Pharmacology/Pharmaceutical Industry
Review: Postpartum use of Long-Acting Contraceptives in Low- and Middle-Income Countries
10 Jan, 2018 | 00:09h | UTC
Free Online Course: Antimicrobial Stewardship
8 Jan, 2018 | 00:52h | UTCNew free online course: Antimicrobial Stewardship: A competency-based approach – World Health Organization (via @snahrgang)
See also other OpenWHO Courses
Guideline: Antibiotic Use in Adults with Acute Upper Respiratory Tract Infections
8 Jan, 2018 | 00:50h | UTC
Meta-Analysis: Effect of PCSK9 Inhibitors on Clinical Outcomes in Patients With Hypercholesterolemia
4 Jan, 2018 | 18:59h | UTCPCSK9 inhibitors were associated with reduced incidence of myocardial infarction (2.3% vs 3,6%), stroke (1.0% vs 1.4%) and coronary revascularization (4,2% vs 5,8%). Overall, no significant change was observed in cardiovascular or all-cause mortality.
Practice Guideline: Mild Cognitive Impairment
4 Jan, 2018 | 17:28h | UTCPractice guideline update summary: Mild cognitive impairment – American Academy of Neurology (free PDF)
Commentary: Mild cognitive impairment: a practice guideline update – Clinical Advisor (free)
“For patients diagnosed with MCI, clinicians may choose NOT to offer cholinesterase inhibitors”.
“If clinicians choose to offer cholinesterase inhibitors, they must first discuss with patients the fact that this is an off-label prescription not currently backed by empirical evidence”.
Delayed Antibiotic Prescribing’ for Respiratory Infections may Reduce Antibiotic Use
4 Jan, 2018 | 17:25h | UTCA strategy of ‘delayed antibiotic prescribing’ for respiratory infections may reduce antibiotic use – NIHR Signal (free)
Original article: Delayed antibiotic prescriptions for respiratory infections – Cochrane Library (free) AND Summary: Delayed antibiotic prescriptions for respiratory tract infections – Cochrane Library (free)
Research: Increased Cardiovascular Risk After Initiation of Inhaled Long-Acting Bronchodilators in Patients With COPD
4 Jan, 2018 | 17:16h | UTCAssociation of Cardiovascular Risk With Inhaled Long-Acting Bronchodilators in Patients With Chronic Obstructive Pulmonary Disease: A Nested Case-Control Study – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Starting new COPD inhaler tied to heart attack risk – Reuters (free) AND New Use of Long-Acting Bronchodilators in COPD Tied to Increased Cardiovascular Risk – Physician’s First Watch (free) AND COPD patients beginning inhaler therapy at greater short-term risk for CVD – Cardiovascular Business (free)
Research: Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression
4 Jan, 2018 | 17:07h | UTCKetamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial – The American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Adjunctive Ketamine Appears to Reduce Suicidal Thoughts in Depressed Patients for Up to Six Weeks – Psychiatric News Alert (free) AND Ketamine Rapidly Reduces Suicidal Ideation – Medscape (free registration required)
Meta-Analysis: Carfilzomib-Associated Cardiovascular Adverse Events
4 Jan, 2018 | 17:01h | UTCCarfilzomib-Associated Cardiovascular Adverse Events: A Systematic Review and Meta-analysis – JAMA Oncology (link to abstract – $ for full-text)
Commentaries: Carfilzomib can lead to cardiovascular toxicity in multiple myeloma patients – eCancer News (free) AND Higher Rates of Cardiovascular Adverse Events in Patients with MM Treated With Carfilzomib – AJMC (free) AND Important CV Risk Seen With Carfilzomib in Multiple Myeloma – Medscape (free registration required)
Research: Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes
4 Jan, 2018 | 16:57h | UTCEffect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Weaning To Hydrolyzed Infant Formula Did Not Reduce Risk of Type 1 Diabetes – MedicalResearch (free) AND Study Finds No Link Between Baby Formula Made From Cow’s Milk And Diabetes Risk – NPR (free) AND Avoiding Cow’s Milk Doesn’t Cut Type 1 Diabetes Risk – Medscape (free registration required) AND Modifying Baby Formula Doesn’t Prevent Type 1 Diabetes in Children – University of Pittsburg (free)
$850,000 per Patient for Blindness Gene Therapy
4 Jan, 2018 | 16:53h | UTCSpark to charge $850,000 per patient for blindness gene therapy – Reuters (free) AND US drug firm offers cure for blindness – at $425,000 an eye – The Guardian (free) AND Spark prices its gene therapy as most expensive U.S. medicine — but with plans to ease cost concerns – STAT (free)
Research: Co-administration of Vancomycin and Piperacillin-Tazobactam and Renal Dysfunction
4 Jan, 2018 | 16:55h | UTCSee also related meta-analysis: Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults
Research: Broad- vs Narrow-Spectrum Antibiotics in Children With Acute Respiratory Tract Infections
3 Jan, 2018 | 13:28h | UTCAssociation of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory Tract Infections – JAMA (link to abstract – $ for full-text)
Commentaries: Study: For kids with respiratory infections, broader isn’t better – CIDRAP (free) AND Treatment Failure, or is Treatment the Failure? – Emergency Medicine Literature of Note Blog (free)
Meta-Analysis: Effectiveness of Pharmacist-Led Medication Reconciliation After Hospital Discharge
3 Jan, 2018 | 13:14h | UTCSource: Hospital Medicine Virtual Journal Club
Systematic Review: Probiotics to Prevent Clostridium Difficile Diarrhea Associated with Antibiotic Use
2 Jan, 2018 | 16:33h | UTCSee related meta-analysis: Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection
“Based on this systematic review and meta-analysis of 31 randomized controlled trials including 8672 patients, moderate certainty evidence suggests that probiotics are effective for preventing C. difficile-associated diarrhea”
Meta-Analysis: Antimicrobials for the Treatment of Drug-Resistant A. Baumannii Pneumonia in Critically Ill Patients
2 Jan, 2018 | 16:29h | UTC
Research: Topiramate Use Early in Pregnancy and the Risk of Oral Clefts
2 Jan, 2018 | 16:27h | UTCTopiramate use early in pregnancy and the risk of oral clefts: A pregnancy cohort study – Neurology (link to abstract – $ for full-text)
Commentaries: Topiramate in early pregnancy increases risk of oral clefts – OnMedica (free) AND Risk of Oral Clefts with Topiramate May Be Dose-Dependent – MedPage Today (free) AND Epilepsy Drug Could Raise Birth Defect Risks – MedlinePlus (free)
Review: The Pharmacologic Management of Endometriosis
2 Jan, 2018 | 15:49h | UTCThe Pharmacologic Management of Endometriosis – U.S. Pharmacist, via Medscape (free registration required)
Guideline: Appropriate Use of Antimicrobial Agents across the Surgical Pathway
1 Jan, 2018 | 12:21h | UTC
Guideline: Administration of Influenza Vaccines to Egg Allergic Recipients
1 Jan, 2018 | 12:19h | UTCCommentaries: Flu vaccine safe for individuals with egg allergy – Clinical Advisor (free) And Egg Allergy No Bar to Flu Vax, Experts Say – MedPage Today (free)
Review: Pharmacotherapy for Obesity
1 Jan, 2018 | 12:16h | UTCPharmacotherapy for obesity: What you need to know – Cleveland Clinic Journal of Medicine (free)
Research: Direct Factor X Inhibitor vs Low-Molecular-Weight Heparin for Cancer-Associated VTE
1 Jan, 2018 | 12:12h | UTCSee original article in the NEJM (free)
Review: The Benefits of Physician-Pharmacist Collaboration
1 Jan, 2018 | 12:09h | UTCThe benefits of physician-pharmacist collaboration – The Journal of Family Practice (free)
Alternative Drug May Prevent Atrial Fibrillation Following Heart Surgery
1 Jan, 2018 | 12:04h | UTCAlternative drug may prevent atrial fibrillation following heart surgery – NIHR Signal (free)
Original article: Colchicine for primary prevention of atrial fibrillation after open-heart surgery: Systematic review and meta-analysis – International Journal of Cardiology (link to abstract – $ for full-text)
Meta-Analysis: Somatostatin Analogues on Postoperative Outcomes Following Pancreatic Surgery
31 Dec, 2017 | 15:50h | UTC