Randomized Trials
#ESCCongress – RCT | In comatose survivors of out-of-hospital cardiac arrest, a restrictive vs. a liberal oxygenation strategy resulted in similar incidences of death, severe disability, and coma.
29 Aug, 2022 | 12:12h | UTCOxygen Targets in Comatose Survivors of Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Restrictive oxygenation in post cardiac arrest patients is not harmful – European Society of Cardiology
Commentary on Twitter
BOX Oxygen: This RCT found no difference in the rate of death or severe disability/coma when mechanically ventilated patients following out-of-hospital cardiac arrest were managed with higher or lower oxygenation targets. #ESCCongress https://t.co/qqtd4SyVrl pic.twitter.com/q73gqSuAn4
— NEJM (@NEJM) August 27, 2022
RCT | Sacituzumab Govitecan in hormone receptor–positive/human epidermal growth factor receptor 2–negative metastatic breast cancer.
29 Aug, 2022 | 12:05h | UTC
RCT | Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis.
29 Aug, 2022 | 11:58h | UTCUpadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT | Self-measurement of blood pressure with a standard device is not enhanced by the use of a connected smartphone application.
26 Aug, 2022 | 13:29h | UTCEffectiveness of Standard vs Enhanced Self-measurement of Blood Pressure Paired With a Connected Smartphone Application: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
News Release: For Checking Blood Pressure at Home, Basic Cuffs Are Just as Good – UC San Francisco
Commentary: App-enabled device no better than standard device for self-measuring blood pressure – ACP Internist
Commentary on Twitter
Monitoring #bloodpressure at home may help with #bloodpressurecontrol, but using an enhanced device pairing with a smartphone application appears to be no more effective than using a standard device. https://t.co/h6zREImCNv #Research pic.twitter.com/T1zWDlp2pC
— JAMA Internal Medicine (@JAMAInternalMed) August 15, 2022
RCT | HPV self-sampling among long-term non-attenders to cervical cancer screening.
26 Aug, 2022 | 13:27h | UTC
Commentary on Twitter
Pragmatic randomised controlled trial of 3 different HPV screening approaches suggests that opt-in and particularlly send-to-all self-sampling increased participation among long-term, higher-risk non-attenders: https://t.co/hBouqoBMnU #GynCSM #hsronc
— NatureRevClinOncol (@NatRevClinOncol) August 25, 2022
RCT | Efficacy of potassium supplementation on the risk of peritonitis in hypokalemic patients receiving peritoneal dialysis.
26 Aug, 2022 | 13:25h | UTCEfficacy of Potassium Supplementation in Hypokalemic Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trial – American Journal of Kidney Diseases (link to abstract – $ for full-text)
Commentary on Twitter
https://twitter.com/AJKDonline/status/1528677142036455425
Secondary analysis of a RCT | Effects of Empagliflozin on symptoms, physical limitations, and quality of life in patients hospitalized for acute heart failure.
26 Aug, 2022 | 13:24h | UTCCommentary: Empagliflozin Offers Clinical Benefit in Heart Failure – HealthDay
Original Study: The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial – Nature Medicine
RCT | Talimogene Laherparepvec plus Pembrolizumab not better than placebo-Pembrolizumab in patients with advanced melanoma.
26 Aug, 2022 | 13:09h | UTC
Long-term results of a RCT | Lenalidomide plus Rituximab vs. Rituximab-chemotherapy followed by Rituximab maintenance in untreated advanced Follicular Lymphoma.
26 Aug, 2022 | 13:03h | UTCCommentaries:
Commentary on Twitter
6-year update from the phase III RELEVANCE trial of lenalidomide-rituximab versus rituximab-chemotherapy in previously untreated patients with advanced-stage follicular lymphoma demonstrates very similar durable efficacy and safety: https://t.co/rMeA2tOoO6 #lymsm #hemeonc
— NatureRevClinOncol (@NatRevClinOncol) August 19, 2022
Randomized Crossover Trial | In patients with diabetic neuropathic pain, amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin were similarly effective.
25 Aug, 2022 | 12:14h | UTC
RCTs | Ublituximab vs. Teriflunomide in relapsing multiple sclerosis.
25 Aug, 2022 | 12:04h | UTCUblituximab versus Teriflunomide in Relapsing Multiple Sclerosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In two parallel randomized trials in patients with MS, ublituximab resulted in lower relapse rates and fewer brain lesions on MRI than teriflunomide over a period of 96 weeks but did not affect disability. https://t.co/fpdtYhTNER pic.twitter.com/EPJEetSVdS
— NEJM (@NEJM) August 24, 2022
RCT | Olokizumab vs. Placebo or Adalimumab in rheumatoid arthritis.
25 Aug, 2022 | 12:04h | UTCOlokizumab versus Placebo or Adalimumab in Rheumatoid Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Novel IL-6 Blocker Matches Humira in Rheumatoid Arthritis – MedPage Today (free registration required)
RCT | Nivolumab vs. nivolumab plus docetaxel for previously treated advanced or recurrent immune checkpoint inhibitor-naïve non-small-cell lung cancer.
25 Aug, 2022 | 11:48h | UTC
RCT | In women at risk of preterm delivery, half dose antenatal Dexamethasone was NOT noninferior compared to full dose Dexamethasone on neonatal outcomes.
24 Aug, 2022 | 14:20h | UTCNeonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
On 50th anniversary of Liggins & Howie's discovery of benefits of antenatal steroids for preterm birth, new study in @TheLancet confirms full dose (11.4 mg x 2) of betamethasone is necessary for optimum benefit. https://t.co/VgjtprM0W8#neoTwitter #obstetrics @EBNEO @ESPR_EBN pic.twitter.com/Cl1GbzWoRl
— Atul Malhotra (@Atul_Monash) August 19, 2022
Long-term results of a RCT | Vasopressin and methylprednisolone did not improve outcomes in patients with in-hospital cardiac arrest.
24 Aug, 2022 | 14:15h | UTC
Cluster RCT | Effect of biannual mass azithromycin distributions to preschool-aged children on trachoma prevalence.
24 Aug, 2022 | 13:55h | UTC
Commentary on Twitter
Cluster-randomized trial in trachoma-hypoendemic region of Niger mass azithromycin distributions targeted to pre-school children did not reduce trachoma. #OAResearch https://t.co/G7rfZShdz7 pic.twitter.com/UGUlc0x8G8
— JAMA Network Open (@JAMANetworkOpen) August 23, 2022
Long-term follow up of a RCT | Precancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine.
24 Aug, 2022 | 13:53h | UTCPrecancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine: an analysis of the long-term follow-up study from the randomised Costa Rica HPV Vaccine Trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
Virological replacement & clinical unmasking are two phenomena of interest following #HPVvaccination. We show that clinical unmasking might attenuate long-term reductions in cervical precancer following successful implementation of HPV vax programs in highly screened populations https://t.co/Z7dGQNG1kG
— Monica Sierra (@MonicaSSierra) June 14, 2022
RCT | Efficacy of Ubrogepant in the acute treatment of migraine with mild pain versus moderate or severe pain.
24 Aug, 2022 | 13:52h | UTC
RCT | Stopping vs. continuing long-term mepolizumab treatment in severe eosinophilic asthma.
23 Aug, 2022 | 12:55h | UTC
Commentary on Twitter
This randomised study demonstrates increased exacerbation risk and a decrease in asthma control in patients with severe eosinophilic asthma who stop mepolizumab treatment after long-term use, when compared with those who continue treatment. https://t.co/HYCH0TsU9E pic.twitter.com/rW6hmHgJlj
— ERS publications (@ERSpublications) January 6, 2022
RCT | Synthetic sling vs. artificial urinary sphincter for men with urodynamic stress incontinence after prostate surgery.
22 Aug, 2022 | 12:18h | UTC
RCT | Effectiveness of an intervention for reducing sitting time and improving health in office workers.
22 Aug, 2022 | 12:19h | UTCEditorial: The importance of sitting less and moving more – The BMJ
News Release: Standing desks alongside other measures cut office workers’ sitting time by an hour a day – BMJ Newsroom
Commentary: SMART Work and Life Intervention Reduces Sitting Time for Office Workers – HealthDay
Commentary on Twitter
Using a standing desk alongside a package of other measures to encourage office workers to sit less and move more, reduced sitting time by about an hour a day over one year, finds a trial published in @bmj_latest today https://t.co/uxaDWnp5WB
— The BMJ (@bmj_latest) August 18, 2022
RCT | Surgical reconstruction is superior to rehabilitation for patients with non-acute anterior cruciate ligament injury with persistent symptoms of instability.
22 Aug, 2022 | 12:16h | UTC
Commentary on Twitter
Surgical reconstruction of non-acute ACL injury with persistent symptoms of instability was superior in comparison with rehabilitation at 18 months (KOOS4 mean difference 7.9 (95% CI 2.5–13.2)): https://t.co/y2taBzHolU pic.twitter.com/n0qW3B6cMv
— Søren T. Skou (@STSkou) August 19, 2022
Under a Creative Commons Attribution (CC BY 4.0) license
RCT | Mepolizumab for urban children with exacerbation-prone eosinophilic asthma.
22 Aug, 2022 | 12:09h | UTCMepolizumab for urban children with exacerbation-prone eosinophilic asthma in the USA (MUPPITS-2): a randomised, double-blind, placebo-controlled, parallel-group trial – The Lancet (link to abstract – $ for full-text)
Commentary: Mepolizumab Cuts Exacerbations in Children With Severe Asthma – HealthDay
RCT | Effectiveness of Etoposide and Cisplatin vs. Irinotecan and Cisplatin therapy for patients with advanced neuroendocrine carcinoma of the digestive system.
22 Aug, 2022 | 11:54h | UTC
Commentary on Twitter
JCOG1213 (TOPIC NEC), the first randomized phase III trial in advanced neuroendocrine carcinoma of the digestive system, shows no significant difference in overall survival for etoposide+cisplatin versus irinotecan+cisplatin therapy https://t.co/JTELRlzTzi #GICSM pic.twitter.com/AQT8U4yd3l
— JAMA Oncology (@JAMAOnc) August 18, 2022
RCT | Fecal microbiota transplantation with anti-inflammatory diet induced and maintained remission in a small trial of patients with mild to moderate ulcerative colitis.
19 Aug, 2022 | 16:08h | UTCFaecal microbiota transplantation with anti-inflammatory diet (FMT-AID) followed by anti-inflammatory diet alone is effective in inducing and maintaining remission over 1 year in mild to moderate ulcerative colitis: a randomised controlled trial – Gut (link to abstract – $ for full-text)
Commentary: Fecal Transplant With Anti-Inflammatory Diet Yields Remissions in UC – MedPage Today (free registration required)