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Pharmacology/Pharmaceutical Industry

Review: Probiotic Supplements Might Not be Universally-effective and Safe

13 Jan, 2019 | 15:59h | UTC

Probiotic supplements might not be universally-effective and safe: A review – Biomedicine & Pharmacotherapy (free)

 


Study: The Best Dose of Aspirin for Cardiovascular protection may Depend on Body Weight

10 Jan, 2019 | 00:14h | UTC

The best dose of aspirin for cardiovascular protection may depend on body weight – NIHR Signal (free)

Original Article: Effects of Aspirin for CV Disease Prevention According to Bodyweight and Dose (free study and commentaries)

 


Randomized Trial: Temporarily Quadrupling the Dose of Inhaled Steroid to Prevent Asthma Exacerbations

10 Jan, 2019 | 00:07h | UTC

Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST – Health Technology Assessment (free)

 

Related Commentary on Twitter

 


Proton Pump Inhibitors: Review of Reported Risks and Controversies

9 Jan, 2019 | 16:40h | UTC

Proton pump inhibitors: Review of reported risks and controversies – Laryngoscope Investigative Otolaryngology (free)

Related: Proton Pump Inhibitors: Review of Emerging Concerns (free reviews) AND Deprescribing Proton Pump Inhibitors (free guidelines and reviews)

 


Systematic Review: Vitamin and Mineral Supplementation for Maintaining Cognitive Function Mid and Late Life

8 Jan, 2019 | 20:12h | UTC

Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life – Cochrane Library (free)

Summary: Vitamin and mineral supplementation for preventing cognitive deterioration in cognitively healthy people in mid and late life – Cochrane Library (free)

Commentary: Preventing dementia: do vitamin and mineral supplements have a role? – Evidently Cochrane (free)

 

Related Commentary on Twitter

 


Cohort Study: Prenatal Exposure to Anticonvulsivant and Risk for ADHD in Offspring

8 Jan, 2019 | 19:53h | UTC

Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring – JAMA Network Open (free)

Invited Commentary: Fetal Valproate Exposure and Attention-Deficit/Hyperactivity Disorder (free)

 


FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones

7 Jan, 2019 | 21:26h | UTC

FDA warns about increased risk of ruptures or tears in the aorta blood vessel with fluoroquinolone antibiotics in certain patients – U.S. Food & Drug Administration (free)

Commentary: FDA: Fluoroquinolones may cause aortic rupture in some – CIDRAP (free)

Related: Meta-analysis: Fluoroquinolones and the Risk of Aortopathy (free) AND Fluoroquinolone use and risk of aortic aneurysm and dissection (free study and commentaries) AND Committee Recommends New Restrictions on the use of Fluoroquinolones (free report and commentaries) AND FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions (free report and commentaries) AND When antibiotics turn toxic (free commentary)

 


Meta-Analysis: Proton Pump Inhibitors and Risk of Hip Fracture

7 Jan, 2019 | 19:35h | UTC

Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies – Osteoporosis International (link to abstract – $ for full-text)

Commentary: PPIs up risk for hip fracture in large meta-analysis – Univadis (free registration required)

 

Related Commentary on Twitter


Consensus Statement on Statin Intolerance

7 Jan, 2019 | 03:45h | UTC

2019 Taiwan Society of Lipids and Atherosclerosis expert consensus statement on statin intolerance – Journal of the Formosan Medical Association (free)

 


Review: Defining Pediatric Polypharmacy

3 Jan, 2019 | 11:17h | UTC

Defining pediatric polypharmacy: A scoping review – PLOS One (free)

 


Guideline: ADA 2019 Standards of Medical Care in Diabetes

22 Dec, 2018 | 12:35h | UTC

Just Out! Guideline: ADA 2020 Standards of Medical Care in Diabetes (free guideline and topics)

 

ADA 2019 Standards of Medical Care in Diabetes (free supplement)

News Release: Patient-centered Care is the Focus and Priority of the 2019 Standards of Medical Care in Diabetes, Published Today by the American Diabetes Association (free)

Summary of Revisions: Standards of Medical Care in Diabetes—2019 (free)

See also: Standards of Medical Care in Diabetes—2019 Abridged for Primary Care Providers (free PDF)

 

Related Commentary on Twitter


A Prescription for Enhancing Electronic Prescribing Safety

13 Dec, 2018 | 23:51h | UTC

A Prescription for Enhancing Electronic Prescribing Safety – Health Affairs (free)

Commentary: A prescription for enhancing electronic prescribing safety – PSNet (free)

 


CDC Report: Drugs Most Frequently Involved in Drug Overdose Deaths

13 Dec, 2018 | 23:48h | UTC

Drugs Most Frequently Involved in Drug Overdose Deaths: United States, 2011–2016 – Centers for Disease Control and Prevention (free PDF)

Commentary: CDC: Top 10 Drugs Involved in Drug Overdose Deaths – MPR (free)

 


Report: Medication Administration Errors and Mortality

13 Dec, 2018 | 19:48h | UTC

Medication administration errors and mortality: Incidents reported in England and Wales between 2007 ̶ 2016 – Research in Social and Administrative Pharmacy (free)

Commentary: New study sheds light on medication administration errors leading to death — omission is a common cause – University of Eastern Finland (free)

 


AHA Statement: Statin Safety and Associated Adverse Events

13 Dec, 2018 | 19:46h | UTC

Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association – Arteriosclerosis, Thrombosis, and Vascular Biology (free PDF)

News Release: Statins have low risk of side effects (free)

 


Special Issue: Comorbidities, Deprescribing, and the Healthcare of Older People

13 Dec, 2018 | 19:24h | UTC

Comorbidities, Deprescribing, and the Healthcare of Older People – Public Policy & Aging Report (free articles)

Commentary: Deprescribing can be valuable tool in managing polypharmacy, experts say – The Gerontological Society of America (free)

Related: Deprescribing: the fightback against polypharmacy has begun – The Pharmaceutical Journal (free) AND Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)

 


Review: Immune-related Adverse Events of Immune Checkpoint Inhibitors

13 Dec, 2018 | 19:02h | UTC

Immune-related adverse events of immune checkpoint inhibitors: a brief review – Current Oncology (free)

Related: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

 


Review: Increased Risk of Metabolic Syndrome in Antidepressants Users

13 Dec, 2018 | 18:06h | UTC

Increased Risk of Metabolic Syndrome in Antidepressants Users: A Mini Review – Frontiers in Psychiatry (free)

 


Guidelines for Older People with Multimorbidity and Life-Limiting Illness: Implications for Deprescribing

4 Dec, 2018 | 00:01h | UTC

Clinical practice guidelines for older people with multimorbidity and life-limiting illness: what are the implications for deprescribing? – Therapeutic Advances in Drug Safety (free)

 


Review: Medical Treatment of Female Overactive Bladder Syndrome and Treatment-Related Effects

2 Dec, 2018 | 21:14h | UTC

Medical treatment of female overactive bladder syndrome and treatment-related effects – Journal of the Formosan Medical Association (free)

 


Meta-analysis: Fluoroquinolones and the Risk of Aortopathy

30 Nov, 2018 | 03:06h | UTC

Fluoroquinolones and the risk of aortopathy: A systematic review and meta-analysis – International Journal of Cardiology (free)

“…current fluoroquinolone use was significantly associated with increased risk of aortic aneurysm and dissection.”

 


Study: Cardiovascular Toxicities Associated with Immune Checkpoint Inhibitors

30 Nov, 2018 | 02:56h | UTC

Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Cardiovascular Toxicities Associated With Immune Checkpoint Inhibitor Treatment – The ASCO Post (free)

Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)

Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

 


Study: Trazodone Associated Risks

30 Nov, 2018 | 02:40h | UTC

Comparative risk of harm associated with trazodone or atypical antipsychotic use in older adults with dementia: a retrospective cohort study – Canadian Medical Association Journal (free)

Commentaries: Study finds alternative to antipsychotic medication for seniors also has drawbacks – The Globe and Mail (free) AND Trazadone linked to more falls, major fractures in dementia patients – UPI (free) AND Trazadone associated with similar risk of falls and major fractures as antipsychotics in seniors with dementia – Canadian Medical Association Journal (free) AND Aggression in Dementia: Alternatives to Antipsychotics Also Have Side Effects – MedicalResearch.com (free)

 


Review: Cannabinoids for Chronic Pain

30 Nov, 2018 | 01:45h | UTC

Cannabinoids for Chronic Pain – Therapeutics Initiative (free)

Related: Meta-Analysis: Cannabinoids for the Treatment of Chronic Noncancer Pain Conditions (free) AND Guideline for Prescribing Medical Cannabinoids in Primary Care (free article and commentary)

“At the present time we lack good evidence that any cannabis-derived product works for chronic pain”

 


Review: Opioids and Cardiac Arrhythmia

30 Nov, 2018 | 01:27h | UTC

Opioids and Cardiac Arrhythmia: A Literature Review – Medical Principles and Practice (free)

 


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