Pharmacology/Pharmaceutical Industry | Page 149 of 165 | Links Medicus Content Curation & Alerts in Medicine

“A formidable group of oncologists has come together with the joint aim of improving access, affordability, and sustainability (value) of cancer therapies”.

Original abstract: A prospective international randomized phase II study evaluating the food effect on the pharmacokinetics (PK) and pharmacodynamics (PD) of abiraterone acetate (AA) in men with castration-resistant prostate cancer (CRPC) (free) AND Commentary: A group of cancer doctors discovered a way to slash the cost of expensive pills by up to 75%, but they’ve hit a wall – Business Insider (free)

Related Website (news section): Value in Cancer Care Consortium (free resources)

Research: Post-Exposure Prophylaxis with Doxycycline to Prevent Sexually Transmitted Infections in Men Who Have Sex With Men

28 Dec, 2017 | 17:26h | UTC

Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentaries: Post Exposure Doxycycline in PReP Users May Reduce Risk of Syphilis and Chlamydiae – MedicalResearch (free) AND Doxycycline After Condomless Sex Lowers STI Risk in High-Risk Men – Physician’s First Watch (free) AND Antibiotics could dramatically reduce STIs, study says, raising tough new questions – STAT (free) AND Antibiotics could ‘dramatically reduce’ STIs, STAT says, though findings apply to small group of men – HealthNewsReview (free) AND

Clinical Trial Transparency: A Guide for Policymakers

28 Dec, 2017 | 17:15h | UTC

Clinical Trial Transparency: A Guide for Policymakers – by Transparency International Pharmaceuticals & Healthcare (PHP), TranspariMED, Cochrane, and Collaboration for Research Integrity and Transparency (CRIT) (free PDF)

Press Release: O pacity over clinical trials of medical treatments putting patients at risk – Transparency International (free)

Source: Rules on reporting trials must be better enforced, say health integrity groups – The BMJ News ($)

HIV Pregnancy Planning Guidelines

27 Dec, 2017 | 22:02h | UTC

Canadian HIV Pregnancy Planning Guidelines – Journal of Obstetrics and Gynaecology Canada (free)

Review: Management of Venous Thromboembolism

27 Dec, 2017 | 21:47h | UTC

Update on the management of venous thromboembolism – Cleveland Clinic Journal of Medicine (free)

Systematic Review: Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies

27 Dec, 2017 | 21:45h | UTC

Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review – Journal of the American Heart Association (free)

Research: Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With NOACs

27 Dec, 2017 | 21:08h | UTC

Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non–Vitamin‐K Oral Anticoagulants (RAF‐NOACs) Study – Journal of the American Heart Association (free)

“Composite rates of recurrence and major bleeding were 12.4% in patients who initiated NOACs within 2 days after acute stroke, 2.1% in those who initiated NOACs between 3 and 14 days, and 9.1% in patients who initiated NOACs >14 days after acute stroke. Future randomized studies to assess timing of initiation and choice of agent in patients with acute stroke and AF are warranted”.

WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage

27 Dec, 2017 | 21:06h | UTC

Updated WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage (free PDF)

Commentary: Updated WHO recommendation on intravenous tranexamic acid for the treatment of post-partum haemorrhage – The Lancet Global Health (free)

Medication Adherence: Evidence Review

27 Dec, 2017 | 20:54h | UTC

Medication adherence: evidence review – Evidently Cochrane (free)

Systematic Review: Smoking Cessation Interventions for Smokers with Current Depression

27 Dec, 2017 | 20:56h | UTC

Psychological, pharmacological, and combined smoking cessation interventions for smokers with current depression: A systematic review and meta-analysis – PLOS One (free)

Guideline: Role of Bone-Modifying Agents in Metastatic Breast Cancer

27 Dec, 2017 | 20:46h | UTC

Role of Bone-Modifying Agents in Metastatic Breast Cancer: An American Society of Clinical Oncology–Cancer Care Ontario Focused Guideline Update – Journal of Clinical Oncology (free)

Systematic Review: Is Treatment With Corticosteroids Beneficial for People With Pneumonia?

26 Dec, 2017 | 23:35h | UTC

Is treatment with corticosteroids beneficial and safe for people with pneumonia? – The Cochrane Library (free)

“Corticosteroid therapy reduced mortality and morbidity in adults with severe CAP; the number needed to treat for an additional beneficial outcome was 18 patients (95% CI 12 to 49) to prevent one death. Corticosteroid therapy reduced morbidity, but not mortality, for adults and children with non-severe CAP”

Cost-Effectiveness Analysis: Individualized Glycemic Control for Adults With Type 2 Diabetes:

26 Dec, 2017 | 23:26h | UTC

Individualized Glycemic Control for U.S. Adults With Type 2 Diabetes: A Cost-Effectiveness Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Individualized Glycemic Control Could Safely Cut Costs in Type 2 Diabetes – Physician’s First Watch (free) AND Individualized HbA_1c Targets for Diabetes Drop Cost, Improve QoL – Medscape (free registration required) AND Personalized Blood Sugar Goals Can Save Diabetes Patients Thousands – University of Chicago Medical Center, via NewsWise (free)

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