Pharmacology/Pharmaceutical Industry
ASCO Annual Report: Clinical Cancer Advances 2018
5 Feb, 2018 | 16:14h | UTCCommentary: CAR T-Cell Immunotherapy Named Advance of the Year in ASCO’s Clinical Cancer Advances 2018 – The ASCO Post (free)
Research: Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease
4 Feb, 2018 | 18:36h | UTCMetformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4 – Diabetes Care (link to abstract – $ for full-text)
Commentaries: How I learned to stop worrying and love metformin – NephJC (free) AND Adjusted-Dose Metformin Appears Safe in Patients With Type 2 Diabetes and Chronic Kidney Disease Stage 3 or 4 – PracticeUpdate (free registration required)
Laxatives Naturally Occurring in Plants Such as Aloe or Senna May Increase Cancer Risk
4 Feb, 2018 | 18:26h | UTCSafety of hydroxyanthracene derivatives for use in food – EFSA Journal (free)
Press release: EFSA confirms health concerns for hydroxyanthracene derivatives in food – European Food Safety Agency (free)
Commentary: Europe’s safety watchdog says laxatives may increase cancer risk – Reuters (free)
“This group of substances naturally occurs in plants such as aloe or senna species. Extracts containing them are used in food supplements for their laxative effect”. (from Press Release)
Stopping Biological Drugs for Rheumatoid Arthritis Can Lead to Twice the Relapse Rate
4 Feb, 2018 | 18:04h | UTCStopping biological drugs for rheumatoid arthritis can lead to twice the relapse rate – NIHR Signal (free)
Original article: Risk of losing remission, low disease activity or radiographic progression in case of bDMARD discontinuation or tapering in rheumatoid arthritis: systematic analysis of the literature and meta-analysis – Annals of Rheumatic Diseases (link to abstract – $ for full-text)
Opinion: Drug treatment of ADHD – tenuous scientific basis
4 Feb, 2018 | 18:00h | UTCDrug treatment of ADHD – tenuous scientific basis – Tidsskrift (free)
Review: Cardiovascular Event Reduction with GLP-1 and SGLT2 Agents
4 Feb, 2018 | 16:54h | UTC
Meta-Analysis: Systemic Pharmacological Treatments for Chronic Plaque Psoriasis
30 Jan, 2018 | 19:21h | UTCSystemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis – Cochrane Library (link to abstract – $ for full-text)
Systematic Review: Bisphosphonates for Paget’s disease of bone in adults
30 Jan, 2018 | 19:19h | UTCBisphosphonates for Paget’s disease of bone in adults – Cochrane Library (link to abstract – $ for full-text)
Guideline: Deprescribing Antipsychotics for Behavioural and Psychological Symptoms of Dementia and Insomnia
26 Jan, 2018 | 01:37h | UTCRelated: Canadian Deprescribing Network (CaDeN) (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)
Guideline: Age-related macular degeneration
26 Jan, 2018 | 01:31h | UTCAge-related macular degeneration – National Institute for Health and Care Excellence (NICE) (free)
Guideline on the Pharmacological Treatment of People with Multiple Sclerosis
26 Jan, 2018 | 01:33h | UTC
Research: Antithyroid Drugs and Congenital Malformations
26 Jan, 2018 | 01:23h | UTCAntithyroid Drugs and Congenital Malformations: A Nationwide Korean Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: First trimester exposure to antithyroid drugs associated with increased risk of birth defects – 2 Minute Medicine (free) AND Use of Antithyroid Drugs Early in Pregnancy Tied to Birth Defect Risk – Physician’s First Watch (free) AND First trimester exposure to antithyroid drugs linked with birth defects – OnMedica (free)
Biological Therapies for Psoriasis do not Increase Serious Infection Risk
26 Jan, 2018 | 00:08h | UTCBiological therapies for psoriasis do not increase serious infection risk – NIHR Signal (free)
Original article: Risk of Serious Infection in Patients with Psoriasis on Biologic Therapies: a Prospective Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR) – Journal of Investigative Dermatology (link to abstract – $ for full-text)
Research: Incidence of STI Before and After Pre-Exposure Prophylaxis for HIV
25 Jan, 2018 | 20:51h | UTCIncidence of sexually transmitted infections before and after Pre-Exposure Prophylaxis for HIV: a cohort study – AIDS (link to abstract – $ for full-text)
Commentary: Preexposure Prophylaxis for HIV Tied to Increased STI Rates – Medscape (free registration required)
Guideline Synopsis: Management of High Blood Pressure in Adults
23 Jan, 2018 | 16:57h | UTCRelated: Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free) AND AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free)
Research: Adjunctive Glucocorticoid Therapy in Patients with Septic Shock
23 Jan, 2018 | 16:58h | UTCAdjunctive Glucocorticoid Therapy in Patients with Septic Shock – New England Journal of Medicine (free)
Commentaries: The Definitive Word on Steroids in Septic Shock – Emergency Medicine Literature of Note (free) AND Adrenal – The Bottom Line (free)
“For the primary outcome, there was no statistically significance difference in mortality at 90 days – 27.9% in the hydrocortisone cohort, and 28.8% with placebo. Looking at secondary outcomes, the results here tended to favor hydrocortisone – a slightly faster resolution of shock, shorter ICU stays, and, oddly, decreased transfusion requirements”. (from Emergency Medicine Literature of Note Blog)
Review: Treatment of Anxiety Disorders
23 Jan, 2018 | 16:55h | UTCReview: Treatment of anxiety disorders – Dialogues in Clinical Neuroscience (free)
Research: Postsurgical Prescriptions for Opioid Naive Patients and Association with Overdose and Misuse
23 Jan, 2018 | 16:40h | UTC“The duration of treatment rather than dose is more strongly associated with opioid misuse after surgery, concludes this study” (via @bmj_latest see Tweet)
Meta-analysis: Staying on Antidepressants May Prevent a Relapse of Anxiety
23 Jan, 2018 | 16:36h | UTCStaying on antidepressants may prevent a relapse of anxiety – NIHR Signals (free)
Original article: Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials – The BMJ (free)
Review: Recent Advances in Pharmacological Management of Urinary Incontinence
23 Jan, 2018 | 14:19h | UTCRecent advances in pharmacological management of urinary incontinence – F1000 Research (free)
Review: Tumor Immunology and Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer
23 Jan, 2018 | 14:17h | UTC
Review: HIV Preexposure Prophylaxis in Women
23 Jan, 2018 | 14:01h | UTCHIV Preexposure Prophylaxis in Women – Journal Watch (free)
Research: Reduction of PTSD Symptoms With Pre-Reactivation Propranolol Therapy
23 Jan, 2018 | 13:55h | UTCReduction of PTSD Symptoms With Pre-Reactivation Propranolol Therapy: A Randomized Controlled Trial – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Propranolol May Help Patients With PTSD – Psychiatric News Alert (free) AND Propranolol May Fill ‘Dire’ Treatment Need for PTSD – Medscape (free registration required)
Guideline: Beta-Blockers and Traumatic Brain Injury
23 Jan, 2018 | 13:40h | UTCBeta-Blockers and Traumatic Brain Injury: A Systematic Review, Meta-Analysis, and Eastern Association for the Surgery of Trauma Guideline – Annals of Surgery, via Medscape (free registration required)
Research: Antipsychotics and Mortality in Patients With Schizophrenia
23 Jan, 2018 | 13:33h | UTCAntipsychotics and mortality in a nationwide cohort of 29,823 patients with schizophrenia – Schizophrenia Research (free) (via @psychopharmacol see Tweet)