Pharmacology/Pharmaceutical Industry
Meta-Analysis of Observational Studies: Proton Pump Inhibitors are Associated with Increased Risk of Kidney Disease
16 Apr, 2018 | 16:54h | UTCAcid‐suppressive drugs and risk of kidney disease: A systematic review and meta‐analysis – Journal of Gastroenterology and Hepatology (link to abstract – $ for full-text)
Source: Hospital Medicine Virtual Journal Club
Proton pump inhibitors were associated with higher risks of acute interstitial nephritis (HR, 2.78; 95% CI, 1.25‐6.17), acute kidney injury (HR, 1.85; 95% CI, 1.33‐2.59), chronic kidney disease (HR, 1.47; 95% CI, 1.03‐2.09), and end‐stage renal disease (HR, 1.61; 95% CI, 1.26‐2.04) than non‐PPI therapy. Similar risks were not identified for H2RA therapy.
Randomized Controlled Trial: Combination Therapy with Immunotherapy Increases Overall Survival in Patients with Lung Cancer
16 Apr, 2018 | 16:34h | UTCCommentaries: AACR 2018: Combination therapy doubles survival in metastatic lung cancer – eCancer News (free) AND Lung Cancer Patients Live Longer With Immune Therapy – New York Times (10 articles per month are free)
News Release: Affordable Hepatitis C Treatment Shows 97 Percent Cure Rate
14 Apr, 2018 | 20:32h | UTCRelated: Non-profit’s $300 hepatitis C cure as effective as $84,000 alternative – The Guardian (free) AND Hepatitis C: simplified curative treatments can drive global scale-up – World Health Organization (free)
Randomized Controlled Trial: Fish Oil Supplements No Better Than Placebo for Dry Eye
14 Apr, 2018 | 20:01h | UTCn−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease – New England Journal of Medicine (free for a limited period)
Commentaries: Omega-3s From Fish Oil Supplements No Better Than Placebo for Dry Eye – NIH, National Eye Institute (NEI), via NewsWise (free) AND Fish oil capsules don’t help dry eye symptoms, study finds – STAT (free) AND Fish oil supplements ineffective against dry eye – Reuters (free)
Review: topical nonsteroid therapy in atopic dermatitis
14 Apr, 2018 | 18:26h | UTCAtopic dermatitis: a review of topical nonsteroid therapy – Drugs in Context (free)
Cohort study: SSRI exposure during pregnancy and MRI-assessed brain abnormalities in infants
12 Apr, 2018 | 02:20h | UTCAssociations Between Brain Structure and Connectivity in Infants and Exposure to Selective Serotonin Reuptake Inhibitors During Pregnancy – JAMA Pediatrics (free for a limited period)
Author interview: Associations Between SSRI Exposure During Pregnancy and MRI-Assessed Brain Structure and Connectivity in Infants (free)
Commentaries: We’re beginning to learn how moms’ antidepressants can affect fetuses – VOX (free) AND MRI study finds prenatal exposure to certain antidepressants may alter brain development – Health Imaging (free) AND SSRI use in pregnancy may affect fetal brain development – OnMedica (free) AND Antidepressants in pregnancy tied to changes in babies’ brains – Reuters (free)
Systematic review: inhaled anti-pseudomonal antibiotics in cystic fibrosis
5 Apr, 2018 | 18:42h | UTCInhaled anti-pseudomonal antibiotics for long-term therapy in cystic fibrosis – Cochrane Library (link to abstract – $ for full-text)
Summary: Inhaling antibiotics to treat lung infection in people with cystic fibrosis – Cochrane Library (free)
Guideline: management of amiodarone-associated thyroid dysfunction
3 Apr, 2018 | 18:03h | UTC
Myocarditis in Patients Treated With Immune Checkpoint Inhibitors
30 Mar, 2018 | 04:37h | UTCMyocarditis in Patients Treated With Immune Checkpoint Inhibitors – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Myocarditis a Risk with Checkpoint Inhibitors – CRTOnline.org (free) AND Myocarditis in Patients Treated With Immune Checkpoint Inhibitors – American College of Cardiology, Latest in Cardiology (free)
Related Guidelines and Reviews: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Guideline – Otitis media (acute): antimicrobial prescribing
30 Mar, 2018 | 04:10h | UTCGuideline: Otitis media (acute): antimicrobial prescribing – National Institute for Health and Care Excellence (NICE) (free)
Commentaries: Most common ear infections should not be treated with antibiotics, says NICE (free) AND Common ear infections don’t need antibiotics, health watchdog says – The Guardian (free) AND Antibiotics not recommended for acute otitis, says NICE – OnMedica (free)
Related guideline: Clinical Practice Guideline: Otitis Media with Effusion (Update) – Otolaryngol Head Neck Surg (free) AND Executive Summary – Otolaryngol Head Neck Surg (free)
A prescription for medication errors
30 Mar, 2018 | 02:44h | UTCA prescription for medication errors – ACP Hospitalist (free)
When antibiotics turn toxic
23 Mar, 2018 | 02:43h | UTCWhen antibiotics turn toxic – Nature News (free)
“Commonly prescribed drugs called fluoroquinolones cause rare, disabling side effects. Researchers are struggling to work out why”.
Systematic Review: Oral vitamin B12 compared with intramuscular vitamin B12
23 Mar, 2018 | 02:32h | UTCCommentary: Oral vs. Intramuscular Vitamin B12: Efficacy, Safety Compared – MPR (free)
Meta-analysis: Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs
22 Mar, 2018 | 23:51h | UTC
From app store to drug store, digital health is redefining pharma’s pipeline
22 Mar, 2018 | 23:46h | UTCFrom app store to drug store, digital health is redefining pharma’s pipeline – STAT (free)
A Quiet Drug Problem Among the Elderly
22 Mar, 2018 | 23:44h | UTCA Quiet Drug Problem Among the Elderly – The New York Times (free)
Related: Our Other Prescription Drug Problem – New England Journal of Medicine (free) AND Benzodiazepines: our other prescription drug epidemic – STAT (free)
“Despite warnings from experts, older people are using more anti-anxiety and sleep medications, putting them at risk of serious side effects and even overdoses”.
Consensus Recommendations on Sulfonylurea and Sulfonylurea Combinations in the Management of Type 2 Diabetes Mellitus
22 Mar, 2018 | 23:35h | UTC
Research: Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care
16 Mar, 2018 | 03:36h | UTC#ACC18 – Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care – American College of Cardiology (free) AND Low-Dose, Three-Drug Polypill TRIUMPHs for Blood Pressure – TCTMD (free)
Do Antidepressants Work?
16 Mar, 2018 | 03:36h | UTCDo Antidepressants Work? – The New York Times (10 articles per month are free)
“The most comprehensive study on them has recently been published, showing mostly modest effects”.
See related meta-analysis and commentaries in our February 23rd issue (see #3)
Did a pricey cholesterol-lowering drug really reduce deaths, as headlines claim?
16 Mar, 2018 | 03:33h | UTCSee original article and commentaries in our March 12th issue (see #2)
The ODYSSEY Trial Ends Well— But Will It Be Enough?
16 Mar, 2018 | 03:32h | UTC#ACC18 – The ODYSSEY Trial Ends Well— But Will It Be Enough? – Cardiobrief (free) AND Ten Quick Thoughts on ODYSSEY – John Mandrola, via Medscape (free registration required)
“An absolute risk reduction of 1.6% in the primary endpoint translates to a number needed to treat of 64. Using the current price of $14,500 per year, Kaul calculated that preventing one event over the trial period of almost 3 years would cost about $2.6 million” (via John Mandrola). This study was presented at #ACC18 and has not been published yet. Among the many commentaries, these two were selected for a balanced point of view.
Research: Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout
16 Mar, 2018 | 02:14h | UTCCommentaries: Gout Drug Febuxostat Linked to More CV Deaths Without Uptick in CV Events: CARES Trial – TCTMD (free) AND CARES: Increased Risk of Death With Febuxostat in Patients With Gout and CV Disease – American College of Cardiology (free) AND
Meta-Analysis: Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis
16 Mar, 2018 | 01:32h | UTC
When Opioids Make Pain Worse
16 Mar, 2018 | 01:17h | UTCWhen Opioids Make Pain Worse – NPR (free)
A Practical Review of the Emerging Direct Anticoagulants, Laboratory Monitoring, and Reversal Agents
16 Mar, 2018 | 01:01h | UTCSource: Critical Care Reviews Newsletter