RCT | In women at risk of preterm delivery, half dose antenatal Dexamethasone was NOT noninferior compared to full dose Dexamethasone on neonatal outcomes.

Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

Commentary on Twitter

On 50th anniversary of Liggins & Howie's discovery of benefits of antenatal steroids for preterm birth, new study in @TheLancet confirms full dose (11.4 mg x 2) of betamethasone is necessary for optimum benefit. https://t.co/VgjtprM0W8#neoTwitter #obstetrics @EBNEO @ESPR_EBN pic.twitter.com/Cl1GbzWoRl

— Atul Malhotra (@Atul_Monash) August 19, 2022