Systematic Reviews & Meta-analysis
SR | Glucocorticoids for croup in children
23 Feb, 2023 | 13:17h | UTCGlucocorticoids for croup in children – Cochrane Library
M-A | Monoclonal antibody for the prevention of respiratory syncytial virus in infants and children
22 Feb, 2023 | 12:24h | UTCCommentary: Study Finds 3 Monoclonal Antibodies Reduce RSV Infections in High-Risk Infants, Children – HCP Live
Commentary on Twitter
Network meta-analysis of 4 monoclonal antibodies for the prevention of RSV in children finds 3 may be useful in preventing RSV; more research to confirm efficacy, safety, and cost effectiveness is needed. https://t.co/wz9yCVAFWo
— JAMA Network Open (@JAMANetworkOpen) February 17, 2023
M-A | Drugs to reduce bleeding in major open vascular or endovascular surgery – not enough evidence to guide treatment
21 Feb, 2023 | 11:44h | UTCSummary: The article is a systematic review and network meta-analysis of randomized controlled trials (RCTs) on the effectiveness and safety of anti-fibrinolytic and hemostatic drugs and agents to reduce bleeding and the need for blood transfusion in people undergoing major vascular surgery or endovascular procedures. The authors searched multiple databases and trial registries and included 22 RCTs with 3,393 participants analyzed. Due to a lack of data, the authors are uncertain whether any systemic or topical treatments may improve outcomes, emphasizing that larger trials with clinically relevant outcomes are needed.
M-A | General Anesthesia vs. to Non-GA in endovascular thrombectomy for ischemic stroke
20 Feb, 2023 | 12:20h | UTCSummary: The study analyzed randomized controlled trials comparing the use of general anesthesia (GA) versus non-GA techniques, such as conscious sedation or local anesthesia for endovascular thrombectomy (EVT) in patients with ischemic stroke. The meta-analysis included seven trials with a total of 980 participants, showing that GA is associated with a 9% improvement in recanalization rates and an 8.4% improvement in functional recovery compared to non-GA techniques. There was no difference in hemorrhagic complications or 3-month mortality. The study recommends that GA be the first choice for most EVT procedures in acute ischemic stroke.
Article: General Anesthesia Compared to Non-GA in Endovascular Thrombectomy for Ischemic Stroke: A Systematic Review and Meta-analysis of Randomized Controlled Trials – Neurology (link to abstract – $ for full-text)
M-A | Financial toxicity among patients with breast cancer worldwide
17 Feb, 2023 | 13:20h | UTCCommentary: Breast Cancer Treatment Is Associated With Financial Toxicity Worldwide, Study Finds – AJMC
Related:
Not Just Nausea And Vomiting: Cancer Docs Now Worry About ‘Financial Toxicity’ – WBUR
Financial Toxicity and Cancer Treatment (PDQ®) – National Institute of Cancer
Commentary on Twitter
Financial toxicity for patients with breast cancer (pooled): 78% in LMICs and 35% in HICs; much higher than other health conditions, including other cancers. Policies to address this huge burden are critical to improve financial and health outcomes. https://t.co/eaB7nCvurU
— JAMA Network Open (@JAMANetworkOpen) February 9, 2023
M-A | Efficacy and safety of drugs for gastroparesis
17 Feb, 2023 | 13:05h | UTCCommentaries:
Review finds only two efficacious medications to treat gastroparesis – ACP Gastroenterology
Two drug classes appear effective for gastroparesis treatment – MDedge
Commentary from the author on Twitter (thread – click for more)
Our latest (and definitely last!) paper of 2022 is now published online in @AGA_Gastro and is a network meta-analysis of drugs in gastroparesis:https://t.co/kpz8nH6ekT
— Alexander Ford (@alex_ford12399) December 26, 2022
M-A | Catheter directed thrombolysis for not immediately threatened acute limb ischemia
17 Feb, 2023 | 13:00h | UTC
M-A | Foot orthoses for flexible flatfeet in children and adults
17 Feb, 2023 | 13:02h | UTC
M-A | Global status of azithromycin and erythromycin resistance rates in Neisseria gonorrhoeae
17 Feb, 2023 | 12:58h | UTC
M-A | Association between antimicrobial stewardship programs and antibiotic use globally
16 Feb, 2023 | 15:21h | UTCCommentaries:
Antimicrobial Stewardship Programs Beneficial for Cutting Antibiotic Use – HealthDay
M-A | Blood pressure lowering effects of B-blockers as add-on or combination therapy
16 Feb, 2023 | 15:10h | UTC
M-A | Worldwide prevalence of antibiotic-associated Stevens-Johnson syndrome and toxic epidermal necrolysis
16 Feb, 2023 | 15:04h | UTCSummary: The article examined the prevalence Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) associated with antibiotics worldwide. The analysis included 38 studies involving 2,917 patients, which showed that 28% of SJS/TEN cases were associated with antibiotics. Among antibiotic-associated SJS/TEN, the sulfonamide class was associated with 32% of cases, followed by penicillins, cephalosporins, fluoroquinolones, and macrolides.
Article: Worldwide Prevalence of Antibiotic-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-analysis – JAMA Dermatology (free for a limited period)
*Note: This summary was created through the collaboration of a medical editor and ChatGPT.
M-A | Radiofrequency therapies for trigeminal neuralgia
16 Feb, 2023 | 14:51h | UTC
M-A | Cost-effectiveness of internet interventions compared with treatment as usual for people with mental disorders
16 Feb, 2023 | 14:43h | UTC
M-A | Relative safety and effectiveness of different erythropoiesis‐stimulating agents for anemia in adults with CKD
15 Feb, 2023 | 15:58h | UTCSummary: The article reviewed the evidence on the safety and effectiveness of different epoetin drugs in treating anemia in people with chronic kidney disease. From the available research, it is uncertain whether various epoetin medications are superior or inferior to each other in terms of the probability of requiring a blood transfusion, mortality, experiencing a heart attack or stroke, developing a clot in a fistula or dialysis vascular catheter, or the likelihood of requiring dialysis for individuals with less severe kidney disease.*
*Note: This summary was created through the collaboration of a medical editor and ChatGPT.
SR | Silicone gel sheeting for treating keloid scars
15 Feb, 2023 | 15:53h | UTCSilicone gel sheeting for treating keloid scars – Cochrane Library
M-A | Risk of bias in randomized clinical trials comparing transcatheter and surgical aortic valve replacement
15 Feb, 2023 | 15:52h | UTCCommentary: Major TAVI Studies Have ‘Methodological Issues,’ INTEGRITTY Group Contends – TCTMD
Commentary on Twitter
Trials comparing TAVI vs SAVR show substantial proportions of deviation from assigned treatment, loss to follow-up, and additional procedures, as well as systematic selective imbalance favoring TAVI that might affect internal validity. https://t.co/n7hwTMEPGu
— JAMA Network Open (@JAMANetworkOpen) January 3, 2023
SR | Prognostic models for mortality risk in patients requiring ECMO
15 Feb, 2023 | 15:49h | UTCPrognostic models for mortality risk in patients requiring ECMO – Intensive Care Medicine
SR | Effect of remote patient monitoring for patients with chronic kidney disease who perform dialysis at home
15 Feb, 2023 | 15:47h | UTC
SR | Cost measurement in value-based healthcare
15 Feb, 2023 | 15:46h | UTCCost measurement in value-based healthcare: a systematic review – BMJ Open
SR | Inspiratory muscle training, with or without concomitant pulmonary rehabilitation, for COPD
15 Feb, 2023 | 15:42h | UTC
M-A | Tenecteplase vs. alteplase for treatment of acute ischemic stroke
13 Feb, 2023 | 12:57h | UTCRelated: Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
M-A | Exercise-based cardiac rehabilitation for coronary heart disease
13 Feb, 2023 | 12:28h | UTC
SR | Cognitive aids in the management of clinical emergencies
10 Feb, 2023 | 13:44h | UTCCognitive aids in the management of clinical emergencies: a systematic review – Anaesthesia
M-A | Pacifier use and breastfeeding in term and preterm newborns
9 Feb, 2023 | 13:41h | UTC