Pharmacology/Pharmaceutical Industry
Guideline: Treatment of infections caused by multidrug-resistant Gram-negative bacteria
8 Mar, 2018 | 22:33h | UTCTreatment of infections caused by multidrug-resistant Gram-negative bacteria: report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party – Journal of Antimicrobial Chemotherapy (free) (via @ABsteward)
One-Month Tuberculosis Prophylaxis as Effective as Nine-Month Regimen for People Living with HIV
8 Mar, 2018 | 22:24h | UTCOne-Month Tuberculosis Prophylaxis as Effective as Nine-Month Regimen for People Living with HIV – National Institute of Allergy and Infectious Diseases (free) (via @iasociety see Tweet)
Related: New ways to fight HIV and tuberculosis emerge at AIDS conference – Science (free)
Research: Fluoroquinolone use and risk of aortic aneurysm and dissection
8 Mar, 2018 | 22:17h | UTCFluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study – The BMJ (free)
Related: Aortic Dissection and Aortic Aneurysms Associated with Fluoroquinolones: A Systematic Review and Meta-Analysis – American Journal of Medicine (free) AND Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study – BMJ Open (free) AND Risk of Aortic Dissection and Aortic Aneurysm in Patients Taking Oral Fluoroquinolone – JAMA Internal Medicine (free)
Proton pump inhibition therapy and risk of oesophageal cancer
8 Mar, 2018 | 22:14h | UTCMaintenance proton pump inhibition therapy and risk of oesophageal cancer – Cancer Epidemiology (link to abstract – $ for full-text)
Commentary: Long-term PPI Use and Increased Esophageal CA Risk – Medscape (free registration required)
Related studies suggesting a link with gastric cancer: Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study – Gut (link to abstract – $ for full-text) AND Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden – BMJ Open (free)
This observational study suggests a possible link.
Research: Metformin use in PCOS pregnancies increases the risk of offspring overweight at 4 years of age
8 Mar, 2018 | 22:13h | UTCMetformin use in PCOS pregnancies increases the risk of offspring overweight at 4 years of age; follow-up of two RCTs – The Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)
Commentaries: Diabetes drug use during pregnancy linked to child’s weight – The Endocrine Society, via ScienceDaily (free) AND Diabetes drug use during pregnancy affects child’s weight – OnMedica (free) AND Metformin in Pregnancy May Increase Childhood Obesity Risk – Medscape (free registration required)
Randomized controled trial: Opioid vs Nonopioid Medications in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain
8 Mar, 2018 | 22:06h | UTCEffect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Opioids Don’t Beat Other Medications For Chronic Pain – NPR (free) AND More Data Opioids No Better for Chronic Back, Arthritis Pain – Medscape (free registration required) AND Opioids no better than NSAIDs for chronic back or arthritis pain – Reuters (free)
Related: Opioid Wisely – Choosing Wisely Canada (free) AND Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free)
Systematic Review: Factor Xa inhibitors vs vitamin K antagonists in patients with atrial fibrillation
8 Mar, 2018 | 22:04h | UTCFactor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation – Cochrane Library (free)
When available, Factor Xa inhibitors seems to be a better choice for treating these patients.
Digoxin and Mortality in Patients With Atrial Fibrillation
8 Mar, 2018 | 21:42h | UTCDigoxin and Mortality in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Digoxin and Mortality in Patients With Atrial Fibrillation – American College of Cardiology, Latest in Cardiology (free) AND Digoxin Associated with Higher Mortality in Patients with Atrial Fibrillation – NEJM Physician’s First Watch (free)
Research: Effect of Offering Same-Day ART vs Usual Health Facility Referral
8 Mar, 2018 | 21:39h | UTCEditorial: The Global HIV Epidemic: What Will It Take to Get to the Finish Line? (free)
Commentary: HIV in sub-Sahara Africa: Testing and treatment start at home improves therapy – Swiss Tropical and Public Health Institute, via EurekAlert (free)
Related: Starting antiretroviral therapy immediately after HIV diagnosis reduces transmission of the virus – NIHR Signal (free)
Authors of premier medical textbook didn’t disclose $11 million in industry payments
8 Mar, 2018 | 21:38h | UTCAuthors of premier medical textbook didn’t disclose $11 million in industry payments – STAT (free)
“’The most recognized book in all of medicine’ is also rife with hidden financial conflicts. Should Harrison’s authors be disclosing $11 million in payments from drug and device makers?” (via @caseymross see Tweet)
Opioid Wisely – Choosing Wisely Canada
8 Mar, 2018 | 21:29h | UTCOpioid Wisely – Choosing Wisely Canada (free)
Related Guideline: Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free)
See complete lists from Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
This campaign encourages thoughtful conversation between clinicians and patients to reduce harms associated with opioid prescribing, with recommendations relevant to different specialties.
Research: Escalating Inhaled Glucocorticoids to Prevent Asthma Exacerbations
8 Mar, 2018 | 21:28h | UTCEditorial: Escalating Inhaled Glucocorticoids to Prevent Asthma Exacerbations (free for a limited period)
Trial 1: Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations – The New England Journal of Medicine (free for a limited period)
Trial 2: Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations – The New England Journal of Medicine (free for a limited period)
Research: Opioid Tapering in Community Outpatients With Chronic Pain
8 Mar, 2018 | 20:43h | UTCCommentary: Chronic Opioid Users May Wish to Taper Opioid Use – Physician’s Weekly (free)
Research: Comparative cardiovascular safety of non-steroidal anti-inflammatory drugs in patients with hypertension
8 Mar, 2018 | 20:44h | UTCComparative cardiovascular safety of non-steroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study – British Journal of Clinical Pharmacology (link to abstract – $ for full-text)
Commentary: Cardiovascular Risk Compared Among COX-2 Selective, Nonselective NSAIDs – MPR (free)
Why Right-to-Try Laws Are Dangerous
8 Mar, 2018 | 20:27h | UTCWhy Right-to-Try Laws Are Dangerous – The ASCO Post (free)
Practical outpatient pharmacotherapy for alcohol use disorder
8 Mar, 2018 | 20:17h | UTCPractical outpatient pharmacotherapy for alcohol use disorder – Drugs in Context (free)
Balanced Crystalloids vs Saline in Hospitalized Patients
2 Mar, 2018 | 02:10h | UTCBalanced Crystalloids versus Saline in Critically Ill Adults – New England Journal of Medicine (free)
Related article: Balanced Crystalloids versus Saline in Noncritically Ill Adults – New England Journal of Medicine (free)
Commentary: Balanced Crystalloids May Be Better Than Saline for Critically Ill Patients – NEJM Physician’s First Watch (free)
“Balanced crystalloids may be superior to saline in critically ill patients — but not in patients hospitalized outside an ICU” (from Physician’s First Watch)
Policy Statement: Pediatric Medication Safety in the Emergency Department
2 Mar, 2018 | 02:00h | UTCPolicy Statement: Pediatric Medication Safety in the Emergency Department – American Academy of Pediatrics (free)
Commentaries: Recommendations Issued on Reducing Pediatric Medication Errors in the ED – NEJM Physician’s First Watch (free) AND Policy statement outlines ways to improve pediatric medication safety – 2 Minute Medicine (free)
Guidelines for the Use of Antiplatelet Therapy
2 Mar, 2018 | 01:57h | UTCRelated guidelines: 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease (free)
Guideline: pharmacological management of patients with type 2 diabetes and cardiovascular diseases
2 Mar, 2018 | 01:55h | UTCRelated guideline: Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes, 2018 – American Diabetes Association (free)
Research: Infant Hospitalizations and Mortality After Maternal Vaccination
2 Mar, 2018 | 01:45h | UTCInfant Hospitalizations and Mortality After Maternal Vaccination – Pediatrics (free)
Commentaries: Maternal vaccination during pregnancy not associated with infant hospitalization, mortality – 2 Minute Medicine (free) AND Getting Recommended Vaccines During Pregnancy Doesn’t Lead to Harm in Infants – Physician’s First Watch (free)
Systematic Review: Antifibrinolytic drugs for treating primary postpartum haemorrhage
2 Mar, 2018 | 01:46h | UTCAntifibrinolytic drugs for treating primary postpartum haemorrhage – Cochrane Library (free)
Related: Updated WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage (free PDF) AND Early use of tranexamic acid reduces bleeding more effectively – NIHR Signal (free) AND Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free)
Meta-Analysis: Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer’s Disease
2 Mar, 2018 | 01:23h | UTCSource: Medscape (free registration required)
“Cognitive enhancers in general have minimal effects on cognition according to minimal clinically important difference and global ratings. The drugs appear safe, but this must be interpreted cautiously because trial participants may have less comorbidity and fewer adverse effects than those treated with these drugs in clinical practice”.
Guidelines for the Pharmacological Treatment of Social Anxiety Disorder
2 Mar, 2018 | 01:17h | UTCRelated guideline: Social anxiety disorder: recognition, assessment and treatment – NICE (free) AND Summary: Recognition, assessment and treatment of social anxiety disorder: summary of NICE guidance – The BMJ (free)
Research: Real-World Effectiveness of Pharmacologic Treatments for Bipolar Disorders
2 Mar, 2018 | 01:14h | UTCReal-World Effectiveness of Pharmacologic Treatments for the Prevention of Rehospitalization in a Finnish Nationwide Cohort of Patients With Bipolar Disorder – JAMA Psychiatry (link to abstract – $ for full-text)
Editorial: Enthusiasm and Skepticism About Using National Registers to Analyze Psychotropic Drug Outcomes (free for a limited period)
Commentaries: Lithium treatment for bipolar disorder linked to lowest risk of rehospitalization – Karolinska Institutet, via EurekAlert (free) AND Lithium Top Choice for Preventing Bipolar Rehospitalization – MedPage Today (free registration required)
Related study: Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: a systematic review of evidence from observational studies – Bipolar Disorders (free)
These observational studies suggest Lithium may be a better choice for treating these patients, but randomized controlled trials are needed to clarify this issue.