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Randomized Trials

RCT | Bedaquiline–Pretomanid–Linezolid regimens for drug-resistant tuberculosis.

2 Sep, 2022 | 13:16h | UTC

Bedaquiline–Pretomanid–Linezolid Regimens for Drug-Resistant Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Three drug regimen with Linezolid 600 mg tied to better outcomes in drug-resistant TB – Medical Dialogues

 

RCT | Fractional flow reserve or intravascular ultrasonography to guide percutaneous coronary intervention.

2 Sep, 2022 | 13:15h | UTC

Fractional Flow Reserve or Intravascular Ultrasonography to Guide PCI – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Fractional Flow Reserve Noninferior to IVUS for Guiding PCI – HealthDay

 

RCT | Driving pressure-guided ventilation and postoperative pulmonary complications in thoracic surgery.

1 Sep, 2022 | 11:52h | UTC

Driving pressure-guided ventilation and postoperative pulmonary complications in thoracic surgery: a multicentre randomised clinical trial – British Journal of Anaesthesia

 

RCT | Placement of an intrauterine device within 48 hours after early medical abortion.

1 Sep, 2022 | 11:51h | UTC

Placement of an intrauterine device within 48 hours after early medical abortion – a randomized controlled trial – American Journal of Obstetrics & Gynecology

 

RCT | In patients with rheumatoid arthritis, Tofacitinib is associated with increased risk of infections compared to TNF inhibitors.

1 Sep, 2022 | 11:50h | UTC

Infections in patients with rheumatoid arthritis receiving tofacitinib versus tumour necrosis factor inhibitors: results from the open-label, randomised controlled ORAL Surveillance trial – Annals of Rheumatic Diseases

 

Commentary on Twitter

 

RCT | The effect of a liberal approach to glucose control in critically ill patients with type 2 diabetes.

1 Sep, 2022 | 11:37h | UTC

The Effect of a Liberal Approach to Glucose Control in Critically Ill Patients with Type 2 Diabetes: A multicenter, parallel-group, open-label, randomized clinical trial – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

 

Commentary from the author on Twitter

 

RCT | Remote physician visits are noninferior to in-home physician visits for patients receiving acute hospital-level care at home (home hospital).

31 Aug, 2022 | 11:49h | UTC

Remote vs In-home Physician Visits for Hospital-Level Care at Home: A Randomized Clinical Trial – JAMA Network Open

Author Interview: Remote vs In-home Physician Visits for Hospital-Level Care at Home – JAMA

 

Commentary on Twitter

 

RCT | Outpatient convalescent plasma therapy for high-risk patients with early COVID-19.

31 Aug, 2022 | 11:48h | UTC

Outpatient convalescent plasma therapy for high-risk patients with early COVID-19. A randomized placebo-controlled trial – Clinical Microbiology and Infection

 

RCT | Efficacy and safety of Vamorolone vs. Placebo and Prednisone among boys with Duchenne Muscular Dystrophy.

31 Aug, 2022 | 11:40h | UTC

Efficacy and Safety of Vamorolone vs Placebo and Prednisone Among Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial – JAMA Neurology

 

Long-term results of a RCT | Self-expanding transcatheter vs. surgical aortic valve replacement in intermediate-risk patients.

31 Aug, 2022 | 11:38h | UTC

Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients: 5-Year Outcomes of the SURTAVI Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)

Original article: Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients – New England Journal of Medicine

 

Commentary on Twitter

 

Cluster RCT | Effect of different interventions to help primary care clinicians avoid unsafe opioid prescribing in opioid-naive patients with acute noncancer pain.

31 Aug, 2022 | 11:33h | UTC

Effect of Different Interventions to Help Primary Care Clinicians Avoid Unsafe Opioid Prescribing in Opioid-Naive Patients With Acute Noncancer Pain: A Cluster Randomized Clinical Trial – JAMA Health Forum

 

Commentary on Twitter

 

Long-term results of a RCT | Long-term outcomes for ibrutinib–rituximab and chemoimmunotherapy in chronic lymphocytic leukemia.

31 Aug, 2022 | 11:32h | UTC

Long-term outcomes for ibrutinib–rituximab and chemoimmunotherapy in CLL: updated results of the E1912 trial – Blood

Commentary: Ibrutinib Plus Rituximab Yields Superior Survival Vs FCR in CLL, Regardless of IGHV Status – Cancer Network

 

RCT | Optical coherence tomography vs. punch biopsy for diagnosis of basal cell carcinoma.

31 Aug, 2022 | 11:31h | UTC

Optical coherence tomography versus punch biopsy for diagnosis of basal cell carcinoma: a multicentre, randomised, non-inferiority trial – The Lancet Oncology (link to abstract – $ for full-text)

News Release: 66% of diagnostic biopsies for common skin cancer can be avoided using Michelson Diagnostics’ VivoSight OCT laser scanner – PR Newswire

 

RCT | Patient preference and treatment satisfaction with a port delivery system for Ranibizumab vs. intravitreal injections in patients with neovascular age-related macular degeneration.

30 Aug, 2022 | 12:06h | UTC

Patient Preference and Treatment Satisfaction With a Port Delivery System for Ranibizumab vs Intravitreal Injections in Patients With Neovascular Age-Related Macular Degeneration: A Randomized Clinical Trial – JAMA Ophthalmology

Commentary: Port Delivery System Preferred Over Intravitreal Injection for Patients with nAMD – HCPLive

 

Commentary on Twitter

 

Single-center RCT | Effectiveness of intrarectal povidone-iodine cleansing plus formalin disinfection of the needle tip in decreasing infectious complications after transrectal prostate biopsy.

30 Aug, 2022 | 12:05h | UTC

Effectiveness of Intrarectal Povidone-Iodine Cleansing plus Formalin Disinfection of the Needle Tip in Decreasing Infectious Complications after Transrectal Prostate Biopsy: A Randomized Controlled Trial – The Journal of Urology (link to abstract – $ for full-text)

 

RCT | Colorectal Endoscopic Stenting Trial (CReST) for obstructing left-sided colorectal cancer.

30 Aug, 2022 | 11:58h | UTC

Colorectal Endoscopic Stenting Trial (CReST) for obstructing left-sided colorectal cancer: randomized clinical trial – British Journal of Surgery

 

#ESCCongress – RCT | In patients with severe ischemic left ventricular systolic dysfunction under optimal medical therapy, revascularization by PCI did not improve outcomes.

29 Aug, 2022 | 12:38h | UTC

Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Coronary stenting does not benefit patients with severe left ventricular dysfunction – European Society of Cardiology

Commentary: DANCAVAS: CV Screening Did Not Significantly Reduce Incidence of Death in Older Males – American College of Cardiology

 

Commentary on Twitter

 

#ESCCongress – RCT | Dapagliflozin reduced the risk of worsening heart failure or cardiovascular death in patients with heart failure with mildly reduced or preserved ejection fraction.

29 Aug, 2022 | 12:36h | UTC

Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Dapagliflozin benefits patients with mildly reduced and preserved ejection fraction – European Society of Cardiology

Related (#ESCCongress 2021): RCT: SGLT2 inhibition reduced the combined risk of cardiovascular death or hospitalization in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes.

 

Commentary on Twitter

 

#ESCCongress – RCT | In patients with rheumatic heart disease–associated atrial fibrillation, treatment with a Vitamin K antagonist led to a lower rate of cardiovascular events or death compared to Rivaroxaban.

29 Aug, 2022 | 12:33h | UTC

Rivaroxaban in Rheumatic Heart Disease–Associated Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Trial backs standard of care for rheumatic heart disease and atrial fibrillation – European Society of Cardiology

Commentary: INVICTUS: More Deaths, Stroke With Rivaroxaban in Rheumatic Heart Disease AF – TCTMD

 

Commentary on Twitter

 

#ESCCongress – RCT | Routine functional testing is not better than standard care in high-risk patients after percutaneous coronary intervention.

29 Aug, 2022 | 12:32h | UTC

Routine Functional Testing or Standard Care in High-Risk Patients after PCI – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | Acetazolamide resulted in faster decongestion in patients with acute decompensated heart failure with volume overload.

29 Aug, 2022 | 12:25h | UTC

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Acetazolamide improves decongestion in patients with acute decompensated heart failure – European Society of Cardiology

Commentary: Acetazolamide in Decompensated Heart Failure With Volume Overload – ADVOR – American College of Cardiology

 

Commentary on Twitter

https://twitter.com/NEJM/status/1563421082505588738

 

#ESCCongress | In patients within 6 months of a myocardial infarction, a polypill containing aspirin, ramipril, and atorvastatin resulted in a lower risk of major adverse cardiovascular events compared to usual care.

29 Aug, 2022 | 12:27h | UTC

Polypill Strategy in Secondary Cardiovascular Prevention – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Polypill reduces cardiovascular events in heart attack patients compared to usual care – European Society of Cardiology

Commentaries:

SECURE: Treatment With Polypill Significantly Lowers Risk of Major CV Events – American College of Cardiology

Polypill Strategy Lowers Adverse CV Event Risk in Secondary Prevention – HCPLive

Related: M-A: Polypills with and without aspirin substantially reduce cardiovascular disease, myocardial infarction, stroke, revascularization, and cardiovascular death in primary cardiovascular disease prevention. (several studies on the subject)

 

#ESCCongress – RCT | A large study with 46.611 individuals between 65 and 74 years of age found that a comprehensive cardiovascular screening program did not significantly reduce the incidence of death from any cause.

29 Aug, 2022 | 12:24h | UTC

Five-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Cardiovascular screening may reduce risk of death and cardiovascular disease – European Society of Cardiology

 

Commentary on Twitter

 

#ESCCongress – RCT | In comatose survivors of out-of-hospital cardiac arrest, targeting a mean arterial blood pressure of 77 mmHg vs. 63 mmHg did not result in different outcomes.

29 Aug, 2022 | 12:13h | UTC

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Trial finds no benefit of raising blood pressure target in post cardiac arrest patients – European Society of Cardiology

Commentary: Blood Pressure Targets Show No Benefit in Comatose Survivors of Cardiac Arrest – HCPLive

 

Commentary on Twitter

 

RCT | Cemiplimab plus chemotherapy vs. chemotherapy alone in non-small cell lung cancer.

29 Aug, 2022 | 12:08h | UTC

Cemiplimab plus chemotherapy versus chemotherapy alone in non-small cell lung cancer: a randomized, controlled, double-blind phase 3 trial – Nature Medicine

 

Commentary on Twitter

 

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