Pharmacology/Pharmaceutical Industry
Guideline: Role of Bone-Modifying Agents in Metastatic Breast Cancer
27 Dec, 2017 | 20:46h | UTC
Systematic Review: Is Treatment With Corticosteroids Beneficial for People With Pneumonia?
26 Dec, 2017 | 23:35h | UTCRelated: Corticosteroids for Pneumonia: Ready for Primetime? – emDocs (free)
“Corticosteroid therapy reduced mortality and morbidity in adults with severe CAP; the number needed to treat for an additional beneficial outcome was 18 patients (95% CI 12 to 49) to prevent one death. Corticosteroid therapy reduced morbidity, but not mortality, for adults and children with non-severe CAP”
Cost-Effectiveness Analysis: Individualized Glycemic Control for Adults With Type 2 Diabetes:
26 Dec, 2017 | 23:26h | UTCIndividualized Glycemic Control for U.S. Adults With Type 2 Diabetes: A Cost-Effectiveness Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Individualized Glycemic Control Could Safely Cut Costs in Type 2 Diabetes – Physician’s First Watch (free) AND Individualized HbA1c Targets for Diabetes Drop Cost, Improve QoL – Medscape (free registration required) AND Personalized Blood Sugar Goals Can Save Diabetes Patients Thousands – University of Chicago Medical Center, via NewsWise (free)
Research: Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital Malformations
26 Dec, 2017 | 23:28h | UTCEditorial: Shedding Light on the Risks of Methylphenidate and Amphetamine in Pregnancy (free)
Commentary: ADHD med use during pregnancy and risk of birth defects – Brigham and Women’s Hospital, via ScienceDaily (free) AND Class of ADHD medication linked to increased risk of congenital heart defects – Cardiovascular Business (free)
“Researchers find small increase in the risk of heart defects following first-trimester exposure to methylphenidate but not to amphetamines” (from ScienceDaily)
Guideline for the Prevention of Venous Thromboembolic Disease in Colorectal Surgery
26 Dec, 2017 | 23:23h | UTC
Supplement: The Economics of Hypertension and Cardiovascular Disease
26 Dec, 2017 | 23:19h | UTCThe Economics of Hypertension and Cardiovascular Disease – American Journal of Preventive Medicine (free editorials, reviews and research articles)
Source: EvidenceAlerts
People Don’t Take Their Pills. Only One Thing Seems to Help
26 Dec, 2017 | 23:20h | UTCPeople Don’t Take Their Pills. Only One Thing Seems to Help. – The New York Times (10 articles per month are free)
“High-tech approaches and “reminder” packaging don’t work well. Reducing prices does”.
Recommendation Statement: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women
26 Dec, 2017 | 23:14h | UTCJAMA Editorials: Menopausal Hormone Therapy for Primary Prevention of Chronic Disease (free) AND Evidence for Postmenopausal Hormone Therapy to Prevent Chronic Conditions: Success, Failure, and Lessons Learned (free) AND Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: Unfulfilled Expectations (free)
Audio Interview: USPSTF Recommendation Statement: Hormone Therapy After Menopause (free)
Summary: Hormone Therapy Not Recommended for Prevention of Chronic Conditions in Postmenopausal Women – The JAMA Network (free)
“The U.S. Preventive Services Task Force (USPSTF) recommends against the use of combined estrogen and progestin in postmenopausal women, or estrogen alone in postmenopausal women who have had a hysterectomy, to prevent chronic conditions such as heart disease, dementia and stroke”.
Research: Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs
26 Dec, 2017 | 23:12h | UTCTopical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs: Randomized Controlled Trial – Academic Emergency Medicine (link to abstract – $ for full-text)
Commentary: Topical TXA in Epistaxis – R.E.B.E.L.em (free)
CAR T-Cell Therapies Drive Outcomes in Lymphoma, Myeloma
26 Dec, 2017 | 23:13h | UTCCAR T-Cell Therapies Drive Outcomes in Lymphoma, Myeloma: Treatments Hold Promise for People with Hard-to-Treat Blood Cancers – 2017 American Society of Hematology Annual Meeting (free)
Related commentary: CAR T-Cell Therapy Makes Further Inroads in Lymphoma and Myeloma – ASCO Post (free)
Related Study: Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas – New England Journal of Medicine (free), Editorial: A Milestone for CAR T Cells (free) AND Visual Abstract (free)
Review: Lithium-Induced Electrocardiographic Changes
26 Dec, 2017 | 20:06h | UTCLithium-induced electrocardiographic changes: A complete review – Clinical Cardiology (free)
Review: Recent advances in pre-exposure prophylaxis for HIV
26 Dec, 2017 | 19:55h | UTCState of The Art Review: Recent advances in pre-exposure prophylaxis for HIV – The BMJ (free fo 2 weeks)
Related Guidelines: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection – World Health Organization (free) AND Summary: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection (free PDF)
Related Commentary: Why PrEP takers should still use condoms with HIV+ partners – The Conversation (free)
Guideline: Myeloid Growth Factors
26 Dec, 2017 | 19:49h | UTC
Review: Pharmacological Therapy of Osteoporosis
26 Dec, 2017 | 18:55h | UTC
The other big drug problem: Older people taking too many pills
12 Dec, 2017 | 12:26h | UTCThe other big drug problem: Older people taking too many pills – The Whashington Post (free)
Related Articles and Commentaries: Current and future perspectives on the management of polypharmacy – BMC Family Medicine (free) 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND Common ED Medication Errors: Polypharmacy – emDocs (free)
Related Website and Guidelines: Canadian Deprescribing Network (CaDeN) (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free)
Research: Mortality Associated with Metformin Versus Sulfonylurea Initiation
12 Dec, 2017 | 12:24h | UTCMortality Associated with Metformin Versus Sulfonylurea Initiation: A Cohort Study of Veterans with Diabetes and Chronic Kidney Disease – Journal of General Internal Medicine (link to abstract – $ for full-text)
Commentaries: Metformin appears better than sulfonylureas as first-line therapy for patients with CKD – ACP Diabetes (free) AND Metformin May Up Survival in Older Men With Moderate CKD – Medscape (free registration required)
Guideline: Standards of Medical Care in Diabetes—2018 Abridged for Primary Care Providers
12 Dec, 2017 | 12:17h | UTCStandards of Medical Care in Diabetes—2018 Abridged for Primary Care Providers – Diabetes Care (free PDF)
Commentary: ADA 2018 Abridged Standards of Medical Care in Diabetes: Update for Primary Care – Medscape (free registration required
Guideline: ADA 2018 Standards of Medical Care in Diabetes
12 Dec, 2017 | 12:18h | UTCADA 2018 Standards of Medical Care in Diabetes – Diabetes Care (Free Supplement)
News Release: American Diabetes Association Releases 2018 Standards of Medical Care in Diabetes, with Notable New Recommendations for People with Cardiovascular Disease and Diabetes (free)
Summary of Revisions: Standards of Medical Care in Diabetes—2018 (free)
Commentaries: ADA 2018 Standards Address Diabetes Drugs With CV Benefit – Medscape (free registration required)
See Updated Guideline: ADA 2019 Standards of Medical Care in Diabetes (free supplement)
Meta-analysis: Efficacy and safety of stress ulcer prophylaxis in critically ill patients
12 Dec, 2017 | 12:15h | UTC“PPIs are the most effective agents in preventing CIB, but they may increase the risk of pneumonia”.
Opinion: The ‘smart pill’ for schizophrenia and bipolar disorder raises tricky ethical questions
10 Dec, 2017 | 15:48h | UTCThe ‘smart pill’ for schizophrenia and bipolar disorder raises tricky ethical questions – STAT (free)
Review: Comprehensive Analysis of the Clinical Immuno-Oncology Landscape
10 Dec, 2017 | 15:42h | UTCComprehensive analysis of the clinical immuno-oncology landscape – Annals of Oncology (free)
Commentary: The Cancer Research Institute Announces Publication of Comprehensive Immuno-Oncology Landscape Analysis in Annals of Oncology – NewsWise (free)
Research: Contemporary Hormonal Contraception and the Risk of Breast Cancer
7 Dec, 2017 | 22:08h | UTCContemporary Hormonal Contraception and the Risk of Breast Cancer – New England Journal of Medicine (free)
Commentaries: Even Low-Dose Contraceptives Slightly Increase Breast Cancer Risk – NPR (free) AND Study confirms higher breast cancer risk with hormone-based contraception – Reuters (free) AND Small risk of breast cancer seen with hormone contraceptives – Associated Press (free) All forms of hormonal contraception carry breast cancer risk, study finds – the Guardian (free) AND Birth Control Pills Still Linked to Breast Cancer, Study Finds – The New York Times (10 articles per month are free)
Two nerve drugs are not suitable for treating long-term low back pain
7 Dec, 2017 | 22:04h | UTCTwo nerve drugs are not suitable for treating long-term low back pain – NIHR Signal (free)
Original Article: Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials – PLOS One (free)
“Evidence supports NICE guidance not to use two nerve drugs (gabapentin and pregabalin) to treat long-term lower back pain”. (RT @NIHR_DC see Tweet)
Guidelines on the Management of Diabetes
5 Dec, 2017 | 18:36h | UTCSIGN Guidelines on Pharmacological management of glycaemic control in people with type 2 diabetes & Management of diabetes – Scottish Intercollegiate Guidelines Network (free guidelines and resources) (via @kamleshkhunti)
Consensus on the Management of Bleeding in Patients on Oral Anticoagulants
5 Dec, 2017 | 18:35h | UTCCommentary and Summary: Consensus for Management of Bleeding on Oral Anticoagulants – American College of Cardiology, Latest in Cardiology (free)