Randomized Trials | Page 45 of 58 | Links Medicus Content Curation & Alerts in Medicine

Cluster RCT: In adults with out-of-hospital cardiac arrest, placement of a supraglottic airway device resulted in similar rates of sustained return of spontaneous circulations compared to endotracheal intubation.

2 Mar, 2022 | 09:07h | UTC

Effect of Placement of a Supraglottic Airway Device vs Endotracheal Intubation on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest in Taipei, Taiwan: A Cluster Randomized Clinical Trial – JAMA Network Open

Commentary: Cardiac Arrest Patients Don’t Necessarily Do Better With Intubation— Debate on prehospital advanced airway management continues – MedPage Today (free registration required)

Commentary on Twitter

RCT of out-of-hospital cardiac arrest patients randomized to intubation or supraglottic airways, finds no difference in the rate of sustained return of spontaneous circulation, survival to hospital discharge or favorable neurologic outcomes. https://t.co/GX80iczmHC

— JAMA Network Open (@JAMANetworkOpen) February 18, 2022

RCT: Arthroscopic hip surgery compared with personalized hip therapy in people over 16 years old with femoroacetabular impingement syndrome.

2 Mar, 2022 | 09:04h | UTC

Abstract: Arthroscopic hip surgery compared with personalised hip therapy in people over 16 years old with femoroacetabular impingement syndrome: UK FASHIoN RCT – Health Technology Assessment

Download Full Report

RCT: Referral for early, supported exercise after breast cancer surgery improves shoulder function and health-related quality of life.

1 Mar, 2022 | 08:50h | UTC

Abstract: Exercise to prevent shoulder problems after breast cancer surgery: the PROSPER RCT – Health Technology Assessment

Full Report: Exercise to prevent shoulder problems after breast cancer surgery: the PROSPER RCT – Health Technology Assessment

RCT: Sublingual dexmedetomidine reduces mild to moderate acute agitation in patients with bipolar disorder.

23 Feb, 2022 | 10:18h | UTC

Effect of Sublingual Dexmedetomidine vs Placebo on Acute Agitation Associated With Bipolar Disorder: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Sublingual Dexmedetomidine as a Potential New Treatment for Agitation – JAMA (free for a limited period)

Commentary on Twitter

Randomized clinical trial found sublingual #dexmedetomidine at a dose of 180 μg or 120 μg reduced mild to moderate agitation in patients with #bipolar disorder. https://t.co/1VK2e15F7s pic.twitter.com/0oHw6eVMIP

— JAMA (@JAMA_current) February 22, 2022

RCT: Full endoscopic discectomy non-inferior to open discectomy in patients with sciatica.

22 Feb, 2022 | 10:11h | UTC

Full endoscopic versus open discectomy for sciatica: randomised controlled non-inferiority trial – The BMJ

Commentary: Full-endoscopic transforaminal discectomy is “an effective alternative” to open microdiscectomy in treating sciatica – Spinal News International

RCT: Time to functional recovery after laser tonsillotomy performed under local anesthesia vs. conventional tonsillectomy with general anesthesia among adults.

22 Feb, 2022 | 08:22h | UTC

Time to Functional Recovery After Laser Tonsillotomy Performed Under Local Anesthesia vs Conventional Tonsillectomy With General Anesthesia Among Adults: A Randomized Clinical Trial – JAMA Network Open

Commentary on Twitter

RCT found laser tonsillotomy under local anesthesia had faster functional recovery but lower resolution of the chief complaint leading to surgery vs conventional tonsillectomy under general anesthesia; it may offer a feasible alternative. https://t.co/yfaWeFJeEl pic.twitter.com/DDYxlEhZEp

— JAMA Network Open (@JAMANetworkOpen) February 21, 2022

RCT: Sub dissociative dose of ketamine with haloperidol vs. fentanyl on pain reduction in patients with acute pain in the emergency department.

21 Feb, 2022 | 08:37h | UTC

Sub dissociative dose of ketamine with haloperidol versus fentanyl on pain reduction in patients with acute pain in the emergency department; a randomized clinical trial – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

RCT: Low-dose aspirin did not significantly reduce the risk of preterm birth in women with a previous spontaneous preterm birth (RR 0.83; 95% CI 0.58 to 1.20; p = 0.32).

21 Feb, 2022 | 08:33h | UTC

Evaluation of low-dose aspirin in the prevention of recurrent spontaneous preterm labour (the APRIL study): A multicentre, randomised, double-blinded, placebo-controlled trial – PLOS Medicine

RCT: Single-dose metronidazole vs. treatment for 7 days for treating Trichomonas vaginalis in women.

21 Feb, 2022 | 08:23h | UTC

A Comparison of Single-Dose Versus Multidose Metronidazole by Select Clinical Factors for the Treatment of Trichomonas vaginalis in Women – Sexually Transmitted Diseases (link to abstract – $ for full-text)

RCT: Two vs. three courses of preoperative cisplatin and fluorouracil plus docetaxel for locally advanced esophageal squamous cell carcinoma.

21 Feb, 2022 | 08:25h | UTC

Multicenter randomised trial of two versus three courses of preoperative cisplatin and fluorouracil plus docetaxel for locally advanced oesophageal squamous cell carcinoma – British Journal of Cancer (link to abstract – read for free here)

Commentary on Twitter

Multicenter randomised trial of two versus three courses of preoperative cisplatin and fluorouracil plus docetaxel for locally advanced oesophageal squamous cell carcinoma

Read for free: https://t.co/vXRAP29FRo #Chemotherapy #Cancer pic.twitter.com/D7KBifTFOS

— British Journal of Cancer (@BrJCancer) February 9, 2022

RCT: Perianal application of glyceryl trinitrate ointment vs. tocopherol acetate ointment for treating chronic anal fissure.

21 Feb, 2022 | 08:26h | UTC

Perianal Application of Glyceryl Trinitrate Ointment Versus Tocopherol Acetate Ointment in the Treatment of Chronic Anal Fissure: A Randomized Clinical Trial – Diseases of the Colon & Rectum (link to abstract – $ for full-text)

RCT: Oral Nirmatrelvir for high-risk adults with Covid-19 reduces the risk of hospitalization by 89%.

17 Feb, 2022 | 10:14h | UTC

Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 – New England Journal of Medicine

Audio Interview: A New Antiviral against Covid-19 – new England Journal of Medicine

[Press release – not published yet] Pfizer’s Covid pill remains 89% effective for reducing the risk of hospitalization or death in final analysis.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

Statement on potential drug-drug interactions between Ritonavir-boosted Nirmatrelvir (Paxlovid) and concomitant medications; antiarrhythmics, oral anticoagulants, immunosuppressants, anticonvulsants, antineoplastics, and neuropsychiatric drugs are among the drugs of concern.

Commentary on Twitter

The Paxlovid pill (Nirmatrelvir) randomized, placebo-controlled trial published @NEJM:
89% efficacy vs Covid hospitalizations or deaths, and quick reduction of viral load.
The active pills had less serious adverse events or discontinuations than placebohttps://t.co/HBMRZt4wBo pic.twitter.com/LDQv41O56c

— Eric Topol (@EricTopol) February 16, 2022

RCT: L-ornithine L-aspartate in acute treatment of severe hepatic encephalopathy.

17 Feb, 2022 | 08:35h | UTC

L-ornithine L-aspartate in acute treatment of severe hepatic encephalopathy: A double-blind randomized controlled trial – Hepatology (link to abstract – $ for full-text)

Efficacy, durability, and safety of intravitreal Faricimab up to every 16 weeks for neovascular age-related macular degeneration: two randomized, double-masked, phase 3, non-inferiority trials.

15 Feb, 2022 | 08:29h | UTC

Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials – The Lancet (link to abstract – $ for full-text)

Commentary: Trials Show Promise for Intravitreal Faricimab in Retinal Disease – HealthDay

RCT: Effects of a 6-month, low-carbohydrate diet on glycemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes.

13 Feb, 2022 | 22:35h | UTC

Effects of a 6-month, low-carbohydrate diet on glycaemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes: An open-label randomized controlled trial – Diabetes, Obesity and Metabolism

RCT: Primary Norfloxacin prophylaxis prevents bacterial infections in patients with acute-on-chronic liver failure.

13 Feb, 2022 | 22:37h | UTC

Primary Norfloxacin Prophylaxis for APASL-Defined Acute-on-Chronic Liver Failure: A Placebo-Controlled Double-Blind Randomized Trial – The American Journal of Gastroenterology (link to abstract – $ for full-text)

RCT: In patients with cardiogenic shock receiving VA-ECMO, moderate hypothermia did not significantly reduce 30-day mortality. 42% of patients in the moderate hypothermia group died vs. 51% in the normothermia group (adjusted odds ratio, 0.71 [95% CI, 0.45 to 1.13], P = .15).

13 Feb, 2022 | 22:11h | UTC

Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Hypothermia vs. Normothermia for Cardiogenic Shock Patients on VA-ECMO – American College of Cardiology

Commentary on Twitter

In this RCT, for patients with cardiogenic shock receiving venoarterial ECMO, moderate hypothermia for 24 hours compared with normothermia did not significantly decrease 30-day mortality. https://t.co/0LKYJ1bNB3 pic.twitter.com/KmXPAlvqh9

— JAMA (@JAMA_current) February 2, 2022

RCT: In patients with contaminated ventral hernias undergoing repair, synthetic Mesh reduced hernia recurrence risk compared with biologic Mesh.

13 Feb, 2022 | 22:05h | UTC

Biologic vs Synthetic Mesh for Single-stage Repair of Contaminated Ventral Hernias: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)

Commentary on Twitter

Multicenter randomized clinical trial found synthetic mesh demonstrated significantly lower hernia recurrence risk than biologic mesh in patients undergoing single-stage repair of clean-contaminated and contaminated ventral hernias. https://t.co/CADZPSYGBc

— JAMA Surgery (@JAMASurgery) January 19, 2022

RCT: Subcutaneous Tirzepatide added to titrated Insulin Glargine improves glycemic control in patients with Type 2 Diabetes.

10 Feb, 2022 | 10:00h | UTC

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Tirzepatide for Patients With Type 2 Diabetes – JAMA

Commentary: SURPASS-5 Data: Tirzepatide Plus Insulin Glargine Improve Glycemic Control in T2D – AJMC

RCT: In patients with Type 2 Diabetes, Tirzepatide is associated with reduced weight, improved glycemic control, and lower risk of hypoglycemia compared to insulin glargine.

RCT: Once-weekly tirzepatide vs. once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes.

RCT: Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2.

RCT: Tirzepatide yielded greater glycated hemoglobin and body weight reductions compared to Semaglutide 1 mg.

RCT: Home phototherapy of term neonates improves parental bonding and stress.

10 Feb, 2022 | 08:25h | UTC

Home phototherapy of term neonates improves parental bonding and stress: Findings from a randomised controlled trial – Acta Paediatrica

Commentary on Twitter

Does treating Jaundice in babies at home, as compared to at hospital, improves parental bonding and reduces parental stress?

A new RCT published @ActaPaediatrica by Swedish researchers #EBNEOAlerts #neoEBM #FOAMNeo https://t.co/InjkdrC5JY pic.twitter.com/BaGs86Hf8t

— Evidence-Based Neo (@EBNEO) January 3, 2022