Pharmacology/Pharmaceutical Industry
Case-Control Study: Metformin Exposure in First Trimester of Pregnancy and Congenital Anomalies
6 Jul, 2018 | 09:28h | UTCIn this large international, population-based database, no evidence was found of an overall increased risk of congenital anomalies after first trimester metformin exposure.
Randomized Trial: Heat-Stable Carbetocin vs Oxytocin to Prevent Hemorrhage after Vaginal Birth
29 Jun, 2018 | 03:08h | UTCCommentaries: Heat-stable drug could save thousands from post-childbirth bleeding: WHO – Reuters (free) AND Saving Moms’ Lives During Childbirth Just Got Easier – NPR (free)
Review: Deprescribing Proton Pump Inhibitors
29 Jun, 2018 | 02:41h | UTCDeprescribing Proton Pump Inhibitors – Therapeutics Initiative (free)
Related guidelines: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing antihyperglycemic agents in older persons: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free)
Retrospective Observational Study: Basal Insulin Analogs vs NPH Insulin for Type 2 Diabetes
24 Jun, 2018 | 19:27h | UTCAssociation of Initiation of Basal Insulin Analogs vs Neutral Protamine Hagedorn Insulin With Hypoglycemia-Related Emergency Department Visits or Hospital Admissions and With Glycemic Control in Patients With Type 2 Diabetes – JAMA (free for a limited period)
Editorial: Revisiting NPH Insulin for Type 2 Diabetes: Is a Step Back the Path Forward? (free for a limited period)
Clinical Review Audio: Health Care Spending Gone Wild: Using Expensive Insulin Analogs With Few Clinical Advantages (free)
“Long-acting insulin analogs not associated with reduced hypoglycemia-related ED visits or hospital admissions when compared with NPH insulin, despite costing 5-10x as much” (via @jsross119 see Tweet)
Randomized Trial: Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss
22 Jun, 2018 | 02:49h | UTCSodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Sodium Thiosulfate for Cisplatin-Induced Hearing Loss (free)
Commentaries: New drug halves hearing loss in children following cancer treatment – Cancer Research UK, via ScienceDaily (free) AND Otoprotectant Guards Against Cisplatin-Induced Hearing Loss – Medscape (free registration required) AND Antioxidant Cuts Hearing Loss in Cisplatin-Treated Kids – MedPage Today (free registration required)
EULAR 2018: NSAIDs Account for Large Part of Osteoarthritis-CVD Link
22 Jun, 2018 | 02:50h | UTCNSAIDs Account for Large Part of Osteoarthritis-CVD Link, Study Suggests – TCTMD (free)
Pharmacoepidemiological Study: Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms
22 Jun, 2018 | 02:28h | UTCAssociation of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study – Journal of Clinical Psychopharmacology (link to abstract – $ for full-text)
Commentaries: Incidence of Extrapyramidal Symptoms Higher With Certain Antidepressants – MPR (free) AND Antidepressants tied to Parkinson’s-like symptoms – Univadis (free registration required)
“Observational study: Incidence of EPSs with antidepressants. RRs: duloxetine, 5.68; mirtazapine, 3.78; citalopram, 3.47; escitalopram, 3.23; paroxetine, 3.07; sertraline, 2.57; venlafaxine, 2.37; bupropion, 2.31; and fluoxetine, 2.03 (all significant)” (via @psychopharmacol see Tweet)
Guideline: Intravenous Ketamine Infusions for Acute Pain Management
22 Jun, 2018 | 01:53h | UTCCommentaries: Johns Hopkins Expert Available to Comment on New Ketamine Guidelines For Chronic and Acute Pain Management – Johns Hopkins Medicine, via NewsWise (free) AND First-Ever Ketamine Guidelines for Acute Pain Management Released – Medscape (free registration required)
Observational Study: Treatments for Acute Agitation in the Emergency Department Compared
22 Jun, 2018 | 01:52h | UTCIntramuscular Midazolam, Olanzapine, Ziprasidone, or Haloperidol for Treating Acute Agitation in the Emergency Department – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentary: Agitation in ED: a comparative study of fast-acting sedatives – Univadis (free)
Randomized Trial: Metabolic Effects of Antipsychotics on Adiposity and Insulin Sensitivity in Youths
18 Jun, 2018 | 22:59h | UTCMetabolic Effects of Antipsychotics on Adiposity and Insulin Sensitivity in Youths: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Study First to Show Antipsychotic Medication Use in Youths Increases Diabetes Risk, Body Fat – Florida Atlantic University, via NewsWise (free) AND Rapid Weight Gain, Decreased Insulin Sensitivity Found in Youth Taking SGAs for First Time – Psychiatric News Alert (free) AND Kids on Antipsychotics May See Adverse Metabolic Effects – MedPage Today (free registration required)
Randomized Trial: Duloxetine in Patients with Knee Osteoarthritis
18 Jun, 2018 | 10:08h | UTC
Guideline: Efficacy and Tolerability of the New Antiepileptic Drugs
18 Jun, 2018 | 00:21h | UTCPractice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs – American Academy of Neurology and the American Epilepsy Society
Part I: Treatment of new-onset epilepsy (free PDF)
Part II: Treatment-resistant epilepsy (free PDF)
Commentary: New Epilepsy Guidelines Shed Light on Explosion of New Drugs – MedPage Today (free registration required)
Review: Optimal Duration of Dual Antiplatelet Therapy for Coronary Artery Disease
15 Jun, 2018 | 02:24h | UTCRelated Guidelines: 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy (free) AND 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease (free)
Cohort Study: Antifungal Drug in Pregnancy Not Associated with Increased Risk of Stillbirth and Neonatal Death
15 Jun, 2018 | 02:21h | UTCOral Fluconazole in Pregnancy and Risk of Stillbirth and Neonatal Death – JAMA (link to abstract – $ for full-text)
Commentaries: No link found between oral antifungal drug and stillbirth – Karolinska Institutet, via ScienceDaily (free) AND Antifungal Use During Pregnancy and Risk of Stillbirth: What’s the Link? – MPR (free) AND Study Finds No Link Between Fluconazole During Pregnancy and Stillbirth or Neonatal Death – MedicalResearch.com (free) AND Oral Fluconazole for Thrush in Pregnancy Doesn’t Up Stillbirth – Medscape (free registration required)
Cross-Sectional Survey: Prevalence of US Adults Using Medications with Depression as a Potential Adverse Effect was 37.2%
15 Jun, 2018 | 02:11h | UTCPrevalence of Prescription Medications With Depression as a Potential Adverse Effect Among Adults in the United States – JAMA (link to abstract – $ for full-text)
Commentaries: One-Third of US Adults May Unknowingly Use Medications That Can Cause Depression – University of Illinois at Chicago, via EurekAlert (free) AND Many U.S. adults take medicines that can cause depression – Reuters (free) AND Rx With Depression as Potential Adverse Effect Widely Used – Medscape (free registration required)
Clinical Update: Antithrombotic Therapy for Peripheral Artery Disease in 2018
15 Jun, 2018 | 02:10h | UTCAntithrombotic Therapy for Peripheral Artery Disease in 2018 – JAMA (free for a limited period)
Review: Antiepileptic Drugs in Critically Ill Patients
15 Jun, 2018 | 02:05h | UTCAntiepileptic drugs in critically ill patients – Critical Care (free)
Randomized Trial: Bezafibrate in Primary Biliary Cholangitis
15 Jun, 2018 | 01:55h | UTCA Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: A Trial of Bezafibrate in Primary Biliary Cholangitis – NEJM Resident 360 (free) AND Bezafibrate Normalizes Liver Enzymes in PBC – MedPage Today (free registration required)
“In a randomized trial of patients with primary biliary cholangitis, bezafibrate and ursodeoxycholic acid resulted in a higher rate of complete biochemical response than ursodeoxycholic acid alone” (via @NEJM see Tweet with visual abstract)
Hydroxychloroquine: An Old Drug with New Relevance
15 Jun, 2018 | 01:50h | UTCHydroxychloroquine: An old drug with new relevance – Cleveland Clinic Journal of Medicine (free)
Source: Hospital Medicine Virtual Journal Club
Retrospective Cohort: Ambulatory Medication Reconciliation and Frequency of Hospitalizations and Emergency Department Visits in Patients With Diabetes
15 Jun, 2018 | 01:03h | UTCAmbulatory Medication Reconciliation and Frequency of Hospitalizations and Emergency Department Visits in Patients With Diabetes – Diabetes Care (link to abstract – $ for full-text)
Commentary: Double-checking diabetes medications may reduce re-hospitalizations – Brigham and Women’s Hospital, via EurekAlert (free)
Expert Consensus: Management of Adverse Effects of Antiplatelet Therapy for Acute Coronary Syndrome
7 Jun, 2018 | 23:33h | UTC
Randomized Trial: Aspirin Starting Five Days After Hip or Knee Arthroplasty for VTE Prophylaxis
7 Jun, 2018 | 23:29h | UTCSee Original Article: Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty – New England Journal of Medicine (link to abstract – $ for full-text) AND Quick Take Video Summary: Preventing VTE after Hip or Knee Arthroplasty (free)
Systematic Review: Nicotine Replacement Therapy vs Control for Smoking Cessation
7 Jun, 2018 | 02:55h | UTCNicotine replacement therapy versus control for smoking cessation – Cochrane Library (free)
Summary: Can nicotine replacement therapy (NRT) help people quit smoking? – Cochrane Library (free)
Systematic Review: Interventions for Preventing Upper GI bleeding in the ICU
7 Jun, 2018 | 02:56h | UTCInterventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units – Cochrane Library (link to abstract – $ for full-text)
Summary: Interventions for preventing upper gastrointestinal bleeding in people on intensive care units – Cochrane Library (free)
Related Observational Study: H2 blockers prevented clinically important GI bleeding better than PPIs in ICU patients – ACP Hospitalist (free)
Randomized Trial Continuous Low-dose Antibiotic Prophylaxis to Prevent UTI in Adults who Perform Clean Intermittent Self-catheterization
7 Jun, 2018 | 02:52h | UTC“The results of this large randomised trial, conducted in accordance with best practice, demonstrate clear benefit for antibiotic prophylaxis in terms of reducing the frequency of UTI for people carrying out CISC”.