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Pharmacology/Pharmaceutical Industry

Guideline: ADA 2018 Standards of Medical Care in Diabetes

12 Dec, 2017 | 12:18h | UTC

ADA 2018 Standards of Medical Care in Diabetes – Diabetes Care (Free Supplement)

News Release: American Diabetes Association Releases 2018 Standards of Medical Care in Diabetes, with Notable New Recommendations for People with Cardiovascular Disease and Diabetes (free)

Summary of Revisions: Standards of Medical Care in Diabetes—2018 (free)

Commentaries: ADA 2018 Standards Address Diabetes Drugs With CV Benefit – Medscape (free registration required)

See Updated Guideline: ADA 2019 Standards of Medical Care in Diabetes (free supplement)

 


Meta-analysis: Efficacy and safety of stress ulcer prophylaxis in critically ill patients

12 Dec, 2017 | 12:15h | UTC

Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials – Intensive Care Medicine (free)

“PPIs are the most effective agents in preventing CIB, but they may increase the risk of pneumonia”.

 


Opinion: The ‘smart pill’ for schizophrenia and bipolar disorder raises tricky ethical questions

10 Dec, 2017 | 15:48h | UTC

The ‘smart pill’ for schizophrenia and bipolar disorder raises tricky ethical questions – STAT (free)

 


Review: Comprehensive Analysis of the Clinical Immuno-Oncology Landscape

10 Dec, 2017 | 15:42h | UTC

Comprehensive analysis of the clinical immuno-oncology landscape – Annals of Oncology (free)

Commentary: The Cancer Research Institute Announces Publication of Comprehensive Immuno-Oncology Landscape Analysis in Annals of Oncology – NewsWise (free)

 


Research: Contemporary Hormonal Contraception and the Risk of Breast Cancer

7 Dec, 2017 | 22:08h | UTC

Contemporary Hormonal Contraception and the Risk of Breast Cancer – New England Journal of Medicine (free)

Commentaries: Even Low-Dose Contraceptives Slightly Increase Breast Cancer Risk – NPR (free) AND Study confirms higher breast cancer risk with hormone-based contraception – Reuters (free) AND Small risk of breast cancer seen with hormone contraceptives – Associated Press (free) All forms of hormonal contraception carry breast cancer risk, study finds – the Guardian (free) AND Birth Control Pills Still Linked to Breast Cancer, Study Finds – The New York Times (10 articles per month are free)

 


Two nerve drugs are not suitable for treating long-term low back pain

7 Dec, 2017 | 22:04h | UTC

Two nerve drugs are not suitable for treating long-term low back pain – NIHR Signal (free)

Original Article: Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials – PLOS One (free)

“Evidence supports NICE guidance not to use two nerve drugs (gabapentin and pregabalin) to treat long-term lower back pain”. (RT @NIHR_DC see Tweet)

 


Guidelines on the Management of Diabetes

5 Dec, 2017 | 18:36h | UTC

SIGN Guidelines on Pharmacological management of glycaemic control in people with type 2 diabetes & Management of diabetes – Scottish Intercollegiate Guidelines Network (free guidelines and resources) (via @kamleshkhunti)

 


Consensus on the Management of Bleeding in Patients on Oral Anticoagulants

5 Dec, 2017 | 18:35h | UTC

2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants – Journal of The American College of Cardiology (free)

Commentary and Summary: Consensus for Management of Bleeding on Oral Anticoagulants – American College of Cardiology, Latest in Cardiology (free)

 


Systematic Review: Vitamin D supplementation during pregnancy

5 Dec, 2017 | 18:32h | UTC

Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials – The BMJ (free)

Commentaries: Evidence Insufficient to Recommend Prenatal Vitamin D Supplementation, Researchers Say – Physician’s First Watch (free) AND Jury Still Out on Vitamin D Supplements in Pregnancy – MedPage Today (free registration required)

 


Research: Risk of death associated with new benzodiazepine use among persons with Alzheimer disease

5 Dec, 2017 | 18:31h | UTC

Risk of death associated with new benzodiazepine use among persons with Alzheimer disease: A matched cohort study – International Journal of Geriatric Psychiatry (link to abstract – $ for full-text) (RT @Deprescribing see Tweet)

Commentaries: Benzodiazepines linked to increased risk of death among Alzheimer’s disease patients – News Medical (free) AND Benzodiazepines Tied to a 41% Increased Mortality Risk in AD – Medscape (free registration required)

 


Research: Treatment eligibility and retention in clinical HIV care:

30 Nov, 2017 | 18:15h | UTC

Treatment eligibility and retention in clinical HIV care: A regression discontinuity study in South Africa – PLOS Medicine (free)

Commentary: Immediate ART treatment improves retention rates – Boston University School of Medicine (free)

 


Computerised decision support can improve antibiotic prescribing in hospitals

30 Nov, 2017 | 18:13h | UTC

Computerised decision support can improve antibiotic prescribing in hospitals – NIHR Signal (free)

Original Article: The effectiveness of computerised decision support on antibiotic use in hospitals: A systematic review – PLOS One (free)

 


Meta-analysis: Oral anticoagulants for prevention of stroke in atrial fibrillation

29 Nov, 2017 | 16:50h | UTC

Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis – The BMJ (free)

Commentary: Comparison of Oral Anticoagulants for Preventing Stroke in AF – MPR (free)

 


Tens of thousands dying from $30 billion fake drugs trade, WHO says

29 Nov, 2017 | 16:48h | UTC

Tens of thousands dying from $30 billion fake drugs trade, WHO says – Reuters Health (free)

Related: About 11 percent of drugs in poor countries are fake, U.N. says – Associated Press (free)

 


Guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis

28 Nov, 2017 | 19:40h | UTC

Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free)

Commentaries: New HIV guideline outlines cost-effective prevention strategies for high-risk people – ScienceDaily (free)

Related Free Online Course (Starts Dec 04): PrEParing: PrEP for Providers and Patients – Johns Hopkins University and Coursera

Related guidance: WHO implementation tool for pre-exposure prophylaxis of HIV infection (free) AND Summary: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection (free)

 


Review: Does contrast cause kidney injury?

28 Nov, 2017 | 19:34h | UTC

Does contrast cause kidney injury? The evidence – First10EM (free)

 


Meta-Analysis: Prolonged Infusion Piperacillin-Tazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients

28 Nov, 2017 | 19:27h | UTC

Prolonged Infusion Piperacillin-Tazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients: Results of a Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

Source: ACP Journal Wise ($)

“Receipt of prolonged infusion of piperacillin-tazobactam was associated with reduced mortality and improved clinical cure rates across diverse cohorts of severely ill patients”.

 


Research: Tolerability profile of glucocorticoids use in early rheumatoid arthritis

28 Nov, 2017 | 19:26h | UTC

Seven-year tolerability profile of glucocorticoids use in early rheumatoid arthritis: data from the ESPOIR cohort – Annals of Rheumatic Diseases (free)

Commentaries: Long-Term Safety of Glucocorticoids in Patients with Early Rheumatoid Arthritis – Journal Watch (free) AND Long-term Low-dose Steroids OK in Early RA – MedPage Today (free registration required)

“Long-Term Safety of Glucocorticoids in Early Rheumatoid Arthritis. Stopping steroids completely is difficult in patients whose disease flares with tapering, but low-dose levels are relatively safe” (RT @JWatch see Tweet)

 


Research: Association of Hormonal Contraception With Suicide Attempts and Suicides

25 Nov, 2017 | 22:51h | UTC

Association of Hormonal Contraception With Suicide Attempts and Suicides – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Hormonal Contraception May Increase Risk of Suicide, Study Suggests – Psychiatric News Alert (free) AND Oral Contraceptives Linked to Suicide – Medscape (free registration required)

 


Guideline for treatment of cancer pain

25 Nov, 2017 | 22:48h | UTC

2017 SEOM clinical guideline for treatment of cancer pain – Clinical and Translational Oncology (free)

 


Guideline: Deprescribing antihyperglycemic agents in older persons

25 Nov, 2017 | 22:45h | UTC

Deprescribing antihyperglycemic agents in older persons: Evidence-based clinical practice guideline – Canadian Family Physician (free)

Related algorithm: Antihyperglycemic deprescribing algorithm (free PDF)

See also other Deprescribing Guidelines and Algorithms (free resources)

 


Choosing Wisely: Six Things Pharmacists and Patients Should Question

25 Nov, 2017 | 22:46h | UTC

New Choosing Wisely Canada list: Six Things Pharmacists and Patients Should Question (RT @CPhAAPhC see Tweet)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

 


Guidelines Synopsis: Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults

25 Nov, 2017 | 22:39h | UTC

Clinical Guidelines Synopsis: Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults – JAMA (free)

Editorial: The New 2017 ACC/AHA Guidelines “Up the Pressure” on Diagnosis and Treatment of Hypertension (free)

Related Viewpoint: The 2017 Clinical Practice Guideline for High Blood Pressure (free)

See original AHA/ACC Hypertension Guidelines and related resources in our November 13th issue (see #1)

 


Review: Practical Considerations for the Diagnosis and Management of Asthma in Older Adults

25 Nov, 2017 | 22:33h | UTC

Practical Considerations for the Diagnosis and Management of Asthma in Older Adults – Mayo Clinic Proceedings (free)

 


Guideline: Pharmacologic management of chronic neuropathic pain

25 Nov, 2017 | 22:32h | UTC

Pharmacologic management of chronic neuropathic pain: Review of the Canadian Pain Society consensus statement – Canadian Family Physician (free)

Related article: Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free)

 


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