Pharmacology/Pharmaceutical Industry | Page 76 of 172 | Links Medicus Content Curation & Alerts in Medicine

RCT: Induction of Labor at Term with Vaginal Misoprostol or a PGE2 Pessary – little difference in outcomes, the clinical risk-benefit ratio justifies the use of both drugs

25 Apr, 2021 | 20:59h | UTC

Induction of Labor at Term With Vaginal Misoprostol or a PGE2 Pessary: a Noninferiority RCT – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

RCT: No benefit from immune checkpoint inhibitors in newly diagnosed stage III or IV ovarian cancer

25 Apr, 2021 | 20:57h | UTC

Atezolizumab, Bevacizumab, and Chemotherapy for Newly Diagnosed Stage III or IV Ovarian Cancer: Placebo-Controlled Randomized Phase III Trial (IMagyn050/GOG 3015/ENGOT-OV39) – Journal of Clinical Oncology

Editorial: Immune Checkpoint Inhibitors in Ovarian Cancer: Can We Bridge the Gap Between IMagynation and Reality?

NIH Updates COVID-19 Treatment Guidelines – adds recommendations on colchicine, fluvoxamine, and monoclonal antibodies

23 Apr, 2021 | 08:46h | UTC

NIH Coronavirus Disease 2019 (COVID-19)
Treatment Guidelines – National Institutes of Health

RCT: COVID outpatients don’t benefit from hydroxychloroquine, lopinavir-ritonavir

23 Apr, 2021 | 08:42h | UTC

COVID outpatients don’t benefit from hydroxychloroquine, lopinavir-ritonavir – CIDRAP

Original study: Effect of Early Treatment With Hydroxychloroquine or Lopinavir and Ritonavir on Risk of Hospitalization Among Patients With COVID-19: The TOGETHER Randomized Clinical Trial – JAMA Network Open

Commentary on Twitter (thread – Click for more)

1/ No benefit from Hydroxychloroquine or Lopinavir-Ritonavir on Hospitalization/Viral clearance for COVID-19 https://t.co/yhXxv26418 via @JAMANetworkOpen part of @JAMANetwork

— Priya Sampathkumar (@PSampathkumarMD) April 22, 2021

RCT: Single-Dose Johnson & Johnson Vaccine has 85% efficacy against severe/critical Covid-19 and maintains efficacy against variant B.1.351

22 Apr, 2021 | 08:50h | UTC

Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19 – New England Journal of Medicine

Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons

22 Apr, 2021 | 08:49h | UTC

Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons – New England Journal of Medicine

Audio Interview: Covid-19 Vaccines and Pregnancy — A Conversation with CDC Director Rochelle Walensky – New England Journal of Medicine

Commentaries: No evidence that Pfizer or Moderna vaccines are unsafe during pregnancy, a preliminary study says. – The New York Times AND Preliminary data show no safety concerns for pregnant women receiving COVID-19 vaccines – AAP News AND Messenger RNA COVID vaccines likely safe for pregnant women: Study – ABC News

COVID vaccines and kids: five questions as trials begin

23 Apr, 2021 | 08:37h | UTC

COVID vaccines and kids: five questions as trials begin – Nature

Systematic review shows there is insufficient evidence on the best approaches to stop long‐term antidepressant use – “Future studies should distinguish carefully between relapse and withdrawal symptoms”

23 Apr, 2021 | 08:19h | UTC

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety disorders in adults – Cochrane Library

Author interview: Stopping long-term antidepressants in people with depression or anxiety – Cochrane Library

Commentary: ‘Urgent’ need for more evidence on safely stopping antidepressants, say experts – Metro

“Future studies should distinguish carefully between relapse and withdrawal symptoms and follow emerging guidance to use taper schemes of many weeks or months (or longer for long-term users) down to very low doses before stopping. Such studies would give us a clearer idea of the ability of antidepressants to prevent relapse.”

Commentary on Twitter (thread – click for more)

Outline of the Cochrane study a bit for those scared of its length. Metro article: https://t.co/3c32xjGJsr Lead author: the dauntless Ellen van Leuween. Co-author @tony_kendrick https://t.co/tt4Lzyacq4 While there are hundreds of studies looking at starting antidepressants(1/n)

— Mark Horowitz @markhoro.bsky.social (@markhoro) April 22, 2021

New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis

23 Apr, 2021 | 08:06h | UTC

New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis – Journal of Clinical Medicine

An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

23 Apr, 2021 | 08:05h | UTC

An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria – Journal of Clinical Medicine

A year in the COVID-19 vaccine scheme COVAX

22 Apr, 2021 | 08:43h | UTC

A year in the COVID-19 vaccine scheme COVAX – Reuters

Perspective | Do Kids Really Need to Be Vaccinated for Covid? Yes. No. Maybe.

22 Apr, 2021 | 08:38h | UTC

Do Kids Really Need to Be Vaccinated for Covid? Yes. No. Maybe. – Undark

Commentary on Twitter

Great article by @Sara_Talpos
key qs:
1 Does a kid need to be vaccinated for their sake?
2 Does a kid need to be vaccinated to protect adults who decline?
3. Does a kid need to be vaccinated to protect adults who were vax'd?

1/2https://t.co/6WpbttIiDo

— Vinay Prasad MD MPH (@VPrasadMDMPH) April 20, 2021

ISTH Interim Guidance for the Diagnosis and Treatment on Vaccine Induced Immune Thrombotic Thrombocytopenia

21 Apr, 2021 | 07:11h | UTC

ISTH Interim Guidance for the Diagnosis and Treatment on VaccineInduced Immune Thrombotic Thrombocytopenia (Updated 20 April, 2021) – International Society on Thrombosis and Haemostasis

Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions

22 Apr, 2021 | 08:19h | UTC

Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions – Agency for Healthcare Research and Quality

See also: Final Report AND Evidence Summary

Cohort study: Increased bleeding risk with no therapeutic benefit with the addition of aspirin to direct oral anticoagulant therapy when there is not a clear indication

21 Apr, 2021 | 06:34h | UTC

Adverse Events Associated With the Addition of Aspirin to Direct Oral Anticoagulant Therapy Without a Clear Indication – JAMA Internal Medicine (free for a limited period)

Commentaries: DOAC + Aspirin Common Without Clear Indication, Tied to More Bleeding – NEJM Journal Watch AND Many AFib patients wrongly prescribed aspirin therapy, study finds – UPI

Commentary on Twitter

Obs study in @JAMAInternalMed finds aspirin is often prescribed along w/ direct acting oral anticoagulant without clear reason and the combo *associates* w higher rates of bleeding https://t.co/nKsWtLnjr9

Good one @GBarnesMD

ASA is the number 1 drug I #deprescribe

— John Mandrola, MD (@drjohnm) April 19, 2021

COVID-19 Vaccine Janssen: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets

21 Apr, 2021 | 07:07h | UTC

COVID-19 Vaccine Janssen: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets – European Medicines Agency

Commentary: Johnson & Johnson vaccine: EU regulator says blood clot very rare side effect – BBC

Commentary on Twitter

https://twitter.com/hildabast/status/1384535676482297865

Vaccine-induced Immune Thrombotic Thrombocytopenia: Frequently Asked Questions

21 Apr, 2021 | 07:09h | UTC

Vaccine-induced Immune Thrombotic Thrombocytopenia: Frequently Asked Questions – American Society of Hematology

WHO panel comes out against requiring vaccination proof for travel

21 Apr, 2021 | 07:03h | UTC

WHO panel comes out against requiring vaccination proof for travel – The Hill

WHO Statement: Statement on the seventh meeting of the International Health Regulations (2005) Emergency Committee regarding the coronavirus disease (COVID-19) pandemic – World Health Organization

Related: Opinion | How to lose friends and alienate people? On the problems of vaccine passports (several texts on the subject)

What do we know about India’s Covaxin vaccine?

21 Apr, 2021 | 07:05h | UTC

What do we know about India’s Covaxin vaccine? – The BMJ

Large clinical trial to study repurposed drugs to treat COVID-19 symptoms

21 Apr, 2021 | 06:59h | UTC

Large clinical trial to study repurposed drugs to treat COVID-19 symptoms – NIH News Releases

M-A: Guided versus standard antiplatelet therapy in patients undergoing percutaneous coronary intervention

20 Apr, 2021 | 05:40h | UTC

Guided versus standard antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis – The Lancet

Commentary on Twitter

Great paper on guided vs standard DAPT.
Interestingly outcomes were found to vary according to the strategy used:
ESCALATION was associated with⬇️ISCHEMIC EVENTS (without⬆️bleedings)
DE-ESCALATION was associated with⬇️ BLEEDINGS (without ⬆️ischemic events). https://t.co/y4ys6tvktw

— Gregory A. Sgueglia (@GregorySgueglia) April 16, 2021