Randomized Trials
RCT | A lower glycemic criteria in not better than higher glycemic criteria for the diagnosis of gestational diabetes.
18 Aug, 2022 | 13:04h | UTCLower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Pros and cons with lower vs higher threshold for gestational diabetes diagnosis – medwire News
Commentary on Twitter (thread – click for more)
1/ Overdiagnosis of Gestational Diabetes (GDM): New large randomized trial compared broader/narrower criteria -> NO improvement in mother/baby outcomes BUT x2 increase in % pregnant women labelled as GDM. Time to reconsider GDM testing – https://t.co/xrr0XrdhaZ
— Paul Glasziou (@PaulGlasziou) August 18, 2022
RCT | Metformin, Ivermectin, and Fluvoxamine are not beneficial for obese outpatients with Covid-19.
18 Aug, 2022 | 13:00h | UTCEditorial: Time to Stop Using Ineffective Covid-19 Drugs – New England Journal of Medicine
Commentary on Twitter
In this trial involving overweight or obese outpatients with Covid-19, investigators found that none of three repurposed drugs (metformin, ivermectin, and fluvoxamine) reduced the risk of serious disease. https://t.co/8sd6R7CDK6 pic.twitter.com/bPZ6zeuZSA
— NEJM (@NEJM) August 17, 2022
RCT | Effectiveness of a long-term home-based exercise training program in patients with COPD following pulmonary rehabilitation.
18 Aug, 2022 | 12:43h | UTC
Commentary on Twitter
Effectiveness of a long-term home-based exercise training program in patients with COPD following pulmonary rehabilitation: A multi-center randomized controlled trialhttps://t.co/8u1nizaDNq pic.twitter.com/QwqzN1dDHK
— Physio Meets Science (@PhysioMeScience) August 17, 2022
Under a Creative Commons license
RCT | Ceftolozane/Tazobactam plus Metronidazole vs. Meropenem in patients with complicated intra-abdominal infections.
18 Aug, 2022 | 12:37h | UTC
RCT | Effect of remote ischemic conditioning vs. usual care on neurologic function in patients with acute moderate ischemic stroke.
17 Aug, 2022 | 14:32h | UTCEffect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Remote Ischemic Conditioning: Feasible and Potentially Beneficial for Ischemic Stroke – JAMA (free for a limited period)
Video Summary: Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke – JAMA
RCT | Chest CT scan plus x-ray vs. chest x-ray for the follow-up of completely resected non-small-cell lung cancer.
16 Aug, 2022 | 13:50h | UTCChest CT scan plus x-ray versus chest x-ray for the follow-up of completely resected non-small-cell lung cancer (IFCT-0302): a multicentre, open-label, randomised, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
Totally unexpected! After resection of early NSCLC in 1775 pts, follow-up by ct-scan did not improve survival vs a simple chest X-Rays! We should ALWAYS questioned our practice. Amazing work from Virginie Westeel @barlesi @IFCTlung https://t.co/iMFGtpkQcF
— Benjamin Besse (@BenjaminBesseMD) August 12, 2022
RCT | Therapist-supported internet-delivered exposure and response prevention for children and adolescents with Tourette Syndrome.
16 Aug, 2022 | 13:18h | UTCCommentaries:
Online Exposure Therapy Improves Tic Symptoms in Youth – Psychiatric News Alert
Commentary on Twitter
In this RCT, 221 youths with #Tourette syndrome or chronic tic disorder received therapist-supported, internet-delivered exposure and response prevention (ERP) or education. Both groups improved over time, with no between-group differences in tic severity. https://t.co/YND2mgPn2Q
— JAMA Network Open (@JAMANetworkOpen) August 15, 2022
Perspective | Pragmatism in clinical trials: essential, not optional.
15 Aug, 2022 | 12:15h | UTCPragmatism in clinical trials: essential, not optional – European Journal of Cardiology (free for a limited period)
Commentary on Twitter
A call for pragmatism in the design and running of clinical trials:https://t.co/bXQ4Wp0x1i#EHJ@escardio pic.twitter.com/ES1X12zTGv
— EHJ Editor-in-Chief (@ehj_ed) August 11, 2022
RCT | Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis.
15 Aug, 2022 | 12:05h | UTC
RCT | Omecamtiv Mecarbil does not improve exercise capacity in chronic heart failure with reduced ejection fraction.
15 Aug, 2022 | 12:07h | UTCEffect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Author Interview: Can Omecamtiv Mecarbil Improve Peak Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF)? – JAMA
Commentaries:
Omecamtiv Mecarbil Fails to Improve Exercise Capacity in HFrEF – Medscape (free registration required)
Commentary on Twitter
#OriginalInvestigation: Multicenter randomized clinical trial found that, in patients with chronic #HFrEF, omecamtiv mecarbil did not significantly improve exercise capacity over 20 weeks compared with placebo. @GLewisCardiol https://t.co/f27Y0oya6S
— JAMA (@JAMA_current) July 20, 2022
RCT | Small trial suggests intraosseous morphine may decrease postoperative pain and pain medication use after total knee arthroplasty.
15 Aug, 2022 | 12:03h | UTCNews Release: A new way to control pain after knee replacement surgery – Houston Methodist
RCT | A small study evaluated the safety and efficacy of prophylactic levetiracetam for prevention of epileptic seizures in the acute phase of intracerebral hemorrhage.
15 Aug, 2022 | 12:01h | UTCSafety and efficacy of prophylactic levetiracetam for prevention of epileptic seizures in the acute phase of intracerebral haemorrhage (PEACH): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Neurology (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
Small study that is not powered to answer this question but raises an interesting ❓ nonetheless: should we use prophylactic antiseizure 💊in #ich? Most recently updated guidelines recommend against this practice. https://t.co/NH45OCtzvv
— Richard Choi, DO, FNCS (@rkchoi) August 11, 2022
RCT | Removal of small, asymptomatic kidney stones and incidence of relapse.
11 Aug, 2022 | 12:23h | UTCRemoval of Small, Asymptomatic Kidney Stones and Incidence of Relapse – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Removal of small, asymptomatic kidney stones during surgery to remove ureteral or contralateral stones resulted in less relapse than nonremoval and in similar numbers of subsequent emergency department visits. https://t.co/MRgFUnF1C0 pic.twitter.com/19ahPuHyNS
— NEJM (@NEJM) August 10, 2022
RCT | In older patients undergoing total intravenous anesthesia, Etomidate is noninferior to Propofol regarding the risk of major postoperative complications.
11 Aug, 2022 | 12:18h | UTC
Commentary on Twitter
General anesthesia with etomidate does not increase postoperative morbidity, as indicated by the rate of major in-hospital post-op complications, in elderly patients undergoing abdominal surgery, as compared with propofol. https://t.co/vjPvle3DQj pic.twitter.com/2k6eSLupbH
— JAMA Surgery (@JAMASurgery) August 10, 2022
RCT | Tobramycin inhalation solution is effective in adults with bronchiectasis with pseudomonas aeruginosa infection.
11 Aug, 2022 | 12:15h | UTCCommentary: Tobramycin Tames Infection in Bronchiectasis – Medscape (free registration required)
RCT | Effect of intranasal Dexmedetomidine or Midazolam for premedication on the occurrence of respiratory adverse events in children undergoing tonsillectomy and adenoidectomy.
11 Aug, 2022 | 12:08h | UTCCommentaries:
Dexmedetomidine Cuts Perioperative Respiratory AEs in Tonsillectomy – HealthDay
Commentary on Twitter
Children often required sedatives before surgery due to anxiety and crying. In this RCT, intranasal midazolam increased the incidence of perioperative respiratory adverse events (PRAEs), while intranasal dexmedetomidine reduced PRAEs. #OrigInvestigation https://t.co/5AAILuzstM pic.twitter.com/WejpGkAGGs
— JAMA Network Open (@JAMANetworkOpen) August 9, 2022
RCT | Low-dose Decitabine vs. low-dose Azacitidine in lower-risk myelodysplastic syndromes.
11 Aug, 2022 | 12:04h | UTCLow-Dose Decitabine versus Low-Dose Azacitidine in Lower-Risk MDS – NEJM Evidence
Commentary on Twitter
Low dose hypomethylating agent therapy led to an overall response rate of 60% in pts with low- or intermediate-risk myelodysplastic syndromes or chronic myelomonocytic leukemia who had not received prior hypomethylating agents. https://t.co/OSpNLzfiKW#MDS #LeuSM #CMML pic.twitter.com/BN1XAhfUBo
— NEJM Evidence (@NEJMEvidence) August 9, 2022
RCT | Topical treatment of diabetic macular edema using dexamethasone ophthalmic suspension.
11 Aug, 2022 | 11:57h | UTCCommentary: Topical Dexamethasone Ophthalmic Suspension OCS-01 Effective in DME Treatment – HCP Live
RCT | Thoracic epidural analgesia vs. rectus sheath catheter analgesia after open midline major abdominal surgery.
10 Aug, 2022 | 12:24h | UTC
RCT | Hughes abdominal closure vs. standard mass closure to reduce incisional hernias following surgery for colorectal cancer.
9 Aug, 2022 | 12:56h | UTC
RCT | Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast.
9 Aug, 2022 | 12:46h | UTCRadiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3–07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study – The Lancet (link to abstract – $ for full-text)
RCT | Effect of a comprehensive telehealth intervention vs. telemonitoring and care coordination in patients with persistently poor type 2 diabetes control.
9 Aug, 2022 | 12:44h | UTCEffect of a Comprehensive Telehealth Intervention vs Telemonitoring and Care Coordination in Patients With Persistently Poor Type 2 Diabetes Control: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentary on Twitter
A comprehensive telehealth intervention improved HbA1c in persistently poorly-controlled type 2 diabetes compared to a simpler telehealth intervention; the comprehensive telehealth approach may warrant implementation in systems with appropriate resources. https://t.co/qXnuclyipQ
— JAMA Internal Medicine (@JAMAInternalMed) July 29, 2022
RCT | Efficacy and safety of intravenous acetaminophen (2 g/day) for reducing opioid consumption in Chinese adults after elective orthopedic surgery.
9 Aug, 2022 | 12:39h | UTC
RCT | Effectiveness of Varenicline and Cytisine for alcohol use reduction among people with HIV and substance use.
9 Aug, 2022 | 12:35h | UTC
Commentary on Twitter
In this RCT, varenicline and cytisine were not more efficacious than nicotine to treat risky drinking and smoking among individuals with HIV; rates of behavior change for alcohol consumption and smoking were high in all treatment groups. #OrigInvestigation https://t.co/h8M6e5nOkf
— JAMA Network Open (@JAMANetworkOpen) August 5, 2022
Two randomized trials found monoclonal antibodies are no better than placebo for Parkinson’s Disease.
8 Aug, 2022 | 11:53h | UTCStudy 1: Trial of Cinpanemab in Early Parkinson’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Study 2: Trial of Prasinezumab in Early-Stage Parkinson’s Diseas – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Monoclonal Antibodies No Better Than Placebo for Early Parkinson Disease – HealthDay