M-A | Drugs to reduce bleeding in major open vascular or endovascular surgery – not enough evidence to guide treatment

Summary: The article is a systematic review and network meta-analysis of randomized controlled trials (RCTs) on the effectiveness and safety of anti-fibrinolytic and hemostatic drugs and agents to reduce bleeding and the need for blood transfusion in people undergoing major vascular surgery or endovascular procedures. The authors searched multiple databases and trial registries and included 22 RCTs with 3,393 participants analyzed. Due to a lack of data, the authors are uncertain whether any systemic or topical treatments may improve outcomes, emphasizing that larger trials with clinically relevant outcomes are needed.

Article: Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and network meta‐analysis – Cochrane Library