M-A: Magnitude of the placebo response across treatment modalities used for treatment-resistant depression in adults.
29 Sep, 2021 | 10:04h | UTCInvited Commentary: Treatment-Resistant Depression—Resistant to Placebos as Well? – JAMA Network Open
Commentaries on Twitter
This systematic review and meta-analysis found that in studies of patients with treatment-resistant depression, the placebo effect was large and consistent despite the modality use. https://t.co/U6efJo7rJ8
— JAMA Network Open (@JAMANetworkOpen) September 24, 2021
Important systematic review study: The placebo effect in clinical trials of depression, even if treatment-resistant, is huge!
Magnitude of the Placebo Response Across Treatment-Resistant Depression in Adults https://t.co/ey2hIpE61r via @JAMANetworkOpen part of @JAMANetwork
— Yasser Ad-Dab'bagh (@yasseraddabbagh) September 25, 2021
Question
Why does research on 'treatment resistance' have such high placebo response?3 Answers
1)Research patients arent nearly as sick as patients in clinical practice
2)Research patients get much more attention than clinical patients
3)Research raises very high expectations https://t.co/f8CyTpKofV— Allen Frances (@AllenFrancesMD) September 26, 2021
(thread – click for more)
The paradox of "treatment resistance" in psychiatry that doesn't seem to generate much discussion: if the depression is so treatment resistant that we are considering things like invasive brain stimulation, how come it responds to "placebo" so robustly?/1https://t.co/oQOBPXtVXO
— Awais Aftab (@awaisaftab) September 26, 2021