Immune Checkpoint Inhibition in Advanced Gastroesophageal Cancer: Systematic Review and Meta-analysis of 17 Phase 3 Randomized Clinical Trials – JAMA Oncology (free for a limited period)
Commentary on Twitter
In this meta-analysis of >11,000 patients with advanced gastroesophageal cancer, tissue PD-L1 expression — more than other variables besides microsatellite-high — identified varying degrees of benefit from immunotherapy-containing therapy. https://t.co/oUEDIEqLFj
— JAMA Oncology (@JAMAOnc) August 25, 2022
Salt substitutes vs. regular salt: a quick look.
30 Aug, 2022 | 12:02h | UTCSalt substitutes vs. regular salt: a quick look – Evidently Cochrane
Original Study: Replacing salt with low‐sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women – Cochrane Library
Related:
Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis – Heart (link to abstract – $ for full-text)
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
Commentary on Twitter
https://twitter.com/CochraneLibrary/status/1563130897159028737
M-A | Utility of the Ages and Stages Questionnaire to identify developmental delay in children aged 12 to 60 months.
30 Aug, 2022 | 12:00h | UTCUtility of the Ages and Stages Questionnaire to Identify Developmental Delay in Children Aged 12 to 60 Months: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)
M-A | Midodrine for the prevention of vasovagal syncope.
30 Aug, 2022 | 11:56h | UTCRelated: RCT: Midodrine can reduce the recurrence of vasovagal syncope.
#ESCCongress – Meta-analysis of randomized trials | SGLT-2 inhibitors in patients with heart failure.
29 Aug, 2022 | 12:35h | UTCSGLT-2 inhibitors in patients with heart failure: a comprehensive meta-analysis of five randomised controlled trials – The Lancet (free registration required)
Commentary on Twitter
Our meta-analysis of SGLT2 inhibitors in HF is now online in @TheLancet showing a
consistent reduction in the risk of CV death and HF hospitalisation in a broad range of 21,947
patients across range of EF and in different care settingshttps://t.co/qnxgayR235 pic.twitter.com/x0RsINoE9y— Kieran Docherty (@Kieranfdocherty) August 27, 2022
Bedtime dosing of antihypertensive medications: systematic review and consensus statement. – “use of bedtime drug dosing of antihypertensive drugs should not be routinely recommended”.
29 Aug, 2022 | 12:28h | UTC
Meta-analysis of randomized trials | Use of dexmedetomidine in patients with sepsis.
29 Aug, 2022 | 12:08h | UTC
M-A | Adverse pregnancy and birth outcomes associated with Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum.
29 Aug, 2022 | 12:06h | UTC
Meta-analysis of randomized trials | Intensive vs. short face-to-face smoking cessation interventions.
29 Aug, 2022 | 12:03h | UTC
Network Meta-Analysis | Antithrombotic therapy for symptomatic peripheral arterial disease.
26 Aug, 2022 | 13:28h | UTC
Scoping review of randomized trials with discontinuation of medicines in older adults.
26 Aug, 2022 | 13:16h | UTCScoping Review of Randomized Trials With Discontinuation of Medicines in Older Adults – JAMDA
Systematic Review | Pulmonary rehabilitation versus usual care for adults with asthma.
26 Aug, 2022 | 13:12h | UTCPulmonary rehabilitation versus usual care for adults with asthma – Cochrane Library
Commentary on Twitter
Very excited to see our new @CochraneAirways review in print! A modest body of evidence highlights likely benefits of #pulmonaryrehab on ex.tol and QoL in people with #asthma. Big thanks to @EvidSynIRL for supporting @ccass2000's mentorship! Link here: https://t.co/DlgdTqETtb pic.twitter.com/RAtOO0Oam6
— Christian Osadnik (@COsadnik) August 23, 2022
Systematic Review | Interventions for preventing venous thromboembolism in adults undergoing knee arthroscopy.
26 Aug, 2022 | 13:10h | UTC
Systematic Review | Therapeutic drug monitoring of biopharmaceuticals in inflammatory rheumatic and musculoskeletal disease.
25 Aug, 2022 | 11:55h | UTC
Study Commentary | Digital youth mental health interventions: will the evidence ever catch up?
25 Aug, 2022 | 11:54h | UTCDigital youth mental health interventions: will the evidence ever catch up? – The Mental Elf
Original Study: Evidence on Digital Mental Health Interventions for Adolescents and Young People: Systematic Overview – JMIR Mental Health
M-A of randomized trials | Risk of cutaneous adverse events in cancer patients treated with phosphatidylinositol-3-kinase inhibitors.
24 Aug, 2022 | 14:12h | UTC
Systematic Review | Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild cognitive impairment or dementia.
24 Aug, 2022 | 14:10h | UTCRelated:
Commonly-prescribed drugs and dementia: should we be worried? – Evidently Cochrane
How well do you know your anticholinergic (antimuscarinic) drugs? – Therapeutics Initiative
Anticholinergic drugs and risk of dementia: case-control study – The BMJ
M-A | Androgen receptor signaling inhibitors in addition to Docetaxel with androgen deprivation therapy for metastatic hormone-sensitive prostate cancer.
24 Aug, 2022 | 13:58h | UTC
Systematic Review | Interventions to reduce computed tomography usage in the emergency department.
24 Aug, 2022 | 13:54h | UTC
Updated systematic review and critical appraisal: prediction models for diagnosis and prognosis of covid-19.
23 Aug, 2022 | 13:31h | UTCCommentary: Update to living systematic review on prediction models for diagnosis and prognosis of covid-19 – The BMJ
Commentary on Twitter
NEW update in @bmj_latest
606 prognostic models for #COVID19 identified – 29 had low risk of bias, 32 had unclear risk of bias, AND 545 HAD HIGH RISK OF BIAS!
+Poorly reported – use TRIPOD please https://t.co/tVA0xHXdRu#epitwitter #statstwitter pic.twitter.com/n71vdgY8wM
— Gary Collins 🇪🇺 (@GSCollins) August 22, 2022
M-A | Incidence and mortality of non-AIDS-defining cancers among people living with HIV.
23 Aug, 2022 | 13:26h | UTCRelated: Study: Cancer Patients with HIV Infection Have Worse Outcomes
M-A | Incubation period of COVID-19 caused by unique SARS-CoV-2 strains.
23 Aug, 2022 | 13:24h | UTC