Pharmacology/Pharmaceutical Industry
Guideline: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy
16 Feb, 2018 | 02:17h | UTCCommentary: New Guidelines for Treating Checkpoint Inhibitor Toxicities – Medscape (free registration required)
Relate guideline: Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free) AND Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Research: Opioid Analgesic Use and Risk for Invasive Pneumococcal Diseases
16 Feb, 2018 | 02:09h | UTCOpioid Analgesic Use and Risk for Invasive Pneumococcal Diseases: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Opioids may be associated with increased risk for serious invasive pneumococcal infections – ACP Internist (free) AND Opioids For Pain Can Exacerbate Pneumococcal Infections – MedicalResearch.com (free) AND Prescription Opioid Use Tied to Higher Pneumonia Risk – MedPage Today (free registration required)
Research: Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak
16 Feb, 2018 | 01:41h | UTCA fractional dose containing one fifth of the standard dose was effective at inducing seroconversion, supporting the use of fractional-dose vaccination for outbreak control.
Randomized Trial of Dexamethasone Versus Prednisone for Children with Acute Asthma Exacerbations
16 Feb, 2018 | 01:35h | UTCRandomized Trial of Dexamethasone Versus Prednisone for Children with Acute Asthma Exacerbations – The Journal of Pediatrics (link to abstract – $ for full-text)
Commentary: Asthma Exacerbation in Kids: A Trial of Two Steroids – Medscape (free registration required)
Related meta-analysis: Dexamethasone for Acute Asthma Exacerbations in Children: A Meta-analysis – Pediatrics (free PDF)
Related study in adults: A Randomized Controlled Noninferiority Trial of Single Dose of Oral Dexamethasone Versus 5 Days of Oral Prednisone in Acute Adult Asthma – Annals of Emergency Medicine (link to abstract – $ for full-text) AND Commentary: Single Dose Dexamethasone or 5 Days of Prednisone in Adult Asthmatics? – R.E.B.E.L.EM commentary (free full-text)
Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism
16 Feb, 2018 | 01:39h | UTCEdoxaban for the Treatment of Cancer-Associated Venous Thromboembolism – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Edoxaban for Cancer-Associated Venous Thromboembolism (free)
Commentaries: Edoxaban Noninferior to Dalteparin for Cancer-Associated VTE – Physician’s First Watch (free) AND Oral Edoxaban Noninferior to Dalteparin for Cancer-Related Venous Thromboembolism – Cardiology Advisor (free)
Research: Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer
16 Feb, 2018 | 01:34h | UTC“Apalutamide improves castration resistant prostate CA survival compared with… placebo. Why wasn’t it compared w bicalutamide?” (via @RichardLehman1 see Tweet). See Richard Lehman’s point of view
Research: Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients
16 Feb, 2018 | 01:26h | UTC“Trimethoprim is associated with a greater risk of acute kidney injury and hyperkalaemia compared with other antibiotics used to treat UTIs, but not a greater risk of death”
Review compares effectiveness, cost, and safety of second-line drugs for diabetes
16 Feb, 2018 | 01:22h | UTCOriginal Report: New Drugs for Type 2 Diabetes: Second-Line Therapy – Canadian Agency for Drugs and Technologies in Health (free)
Research: Extrafine Inhaled Triple Therapy Versus Dual Bronchodilator Therapy in COPD
16 Feb, 2018 | 01:05h | UTCExtrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
“Steroid-containing fine-mist triple inhaler comp with dry powder double inhaler resulting in 0.09 fewer exacerbations per year. Yup.” (via @RichardLehman1 see Tweet) See Richard Lehman’s point of view
Atypical Antipsychotics, Insulin Resistance and Weight; a Meta-Analysis of Healthy Volunteer Studies
16 Feb, 2018 | 01:01h | UTCAtypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies – Progress in Neuro-Psychopharmacology and Biological Psychiatry (link to abstract – $ for full-text) (via @psychopharmacol see Tweet)
“These findings provide preliminary evidence that atypical antipsychotics cause insulin resistance and weight gain directly, independent of psychiatric disease and may be associated with length of treatment”.
Urothelial Carcinoma: The Evolving Landscape of Immunotherapy for Patients with Advanced Disease
16 Feb, 2018 | 00:32h | UTC
Risky Antipsychotic Drugs Still Overprescribed In Nursing Homes
15 Feb, 2018 | 11:26h | UTCRisky Antipsychotic Drugs Still Overprescribed In Nursing Homes – NPR (free)
Original article: How Nursing Homes in the United States Overmedicate People with Dementia – Human Rights Watch (free)
Guideline for CYP2D6 and Tamoxifen Therapy in Breast Cancer
15 Feb, 2018 | 11:16h | UTCCommentary: New international practice guidelines for tamoxifen treatment based on CYP2D6 genotype – eCancer News (free)
Guideline: Antibiotics After Incision and Drainage for Uncomplicated Skin Abscesses
9 Feb, 2018 | 12:48h | UTCRapid Recommendations: Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline – The BMJ (free text and infographics)
Guideline: Management of patients on antithrombotic agents undergoing emergency and elective endoscopy
9 Feb, 2018 | 12:36h | UTC
Research: Clinical Pharmacist Intervention on the Risk of Readmission
9 Feb, 2018 | 12:15h | UTCEffect of an In-Hospital Multifaceted Clinical Pharmacist Intervention on the Risk of Readmission: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Clinical Pharmacist Intervention Can Reduce ED Visits and Hospital Readmissions – MedicalResearch.com (free) AND Pharmacist-led extended medication review and follow-up on discharge may decrease risk of readmission – 2 Minute Medicine (free)
Vitamin and Mineral Supplements: What Clinicians Need to Know
9 Feb, 2018 | 12:10h | UTCViewpoint: Vitamin and Mineral Supplements: What Clinicians Need to Know – JAMA Internal Medicine (free for a period)
Guideline: Biosimilars in Rheumatology
9 Feb, 2018 | 11:44h | UTCNews release: The American College of Rheumatology Recommends Biosimilar Use in New White Paper (free)
Hydroxyethyl-starch Solutions (HES) Should no Longer be Used
9 Feb, 2018 | 11:47h | UTCPress release: Hydroxyethyl-starch solutions for infusion to be suspended (free)
Source: EMA calls for hydroxyethyl starch solutions to be taken off market – The BMJ News ($)
Meta-Analysis: Beta-Blockers for Heart Failure with Reduced, Mid-Range, and Preserved Ejection Fraction
9 Feb, 2018 | 11:34h | UTC
Early use of tranexamic acid reduces bleeding more effectively
5 Feb, 2018 | 16:51h | UTCEarly use of tranexamic acid reduces bleeding more effectively – NIHR Signal (free)
Original article: Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free) AND Invited Commentary: Tranexamic acid: is it about time? (free)
“It is now clearer that every 15-minute delay after the first hour can reduce survival by about 10%”.
Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis
5 Feb, 2018 | 16:50h | UTCIntravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis – NIHR Signal (free)
Original article: Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Proton Pump Inhibitors: Review of Emerging Concerns
5 Feb, 2018 | 16:23h | UTCProton Pump Inhibitors: Review of Emerging Concerns – Mayo Clinic Proceedings (free)
Related reviews: Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free) AND Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free)
Related guideline: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free)
Meta-analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk
5 Feb, 2018 | 16:18h | UTCCommentary: Omega-3 Supplements Don’t Protect Against Heart Disease – The New York Times (10 articles per month are free)
Omega-3 fatty acids did not prevent fatal or nonfatal coronary heart disease or any major vascular events.
Reviews: CAR T-Cell Therapy Toxicities and Side Effects
5 Feb, 2018 | 16:13h | UTCCAR T-Cell Therapy – What do you need to know for the ED? – emDocs (free)
Related reviews: Toxicities of chimeric antigen receptor T cells: recognition and management – Blood (free) AND Toxicity and management in CAR T-cell therapy – Molecular Therapy Oncolytics (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)