Pharmacology/Pharmaceutical Industry
Cohort Study: Metformin Safe for Many Patients with Chronic Kidney Disease
7 Jun, 2018 | 02:49h | UTCAssociation of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Study Supports Metformin Use at eGFRs as Low as 30 – NEJM Physician’s First Watch (free) AND Metformin safe for most diabetics with kidney disease – UPI (free) AND Evidence Growing Metformin Safe in Many With Diabetes and CKD – Medscape (free registration required)
Related Studies: Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease (link to abstract and commentaries) AND Metformin is linked to reduced mortality in type 2 diabetes with comorbid CKD and CHF – ACP Diabetes Monthly (free)
Short Review: Stimulants for ADHD in children
7 Jun, 2018 | 02:50h | UTCStimulants for ADHD in children: Revisited – Therapeutics Initiative (via @AllenFrancesMD)
“There is convincing evidence that a proportion of boys and girls treated with stimulants in BC and around the world are simply the youngest in their class”
ASCO 2018: Many Women with Early-Stage Breast Cancer Can Forgo Chemotherapy When Guided by a 21-Gene Expression Assay
7 Jun, 2018 | 02:23h | UTCCommentaries: 2018 ASCO: TAILORx: Most Women With Early-Stage Breast Cancer Can Forgo Chemotherapy When Guided by a Diagnostic Test – The ASCO Post (free) AND Many breast cancer patients can skip chemo, big study finds – STAT (free) AND Many women with early-stage breast cancer can skip chemotherapy: study – Reuters (free) AND For Some Breast Cancer Patients, The Chemo Decision Just Got Easier – NPR (free) AND Breast cancer: Test means fewer women will need chemotherapy – BBC (free) AND Good News for Women With Breast Cancer: Many Don’t Need Chemo – The New York Times (10 articles per month are free)
Research: Affordability and Price Increases of New Cancer Drugs in Clinical Guidelines
7 Jun, 2018 | 02:18h | UTCAffordability and Price Increases of New Cancer Drugs in Clinical Guidelines, 2007–2016 – Cancer Spectrum (free) (via @oncology_bg see Tweet)
Case-Control Study: Possible Association of Hydrochlorothiazide Use and Risk of Melanoma
6 Jun, 2018 | 21:53h | UTCAssociation of Hydrochlorothiazide Use and Risk of Malignant Melanoma – JAMA Internal Medicine (free)
Commentaries: Hydrochlorothiazide Associated with Melanoma Risk – NEJM Physician’s First Watch (free) AND Hydrochlorothiazide Tied to Increased Melanoma Risk – MedPage Today (free registration required)
This observational data suggests a possible association. Needs to be confirmed by other studies.
ASCO 2018: Matching Treatment to Genetic Changes in the Tumor Improves Survival Across Multiple Cancer Types
6 Jun, 2018 | 21:31h | UTC
Research: Venous Thromboembolism Prophylaxis Overused in Hospitalized Patients
6 Jun, 2018 | 21:25h | UTCUse of Venous Thromboembolism Prophylaxis in Hospitalized Patients – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentary: Study: Hospitals Overuse VTE Prophylaxis – MedPage Today (free registration required) AND Excess venous thromboembolism prophylaxis common among low-, high-risk patients – Healio (free registration required) AND Venous Thromboembolism Prophylaxis Over & Underutilized in Some Hospitalized Patients – MedicalResearch.com (free)
Meta-Analysis: Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality
1 Jun, 2018 | 03:51h | UTCEditorial: Prenatal Vitamin D Supplementation to Improve Health in Offspring (free)
Commentary: Vitamin D Supplementation of Moms Linked to Better Outcomes for Newborns – Physician’s First Watch (free)
Review: Supplements Not Effective for CVD Prevention and Treatment
29 May, 2018 | 20:15h | UTCSupplemental Vitamins and Minerals for CVD Prevention and Treatment – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Most vitamin, mineral supplements not shown to lower heart disease risk – American College of Cardiology, via ScienceDaily (free) AND Aside From Folate, Vitamins Appear Largely Ineffective For Prevention, Study Finds – Forbes (free) AND Most popular vitamin and mineral supplements provide no health benefit, study finds – St. Michael’s Hospital, via EurekAlert (free)
Review: Clinical Pharmacology of Oral Anticoagulants in Patients with Kidney Disease
29 May, 2018 | 18:39h | UTC
Randomized Trial: New Treatment for Prevention of Episodic Migraine Assessed
29 May, 2018 | 18:30h | UTCEffect of Fremanezumab Compared With Placebo for Prevention of Episodic Migraine: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Fremanezumab effective in preventing episodic migraine – 2 Minute Medicine (free)
“Among patients with episodic migraine in whom multiple medication classes had not previously failed, subcutaneous fremanezumab, compared with placebo, resulted in a statistically significant 1.3- to 1.5-day reduction in the mean number of monthly migraine days over a 12-week period”. (from JAMA)
“The small effect size in terms of reduction in number of days with migraine dampens enthusiasm for this medication, though without head-to-head comparison against other prophylactics, this is hard to assess” (from 2 Minute Medicine)
New Therapy Assessed for Children with X-Linked Hypophosphatemia
29 May, 2018 | 18:27h | UTCBurosumab Therapy in Children with X-Linked Hypophosphatemia – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Burosumab for X-Linked Hypophosphatemia (free)
Meta-Analysis: Pharmacological Therapies for the Treatment of Opioid-induced Constipation
29 May, 2018 | 17:50h | UTCEfficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis – Gut (link to abstract – $ for full-text)
Commentary: Naloxone, naldemedine appear best for opioid-induced constipation after laxatives – ACP Gastroenterology (free)
IDSA & AASLD Hepatitis C Guidance Updates
28 May, 2018 | 12:56h | UTCNews Release: HCV Guidance Updates Recommendations for Screening and Treating Key Populations (free)
Related Guideline: EASL Recommendations on Treatment of Hepatitis C 2018 – Journal of Hepatology (free)
Cohort Study: Weight Gain with Antidepressant Utilization
28 May, 2018 | 12:38h | UTCEditorial: Antidepressant induced weight gain (free)
Commentaries: Antidepressant therapy and risk of weight gain – The BMJ Opinion (free) AND Taking antidepressants could be linked to weight gain, according to a new study — and some drugs heighten the risk more than others – Business Insider (free) AND Antidepressants linked to risk of weight gain, study shows – OnMedica (free) AND Antidepressant use linked with weight gain – NHS Choices (free)
Cohort Study: Incidence and Cost of Medication Harm in Older Adults Following Hospital Discharge
24 May, 2018 | 23:35h | UTCCommentaries: Medication-related harm is common in older adults after hospital discharge – OnMedica (free) AND Medication-related harm found to be common among older adults, but preventable – News Medical (free)
Review: Pitfalls on the Replacement Therapy for Hypothyroidism
24 May, 2018 | 23:13h | UTC
Randomized Controlled Trial: Dupilumab in Glucocorticoid-Dependent Severe Asthma
23 May, 2018 | 12:39h | UTCRelated Article: Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma – New England Journal of Medicine (free)
Editorial: New Biologics for Asthma (free)
Commentary: Dupilumab Improves Severe Asthma – NEJM Physician’s First Watch (free)
Meta-Analysis: Aldosterone Antagonists for ST-Segment Elevation Myocardial Infarction Without Heart Failure
23 May, 2018 | 12:28h | UTCAldosterone Antagonist Therapy and Mortality in Patients With ST-Segment Elevation Myocardial Infarction Without Heart Failure: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Invited Commentary: Mineralocorticoid Receptor Antagonists in ST-Segment Elevation Myocardial Infarction – JAMA Internal Medicine (free for a limited period)
Aldosterone antagonists are beneficial for patients with STEMI and reduced ejection fraction. This meta-analysis suggests that patients with STEMI and LVEF greater than 40% or without heart failure also have improved outcomes with aldosterone antagonists.
Randomized Trial: Cannabidiol Reduces Seizures in Patients with Lennox–Gastaut Syndrome
23 May, 2018 | 12:22h | UTCEffect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Cannabidiol significantly reduces seizures in patients with severe form of epilepsy – NYU School of Medicine (free) AND Cannabis Drug Reduces Drop Seizures in Severe Epilepsy – Medscape (free registration required) AND Cannabidiol Significantly Reduces Seizures in Patients with Lennox-Gastaut Syndrome – MD Magazine (free)
Register-based Retrospective Study: Pediatric Exposures to ADHD Medications are an Increasing Problem
23 May, 2018 | 12:15h | UTCPediatric ADHD Medication Exposures Reported to US Poison Control Centers – Pediatrics (link to abstract – $ for full-text)
Commentaries: Unnecessary and accidental use of ADHD drugs increases over 60%, study suggests – CNN (free) AND Add ADHD Meds To Call Burden For Poison Control Centers – American Council on Science and Health (free) AND As ADHD Diagnoses Increased, So Did Calls to Poison Control – U.S. News (free) AND More U.S. kids overdosing on ADHD drugs – Reuters (free)
Randomized Controlled Trial: Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes
23 May, 2018 | 12:13h | UTCCanakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Autoinflammatory Syndromes Show Dramatic Response to Canakinumab – RheumNow (free)
Meta-Analysis: Dose Increase vs. Unchanged Continuation of Antidepressants After Initial Treatment Failure
21 May, 2018 | 13:11h | UTCDose Increase Versus Unchanged Continuation of Antidepressants After Initial Antidepressant Treatment Failure in Patients With Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized, Double-Blind Trials – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)
Commentary: Depression: boosting SSRIs doesn’t work – Univadis (free registration required)
“Meta-analysis: there is evidence from RCTs against increasing the dose of SSRIs (with the possible exception of citalopram) in adult patients with major depression and antidepressant treatment failure” (via @psychopharmacol see Tweet)
Review: Pitfalls on the Replacement Therapy for Hypothyroidism
21 May, 2018 | 13:03h | UTC
Randomized Trial: Shortening Adjuvant Trastuzumab to 6 Months in Selected Patients with Breast Cancer
18 May, 2018 | 02:44h | UTCASCO 2018: Shortening Adjuvant Trastuzumab to 6 Months in Patients With HER2-Positive Early Breast Cancer Is Effective and Reduces Cardiac Toxicities – The ASCO Post (free)
Commentaries: Test of Herceptin Finds Briefer Treatment Can Work, With Fewer Side Effects – NPR (free) AND Shorter drug treatment OK for many breast cancer patients – Associated Press (free) AND For Women With Early Breast Cancer, Herceptin Treatment Can Be Much Shorter – The New York Times (10 articles per month are free)
““For women with early-stage breast cancer who needed the drug Herceptin, 6 months of treatment were as good as 12, a major study found. Less risk of side effects, less cost, less time “being a patient.”” (via @NYTHealth see Tweet)