RCT: Low-dose aspirin did not significantly reduce the risk of preterm birth in women with a previous spontaneous preterm birth (RR 0.83; 95% CI 0.58 to 1.20; p = 0.32). 21 Feb, 2022 | 08:33h | UTC Evaluation of low-dose aspirin in the prevention of recurrent spontaneous preterm labour (the APRIL study): A multicentre, randomised, double-blinded, placebo-controlled trial – PLOS Medicine