Pharmacology/Pharmaceutical Industry
Cohort Study: Cardiovascular disease risk and androgen deprivation therapy in patients with prostate cancer
9 Sep, 2017 | 14:28h | UTCCardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study – British Journal of Cancer (link to abstract – $ for full-text)
Commentaries: Prostate cancer treatment associated with higher risk of heart failure – Cardiovascular Business (free) AND Hormone Treatment for Prostate Cancer Tied to Heart Risks – New York Times (10 articles per month are free)
Study: Impact of early in-hospital medication review by clinical pharmacists on health services utilization
8 Sep, 2017 | 02:16h | UTCSource: Hospital Medicine Virtual Journal Club
Guideline: Therapeutic Drug Monitoring in Inflammatory Bowel Disease
8 Sep, 2017 | 01:13h | UTCCommentaries: AGA releases recommendations on therapeutic drug monitoring in IBD – ACP Gastroenterology (free) AND New Guideline for Therapeutic Drug Monitoring in Inflammatory Bowel Disease – Journal Watch (free)
Meta-analysis: Intravenous Versus Nonintravenous Benzodiazepines for the Cessation of Seizures
8 Sep, 2017 | 00:25h | UTCIntravenous Versus Nonintravenous Benzodiazepines for the Cessation of Seizures: A Systematic Review and Meta-analysis of Randomized Controlled Trials – Academic Emergency Medicine (link to abstract – $ for full-text)
Source: Hospital Medicine Virtual Journal Club
“Should you give your preferred benzo by the fastest means possible? Or establish an IV and administer via that route? The short answer provided by this study, is to give your benzo IM or IN. While seizures stopped sooner after IV administration, the additional time needed to establish an IV resulted in overall longer seizure time when administered via that method” (by Jeremy Fried in Research and Reviews in the Fastlane 182).
Review: Role of Combination Antimicrobial Therapy for Vancomycin-Resistant Enterococcus faecium Infections
8 Sep, 2017 | 00:15h | UTCSource: Hospital Medicine Virtual Journal Club
Study: Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes
7 Sep, 2017 | 23:44h | UTCEfficacy and Safety of Degludec versus Glargine in Type 2 Diabetes – New England Journal of Medicine (free)
Commentary: Degludec versus Glargine in Type 2 Diabetes – NEJM Resident 360 (free)
New Economic Analyses Fail To Make Case For PCSK9 Inhibitors
7 Sep, 2017 | 20:52h | UTCNew Economic Analyses Fail To Make Case For PCSK9 Inhibitors – Cardiobrief (free)
Cohort Study: Antidepressant use during pregnancy and psychiatric disorders in offspring
7 Sep, 2017 | 20:19h | UTCEditorial: Prenatal exposure to antidepressants and increased risk of psychiatric disorders (free)
Commentary: Antidepressant Use During Pregnancy Linked to Psychiatric Disorders in Offspring – Physician’s First Watch (free)
Review: The Diagnosis and Management of Bipolar I and II Disorders
7 Sep, 2017 | 20:15h | UTCThe Diagnosis and Management of Bipolar I and II Disorders – Mayo Clinic Proceedings (free)
Meta-analysis: Cognitive Behavioral Therapy and Pharmacotherapy for Childhood Anxiety Disorders
4 Sep, 2017 | 15:27h | UTCEditorial: Medication and Cognitive Behavioral Therapy for Pediatric Anxiety Disorders: No Need for Anxiety in Treating Anxiety (free)
Commentary: SSRIs, Cognitive-Behavioral Therapy Effective for Childhood Anxiety – Physician’s First Watch (free) AND SSRIs, SNRIs Provide Modest Benefit to Kids with Mental Disorders – MedPage Today (free registration required)
FDA approval brings first gene therapy to the United States
3 Sep, 2017 | 21:19h | UTCFDA News Release: FDA approval brings first gene therapy to the United States (free)
Commentaries: A $475,000 cancer drug: Wall Street sees ‘bargain’; patients see ‘completely broken’ system – HealthNewsReview (free) FDA Approves First CAR-T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia – National Institutes of Health (free) AND FDA Approves First Gene-Altering Leukemia Treatment, Costing $475.000 – New York Times (10 articles per month are free) AND The FDA Approves a Landmark Cancer Drug – The Atlantic (free)
“…is a cancer therapy that represents several things at once: a game-changing way to treat cancer through genetic engineering, a novel paradigm for the biotech business, and the latest turn in the debate over just how astronomically expensive a life-saving therapy can be”. (from The Atlantic)
Guideline: Psoriasis: assessment and management
3 Sep, 2017 | 21:20h | UTCPsoriasis: assessment and management – National Institute for Health and Care Excellence (NICE) (free)
Study: Corticosteroid Premedication 5 Hours Before CT Compared with a 13-Hour Oral Regimen
1 Sep, 2017 | 17:57h | UTCIntravenous Corticosteroid Premedication Administered 5 Hours Before CT Compared with a Traditional 13-Hour Oral Regimen – Radiology (link to abstract – $ for full-text)
Source: Journal Watch ($)
“Accelerated intravenous premedication with corticosteroids beginning 5 hours before contrast-enhanced CT has a breakthrough reaction rate noninferior to that of a 13-hour oral premedication regimen”.
Meta-analysis: fibrinolytic agents in patients with ST-segment elevation myocardial infarction
1 Sep, 2017 | 17:44h | UTCComparative efficacy and safety of reperfusion therapy with fibrinolytic agents in patients with ST-segment elevation myocardial infarction: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)
Commentary: Fibrinolytic Agents for STEMI: Meta-analysis Explores the Differences – TCTMD (free)
Studies: Intensive versus Standard Blood-Pressure Control
31 Aug, 2017 | 20:35h | UTCOriginal articles: Cost-Effectiveness of Intensive versus Standard Blood-Pressure Control – New England Journal of Medicine (link to abstract – $ for full-text) AND Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Analyses from SPRINT examine cost-effectiveness, patient-reported outcomes with intensive BP control – ACP Internist (free) AND Intensive BP Management Well Tolerated, Cost-effective: SPRINT – Medscape (free registration required) AND Can SPRINT Be Used To Inform Hypertension Treatment? – Cardiobrief (free)
Be sure to measure the patient’s blood pressure in the same way it was done in the SPRINT trial before adopting this results to clinical practice (see Cardiobrief commentary)
Systematic Review: Pharmacotherapy for hypertension in adults aged 18 to 59 years
31 Aug, 2017 | 20:44h | UTCPharmacotherapy for hypertension in adults aged 18 to 59 years – Cochrane Library (link to abstract – $ for full-text)
Commentary: Antihypertensive Tx Analyzed in Younger, Predominantly Healthy Adults – MPR (free)
Guideline: Vitamin D Supplementation
31 Aug, 2017 | 19:42h | UTCPublic Health Guideline: Vitamin D: supplement use in specific population groups – National Institute for Health and Care Excellence (NICE) (free)
“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk”
Study: effects of probiotic and peanut oral immunotherapy for peanut allergy
31 Aug, 2017 | 15:53h | UTCLong-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)
Commentaries: Benefits of Immunotherapy-Probiotic Combo for Peanut Allergy Sustained at 4 Years – Physician’s First Watch (free) AND Peanut Allergy: Is Oral Immunotherapy With Probiotic a Cure? – Medscape (free registration required) AND Peanut Allergy Tx Efficacy Examined in 4-Year Follow-Up Study – MPR (free)
Study: Cognitive Function in a Randomized Trial of Evolocumab
31 Aug, 2017 | 15:35h | UTCCognitive Function in a Randomized Trial of Evolocumab – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Cholesterol-Lowering Drug Evolocumab Doesn’t Seem to Impair Cognition – Physician’s First Watch (free)
“The authors caution that most people take cholesterol-lowering medications for decades, and this was a much shorter follow-up period” (from Physician’s First Watch).
#ESCCongress – Observational Study: Clopidogrel or ticagrelor in acute coronary syndrome patients treated with newer-generation drug-eluting stents
30 Aug, 2017 | 19:01h | UTC#ESCCongress – Clopidogrel or ticagrelor in acute coronary syndrome patients treated with newer-generation drug-eluting stents: CHANGE DAPT – EuroIntervention (link to abstract – $ for full-text)
Commentaries: Rethinking dual antiplatelet guidelines in acute coronary syndrome? (CHANGE-DAPT) – ESC Press Releases (free) AND Ticagrelor for DAPT Again Questioned in Current Era of PCI for ACS: CHANGE DAPT – Medscape (free registration required)
CHANGE DAPT: Study Contests Benefit of Ticagrelor Over Clopidogrel After PCI in ACS – TCTMD (free)
Systematic Review: Chemotherapy for advanced gastric cancer
30 Aug, 2017 | 18:51h | UTCChemotherapy for advanced gastric cancer – Cochrane Library (free)
Full Review: Chemotherapy for advanced gastric cancer – Cochrane Library (link to abstract – $ for full-text)
#ESCCongress – Study: Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
30 Aug, 2017 | 18:29h | UTCCommentaries: Anacetrapib REVEALs ‘Modest’ Effect on Cardiovascular Outcomes – Medscape (free registration required) AND Anacetrapib Finds (Modest) Success Where All Other CETP Inhibitors Failed – TCTMD (free) AND REVEAL Revealed: A Slightly Positive CETP Inhibitor Trial – Cardiobrief (free)
Interesting new drug, but with modest benefits. During the median follow-up period of 4.1 years, the primary outcome occurred in fewer patients in the anacetrapib group than in the placebo group (10.8% vs. 11.8% / absolute risk difference = 1%, meaning 100 patients would have to be treated for 4.1 years to benefit 1 patient)
Systematic Review: Efficacy of selective serotonin reuptake inhibitors in the absence of side effects
30 Aug, 2017 | 18:18h | UTCCommentary: Final Word? Antidepressants ‘Do Work’ – Medscape (free registration required)
Review of systematic reviews: Pharmacological and non-pharmacological treatments for major depressive disorder
30 Aug, 2017 | 18:14h | UTC
Guidelines for the management of acute joint bleeds and chronic synovitis in haemophilia
30 Aug, 2017 | 18:10h | UTCSource: Medscape New Guidelines and Recommendations (free registration required)