Systematic Reviews & Meta-analysis
SR | Interventions for acute non‐arteritic central retinal artery occlusion
3 Mar, 2023 | 13:36h | UTCInterventions for acute non‐arteritic central retinal artery occlusion – Cochrane Library
Commentary on Twitter
Updated #Cochrane Review finds that treatments for acute non-arteritic #CRAO —the blockage of blood to the retina—are ineffective for visual acuity, and tissue plasminogen activator had serious adverse effectshttps://t.co/RmkLD0te2d@johnclin_ @BrownUResearch @VAResearch pic.twitter.com/BjajHtvWaL
— CochraneEyes (@CochraneEyes) February 2, 2023
SR | Erythromycin prior to endoscopy for acute upper gastrointestinal hemorrhage
3 Mar, 2023 | 13:33h | UTCErythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage – Cochrane Library
SR | Endovascular therapy vs. medical treatment for symptomatic intracranial artery stenosis
3 Mar, 2023 | 13:35h | UTC
SR | Neoadjuvant treatment for stage III and IV cutaneous melanoma
3 Mar, 2023 | 13:32h | UTCNeoadjuvant treatment for stage III and IV cutaneous melanoma – Cochrane Library
M-A | Thromboprophylaxis in patients with Fontan circulation
2 Mar, 2023 | 12:57h | UTCThromboprophylaxis in Patients With Fontan Circulation – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: Thromboprophylaxis in Patients With Fontan Circulation – American College of Cardiology
Commentary from the author on Twitter (thread – click for more)
?Hot off the press?Read our new paper about #Thromboprophylaxis in patients with #Fontan #circulation just published in @JACCJournals@ACCinTouch.
Article link: https://t.co/eeu6kT7PDH— Jef Van den Eynde (@JefVandenEynde) January 23, 2023
M-A | Prevalence and odds of depressive and anxiety disorders and symptoms in children and adults with alopecia areata
2 Mar, 2023 | 12:59h | UTCPrevalence and Odds of Depressive and Anxiety Disorders and Symptoms in Children and Adults With Alopecia Areata: A Systematic Review and Meta-analysis – JAMA Dermatology (link to abstract – $ for full-text)
Commentary: Anxiety, Depressive Disorder Prevalence Greater Among Alopecia Areata Patients – HCP Live
M-A | Incidence, indications, risk factors, and outcomes of emergency peripartum hysterectomy worldwide
2 Mar, 2023 | 12:54h | UTC
SR | Trifocal intraocular lenses vs. bifocal intraocular lenses after cataract extraction among participants with presbyopia
2 Mar, 2023 | 12:46h | UTCSummary: Trifocal versus bifocal lenses implantation after cataract surgery – Cochrane Library
M-A | Eccentric exercise vs. other exercises in the treatment of mid-portion Achilles tendinopathy
2 Mar, 2023 | 12:40h | UTC
M-A | Comparison of suture button and syndesmotic screw for ankle syndesmotic injuries
1 Mar, 2023 | 13:50h | UTC
M-A | Catheter directed thrombolysis for not immediately threatened acute limb ischemia
1 Mar, 2023 | 13:49h | UTC
Is a one-size-fits-all ‘12-month rule’ appropriate when it comes to the last search date in systematic reviews?
1 Mar, 2023 | 13:48h | UTC
Commentary on Twitter
Is a one-size-fits-all ‘12-month rule’ appropriate when it comes to the last search date in systematic reviews?
Analysis by @gillianstokesm @EPPICentre @KatySutcliffe @UCLSocRes @James_M_Thomas #OpenAccess
Link: https://t.co/aNAdDXgphn pic.twitter.com/f2JZiaVDtz
— BMJ Evidence-Based Medicine (@BMJ_EBM) January 17, 2023
SR | Surgical versus non‐surgical interventions for treating patellar dislocation
1 Mar, 2023 | 13:45h | UTCSurgical versus non‐surgical interventions for treating patellar dislocation – Cochrane Library
SR | Insufficient evidence to recommend Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia
28 Feb, 2023 | 13:39h | UTC
M-A | Effect of posterior pericardiotomy in cardiac surgery
28 Feb, 2023 | 13:34h | UTC
M-A | Adverse perinatal outcomes associated with antiretroviral therapy in women living with HIV
27 Feb, 2023 | 12:48h | UTC
Innovative models of healthcare delivery: an umbrella review of reviews
27 Feb, 2023 | 12:37h | UTCInnovative models of healthcare delivery: an umbrella review of reviews – BMJ Open
M-A | Efficacy of elimination diets in eosinophilic esophagitis
24 Feb, 2023 | 13:47h | UTCSummary: This systematic review and meta-analysis evaluated the effectiveness of various dietary treatment regimens for eosinophilic esophagitis (EoE). After analyzing 34 studies with 1762 patients, it was concluded that dietary therapy is a viable and efficacious option for individuals with EoE of all ages, with an overall histological remission rate of 53.8% and a clinical response rate of 80.8%. The study also found that highly restrictive dietary regimes, such as a six-food elimination diet, may not be superior to less restrictive dietary regimens, such as a four-food elimination diet or one-food elimination diet, in achieving histological remission, supporting less restrictive dietary regimens as a treatment option. The study has several limitations, such as the observational nature of most studies included.
Commentary: Elimination diets effective for patients with eosinophilic esophagitis – ACP Gastroenterology
Commentary on Twitter
Efficacy of dietary therapy in eosinophilic esophagitis for (1) histologic remission & (2) clinical response
6⃣-food elimination diet: 61%, 93%
4⃣-food elimination diet: 49%, 74%
1⃣-food elimination diet: 51%, 87%
Targeted elimination diet: 46%, 69%#EoEhttps://t.co/VKXgCQO9O6 pic.twitter.com/KfpSburuwN— John Damianos, M.D. (@john_damianosMD) February 1, 2023
Article under a Creative Commons Attribution (CC BY 4.0) license
SR | Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery
24 Feb, 2023 | 13:39h | UTC
M-A | Association of brain metastases with survival in patients with limited or stable extracranial disease
24 Feb, 2023 | 13:34h | UTC
M-A | Adjuvant chemotherapy for resected triple negative breast cancer patients
24 Feb, 2023 | 13:30h | UTC
SR | The impact of Antimicrobial Stewardship Programs in pediatric emergency departments and primary care
24 Feb, 2023 | 13:20h | UTC
M-A | Low-dose insulin infusion is safe and effective in treating diabetic ketoacidosis in children
23 Feb, 2023 | 13:40h | UTCSummary: The article discusses a systematic review and meta-analysis of randomized controlled trials comparing low-dose insulin at 0.05 units/kg/hr to standard dose at 0.1 units/kg/hr for children with diabetic ketoacidosis (DKA). The study found that low-dose insulin infusion is probably as efficacious and safer than standard-dose insulin in treating DKA in children, as it has no effect on the time to resolution of hyperglycemia or acidosis and probably reduces the risk of developing hypokalemia and hypoglycemia. However, the results are limited by imprecision and generalizability to other settings since all studies were performed in a single country. Therefore, further studies are required to identify the optimal insulin dose for children with DKA in terms of safety and effectiveness.
M-A | Disordered eating affects 1 in 5 children and adolescents
23 Feb, 2023 | 13:33h | UTCSummary: The text reports the findings of a systematic review and meta-analysis that included 32 studies on the global proportion of disordered eating in children and adolescents aged 6 to 18 years, assessed with the SCOFF questionnaire, a widely used screening measure for eating disorders. The review found that approximately 22% of children and adolescents showed disordered eating, which was higher among girls, older adolescents, and those with higher body mass index. The high figures are concerning from a public health perspective and highlight the need for prevention strategies to address disordered eating. The study has limitations, including the cross-sectional nature of most of the included studies and the use of self-report questionnaires to assess disordered eating, which may be subject to bias.
Article: Global Proportion of Disordered Eating in Children and Adolescents: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)
Commentary: What is disordered eating? And why do 20% of the world’s kids show signs of it? Experts explain – CNN
M-A | Metabolic side effects in persons with schizophrenia during mid- to long-term treatment with antipsychotics
23 Feb, 2023 | 13:26h | UTCSummary: This study aimed to evaluate the mid- to long-term metabolic side effects of 31 antipsychotics in persons with schizophrenia by analyzing 137 eligible randomized controlled trials with 35,007 participants. The primary outcome was weight gain, with secondary outcomes including fasting glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. The study found that antipsychotic drugs differ in their propensity to induce metabolic side effects. Chlorpromazine, clozapine, olanzapine, and zotepine produced the most weight gain. The confidence in the evidence ranged from low to moderate. The study suggests that differences in weight gain were more pronounced than previously published short-term data and that weight gain is most pronounced at the beginning of treatment and then remains stable.
Article: Metabolic side effects in persons with schizophrenia during mid- to long-term treatment with antipsychotics: a network meta-analysis of randomized controlled trials – World Psychiatry (free for a limited period)