Pharmacology/Pharmaceutical Industry
ACOG Committee Opinion: Adolescents and Long-Acting Reversible Contraception
27 Apr, 2018 | 02:57h | UTCCommittee Opinion: Adolescents and Long-Acting Reversible Contraception: Implants and Intrauterine Devices – American College of Obstetrics and Gynecology (free)
Commentary: ACOG Committee Opinion: adolescents should be offered LARC – Univadis (free registration required)
Incorporating Medication Indications Into the Prescribing Process
27 Apr, 2018 | 02:53h | UTCSource: Hospital Medicine Virtual Journal Club (free)
Case-control Study: Anticholinergic Drugs and Risk of Dementia
27 Apr, 2018 | 02:38h | UTCAnticholinergic drugs and risk of dementia: case-control study – The BMJ (free)
Editorial: Anticholinergic drugs and dementia in older adults (free)
Commentaries: Expert reaction to study investigating the association between different types of anticholinergic drugs and risk of dementia – Science Media Centre (free) AND Anticholinergic drugs may be linked to increased risk of dementia – OnMedica (free)
“The effect of anticholinergic therapy is relatively small (odds ratio 1.1 – 1.2) and establishing an association does not prove a causal link. Nevertheless, the paper may act as a useful guide for future research and clinical practice”. (by Prof Les Iversen, in Science Media Centre)
Meta-Analysis: Probiotics for the Prevention of Clostridium difficile
27 Apr, 2018 | 02:36h | UTCCommentary: Probiotics may be safe, low-cost prevention tool for Clostridium difficile infections – News Medical (free)
Related Articles: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use – Cochrane Library (free) AND Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis – Antibiotics (free) AND Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis – Gastroenterology (free)
NICE Guideline Update: Neuropathic pain in adults
27 Apr, 2018 | 02:29h | UTCGuideline Update: Neuropathic pain in adults: pharmacological management in non-specialist settings – National Institute for Health and Care Excellence (free)
Things We Do For No Reason: Periprocedural Bridging Anticoagulation
27 Apr, 2018 | 01:25h | UTCThings We Do For No Reason: Periprocedural Bridging Anticoagulation – Journal of Hospital Medicine (free)
Retrospective Cohort: Recent Opioid Use and Fall-related Injury Among Older Patients With Trauma
25 Apr, 2018 | 13:48h | UTCCommentary: Opioid use linked to increased risk of falls, death in older adults – CMAJ, via EurekAlert (free)
Meta-Analysis: Prenatal Exposure to Acetaminophen and Risk for ADHD and Autistic Spectrum Disorder
25 Apr, 2018 | 12:52h | UTCCommentary: Prolonged acetaminophen use during pregnancy linked to increased ASD and ADHD risk – The Hebrew University of Jerusalem, via EurekAlert (free)
AAN Guideline: Disease-modifying Therapies for Adults with Multiple Sclerosis
24 Apr, 2018 | 19:33h | UTCSee also: Related Physician Tools and Materials (free clinician summary, slides and more)
Commentaries: New guideline: Start taking MS drugs early on – American Academy of Neurology, via EurekAlert (free)
New MS Guideline Addresses Starting, Switching, and Stopping Disease-modifying Therapy – MD Magazine (free) AND Start MS Drugs Early, New Guideline Says – MedPage Today (free registration required)
Cohort Study: Proton‐Pump Inhibitors and Risk of Pneumonia in Older Adults
24 Apr, 2018 | 19:29h | UTCCommentary: Commonly prescribed heartburn drug linked to Pneumonia in Older Adults – University of Exeter (free)
Related: Proton Pump Inhibitors: Review of Emerging Concerns – Mayo Clinic Proceedings (free) AND Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free) AND Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free)
Source: Hospital Medicine Virtual Journal Club
Research: Antibiotic Use After Removal of Penicillin Allergy Label
24 Apr, 2018 | 18:04h | UTCAntibiotic Use After Removal of Penicillin Allergy Label – Pediatrics (link to abstract – $ for full-text)
Commentaries: Penicillin Allergy Testing Could Save Money, Improve Care – American Academy of Pediatrics (free) AND Delabeling for Penicillin Allergy Found Safe in Children – Medscape (free registration required) AND Removing penicillin allergy label from kids saves antibiotics, money – CIDRAP, in Resistance Scan for Apr 20, 2018 (free)
Randomized Controlled Trial: Ketamine for Rapid Reduction of Symptoms of Depression and Suicidality
23 Apr, 2018 | 21:08h | UTCEfficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Intranasal Esketamine Found Effective in Rapid Reduction of Depression, Suicidal Thoughts – Psychiatric News Alert (free) AND Fast-acting benefits of ketamine for depression and suicidality – American Psychiatric Association, via ScienceDaily (free) AND Ketamine ‘shows promise’ in treating depression – OnMedica (free) AND Ketamine Spray Effective for Suicidality, but Abuse Concerns Linger – Medscape (free registration required)
Related: ‘Cautious Optimism’ Marks Outlook for Ketamine, Mood Disorders – Psychiatric News (free)
Report: Drugs for the Management of Rheumatoid Arthritis
23 Apr, 2018 | 21:00h | UTCSource: EvidenceAlerts
Perspective: Why Do We Need Vaccines?
23 Apr, 2018 | 16:42h | UTCWhy do we need vaccines? – Welcome Trust (free) (via @greg_folkers)
New U.S. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV
23 Apr, 2018 | 16:41h | UTCGuidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV – AIDSInfo (free)
Research :Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia
20 Apr, 2018 | 01:57h | UTCGene Therapy in Patients with Transfusion-Dependent β-Thalassemia – New England Journal of Medicine (free)
Editorial: Gene Therapy as a Curative Option for β-Thalassemia (free)
Quick Take Video Summary: LentiGlobin Gene Therapy for β-Thalassemia (free)
Commentaries: Gene therapy could free some people from a lifetime of blood transfusions – MIT Technology Review (free) AND Gene Therapy For Inherited Blood Disorder Reduced Transfusions – NPR (free) AND Expert reaction to study on gene therapy for beta-thalassaemia – Science Media Centre (free)
Research: Low-Dose Abiraterone With Food vs Standard Dose Abiraterone In Prostate Cancer
20 Apr, 2018 | 01:44h | UTCCommentaries: Taking a Standard Prostate Cancer Drug with Food Boosts Impact, Lowers Cost – University of Chicago Medical Center, via NewsWise (free) AND Low-Dose Prostate Drug Can Match Standard Dose, Cut Costs – Medscape (free registration required)
Related: Tackling the High Cost of Cancer Care (free commentaries issued when this paper was first presented at the 2017 ASCO annual meeting)
“Savings per patient could reach as high as $300,000” (from NewsWise)
Perspective: Three Steps Toward a More Sustainable Path for Targeted Cancer Drugs
20 Apr, 2018 | 01:39h | UTCThree Steps Toward a More Sustainable Path for Targeted Cancer Drugs – JAMA (free for a limited period)
Viewpoint: Another Nail in the Coffin for Fish Oil Supplements
20 Apr, 2018 | 01:36h | UTCAnother Nail in the Coffin for Fish Oil Supplements – JAMA (free for a limited period)
Systematic Review: First-line Drugs for Hypertension
20 Apr, 2018 | 01:34h | UTCFirst-line drugs for hypertension – Cochrane Library (free)
Summary: Thiazides best first choice for hypertension – Cochrane Library (free)
“First-line low-dose thiazides reduced all morbidity and mortality outcomes in adult patients with moderate to severe primary hypertension. First-line ACE inhibitors and calcium channel blockers may be similarly effective, but the evidence was of lower quality”.
Medication Errors 2018: The Year in Review
20 Apr, 2018 | 00:56h | UTCMedication Errors 2018: The Year in Review – Pharmacy Practice News (free)
Cohort Study: Racial/Ethnic Variation and Risk Factors for Allopurinol-Associated Severe Cutaneous Adverse Reactions
20 Apr, 2018 | 00:52h | UTCCommentaries: Ethnicity Matters in Allopurinol Reactions – MedPage Today (free registration required) AND Allopurinol: Extra Caution Urged in High-Risk Groups – Medscape (free registration required)
Systematic Review: Lorazepam Confirmed as First-line Treatment for Prolonged Seizures in Children
20 Apr, 2018 | 00:55h | UTCOriginal article: Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children – Cochrane Library (free)
Research: Estimation of The Percentage of Patients With Cancer Who Benefit From Genome-Driven Oncology
20 Apr, 2018 | 00:54h | UTCEstimation of The Percentage of US Patients With Cancer Who Benefit From Genome-Driven Oncology – JAMA Oncology (free for a limited period)
Meta-Analysis: Association Between Newer Antidiabetic Drug Classes and Mortality
18 Apr, 2018 | 00:56h | UTCMultimedia (2 minute video): Association Between Newer Antidiabetic Drug Classes and Mortality in Patients With Type 2 Diabetes (free)
Commentary: Diabetes drug may not reduce risk of death – Imperial College London (free)