Pharmacology/Pharmaceutical Industry
Randomized Controlled Trial: Tranexamic Acid for Hyperacute Primary Intracerebral Hemorrhage
18 May, 2018 | 02:36h | UTCEditorial: Haemostatic treatment for intracerebral haemorrhage (free)
Commentaries: Study: Drug to treat bleeding may reduce stroke deaths – UPI (free) AND Drug to treat bleeding may benefit some stroke patients, study finds – University of Nottingham, via EurekAlert (free)
Randomized Trial: Rivaroxaban Not Effective for Stroke Prevention after Embolic Stroke of Undetermined Source
18 May, 2018 | 02:38h | UTCCommentaries: NAVIGATE ESUS: Rivaroxaban Fails to Prevent More Recurrent Cryptogenic Strokes Than Aspirin – TCTMD (free) AND Rivaroxaban Not Superior to Aspirin for Patients with Embolic Stroke of Unknown Source – NEJM Physician’s First Watch (free)
Consensus: Adverse Effects of Statin Therapy
18 May, 2018 | 02:34h | UTCCommentary: EAS Consensus Document Examines Safety of Statins Beyond Muscle Symptoms – TCTMD (free)
Clinical Guideline: Pharmacotherapy for Neuropathic Pain
18 May, 2018 | 02:33h | UTC
Meta-Analysis: Cancer Immunotherapy Efficacy Influenced by Patient’s Sex
18 May, 2018 | 02:29h | UTCCancer immunotherapy efficacy and patients’ sex: a systematic review and meta-analysis – The Lancet Oncology (link to abstract – $ for full-text)
Commentaries: Patient’s sex might affect immunotherapy outcomes – OnMedica (free) AND Men Do Better than Women on Cancer Immunotherapies – MedPage Today (free registration required) AND Patients’ sex may impact efficacy of immunotherapy in cancer treatment – eCancer News (free)
Randomized Trial: Intravesical Gemcitabine Following Resection of Suspected Low-Grade Non–Muscle-Invasive Bladder Cancer
16 May, 2018 | 01:16h | UTCEffect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non–Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Intravesical Gemcitabine Therapy Cuts Bladder Cancer Recurrence – MPR (free) AND Simple post-surgery step reduces bladder cancer recurrence – SWOG, via EurekAlert (free)
News Story: Experimental Vaccine to be Used Against New Ebola Outbreak in the DRC
16 May, 2018 | 01:11h | UTCExperimental vaccine to be used against Ebola outbreak in the DRC – STAT (free)
Related: WHO to send vaccines to fight new Ebola outbreak – NBC News (free) AND The New Ebola Outbreak Could Take ‘Three, Maybe Four’ Months to Control – The Atlantic (free)
See also: WHO News: Ebola Outbreak Declared in Democratic Republic of the Congo (free news release and commentaries)
Guideline: Deprescribing Benzodiazepines
16 May, 2018 | 01:01h | UTCDeprescribing benzodiazepine receptor agonists – Canadian Family Physician (free) (via @Deprescribing)
Related: CaDeN Deprescribing Guidelines and Algorithms (free) AND 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)
Case Control Study: Oral Antibiotic Exposure and Kidney Stone Disease
16 May, 2018 | 00:56h | UTCOral Antibiotic Exposure and Kidney Stone Disease – Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentaries: Study suggests oral antibiotics may increase kidney stone risk – CIDRAP (free) AND Antibiotics May Raise the Risk for Kidney Stones – The New York Times (free) AND Oral Antibiotics May Raise Risk of Kidney Stones – Children’s Hospital of Philadelphia, via NewsWise (free)
Systematic Review: Adverse Events of Methylphenidate for ADHD in Children and Adolescents
16 May, 2018 | 00:52h | UTCMethylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of adverse events in non-randomised studies – Cochrane Library (link to abstract – $ for full-text)
“Our findings suggest that methylphenidate may be associated with a number of serious adverse events as well as a large number of non-serious adverse events in children and adolescents, which often lead to withdrawal of methylphenidate”.
Meta-Analysis: Domperidone for Increasing Breast Milk in Mothers of Premature Babies
16 May, 2018 | 00:37h | UTCDomperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants: a systematic review and meta‐analysis – BJOG (link to abstract – $ for full-text)
Commentaries: Domperidone increases breast milk production in mothers of premature babies – NIHR Signals (free) AND Domperidone can boost breast milk supply – here’s what you need know – The Conversation (free) AND Domperidone tied to modest increase in breast milk supply – MedicalXpress (free)
EULAR Recommendations: Pain Management in Inflammatory Arthritis and Osteoarthritis
11 May, 2018 | 02:58h | UTCCommentary: EULAR Releases Recommendations for Pain Management in OA, Inflammatory Arthritis – Rheumatology Advisor (free)
AUA Guideline: Erectile Dysfunction
11 May, 2018 | 02:56h | UTCErectile Dysfunction – American Urology Association (2018) (free)
Systematic Review: Prophylactic Vaccination Against HPV to Prevent Cervical Cancer
10 May, 2018 | 17:56h | UTCProphylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors – Cochrane Library (link to abstract and summary – $ for full-text)
News Release: Does HPV vaccination prevent the development of cervical cancer? Are there harms associated with being vaccinated? – Cochrane Library (free)
Scientific Expert Reaction: Cochrane Review on HPV vaccine for cervical cancer prevention in girls and women – Cochrane Library (free)
Commentary: Major review backs cervical cancer shots, especially for teens – Reuters (free)
Canadian Guideline: Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children
10 May, 2018 | 17:47h | UTC
Randomized Controlled Trial: Folic Acid for Stroke Prevention in High-Risk Hypertensive Patients
10 May, 2018 | 17:40h | UTCPlatelet Count Affects Efficacy of Folic Acid in Preventing First Stroke – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Folic acid ‘may help reduce stroke risk in people with high blood pressure’ – NHS Choices (free) AND Folic Acid Supplements May Reduce Stroke Risk in Hypertensive Patients – American College of Cardiology (free) AND Folic Acid Cut Strokes in Hypertensive Patients on Enalapril – MedPage Today (free registration required) AND Folic acid supplementation may help prevent first stroke in high-risk patients with hypertension – ACP Internist (free)
Case Series: Uveal Effusion After Immune Checkpoint Inhibitors
9 May, 2018 | 16:24h | UTCUveal Effusion After Immune Checkpoint Inhibitor Therapy – JAMA Ophthalmology (link to abstract – $ for full-text)
Commentary: Ophthalmologists link immunotherapy with a serious eye condition – eCancer News (free)
Guideline: Use of Hydroxycarbamide in Patients with Sickle Cell Disease
9 May, 2018 | 16:19h | UTC
Randomized Controlled Trial: Emollient Bath Additives for the Treatment of Childhood Eczema
4 May, 2018 | 02:07h | UTCEditorial: New evidence challenges use of bath emollients for children with eczema (free)
Commentary: Trial finds no benefit of bath emollients beyond standard eczema care for children – The BMJ, via ScienceDaily (free) AND Bath oils for childhood eczema provide ‘no clinical benefit’ – NHS Choices (free)
Meta-Analysis: Direct Oral Anticoagulant vs Low-Molecular-Weight Heparin in Cancer Associated Thrombosis
4 May, 2018 | 01:59h | UTCSource: EvidenceAlerts
Randomized Controlled Trial: Glyburide vs Insulin for the Treatment of Gestational Diabetes
3 May, 2018 | 20:04h | UTCEffect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Glyburide Should Not Be First-Line for Gestational Diabetes – Medscape (free registration required) AND Glyburide Compared With Insulin for First-Line Tx of Gestational Diabetes – MPR (free)
Randomized Controlled Trial: Tenecteplase vs Alteplase before Thrombectomy for Ischemic Stroke
3 May, 2018 | 19:52h | UTCTenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Stroke: Which Clot Buster Drug Works Best? – MedicalResearch.com (free) AND Tenecteplase Appears Superior to Alteplase After Ischemic Stroke – Cardiology Advisor (free)
Viewpoint: Value-Based Pricing for Drugs
3 May, 2018 | 19:32h | UTCValue-Based Pricing for Drugs: Theme and Variations – JAMA (free for a limited period)
Polypharmacy Guidance, Realistic Prescribing
27 Apr, 2018 | 02:58h | UTCPolypharmacy Guidance, Realistic Prescribing 3 rd Edition, 2018 – Scottish Government Polypharmacy Model of Care Group (free PDF) (via @trishgreenhalgh)
Related Reviews: Current and future perspectives on the management of polypharmacy – BMC Family Medicine (free) AND Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety (free) AND Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international (free) AND Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety (free)
Guideline: Pharmacologic Glycemic Management of Type 2 Diabetes in Adults
27 Apr, 2018 | 02:59h | UTCGuideline: Pharmacologic Glycemic Management of Type 2 Diabetes in Adults – Canadian Journal of Diabetes (free)
Related Guidelines: ADA 2018 Standards of Medical Care in Diabetes (free) AND ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes (free)
In this new guideline Hemoglobin A1c Targets are similar from ADA 2018 Standards.