Pharmacology/Pharmaceutical Industry
RCTs: Once daily oral relugolix combination therapy vs. placebo in patients with endometriosis-associated pain.
23 Jun, 2022 | 10:30h | UTCCommentaries:
Relugolix combination therapy for endometriosis pain – The Lancet (free registration required)
Commentary on Twitter
Treatment options for #endometriosis-associated pain are suboptimal.
Two new studies indicate once-daily relugolix combination therapy significantly improved pain and was well tolerated. 1/2 https://t.co/LBFgTMZSO2
— The Lancet (@TheLancet) June 21, 2022
Metformin and reduced vitamin B12 levels: new advice for monitoring patients at risk.
23 Jun, 2022 | 10:22h | UTC
M-A: Intravenous iron vs. oral iron vs. no iron with or without erythropoiesis‐ stimulating agents for cancer patients with anemia.
23 Jun, 2022 | 10:10h | UTC
USPSTF Statement: The current evidence is insufficient to recommend vitamins for the prevention of cardiovascular disease or cancer.
22 Jun, 2022 | 12:21h | UTCEvidence Report and Systematic Review: Vitamin and Mineral Supplements for the Primary Prevention of Cardiovascular Disease and Cancer – JAMA
Patient Page: Vitamins and Minerals to Prevent Cardiovascular Disease and Cancer – JAMA
Editorial: Why Too Many Vitamins Feels Just About Right – JAMA Internal Medicine
Author Interview: Why Too Many Vitamins Feels Just About Right – JAMA
Commentary: Vitamins, Supplements Useless for Most People: Expert Panel – HealthDay
Cohort Study: Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA.
22 Jun, 2022 | 12:07h | UTCCommentaries:
COVID-19 mRNA vaccination and myocarditis or pericarditis – The Lancet
Myocarditis and Pericarditis After the COVID-19 mRNA Vaccination – American College of Cardiology
Related:
Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.
Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.
Myocarditis after BNT162b2 vaccination in Israeli adolescents.
[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.
Heart-inflammation risk from Pfizer COVID vaccine is very low.
Review: SARS-CoV-2 infection and COVID-19 vaccination in pregnancy.
22 Jun, 2022 | 12:09h | UTCSARS-CoV-2 infection and COVID-19 vaccination in pregnancy – Nature Reviews Immunology
Comparing the Pfizer and Moderna Covid vaccines for young children.
22 Jun, 2022 | 12:02h | UTCComparing the Pfizer and Moderna Covid vaccines for young children – STAT
Related: FDA advisers OK COVID-19 vaccines for youngest kids – CIDRAP
Position Paper: Diagnosis and management of infections caused by multidrug-resistant bacteria.
22 Jun, 2022 | 11:23h | UTCRelated Guideline:
RCT: Efficacy and safety of varenicline for smoking cessation in patients with type 2 diabetes.
22 Jun, 2022 | 11:16h | UTCAuthor Interview: Efficacy and Safety of Varenicline in Patients With Type 2 Diabetes – JAMA
Commentary on Twitter
This randomized clinical trial (CoEHAR) found the use of varenicline in smoking cessation programs for patients with diabetes resulted in prolonged abstinence. @CoeharUnict @RiccardoPolosa https://t.co/Sd57LMcsbJ
— JAMA Network Open (@JAMANetworkOpen) June 21, 2022
RCT: Multispecies probiotic for the prevention of antibiotic-associated diarrhea in children.
22 Jun, 2022 | 11:12h | UTCMultispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)
Commentary: Mixed Results With Probiotic for Kids’ Antibiotic-Related Diarrhea— Randomized trial misses strictly defined endpoint, but researchers point to benefit – MedPage Today (free registration required)
Commentary on Twitter
Study found administration of a multispecies #probiotic to children had no significant effect on the risk of antibiotic-associated diarrhea caused by #Cdifficile or of unknown etiology, but reduced the overall risk of diarrhea regardless of the etiology. https://t.co/Mdq3tl8csb
— JAMA Pediatrics (@JAMAPediatrics) June 21, 2022
Cohort Study: Polypharmacy, potentially inappropriate medications, and drug-drug interactions in vulnerable older adults with advanced cancer initiating cancer treatment.
22 Jun, 2022 | 10:51h | UTCCommentaries:
Polypharmacy can lead to harmful drug interactions, especially among cancer patients – News Medical
Analysis Underscores Risks of Polypharmacy in Elderly Patients With Cancer – AJMC
Commentary on Twitter
Our new article in @OncJournal : In a large cohort of older adults with advanced cancer, polypharmacy &PIM are very common. Nonprescription meds are frequently PIMs &involved in potential harmful drug interactions @WilmotCancer @rochgerionc @myCARGhttps://t.co/bA7W4kyybm pic.twitter.com/zFI3EgS320
— Mostafa R Mohamed (@m_refaat84) April 2, 2022
Under a https://creativecommons.org/licenses/by/4.0/ license
M-A: Opioid versus opioid-free analgesia after surgical discharge.
21 Jun, 2022 | 11:08h | UTCOpioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials – The Lancet (link to abstract – $ for full-text)
News Release: Taking opioids at home after surgery: More harms than benefits – McGill University Health Center
Onconephrology: Update in anticancer drug-related nephrotoxicity.
21 Jun, 2022 | 10:47h | UTCOnconephrology: Update in Anticancer Drug-Related Nephrotoxicity – Nephron
Related:
Commentary from the author on Twitter
Just published! Our review about anticancer drugs related kidney injury with @PepaSolerR and @julianadraibe @SENefrologia @onconephsociety @onconefrologia @senjoven @ERAkidney @womeninnephro https://t.co/jFStKwym5z @KargerPublisher pic.twitter.com/zvbl7wxAbD
— Clara García Carro (@ClaraGCarro) June 20, 2022
M-A: Benefits and risks of rapid initiation of antiretroviral therapy in patients with HIV.
21 Jun, 2022 | 10:41h | UTC
Cluster RCT: Evaluation of a multicomponent intervention consisting of education and feedback to reduce benzodiazepine prescriptions by general practitioners.
21 Jun, 2022 | 10:29h | UTC
WHO Interim statement on decision-making considerations for the use of variant updated COVID-19 vaccines.
20 Jun, 2022 | 10:42h | UTCSee also: Interim statement on the composition of current COVID-19 vaccines – World Health Organization
Commentary on Twitter (thread – click for more)
Current #COVID19 vaccines provide high levels of protection against severe disease and death from all variants. They should continue to be used.
🆕 interim statement:https://t.co/bVzzx1HnG2 pic.twitter.com/CJlAJqFr3C
— World Health Organization (WHO) (@WHO) June 17, 2022
[Preprint] Open-label RCT: Baricitinib noninferior to Tocilizumab in hospitalized patients with severe COVID-19.
20 Jun, 2022 | 10:28h | UTCRelated:
WHO recommends two new drugs to treat COVID-19 – World Health Organization
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine
Commentary on Twitter
Preprint⚡⚡
Baricitinib Vs Tocilizumab open label RCT
Baricitinib was non-inferior to tocilizumab with regards to the composite outcome of mechanical ventilation or death by day 28 and the time to discharge by day 28 in patients with severe #COVID19 https://t.co/sQkhATkjEd— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 16, 2022
RCT: Safety and efficacy of Eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures.
20 Jun, 2022 | 01:01h | UTCSafety and efficacy of eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures (DELIVER): a multi-arm, randomised, double-blind, placebo-controlled, phase 3b trial – The Lancet Neurology (link to abstract – $ for full-text)
FDA advisers OK COVID-19 vaccines for youngest kids.
17 Jun, 2022 | 11:43h | UTCFDA advisers OK COVID-19 vaccines for youngest kids – CIDRAP
See also: FDA advisers endorse 1st COVID-19 shots for kids under 5 – Associated Press
Test-negative, case–control study: Effects of previous infection and vaccination on symptomatic omicron infections.
17 Jun, 2022 | 11:44h | UTCRelated:
Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2 – New England Journal of Medicine
Two new studies show vaccination provides additional protection after Covid-19 infection.
Commentary on Twitter
A study in Qatar assessed the effectiveness of previous infection, vaccination, and both against symptomatic SARS-CoV-2 caused by omicron BA.1 and BA.2 and against severe, critical, or fatal #COVID19. https://t.co/bEVD3Y1sUn pic.twitter.com/Y38a0xxead
— NEJM (@NEJM) June 15, 2022
Pfizer’s Paxlovid study fails to answer key questions over benefit for broader populations.
15 Jun, 2022 | 11:22h | UTCPfizer’s Paxlovid study fails to answer key questions over benefit for broader populations – STAT
RCT: Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema.
15 Jun, 2022 | 11:20h | UTCNews Release: The right moisturiser for children with eczema is the one that they like to use, study finds – University of Nottingham
Commentary: Lotion, Cream, Gel, and Ointment Similarly Effective for Childhood Eczema – HealthDay
Commentary on Twitter
New: @bee_study led by @riddmj found no difference in effectiveness between the four main types of emollients —lotions, creams, gels, and ointments—for childhood #eczema
The right #moisturizer is the one that children will use. https://t.co/45N5A136Kx
— The Lancet Child & Adolescent Health (@LancetChildAdol) May 24, 2022
Phase 2 RCT: Safety and immunogenicity of the AstraZeneca vaccine in children aged 6–17 years.
15 Jun, 2022 | 11:15h | UTCInvited Commentary: Increasing children’s global access to COVID-19 vaccines – The Lancet
Analysis of thromboembolic and thrombocytopenic events after the AstraZeneca, Pfizer, and Moderna COVID-19 vaccines in 3 Nordic countries.
15 Jun, 2022 | 11:17h | UTC
Systematic Review: Janus kinase inhibitors for the treatment of COVID‐19.
14 Jun, 2022 | 11:14h | UTCJanus kinase inhibitors for the treatment of COVID‐19 – Cochrane Library