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Psychiatry

Large observational study suggests prolactin-increasing antipsychotics are associated with increased risk of breast cancer (OR=1.56 for over 5 years of exposure); prolactin-sparing antipsychotics (including clozapine, quetiapine, or aripiprazole), on the other hand, were not associated with increased risk.

10 Nov, 2021 | 06:57h | UTC

Antipsychotic use and risk of breast cancer in women with schizophrenia: a nationwide nested case-control study in Finland – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentary: Choosing between antipsychotics to reduce the risk of breast cancer in women with schizophrenia – The Mental Elf

 

Commentary on Twitter

 


Adolescents’ recreational screen time doubled during pandemic, affecting mental health.

3 Nov, 2021 | 10:06h | UTC

News release: Adolescents’ recreational screen time doubled during pandemic, affecting mental health – University of California, San Francisco

Original Study: Screen Time Use Among US Adolescents During the COVID-19 Pandemic: Findings From the Adolescent Brain Cognitive Development (ABCD) Study – JAMA Pediatrics

Commentary: Kids nearly doubled screen time during the pandemic, but there is something you can do about it – CNN

 

Commentary from the author on Twitter

 


NICE Guideline | Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management.

31 Oct, 2021 | 20:03h | UTC

Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management – National Institute for Health and Care Excellence

Commentaries:

Chronic fatigue syndrome advice scraps exercise therapy – BBC

ME exercise therapy guidance scrapped by health watchdog Nice – The Guardian

 


Stimulant prescription linked to increased short-term risks of cardiovascular events in older adults.

29 Oct, 2021 | 09:47h | UTC

Assessment of Stimulant Use and Cardiovascular Event Risks Among Older Adults – JAMA Network Open

Commentaries:

Use of stimulants in older adults associated with higher risk for cardiovascular events in first month – University of Toronto

Stimulants Linked to Early Risk of CV Events in Elderly – TCTMD

Stimulants May Pose Short-Term Cardiovascular Risks in Older Adults – Psychiatric News Alert

 


RCT: Early treatment with fluvoxamine reduced the risk of emergency care and hospitalization among patients with COVID-19.

28 Oct, 2021 | 10:22h | UTC

Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial – The Lancet Global Health

Commentaries:

Expert reaction to study looking at fluvoxamine as a COVID-19 treatment in high-risk outpatients with early-diagnosed COVID-19 – Science Media Centre

The TOGETHER Trial: COVID-19 and Fluvoxamine Take Two – REBEL EM

The antidepressant fluvoxamine can keep COVID-19 patients out of the hospital – ScienceNews

Related:

[Preprint] RCT: Fluvoxamine reduced the risk for ER visits and hospitalization among patients with Covid-19.

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

Commentary on Twitter

 


Brain fog can persist for months after COVID diagnosis.

28 Oct, 2021 | 10:13h | UTC

Assessment of Cognitive Function in Patients After COVID-19 Infection – JAMA Network Open

Commentaries:

Brain fog can persist 8 months after COVID diagnosis – CIDRAP

Brain fog in Covid-19 patients can persist for months, even in those who were not hospitalized, study finds – CNN

 


M-A: The efficacy of pharmacotherapies for the treatment of borderline personality disorder is limited.

27 Oct, 2021 | 01:11h | UTC

Pharmacological Treatments for Borderline Personality Disorder: A Systematic Review and Meta-Analysis – CNS Drugs

 


RCT: The association of Varenicline and Nicotine patch was not better than Varenicline alone to increase smoking abstinence; there was also no difference between 24-week vs. 12-week treatment courses in abstinence rates.

24 Oct, 2021 | 23:45h | UTC

Effects of Combined Varenicline With Nicotine Patch and of Extended Treatment Duration on Smoking Cessation: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Is There a Role for Combined Use of Varenicline and Nicotine Patch or Extended Treatment Duration to Enhance Smoking Cessation? – JAMA (free for a limited period)

Commentary: Varenicline Combo, Extension No Better for Quitting Smoking – HealthDay

 

Commentary on Twitter

 


M-A: Clinical interventions for adults with comorbid alcohol use and depressive disorders.

24 Oct, 2021 | 23:39h | UTC

Clinical interventions for adults with comorbid alcohol use and depressive disorders: A systematic review and network meta-analysis – PLOS Medicine

 


RCT: Mirtazapine not better than placebo for the treatment of agitation in people with dementia and was possibly associated with increased mortality (7 vs.1 deaths, difference not statistically significant; p=0·065).

22 Oct, 2021 | 10:19h | UTC

Study of mirtazapine for agitated behaviours in dementia (SYMBAD): a randomised, double-blind, placebo-controlled trial – The Lancet

Commentary: Common antidepressant should no longer be used to treat people with dementia – University of Exeter

 


The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

21 Oct, 2021 | 09:48h | UTC

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use – Addiction

Commentary: How to measure cannabis use: introducing the ‘International Cannabis Toolkit’ or iCannToolkit – The Mental Elf

 


Systematic Review: Restricting access to poisons is associated with decreases in suicide by poisoning without an equivalent shift toward other methods.

20 Oct, 2021 | 09:48h | UTC

Association Between Means Restriction of Poison and Method-Specific Suicide Rates: A Systematic Review – JAMA Network Open

 

Commentary on Twitter

 


Cluster RCT: An exercise intervention may improve academic achievement among children.

19 Oct, 2021 | 09:45h | UTC

Exercise Intervention for Academic Achievement Among Children: A Randomized Controlled Trial – Pediatrics

 

Commentary on Twitter

 


M-A: Psychosocial and psychological interventions for relapse prevention in schizophrenia.

17 Oct, 2021 | 21:12h | UTC

Psychosocial and psychological interventions for relapse prevention in schizophrenia: a systematic review and network meta-analysis – The Lancet Psychiatry

 

Commentary on Twitter

 


RCT: Oxytocin does not improve social functioning in children with autism spectrum disorder.

14 Oct, 2021 | 09:52h | UTC

News release: Oxytocin does not improve social functioning in children with autism spectrum disorder, NIH-funded study suggests – National Institutes of Health

Original study: Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder – New England Journal of Medicine

 


New Global Burden of Disease analyses show depression and anxiety among the top causes of health burden worldwide, and a significant increase due to the COVID-19 pandemic.

10 Oct, 2021 | 21:57h | UTC

News release: New Global Burden of Disease analyses show depression and anxiety among the top causes of health burden worldwide, and a significant increase due to the COVID-19 pandemic – Institute for Health Metrics and Evaluation

Original study: Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic – The Lancet

Commentaries:

Depression and anxiety disorders during the COVID-19 pandemic: knowns and unknowns – The Lancet

COVID-19 pandemic led to stark rise in depressive and anxiety disorders globally in 2020: study – The Lancet

Covid crisis dramatically worsened global mental health, study finds – The Guardian

 

Commentary on Twitter (thread – click for more)

 


World Mental Health Day: prioritize social justice, not only access to care.

10 Oct, 2021 | 21:37h | UTC

World Mental Health Day: prioritise social justice, not only access to care – The Lancet (free registration required)

 

Commentary on Twitter

 


M-A: Accuracy of the Patient Health Questionnaire-9 for screening to detect major depression.

10 Oct, 2021 | 21:34h | UTC

Accuracy of the Patient Health Questionnaire-9 for screening to detect major depression: updated systematic review and individual participant data meta-analysis – The BMJ

See calculator: PHQ-9 (Patient Health Questionnaire-9)

 

Commentary on Twitter

 


Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies.

10 Oct, 2021 | 21:31h | UTC

Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies – Molecular Psychiatry

Commentary: Age at onset of mental disorders: global meta-analysis provides data for targeting effective interventions – The Mental Elf

 


Editorial: Brain health and its social determinants.

10 Oct, 2021 | 21:35h | UTC

Brain health and its social determinants – The Lancet

 

Commentary on Twitter

 


The German Guidelines for the treatment of anxiety disorders.

8 Oct, 2021 | 10:16h | UTC

The German Guidelines for the treatment of anxiety disorders: first revision – European Archives of Psychiatry and Clinical Neuroscience

 


Saying ‘person with schizophrenia,’ not ‘schizophrenic,’ can affect clinician beliefs, study finds.

1 Oct, 2021 | 10:05h | UTC

Saying ‘person with schizophrenia,’ not ‘schizophrenic,’ can affect clinician beliefs, study finds – STAT

Original article: It’s Time for Counselors to Modify Our Language: It Matters When We Call Our Clients Schizophrenics Versus People With Schizophrenia – Journal of Counseling & Development ($)

 


RCT: Maintenance vs. discontinuation of antidepressants in patients who felt well enough to discontinue antidepressant therapy.

30 Sep, 2021 | 10:22h | UTC

Maintenance or Discontinuation of Antidepressants in Primary Care – New England Journal of Medicine

Commentaries:

Many can stop anti-depressants without relapse – BBC

Study highlights difficulty of stopping antidepressants – Associated Press

 


Methylphenidate for attention-deficit/hyperactivity disorder in adults: a narrative review.

30 Sep, 2021 | 10:07h | UTC

Methylphenidate for attention-deficit/hyperactivity disorder in adults: a narrative review – Psychopharmacology

 

Commentary on Twitter

 


M-A: Magnitude of the placebo response across treatment modalities used for treatment-resistant depression in adults.

29 Sep, 2021 | 10:04h | UTC

Magnitude of the Placebo Response Across Treatment Modalities Used for Treatment-Resistant Depression in Adults: A Systematic Review and Meta-analysis – JAMA Network Open

Invited Commentary: Treatment-Resistant Depression—Resistant to Placebos as Well? – JAMA Network Open

 

Commentaries on Twitter

(thread – click for more)

 


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