Pharmacology/Pharmaceutical Industry
Systematic Review: Interventions for paracetamol (acetaminophen) overdose
2 Mar, 2018 | 01:01h | UTCInterventions for paracetamol (acetaminophen) overdose – Cochrane Library (free)
Original article: Interventions for paracetamol (acetaminophen) overdose – Cochrane Library (link to abstract – $ for full-text)
FDA Safety Alert: Clarithromycin Associated with Increased Risk of Heart Problems or Death in Patients With Heart Disease
2 Mar, 2018 | 00:59h | UTCFDA Safety Alert: Clarithromycin (Biaxin): Drug Safety Communication – Potential Increased Risk of Heart Problems or Death in Patients With Heart Disease (free)
Commentaries: FDA: Antibiotic Linked to Increased Risk of Death in Heart Disease Patients – MPR (free) AND FDA: Clarithromycin Risks Persist in Patients With CAD – TCTMD (free) FDA Alert: Clarithromycin Risky in Patients With Heart Disease – Medscape (free registration required)
Big pharma, big data: why drugmakers want your health records
1 Mar, 2018 | 22:08h | UTCBig pharma, big data: why drugmakers want your health records – Reuters (free)
Review: Targeted drugs for systemic therapy of lung cancer with brain metastases
1 Mar, 2018 | 22:01h | UTCTargeted drugs for systemic therapy of lung cancer with brain metastases – Oncotarget (free)
Review: Cardiovascular, pulmonary, and metabolic toxicities complicating tyrosine kinase inhibitor therapy in chronic myeloid leukemia
27 Feb, 2018 | 16:31h | UTC
Research: Oral Contraceptive Use and Ovarian, Endometrial, Breast, and Colorectal Cancers
27 Feb, 2018 | 15:54h | UTCModification of the Associations Between Duration of Oral Contraceptive Use and Ovarian, Endometrial, Breast, and Colorectal Cancers – JAMA Oncology (link to abstract – $ for full-text)
Commentaries: Reassurance About Oral Contraception and Cancer Risk – NEJM Journal Watch (free for a limited period) AND Ovarian cancer risk reduced with oral contraceptives – Clinical Advisor (free)
Research: Prevalence and Economic Burden of Medication Errors
27 Feb, 2018 | 15:47h | UTCPrevalence and Economic Burden of Medication Errors in The NHS in England. Rapid evidence synthesis and economic analysis of the prevalence and burden of medication error in the UK – Policy Research Unit in Economic Evaluation of Health & Care Interventions (EEPRU) (free PDF)
Commentaries: More than 200 million medication errors occur in NHS per year, say researchers – The University of Sheffield News (free) AND Drug errors cause appalling harm and deaths, says Hunt – BBC (free)
Review: Immunotherapy-Induced Colitis
27 Feb, 2018 | 15:42h | UTCImmunotherapy-Induced Colitis: An Emerging Problem for the Hospitalist – Journal of Hospital Medicine (free PDF)
Source: Hospital Medicine Virtual Journal Club
Research: Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty
23 Feb, 2018 | 01:09h | UTCAspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Preventing VTE after Hip or Knee Arthroplasty (free)
“Among patients who received 5 days of rivaroxaban prophylaxis after total hip or total knee arthroplasty, extended prophylaxis with aspirin was not significantly different from rivaroxaban in the prevention of symptomatic venous thromboembolism”.
Potential workload in applying clinical practice guidelines for patients with chronic conditions and multimorbidity
23 Feb, 2018 | 01:08h | UTCPotential workload in applying clinical practice guidelines for patients with chronic conditions and multimorbidity: a systematic analysis – BMJ Open (free) (via @acpatient and @MaryDixonWoods)
Research: Human Neonatal Rotavirus Vaccine (RV3-BB) to Target Rotavirus from Birth
22 Feb, 2018 | 23:38h | UTCCommentaries: New rotavirus vaccine to curb child deaths in developing countries – New Zealand Doctor (free) AND Researchers successfully develop a rotavirus vaccine which could benefit millions of children – MedicalXpress (free)
Benzodiazepines: Our Other Prescription Drug Epidemic
22 Feb, 2018 | 23:37h | UTCPerspective: Our Other Prescription Drug Problem – New England Journal of Medicine (free)
Related opinion: Benzodiazepines: our other prescription drug epidemic – STAT (free)
Opinion: Stories about tragic flu deaths wrongly portray Tamiflu as a panacea
22 Feb, 2018 | 23:25h | UTCOpinion: Stories about tragic flu deaths wrongly portray Tamiflu as a panacea – HealthNewsReview (free)
Related: Tamiflu and Relenza: getting the full evidence picture – Cochrane Library (free)
“The review confirms small benefits on symptom relief, namely shortening duration of symptoms by half a day on average. However, there is little evidence to support any belief that use of NIs reduces hospital admission or the risk of developing confirmed pneumonia”. (from Cochrane)
Guideline for Prescribing Medical Cannabinoids in Primary Care
22 Feb, 2018 | 23:22h | UTCCommentary: New guideline warns pain benefits of medical cannabis overstated – University of Alberta Faculty of Medicine & Dentistry, via ScienceDaily (free)
Interim Estimates of 2017–18 Seasonal Influenza Vaccine Effectiveness
22 Feb, 2018 | 23:20h | UTCCommentaries: US study finds 36% flu vaccine protection, 25% against H3N2 – CIDRAP (free) AND Three-quarters of people who got flu shot this year weren’t protected against most common strain – STAT (free)
Meta-Analysis: Effects of uric acid-lowering therapy in patients with chronic kidney disease
22 Feb, 2018 | 23:05h | UTCCommentary: Gout medication may slow progression of chronic kidney disease – NIHR Signal (free)
Meta-Analysis: Lithium vs Other Mood Stabilizers in Monotherapy and in Combinations
22 Feb, 2018 | 22:59h | UTC
Research: Beta-blocker Therapy and Clinical Outcomes in Patients with Moderate COPD and Heightened Cardiovascular Risk
22 Feb, 2018 | 22:55h | UTCBeta-blocker Therapy and Clinical Outcomes in Patients with Moderate COPD and Heightened Cardiovascular Risk: An Observational Sub-study of SUMMIT – Annals of the American Thoracic Society (link to abstract – $ for full-text)
Related review and meta-analysis: Beta-blockers in patients with chronic obstructive disease and coexistent cardiac illnesses – COPD Research and Practice (free) AND Beta-blocker use and COPD mortality: a systematic review and meta-analysis – BMC Pulmonary Medicine (free)
Related observational studies: β-Blockers in COPD: A Cohort Study From the TONADO Research Program – CHEST (free) AND Effect of β blockers in treatment of chronic obstructive pulmonary disease: a retrospective cohort study – The BMJ (free)
Commentary: Beta-blockers may not change COPD lung function – Univadis (free registration required)
Research: Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy
22 Feb, 2018 | 21:52h | UTCComparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy – JAMA Pediatrics (link to abstract – $ for full-text)
Commentaries: Which Commonly Prescribed Drug is More Effective for Infants with Epilepsy? – Ann & Robert H. Lurie Children’s Hospital of Chicago, via NewsWise (free) AND Levetiracetam Bests Phenobarbital in Infantile Epilepsy – MedPage Today (free)
Review: Evidence Gaps in the Era of Non–Vitamin K Oral Anticoagulants
22 Feb, 2018 | 21:50h | UTCReview: Evidence Gaps in the Era of Non–Vitamin K Oral Anticoagulants – Journal of the American Heart Association (free)
Source: Critical Care Reviews Newsletter
Research: Probiotics in Young Patients With Moderate Atopic Dermatitis
22 Feb, 2018 | 21:41h | UTCEffect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis: A Randomized Clinical Trial – JAMA Dermatology (link to abstract – $ for full-text)
Commentaries: Probiotics may improve pediatric AD symptoms – DermatologyTimes (free) AND Probiotics May Improve Pediatric AD Symptoms – MedPage Today (free registration required)
Updates in Palliative Care – Recent Advancements in the Pharmacological Management of Symptoms
22 Feb, 2018 | 21:36h | UTCSource: Critical Care Reviews Newsletter
Updates in Palliative Care – Overview and Recent Advancements in the Pharmacological Management of Cancer Pain
22 Feb, 2018 | 21:37h | UTCSource: Critical Care Reviews Newsletter
Research: Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine
16 Feb, 2018 | 02:32h | UTCOutcomes after Angiography with Sodium Bicarbonate and Acetylcysteine – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: No benefit of sodium bicarbonate or acetylcysteine for prevention of complications after angiography: The PRESERVE trial – 2 Minute Medicine (free) AND Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine – NEJM Resident 360 (free)
“Among patients at high risk for renal complications who were undergoing angiography, there was no benefit of intravenous sodium bicarbonate over intravenous sodium chloride or of oral acetylcysteine over placebo for the prevention of death, need for dialysis, or persistent decline in kidney function at 90 days or for the prevention of contrast-associated acute kidney injury”.
Guideline: Antiarrhythmic drugs–clinical use and clinical decision making
16 Feb, 2018 | 02:31h | UTCGuideline: Antiarrhythmic drugs–clinical use and clinical decision making: a consensus document from EHRA, ESC, HRS, APHRS and ISCP (free)
Source: Antiarrhythmics: multinational consensus recommendations – Univadis (free registration required)