Pharmacology/Pharmaceutical Industry
Randomized Trial: Glutamine to Treat Sickle Cell Disease
20 Jul, 2018 | 03:29h | UTCA Phase 3 Trial of l-Glutamine in Sickle Cell Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Glutamine to Treat Sickle Cell Disease (free)
Commentaries: Drug may ease pain, lessen hospitalization from sickle cell disease – UPI (free)
Clinical Evidence Synopsis: Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics
20 Jul, 2018 | 03:23h | UTCProbiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics – JAMA (free for a limited period)
Original Article: Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children – Cochrane Library (link to abstract – $ for full-text) AND Summary: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use (free)
Related Meta-Analysis: Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection (free)
Study: Clinical Trial Evidence Supporting FDA Approval of Drugs Granted Breakthrough Therapy Designation
20 Jul, 2018 | 02:50h | UTCClinical Trial Evidence Supporting FDA Approval of Drugs Granted Breakthrough Therapy Designation – JAMA (link to abstract – $ for full-text)
Commentaries: Are ‘breakthrough’ drugs as safe as other FDA-approved medicines? – CNN (free) AND Evidence to support ‘breakthrough’ drugs often very limited: study – Reuters (free)
Position Statement: Reducing Inappropriate Medication Use & Polypharmacy
20 Jul, 2018 | 02:21h | UTCRelated: Polypharmacy Guidance, Realistic Prescribing 3 rd Edition, 2018 – Scottish Government Polypharmacy Model of Care Group (free PDF) AND The Challenge of Polypharmacy: From Rhetoric to Reality – Royal Pharmaceutical Society and Royal College of General Practitioners Partnership (free PDF) AND Common ED Medication Errors: Polypharmacy – emDocs (free) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free) AND The other big drug problem: Older people taking too many pills – The Whashington Post (free) AND Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety (free) AND Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international (free) AND Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety (free)Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND CaDeN Deprescribing Guidelines and Algorithms (free)
Meta-Analysis: Effects of Aspirin for CV Disease Prevention According to Bodyweight and Dose
20 Jul, 2018 | 02:20h | UTCCommentaries: Weight-adjusted aspirin for cardiovascular prevention – The Lancet (free) AND One dose of aspirin doesn’t fit all – University of Oxford (free)
Practice Changing Article. “Low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and had no benefit in the 80% of men and nearly 50% of all women weighing 70 kg or more. By contrast, higher doses of aspirin were only effective in patients weighing 70 kg or more.”
Study: Machine Learning of Toxicological Big Data May Outperforming Animal Tests
20 Jul, 2018 | 02:12h | UTCCommentaries: New digital chemical screening tool could help eliminate animal testing – Science (free) AND Database Analysis More Reliable Than Animal Testing For Toxic Chemicals – Johns Hopkins Bloomberg School of Public Health (free) AND Software beats animal tests at predicting toxicity of chemicals – Nature News (free)
Study: Bleeding Risk with Concomitant NSAIDs and Anticoagulants in Atrial Fibrillation
13 Jul, 2018 | 03:04h | UTCConcomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Bleeding Risk Increased With NSAID Use in Anticoagulated A-fib Patients: RE-LY Analysis – TCTMD (free) AND NSAID, anticoagulant combo ups risk for bleeding events in AFib patients – Cardiovascular Business (free) Concomitant NSAIDs and Anticoagulants in Atrial Fibrillation – American College of Cardiology (free)
Study: The Right Diet Can Boost Potency of Cancer Drugs (in mice)
13 Jul, 2018 | 03:02h | UTCThe right diet can boost potency of cancer drugs – Nature News (free)
Original article: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors – Nature (link to abstract – $ for full-text)
Related: Top oncologist to study effect of diet on cancer drugs – The Guardian (free)
“Diets appear to matter in mouse cancer Rx – can these preclinical findings be translated to humans?” (via @Aiims1742 see Tweet)
Systematic Review: Anticoagulation for Perioperative Thromboprophylaxis in People with Cancer
13 Jul, 2018 | 02:59h | UTCAnticoagulation for perioperative thromboprophylaxis in people with cancer – Cochrane Library (free)
Summary: Blood thinners for the prevention of blood clots in people with cancer undergoing surgery – Cochrane Library (free)
FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions
13 Jul, 2018 | 02:50h | UTCNews Release: FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions – U.S. Food and Drug Administration (free)
Commentaries: FDA Strengthens Warnings for Fluoroquinolone Antibiotics – MPR (free) AND FDA Announces Labeling Changes for Fluoroquinolones Due to Mental Health AEs, Blood Sugar Disturbances – MD Magazine (free)
Perspective: Fractional-Dose Yellow Fever Vaccination
13 Jul, 2018 | 02:52h | UTCRelated Research: Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Preliminary Report – The New England Journal of Medicine (free)
Meta-Analysis: Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes
13 Jul, 2018 | 02:46h | UTCComparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Newer, older insulin formulations may offer similar glucose-lowering effects – ACP Internist (free) AND HbA1c Reduction Similar in Old, New Basal Insulin Analogues – MedPage Today (free registration required)
Meta-Analysis: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality
13 Jul, 2018 | 02:47h | UTCAssociation of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free for a limited period)
Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)
Commentaries: Study: Multivitamins Do Not Prevent Strokes, Heart Attacks or Cardiovascular Disease Deaths – University of Alabama at Birmingham, via NewsWise (free) AND Multivitamin-mineral supplements do not reduce heart disease, deaths – Reuters (free)
Related: Supplements Not Effective for CVD Prevention and Treatment (link to abstract and commentaries) AND Multivitamins are probably a waste of money (free commentaries)
NICE Draft Guidance: Antibiotics Should be Restricted for COPD
13 Jul, 2018 | 02:36h | UTCAntibiotics should be restricted for COPD – National Institute for Health and Care Excellence (free)
Commentaries: Antibiotics should be restricted for COPD, says NICE – OnMedica (free) AND UK officials recommend limits on antibiotics for COPD – CIDRAP (free)
“The draft antimicrobial guidance recommends that antibiotics should be offered to people who have a severe flare up of symptoms, also known as a severe acute exacerbation”
Clinical Update: Long-acting Reversible Contraception
13 Jul, 2018 | 02:27h | UTCLong-acting Reversible Contraception—Highly Efficacious, Safe, and Underutilized – JAMA (free for a limited period)
Clinical Review Audio: Return of the IUD: Long-acting Reversible Contraception Is Safe and Effective (free)
Meta-Analysis: Risk of Weight Gain for Specific Antipsychotic Drugs
13 Jul, 2018 | 01:34h | UTCRisk of weight gain for specific antipsychotic drugs: a meta-analysis – npj Schizophrenia (free)
Related Study: Cohort Study: Weight Gain with Antidepressant Utilization (free research and commentaries)
Review: New Drugs and Regimens for Tuberculosis
13 Jul, 2018 | 01:22h | UTCNew drugs and regimens for tuberculosis – Respirology (free)
Source: Critical Care Reviews Newsletter
Cohort Study: Direct Oral Anticoagulants vs Warfarin
6 Jul, 2018 | 09:49h | UTCCommentary: Analysis Finds Less Bleeding — But Potentially Greater Mortality Risk — with Some Newer Anticoagulants – NEJM Physician’s First Watch (free)
Study: Species-Specific Activity of Antibacterial Drug Combinations
6 Jul, 2018 | 09:48h | UTCSpecies-specific activity of antibacterial drug combinations – Nature (link to abstract – $ for full-text)
Commentaries: Study: For antibiotics, good things may come in pairs – CIDRAP (free) AND Combining antibiotics alters effectiveness, study says – UPI (free) AND As drug resistance grows, combining antibiotics could turn up new treatments – STAT (free)
Review: Treatment of Angina
6 Jul, 2018 | 09:42h | UTCTreatment of Angina: Where Are We? – Cardiology (free)
Source: Critical Care Reviews Newsletter
Meta-Analysis: Anticonvulsants in the Treatment of Low Back Pain and Lumbar Radicular Pain
6 Jul, 2018 | 09:37h | UTCCommentaries: Class of drugs used as alternative to opioids for back pain are ineffective, have potentially serious side effects: report – The Globe and Mail (free) AND Anticonvulsant drugs ineffective for low back pain and can cause harm, despite increased prescribing – CMAJ, via EurekAlert (free)
Related Meta-Analysis: Benefits and safety of gabapentinoids in chronic low back pain (free research and commentaries)
Randomized Trial: Epinephrine vs Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction
6 Jul, 2018 | 09:35h | UTCEpinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Epinephrine vs. Norepinephrine for Cardiogenic Shock – American College of Cardiology (free) AND Norepinephrine Bests Epinephrine in Battle of the Vasopressors in Cardiogenic Shock – TCTMD (free)
Randomized Trial: Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer
6 Jul, 2018 | 09:34h | UTCEnzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Related Perspective: Metastasis-free Survival — A New End Point in Prostate Cancer Trials – New England Journal of Medicine (free)
Commentaries: Enzalutamide: Now Also for Earlier Use in Prostate Cancer? – Medscape (free registration required) AND Enzalutamide Improves Outcomes for Aggressive Prostate Cancer – MPR (free) AND Enzalutamide Postpones Metastasis for a Subset of High-Risk Patients With Prostate Cancer – Cancer Therapy Advisor (free)
Immunotherapy: Hype and Hope
6 Jul, 2018 | 09:32h | UTCEditorial: Immunotherapy: hype and hope – The Lancet Oncology (free) (via @OphiraG)
Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free) AND Hope and hype around cancer immunotherapy – CNN (free)
Meta-Analysis: Lithium Exposure in First Trimester Associated with Increased Risk of Birth Defects
6 Jul, 2018 | 09:29h | UTCMaternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies – The Lancet (link to abstract – $ for full-text)
Commentaries: Increased risk of birth defects in babies after first-trimester exposure to lithium – Mount Sinai School of Medicine, via ScienceDaily (free) AND Lithium in Pregnancy Tied to Infant Morbidity, Malformation Risk – Medscape (free)